Match tier
Confirmed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
D
Darshan Mehta
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Visiting Scientist
Also affiliated: United States Food and Drug Administration (2019–2025); Dwarkadas J. Sanghvi College of Engineering (2023); Sunovion (United States) (2019); The Ohio State University (2016–2018); Vion Pharmaceuticals (United States) (2019)
7 h-index
31 pubs
289 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Darshan Mehta's research investigates the characterization of potential drug compounds and the assessment of drug safety. His work includes studies on serious adverse drug reactions by analyzing FDA-approved drug labeling and the Medical Dictionary for Regulatory Activities (MedDRA). Mehta also explores the application of pharmacogenomic information within FDA drug labeling to advance precision medicine. His research has extended to evaluating the biopersistence and toxicity of specific chemical compounds, such as fluorotelomer carboxylic acid and NNK, utilizing various exposure routes and animal models. He also employs physiologically based pharmacokinetic (PBPK) modeling for estimating drug metabolism and ADME processes in different populations, including neonates. Mehta has authored 31 publications and has an h-index of 7 with 289 citations. He has collaborated with researchers at the National Center for Toxicological Research, including Matthew Bryant, Kiara Fairman, Noriko Nakamura, and Mani Chidambaram.
Metrics
- h-index: 7
- Publications: 31
- Citations: 289
Positions
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Visiting Scientist 2019–presentNational Center for Toxicological Research Division of Biochemical Toxicology ORCID
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ORISE Fellow 2018–2019National Center for Toxicological Research Division of Biochemical Toxicology ORCID
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ORISE Research Participant 2017–2018National Center for Toxicological Research Office of Scientific Coordination ORCID
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ORISE Research Participant 2016–2017Center for Food Safety and Applied Nutrition Office of Food Additive Safety ORCID
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Manager 2008–2010Reliance Industries Limited Central Technical Services ORCID
Selected Publications
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Physiologically based pharmacokinetic modeling of oseltamivir in pregnant rhesus macaques to inform clinical dosing across trimesters (2025)
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Applications of PBPK Modeling to Estimate Drug Metabolism and Related ADME Processes in Specific Populations (2025)
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Evaluation of a microphysiological human placental barrier model for studying placental drug transfer (2023)
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Physiologically Based Pharmacokinetic Modeling of Extracellular Vesicles (2023)
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Single Gene Mutations in Pkd1 or Tsc2 Alter Extracellular Vesicles Production and Trafficking (2022)
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In vivo pharmacokinetic analyses of placental transfer of three drugs of different physicochemical properties in pregnant rats (2022)
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Single Gene Mutations in Pkd1 or Tsc2 Alter Extracellular Vesicle Production and Trafficking (2022)
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Challenges in predicting the pharmacokinetics of drugs in premature and mature newborns (2021)
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Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage (2021)
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List of contributors (2020)
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Chemical absorption and writing code for portals of entry (2020)
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Fundamentals of physiologically based pharmacokinetic modeling (2020)
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Study of pharmacogenomic information in FDA-approved drug labeling to facilitate application of precision medicine (2020)
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Characterizing biopersistence potential of the metabolite 5:3 fluorotelomer carboxylic acid after repeated oral exposure to the 6:2 fluorotelomer alcohol (2020)
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Ontogeny equations with probability distributions for anthropomorphic measurements in preterm and term neonates and infants for use in a PBPK model (2019)
Collaboration Network
Top Collaborators
Jeffrey W. Fisher
National Center for Toxicological Research (US)
7 shared publications
- Characterizing biopersistence potential of the metabolite 5:3 fluorotelomer carboxylic acid after repeated oral exposure to the 6:2 fluorotelomer alcohol
- Ontogeny equations with probability distributions for anthropomorphic measurements in preterm and term neonates and infants for use in a PBPK model
- In vivo pharmacokinetic analyses of placental transfer of three drugs of different physicochemical properties in pregnant rats
- Fundamentals of physiologically based pharmacokinetic modeling
- Chemical absorption and writing code for portals of entry
Showing 5 of 7 shared publications
Xiaoxia Yang
Center for Drug Evaluation and Research (US)
3 shared publications
- Ontogeny equations with probability distributions for anthropomorphic measurements in preterm and term neonates and infants for use in a PBPK model
- Fundamentals of physiologically based pharmacokinetic modeling
- Challenges in predicting the pharmacokinetics of drugs in premature and mature newborns
Matthew Bryant
National Center for Toxicological Research
3 shared publications
In database
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- In vivo pharmacokinetic analyses of placental transfer of three drugs of different physicochemical properties in pregnant rats
- Evaluation of a microphysiological human placental barrier model for studying placental drug transfer
Prashant Kumar
National Center for Toxicological Research (US)
3 shared publications
- Physiologically Based Pharmacokinetic Modeling of Extracellular Vesicles
- Single Gene Mutations in Pkd1 or Tsc2 Alter Extracellular Vesicle Production and Trafficking
- Single Gene Mutations in Pkd1 or Tsc2 Alter Extracellular Vesicles Production and Trafficking
John J. Bissler
St. Jude Children's Research Hospital (US)
3 shared publications
- Physiologically Based Pharmacokinetic Modeling of Extracellular Vesicles
- Single Gene Mutations in Pkd1 or Tsc2 Alter Extracellular Vesicle Production and Trafficking
- Single Gene Mutations in Pkd1 or Tsc2 Alter Extracellular Vesicles Production and Trafficking
Leihong Wu
National Center for Toxicological Research
2 shared publications
In database
- Study of serious adverse drug reactions using FDA-approved drug labeling and MedDRA
- Study of pharmacogenomic information in FDA-approved drug labeling to facilitate application of precision medicine
Taylor Ingle
National Center for Toxicological Research
2 shared publications
In database
- Study of serious adverse drug reactions using FDA-approved drug labeling and MedDRA
- Study of pharmacogenomic information in FDA-approved drug labeling to facilitate application of precision medicine
Zhichao Liu
National Center for Toxicological Research (US)
2 shared publications
- Study of serious adverse drug reactions using FDA-approved drug labeling and MedDRA
- Study of pharmacogenomic information in FDA-approved drug labeling to facilitate application of precision medicine
Shraddha Thakkar
National Center for Toxicological Research (US)
2 shared publications
- Study of serious adverse drug reactions using FDA-approved drug labeling and MedDRA
- Study of pharmacogenomic information in FDA-approved drug labeling to facilitate application of precision medicine
Guangxu Zhou
National Center for Toxicological Research (US)
2 shared publications
- Study of serious adverse drug reactions using FDA-approved drug labeling and MedDRA
- Study of pharmacogenomic information in FDA-approved drug labeling to facilitate application of precision medicine
Junshuang Yang
National Center for Toxicological Research
2 shared publications
In database
- Study of serious adverse drug reactions using FDA-approved drug labeling and MedDRA
- Study of pharmacogenomic information in FDA-approved drug labeling to facilitate application of precision medicine
Joshua Xu
National Center for Toxicological Research
2 shared publications
In database
- Study of serious adverse drug reactions using FDA-approved drug labeling and MedDRA
- Study of pharmacogenomic information in FDA-approved drug labeling to facilitate application of precision medicine
Weida Tong
National Center for Toxicological Research
2 shared publications
In database
- Study of serious adverse drug reactions using FDA-approved drug labeling and MedDRA
- Study of pharmacogenomic information in FDA-approved drug labeling to facilitate application of precision medicine
Hong Fang
National Center for Toxicological Research
2 shared publications
In database
- Study of serious adverse drug reactions using FDA-approved drug labeling and MedDRA
- Study of pharmacogenomic information in FDA-approved drug labeling to facilitate application of precision medicine
Shruti V. Kabadi
Center for Food Safety and Applied Nutrition (US)
2 shared publications
- Characterizing biopersistence potential of the metabolite 5:3 fluorotelomer carboxylic acid after repeated oral exposure to the 6:2 fluorotelomer alcohol
- List of contributors
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