Karl D. Straub

High Impact

Researcher

UAMS primary University of Arkansas

Also affiliated: AT&T (United States) (1984); National Institute of Standards and Technology (1997); United States Department of Veterans Affairs (1982–1998); University of Freiburg (1970); Duke University (1965–1998); Universität Ulm (1969–1972); University of California, Irvine (1989–1994); University of Arkansas Medical Center (1974–2003); Heinz Maier-Leibnitz Zentrum (2011–2014); Central Arkansas Veterans Healthcare System (2015–2024); The Ark (1976); Duke Medical Center (1969); Irvine University (1988–1994); Center for Free-Electron Laser Science (1994); Zentrum für Kinderheilkunde (1970); John L. McClellan Memorial Veterans Hospital (1986–2013); Arkansas Department of Agriculture (1977); Institute of Chemical Kinetics and Combustion (1997); University of Oklahoma Health Sciences Center (1984); Technical University of Munich (2011–2021); Nokia (United States) (1979); Mathematical Sciences Research Institute (1979)

Faculty Researcher

29 h-index 136 pubs 2,948 cited

Research Areas

Biomedical Subjects

Links

Lab Website

OverviewAI-generated summary

Karl D. Straub's research investigates the biochemical reactions of hydrogen sulfide (H2S) with quinones, particularly focusing on how polyphenols, coenzyme Q10, and naphthoquinones facilitate the oxidation of H2S to polysulfides and thiosulfate. This work explores novel mechanisms underlying the biological actions of various compounds, including antioxidant nutraceuticals, and their effects on cellular sulfur metabolism and signaling. His investigations delve into the reaction mechanisms of H2S oxidation by naphthoquinones, with implications for potential therapeutic applications.

Straub has published extensively on these topics, with his recent work appearing in journals such as Free Radical Biology and Medicine and Redox Biology. His scholarship metrics include an h-index of 28 and over 2,800 citations from 135 publications, recognizing him as a highly cited researcher. He maintains an active laboratory website to share his research findings.

Metrics

h-index: 29
Publications: 136
Citations: 2,948

Selected Publications

The SOD1 Inhibitor, LCS-1, Oxidizes H2S to Reactive Sulfur Species, Directly and Indirectly, through Conversion of SOD1 to an Oxidase (2024)

Antioxidants 4 citations DOI OpenAlex
Reaction Mechanisms of H2S Oxidation by Naphthoquinones (2024)

Antioxidants 5 citations DOI OpenAlex
Redox and Nucleophilic Reactions of Naphthoquinones with Small Thiols and Their Effects on Oxidization of H2S to Inorganic and Organic Hydropolysulfides and Thiosulfate (2023)

International Journal of Molecular Sciences 7 citations DOI OpenAlex
Naphthoquinones Oxidize H2S to Polysulfides and Thiosulfate, Implications for Therapeutic Applications (2022)

International Journal of Molecular Sciences 7 citations DOI OpenAlex
The Effects of Antioxidant Nutraceuticals on Cellular Sulfur Metabolism and Signaling (2022)

Antioxidants and Redox Signaling 8 citations DOI OpenAlex
Coenzyme Q10 and related quinones oxidize H2S to polysulfides and thiosulfate (2022)

Free Radical Biology and Medicine 16 citations DOI OpenAlex
‘Antioxidant’ berries, anthocyanins, resveratrol and rosmarinic acid oxidize hydrogen sulfide to polysulfides and thiosulfate: A novel mechanism underlying their biological actions (2021)

Free Radical Biology and Medicine 24 citations DOI OpenAlex
Oxidation of Hydrogen Sulfide by Quinones: How Polyphenols Initiate Their Cytoprotective Effects (2021)

International Journal of Molecular Sciences 25 citations DOI OpenAlex
Manganese Porphyrin-Based SOD Mimetics Produce Polysulfides from Hydrogen Sulfide (2019)

Antioxidants 25 citations DOI OpenAlex
An Effective Electric Dipole Model for Voltage-induced Gating Mechanism of Lysenin (2019)

Scientific Reports 4 citations DOI OpenAlex
Fluorescence quenching by metal centered porphyrins and poryphyrin enzymes (2017)

PMC OpenAlex
Metabolism of hydrogen sulfide (H2S) and Production of Reactive Sulfur Species (RSS) by superoxide dismutase (2017)

PMC 3 citations OpenAlex
Metabolism of hydrogen sulfide (H2S) and Production of Reactive Sulfur Species (RSS) by superoxide dismutase (2017)

Redox Biology 174 citations DOI OpenAlex
Fluorescence quenching by metal centered porphyrins and poryphyrin enzymes (2017)

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 22 citations DOI OpenAlex
Catalase as a sulfide-sulfur oxido-reductase: An ancient (and modern?) regulator of reactive sulfur species (RSS) (2017)

PMC OpenAlex