Match tier
Confirmed
Presence
Current · Arkansas
Last published
2025
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
M
Matthew Bryant
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
High Impact
Supervisory Toxicologist
Also affiliated: Boston University (1986); Merck & Co., Inc., Rahway, NJ, USA (United States) (2012); United States Food and Drug Administration (2014–2025); Massachusetts Institute of Technology (1984–1988)
35 h-index
88 pubs
3,644 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Matthew Bryant's research focuses on the toxicological evaluation of various chemical compounds and their effects on biological systems, with a particular emphasis on carcinogenicity and DNA damage. His work has investigated the toxicity of substances including Bisphenol A, silver nanoparticles, and aromatic amines. Bryant has studied the accumulation, distribution, and toxicity of these agents in animal models, such as Sprague Dawley rats and wap-ras transgenic mice, examining dose-response relationships and potential health impacts.
His research also extends to the antitumor activity of pharmaceutical agents, exploring their efficacy in human tumor xenograft models and transgenic mice. Bryant has contributed to studies on hemoglobin adducts of aromatic amines, examining their association with smoking status and passive smoke exposure. His publications include investigations into the effects of environmental stressors on biological organisms and the development of novel therapeutic agents, such as antithrombotic compounds. Bryant holds a high-impact researcher designation, evidenced by his h-index of 36 and over 3,880 citations across 94 publications. He actively collaborates with researchers at the National Center for Toxicological Research, including Xiaobo He, Nan Mei, Qiangen Wu, and Xilin Li.
Metrics
- h-index: 35
- Publications: 88
- Citations: 3,644
Positions
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Supervisory Toxicologist 2010–presentNational Center for Toxicological Research Office of Scientific Coordination ORCID
Selected Publications
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Mechanistic study of pexidartinib-induced toxicity in human hepatic cells (2025)
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Comparative DNA damage induced by eight nitrosamines in primary human and macaque hepatocytes (2025)
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An efficient enzymatic system for studying structure-carcinogenicity relationships: metabolism of pyrrolizidine alkaloids by human liver microsomes in the presence of calf thymus DNA, resulting in the formation of DNA adducts (2024)
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Pharmacokinetic analysis of nicotine and its metabolites (cotinine and <i>trans</i>-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine (2024)
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CarcSeq detection of lorcaserin-induced clonal expansion of<i>Pik3ca</i>H1047R mutants in rat mammary tissue (2024)
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The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model (2024)
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Evaluation of a microphysiological human placental barrier model for studying placental drug transfer (2023)
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The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib (2023)
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Formation of DHP-DNA Adducts from Rat Liver Microsomal Metabolism of 1,2-Unsaturated Pyrrolizidine Alkaloid-Containing Plant Extracts and Dietary Supplements (2023)
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Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s (2022)
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In vivo pharmacokinetic analyses of placental transfer of three drugs of different physicochemical properties in pregnant rats (2022)
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90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats (2021)
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Genotoxicity evaluation using primary hepatocytes isolated from rhesus macaque (Macaca mulatta) (2021)
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14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats (2021)
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Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage (2021)
Collaboration Network
Top Collaborators
Qiangen Wu
National Center for Toxicological Research
17 shared publications
In database
- Effects of 31 FDA approved small-molecule kinase inhibitors on isolated rat liver mitochondria
- The role of CYP 3A4 and 1A1 in amiodarone-induced hepatocellular toxicity
- Quantitative comparison of in vitro genotoxicity between metabolically competent HepaRG cells and HepG2 cells using the high-throughput high-content CometChip assay
- Evaluating Mode of Action of Acrolein Toxicity in an In Vitro Human Airway Tissue Model
- Cytotoxicity of 34 FDA approved small-molecule kinase inhibitors in primary rat and human hepatocytes
Showing 5 of 17 shared publications
Kelly J. Davis
National Center for Toxicological Research
11 shared publications
In database
- Toxicity Evaluation of Bisphenol A Administered by Gavage to Sprague Dawley Rats From Gestation Day 6 Through Postnatal Day 90
- A two-year toxicology study of bisphenol A (BPA) in Sprague-Dawley rats: CLARITY-BPA core study results
- Evaluating Mode of Action of Acrolein Toxicity in an In Vitro Human Airway Tissue Model
- Disease-related responses induced by cadmium in an in vitro human airway tissue model
- Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model
Showing 5 of 11 shared publications
Xiaobo He
National Center for Toxicological Research
11 shared publications
In database
- The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- Evaluation of pyrrolizidine alkaloid-induced genotoxicity using metabolically competent TK6 cell lines
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Pharmacokinetic analysis of nicotine and its metabolites (cotinine and <i>trans</i>-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine
Showing 5 of 11 shared publications
Hans Rosenfeldt
Japan Tobacco (United States) (US)
9 shared publications
- Evaluating Mode of Action of Acrolein Toxicity in an In Vitro Human Airway Tissue Model
- Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model
- In vitro dosimetry analyses for acrolein exposure in normal human lung epithelial cells and human lung cancer cells
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- Effects of cellular differentiation in human primary bronchial epithelial cells: Metabolism of 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone
Showing 5 of 9 shared publications
Nan Mei
Genetic Analysis (Norway)
9 shared publications
In database
- The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells
- Quantitative comparison of in vitro genotoxicity between metabolically competent HepaRG cells and HepG2 cells using the high-throughput high-content CometChip assay
- The role of hepatic cytochrome P450s in the cytotoxicity of sertraline
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- Performance of high-throughput CometChip assay using primary human hepatocytes: a comparison of DNA damage responses with in vitro human hepatoma cell lines
Showing 5 of 9 shared publications
Sherry M. Lewis
National Center for Toxicological Research
8 shared publications
In database
- Toxicity Evaluation of Bisphenol A Administered by Gavage to Sprague Dawley Rats From Gestation Day 6 Through Postnatal Day 90
- NIEHS/FDA CLARITY-BPA research program update
- A two-year toxicology study of bisphenol A (BPA) in Sprague-Dawley rats: CLARITY-BPA core study results
- Comparison of endpoints relevant to toxicity assessments in 3 generations of CD-1 mice fed irradiated natural and purified ingredient diets with varying soy protein and isoflavone contents
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
Showing 5 of 8 shared publications
Raúl Trbojevich
National Center for Toxicological Research
8 shared publications
In database
- Toxicity Evaluation of Bisphenol A Administered by Gavage to Sprague Dawley Rats From Gestation Day 6 Through Postnatal Day 90
- Effects of Maternal and Lactational Exposure to 2‐Hydroxy‐4‐Methoxybenzone on Development and Reproductive Organs in Male and Female Rat Offspring
- Disease-related responses induced by cadmium in an in vitro human airway tissue model
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- Comparative study of silver nanoparticle permeation using Side-Bi-Side and Franz diffusion cells
Showing 5 of 8 shared publications
Lei Guo
Biochemical Society
8 shared publications
In database
- The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells
- The role of CYP 3A4 and 1A1 in amiodarone-induced hepatocellular toxicity
- The role of hepatic cytochrome P450s in the cytotoxicity of sertraline
- Evaluation of pyrrolizidine alkaloid-induced genotoxicity using metabolically competent TK6 cell lines
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
Showing 5 of 8 shared publications
Xuefei Cao
National Center for Toxicological Research
8 shared publications
In database
- Evaluating Mode of Action of Acrolein Toxicity in an In Vitro Human Airway Tissue Model
- Disease-related responses induced by cadmium in an in vitro human airway tissue model
- Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model
- Assessing the respiratory toxicity of dihydroxyacetone using an in vitro human airway epithelial tissue model
- In vitro dosimetry analyses for acrolein exposure in normal human lung epithelial cells and human lung cancer cells
Showing 5 of 8 shared publications
Levan Muskhelishvili
7 shared publications
- Evaluating Mode of Action of Acrolein Toxicity in an In Vitro Human Airway Tissue Model
- Disease-related responses induced by cadmium in an in vitro human airway tissue model
- Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model
- Interstrain differences in the progression of nonalcoholic steatohepatitis to fibrosis in mice are associated with altered hepatic iron metabolism
- Assessing the respiratory toxicity of dihydroxyacetone using an in vitro human airway epithelial tissue model
Showing 5 of 7 shared publications
Xiaoqing Guo
National Center for Toxicological Research
7 shared publications
In database
- Quantitative comparison of in vitro genotoxicity between metabolically competent HepaRG cells and HepG2 cells using the high-throughput high-content CometChip assay
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
- Performance of high-throughput CometChip assay using primary human hepatocytes: a comparison of DNA damage responses with in vitro human hepatoma cell lines
- Evaluation of pyrrolizidine alkaloid-induced genotoxicity using metabolically competent TK6 cell lines
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
Showing 5 of 7 shared publications
Kellie A. Woodling
National Center for Toxicological Research
6 shared publications
In database
- Toxicity Evaluation of Bisphenol A Administered by Gavage to Sprague Dawley Rats From Gestation Day 6 Through Postnatal Day 90
- NIEHS/FDA CLARITY-BPA research program update
- A two-year toxicology study of bisphenol A (BPA) in Sprague-Dawley rats: CLARITY-BPA core study results
- Comparison of endpoints relevant to toxicity assessments in 3 generations of CD-1 mice fed irradiated natural and purified ingredient diets with varying soy protein and isoflavone contents
- Rapid quantitation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in rat urine using ultra-fast liquid chromatography mass spectrometry (UFLC/MS/MS)
Showing 5 of 6 shared publications
Ralph E. Patton
6 shared publications
In database
- A two-year toxicology study of bisphenol A (BPA) in Sprague-Dawley rats: CLARITY-BPA core study results
- Effects of Maternal and Lactational Exposure to 2‐Hydroxy‐4‐Methoxybenzone on Development and Reproductive Organs in Male and Female Rat Offspring
- Comparison of endpoints relevant to toxicity assessments in 3 generations of CD-1 mice fed irradiated natural and purified ingredient diets with varying soy protein and isoflavone contents
- 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats
- 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats
Showing 5 of 6 shared publications
Estatira Sepehr
National Center for Toxicological Research (US)
6 shared publications
- Comparison of endpoints relevant to toxicity assessments in 3 generations of CD-1 mice fed irradiated natural and purified ingredient diets with varying soy protein and isoflavone contents
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage
- Rapid quantitation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in rat urine using ultra-fast liquid chromatography mass spectrometry (UFLC/MS/MS)
- Pharmacokinetic analysis of nicotine and its metabolites (cotinine and <i>trans</i>-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine
- 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats
Showing 5 of 6 shared publications
Luísa Camacho
National Center for Toxicological Research
5 shared publications
In database
- Toxicity Evaluation of Bisphenol A Administered by Gavage to Sprague Dawley Rats From Gestation Day 6 Through Postnatal Day 90
- NIEHS/FDA CLARITY-BPA research program update
- A two-year toxicology study of bisphenol A (BPA) in Sprague-Dawley rats: CLARITY-BPA core study results
- Comparison of endpoints relevant to toxicity assessments in 3 generations of CD-1 mice fed irradiated natural and purified ingredient diets with varying soy protein and isoflavone contents
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
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