Mona I. Churchwell
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Also affiliated: University of Southern California (2007); Centers for Disease Control and Prevention (2005); Roswell Park Comprehensive Cancer Center (2008); National Institutes of Health (1998–2005); United States Food and Drug Administration (1993–2023); University of British Columbia (1996); University of Illinois Urbana-Champaign (2005); University of Rhode Island (2003); United States Public Health Service (2000); National Institute of Environmental Health Sciences (2000); Orszagos Kornyezetegeszsegugyi Intezet (2005); National Cancer Institute (1998–2005); National Center for Epidemiology (2005); Instituto Superior Técnico (1998–2010); Centro de Química Estrutural (1998–2010); Universidade Técnica de Lisboa (2010)
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Mona I. Churchwell's research focuses on the toxicological effects of various compounds, particularly in relation to DNA damage and metabolic pathways. Her work has investigated the formation of DNA adducts from acrylamide, exploring its conversion to glycidamide in both adult and neonatal mice. She has also studied the distribution and pharmacokinetics of compounds like genistein and bisphenol A (BPA) in animal models and humans. This includes analyzing tissue distribution of genistein in Sprague-Dawley rats and examining 24-hour human urine and serum profiles of BPA following high dietary exposure. More recently, her research has delved into the presence of BPA, bisphenol S, and related compounds in human biological samples from cashiers.
Her publications also touch upon the activation of procaspase-3 to caspase-3 as a potential anticancer strategy and the analysis of soy isoflavone conjugation using liquid chromatography-mass spectrometry. Churchwell has a substantial publication record, with 114 total publications and an h-index of 50, indicating significant impact in her field. She has collaborated with other researchers at the National Center for Toxicological Research, including Volodymyr Tryndyak, Frederick A. Beland, Michelle M. Vanlandingham, and Daniel R. Doerge.
Metrics
- h-index: 50
- Publications: 114
- Citations: 6,998
Selected Publications
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Evaluating the toxicokinetics of some metabolites of a C6 polyfluorinated compound, 6:2 fluorotelomer alcohol in pregnant and nonpregnant rats after oral exposure to the parent compound (2023)
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Reduction by, ligand exchange among, and covalent binding to glutathione and cellular thiols link metabolism and disposition of dietary arsenic species with toxicity (2020)
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In vivo localization and postmortem stability of benzo[a]pyrene‐DNA adducts (2019)
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A two-year toxicology study of bisphenol A (BPA) in Sprague-Dawley rats: CLARITY-BPA core study results (2019)
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Experimental and pan-cancer genome analyses reveal widespread contribution of acrylamide exposure to carcinogenesis in humans (2019)
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Genotoxic and Epigenotoxic Alterations in the Lung and Liver of Mice Induced by Acrylamide: A 28 Day Drinking Water Study (2019)
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Comparative estrogenicity of endogenous, environmental and dietary estrogens in pregnant women II: Total estrogenicity calculations accounting for competitive protein and receptor binding and potency (2018)
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Acrylamide Production in Autoclaved Rodent Feed (2018)
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Effect of aflatoxin B1, benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells (2018)
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Abstract 3088: Deciphering components of mutational signatures arising from carcinogen co-exposures: A genome-scale experimental approach (2018)
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Comparative estrogenicity of endogenous, environmental and dietary estrogens in pregnant women I: Serum levels, variability and the basis for urinary biomonitoring of serum estrogenicity (2018)
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Experimental analysis of exome-scale mutational signature of glycidamide, the reactive metabolite of acrylamide (2018)
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Metabolism and disposition of arsenic species from controlled oral dosing with sodium arsenite in adult female CD-1 mice. I. Pilot study to determine dosing, analytical measurements, and sampling strategies (2017)
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Metabolism and pharmacokinetics of zearalenone following oral and intravenous administration in juvenile female pigs (2017)
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Urine and serum biomonitoring of exposure to environmental estrogens II: Soy isoflavones and zearalenone in pregnant women (2016)
Collaboration Network
Top Collaborators
- Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy
- Pharmacokinetics of bisphenol A in humans following a single oral administration
- Identification of the Colored Guaiacol Oxidation Product Produced by Peroxidases
- Mass Spectrometric Determination of Genistein Tissue Distribution in Diet-Exposed Sprague-Dawley Rats
- DNA Adduct Formation from Acrylamide via Conversion To Glycidamide in Adult and Neonatal Mice
Showing 5 of 80 shared publications
- DNA Adduct Formation from Acrylamide via Conversion To Glycidamide in Adult and Neonatal Mice
- DNA adducts derived from administration of acrylamide and glycidamide to mice and rats
- Synthesis and Characterization of N-Demethylated Metabolites of Malachite Green and Leucomalachite Green
- High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry for the Detection and Quantitation of Benzo[a]pyrene−DNA Adducts
- Experimental and pan-cancer genome analyses reveal widespread contribution of acrylamide exposure to carcinogenesis in humans
Showing 5 of 32 shared publications
- Pharmacokinetics of bisphenol A in humans following a single oral administration
- DNA adducts derived from administration of acrylamide and glycidamide to mice and rats
- Toxicokinetics of acrylamide and glycidamide in Fischer 344 rats
- NIEHS/FDA CLARITY-BPA research program update
- 24-hour human urine and serum profiles of bisphenol A: Evidence against sublingual absorption following ingestion in soup
Showing 5 of 24 shared publications
- DNA Adduct Formation from Acrylamide via Conversion To Glycidamide in Adult and Neonatal Mice
- DNA adducts derived from administration of acrylamide and glycidamide to mice and rats
- NIEHS/FDA CLARITY-BPA research program update
- Cytogenetic Damage Induced by Acrylamide and Glycidamide in Mammalian Cells: Correlation with Specific Glycidamide-DNA Adducts
- Inhibition of Extrahepatic Human Cytochromes P450 1A1 and 1B1 by Metabolism of Isoflavones Found in Trifolium pratense (Red Clover)
Showing 5 of 15 shared publications
- DNA Adduct Formation from Acrylamide via Conversion To Glycidamide in Adult and Neonatal Mice
- Metabolism of Biochanin A and Formononetin by Human Liver Microsomes in Vitro
- Formation of N-(Carboxymethyl)fumonisin B1, Following the Reaction of Fumonisin B1 with Reducing Sugars
- Cytogenetic Damage Induced by Acrylamide and Glycidamide in Mammalian Cells: Correlation with Specific Glycidamide-DNA Adducts
- Synthesis, Characterization, and Quantitation of a 4-Aminobiphenyl−DNA Adduct Standard
Showing 5 of 14 shared publications
- Mass Spectrometric Determination of Genistein Tissue Distribution in Diet-Exposed Sprague-Dawley Rats
- Placental transfer of the soy isoflavone genistein following dietary and gavage administration to Sprague Dawley rats
- NIEHS/FDA CLARITY-BPA research program update
- Comparison of Life-Stage-Dependent Internal Dosimetry for Bisphenol A, Ethinyl Estradiol, a Reference Estrogen, and Endogenous Estradiol to Test an Estrogenic Mode of Action in Sprague Dawley Rats
- A two-year toxicology study of bisphenol A (BPA) in Sprague-Dawley rats: CLARITY-BPA core study results
Showing 5 of 11 shared publications
- NIEHS/FDA CLARITY-BPA research program update
- Formation of N-(Carboxymethyl)fumonisin B1, Following the Reaction of Fumonisin B1 with Reducing Sugars
- Photodecomposition of Pigment Yellow 74, a Pigment Used in Tattoo Inks¶
- Identification of Ceramides in Human Cells Using Liquid Chromatography with detection by Atmospheric Pressure Chemical Ionization-Mass Spectrometry
- DNA adduct formation by Fusarium culture extracts: lack of role of fusarin C
Showing 5 of 8 shared publications
- Mass Spectrometric Determination of Genistein Tissue Distribution in Diet-Exposed Sprague-Dawley Rats
- Placental transfer of the soy isoflavone genistein following dietary and gavage administration to Sprague Dawley rats
- NIEHS/FDA CLARITY-BPA research program update
- Mass spectrometric determination of p-nonylphenol metabolism and disposition following oral administration to Sprague-Dawley rats
- Lactational transfer of the soy isoflavone, genistein, in Sprague–Dawley rats consuming dietary genistein
Showing 5 of 7 shared publications
- NIEHS/FDA CLARITY-BPA research program update
- Comparison of Life-Stage-Dependent Internal Dosimetry for Bisphenol A, Ethinyl Estradiol, a Reference Estrogen, and Endogenous Estradiol to Test an Estrogenic Mode of Action in Sprague Dawley Rats
- A two-year toxicology study of bisphenol A (BPA) in Sprague-Dawley rats: CLARITY-BPA core study results
- Quantification of deuterated bisphenol A in serum, tissues, and excreta from adult Sprague‐Dawley rats using liquid chromatography with tandem mass spectrometry
- Metabolism and disposition of arsenic species from controlled oral dosing with sodium arsenite in adult female CD-1 mice. I. Pilot study to determine dosing, analytical measurements, and sampling strategies
Showing 5 of 7 shared publications
- Twenty-Four Hour Human Urine and Serum Profiles of Bisphenol A during High-Dietary Exposure
- 24-hour human urine and serum profiles of bisphenol A: Evidence against sublingual absorption following ingestion in soup
- Urine and serum biomonitoring of exposure to environmental estrogens II: Soy isoflavones and zearalenone in pregnant women
- Urine and serum biomonitoring of exposure to environmental estrogens I: Bisphenol A in pregnant women
- 24-hour human urine and serum profiles of bisphenol A following ingestion in soup: Individual pharmacokinetic data and emographics
Showing 5 of 7 shared publications
- DNA Adduct Formation from Acrylamide via Conversion To Glycidamide in Adult and Neonatal Mice
- High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry for the Detection and Quantitation of Benzo[a]pyrene−DNA Adducts
- DNA adduct formation and induction of micronuclei and mutations in B6C3F1/Tk mice treated neonatally with acrylamide or glycidamide
- Evaluation of serum and liver toxicokinetics for furan and liver DNA adduct formation in male Fischer 344 rats
- In vivo localization and postmortem stability of benzo[a]pyrene‐DNA adducts
Showing 5 of 6 shared publications
- Metabolism of Biochanin A and Formononetin by Human Liver Microsomes in Vitro
- Inhibition of Extrahepatic Human Cytochromes P450 1A1 and 1B1 by Metabolism of Isoflavones Found in Trifolium pratense (Red Clover)
- Identification of Ceramides in Human Cells Using Liquid Chromatography with detection by Atmospheric Pressure Chemical Ionization-Mass Spectrometry
- Effect of p53 Genotype on Gene Expression and DNA Adducts in ENU‐Exposed Mice
- Identification of Ceramides in Human Cells Using Liquid Chromatography with detection by Atmospheric Pressure Chemical Ionization‐Mass Spectrometry
- DNA adducts derived from administration of acrylamide and glycidamide to mice and rats
- Toxicokinetics of acrylamide and glycidamide in Fischer 344 rats
- Determination of acrylamide and glycidamide serum toxicokinetics in B6C3F1 mice using LC–ES/MS/MS
- Relationships between biomarkers of exposure and toxicokinetics in Fischer 344 rats and B6C3F1 mice administered single doses of acrylamide and glycidamide and multiple doses of acrylamide
- Autoclave Sterilization Produces Acrylamide in Rodent Diets: Implications for Toxicity Testing
- High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry for the Detection and Quantitation of Benzo[a]pyrene−DNA Adducts
- High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry for the Detection and Quantitation of Pyrrolizidine Alkaloid-Derived DNA Adducts in Vitro and in Vivo
- Identification of DNA Adducts Derived from Riddelliine, a Carcinogenic Pyrrolizidine Alkaloid
- Development of a 32P-Postlabeling/HPLC Method for Detection of Dehydroretronecine-Derived DNA Adducts in Vivo and in Vitro
- Mass spectrometric analysis of 2′-deoxyribonucleoside and 2′-deoxyribonucleotide adducts with aldehydes derived from lipid peroxidation
- Mass Spectrometric Determination of Genistein Tissue Distribution in Diet-Exposed Sprague-Dawley Rats
- Placental transfer of the soy isoflavone genistein following dietary and gavage administration to Sprague Dawley rats
- Mass spectrometric determination of p-nonylphenol metabolism and disposition following oral administration to Sprague-Dawley rats
- Mechanism for Inhibition of Thyroid Peroxidase by Leucomalachite Green
- Inactivation of Coprinus cinereus peroxidase by 4-chloroaniline during turnover: comparison with horseradish peroxidase and bovine lactoperoxidase
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