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Presence Current · Arkansas
Last published 2026
Sources OpenAlex · ORCID
Refreshed 2026-08-08
Lee Isaac profile photo

Lee Isaac

Assistant Professor

Also affiliated: Children's Hospital of Philadelphia (2019); University of Arkansas Medical Center (2026)

Faculty Researcher

College of Medicine Administration

1 h-index 8 pubs 18 cited

  • Female
  • Humans
  • Male
  • Adult
  • Retrospective Studies
  • Young Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Brain
  • Cognition
  • Middle Aged
  • Executive Function
  • White Matter
  • Orientation, Spatial

Biography and Research Information

OverviewAI-generated summary

Dr. Lee Isaac's research focuses on geriatric neuropsychology, with scholarly interests in diagnostic specificity in dementia, the prediction of amyloid-related imaging abnormalities (ARIA), and the relationship between neuropsychiatric symptoms and white matter integrity in aging brains. He holds several leadership positions within the University of Arkansas for Medical Sciences' College of Medicine, including director of the Neuropsychology Service and co-director of the Behavioral Neurology Clinic. Dr. Isaac is also involved in the training of fellows and interns in neuropsychology. His recent publications investigate dementia risk factor knowledge in rural older adults, age-related effects on white matter structure related to cognitive flexibility, and the use of embedded measures to distinguish cognitive impairment severity in older adults. His work includes retrospective studies and examines populations across the adult lifespan.

Research Overview

Dr. Lee Isaac is a geriatric neuropsychologist in the Department of Psychiatry. He holds several director roles, including director of the Neuropsychology Service, co-director of the Behavioral Neurology Clinic, and Associate Director of the Psychiatry Resident Academic Track. Dr. Isaac is also involved in training as a part of the Neuropsychology APPCN fellowship and internship at UAMS, and his current scholarly interests include diagnostic specificity in dementia, prediction of ARIA, and the relationship between neuropsychiatric symptoms and white matter integrity.

Metrics

  • h-index: 1
  • Publications: 8
  • Citations: 18

Selected Publications

  • Population-Level Age Effects on the White Matter Structure Subserving Cognitive Flexibility in the Human Brain (2026)
    eNeuro 1 citation DOI OpenAlex
  • Judgement of Line Orientation error analysis distinguishes between severity of cognitive impairment in older adults (2025)
    Journal of Clinical and Experimental Neuropsychology DOI OpenAlex
  • Population-level age effects on the white matter structure subserving cognitive flexibility in the human brain (2024)
    bioRxiv (Cold Spring Harbor Laboratory) DOI OpenAlex
  • 60 Are all Embedded Measures Created Equal? A look at Embedded PVTs in Major Neurocognitive Disorder (2023)
    Journal of the International Neuropsychological Society DOI OpenAlex

View all publications on OpenAlex →

Collaboration Network

17 Collaborators 3 Institutions 1 Country

Top Collaborators

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