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Presence
Current · Arkansas
Last published
2024
Sources
OpenAlex · ORCID
Refreshed
2026-10-01
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Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Julian E A Leakey's research has focused on the metabolic effects of caloric restriction and the development of enzymes involved in xenobiotic metabolism. His work includes studies on the impact of chronic caloric restriction on physiological variables and hepatic enzymes in male Fischer 344 rats. Leakey has also investigated the developmental expression of UDP-glucuronosyltransferase isoenzymes in rat and human liver microsomes, contributing to the understanding of perinatal glucuronidation. Further research has explored the metabolic capabilities of Cunninghamella elegans for xenobiotic metabolism and reviewed the toxicity of Usnic Acid and Usnea Barbata. Leakey has collaborated with researchers from the National Center for Toxicological Research, including Anil K. Patri, Kuppan Gokulan, Mugimane G. Manjanatha, and Nathan A. Koonce.
Metrics
- h-index: 1
- Publications: 1
- Citations: 5
Selected Publications
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Biodistribution and toxic potential of silver nanoparticles when introduced to the female rat reproductive tract (2024)
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Evaluation of Hepatic Mitochondria and Hematological Parameters in Zidovudine-Treated B6C3F1 Mice (2012)
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Assessment of usnic acid toxicity in rat primary hepatocytes using 13C isotopomer distribution analysis of lactate, glutamate and glucose (2011)
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Oral glucosamine increases expression of transforming growth factor β1 (TGFβ1) and connective tissue growth factor (CTGF) mRNA in rat cartilage and kidney: Implications for human efficacy and toxicity (2011)
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Modifying a displacement pump for oral gavage dosing of solution and suspension preparations to adult and neonatal mice (2010)
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Effect of (+)-usnic acid on mitochondrial functions as measured by mitochondria-specific oligonucleotide microarray in liver of B6C3F1 mice (2009)
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Development of the Rat Hepatic Microsomal Glucose-6-Phosphatase System and Its Glucocorticoid Inducibility (2009)
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Nucleoside reverse transcriptase inhibitors (NRTIs)-induced expression profile of mitochondria-related genes in the mouse liver (2008)
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Review of Usnic Acid and Usnea Barbata Toxicity (2008)
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Development of mitochondria-specific mouse oligonucleotide microarray and validation of data by real-time PCR (2007)
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Frequency of Hprt mutant lymphocytes and micronucleated erythrocytes in p53‐haplodeficient mice treated perinatally with AZT and AZT in combination with 3TC (2007)
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Toxicokinetics of chloral hydrate in ad libitum-fed, dietary-controlled, and calorically restricted male B6C3F1 mice following short-term exposure (2003)
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Dietary controlled carcinogenicity study of chloral hydrate in male B6C3F1 mice (2003)
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Body weight considerations in the B6C3F1 mouse and the use of dietary control to standardize background tumor incidence in chronic bioassays (2003)
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Determination of hyperforin in human plasma using solid-phase extraction and high-performance liquid chromatography with ultraviolet detection (2002)
Collaboration Network
Top Collaborators
Ronald Wilson Hart
National Center for Toxicological Research (US)
17 shared publications
- Effect of Chronic Caloric Restriction on the Synchronization of Various Physiological Measures in Old Female Fischer 344 Rats
- The Physiologic, Neurologic, and Behavioral Effects of Caloric Restriction Related to Aging, Disease, and Environmental Factors
- Effects of caloric restriction on rodent drug and carcinogen metabolizing enzymes: implications for mutagenesis and cancer
- Role of Glucocorticoids and “Caloric Stress” in Modulating the Effects of Caloric Restriction in Rodentsa
- FDA Points-to-Consider Documents: The Need for Dietary Control for the Reduction of Experimental Variability within Animal Assays and the Use of Dietary Restriction to Achieve Dietary Control
Showing 5 of 17 shared publications
P. H. Duffy
National Center for Toxicological Research (US)
15 shared publications
- Effect of chronic caloric restriction on physiological variables related to energy metabolism in the male Fischer 344 rat
- Effect of chronic caloric restriction on hepatic enzymes of intermediary metabolism in the male Fischer 344 rat
- Effects of aging and caloric restriction on hepatic drug metabolizing enzymes in the Fischer 344 rat. I: The cytochrome P-450 dependent monooxygenase system
- Effect of Chronic Caloric Restriction on the Synchronization of Various Physiological Measures in Old Female Fischer 344 Rats
- The Physiologic, Neurologic, and Behavioral Effects of Caloric Restriction Related to Aging, Disease, and Environmental Factors
Showing 5 of 15 shared publications
Ritchie J. Feuers
National Center for Toxicological Research (US)
13 shared publications
- Effect of chronic caloric restriction on physiological variables related to energy metabolism in the male Fischer 344 rat
- Effect of chronic caloric restriction on hepatic enzymes of intermediary metabolism in the male Fischer 344 rat
- Effects of aging and caloric restriction on hepatic drug metabolizing enzymes in the Fischer 344 rat. I: The cytochrome P-450 dependent monooxygenase system
- Effect of Chronic Caloric Restriction on the Synchronization of Various Physiological Measures in Old Female Fischer 344 Rats
- Effects of aging and caloric restriction on hepatic drug metabolizing enzymes in the fischer 344 rat II: Effects on conjugating enzymes
Showing 5 of 13 shared publications
Angelo Turturro
National Center for Toxicological Research (US)
11 shared publications
- Effect of chronic caloric restriction on physiological variables related to energy metabolism in the male Fischer 344 rat
- Effect of chronic caloric restriction on hepatic enzymes of intermediary metabolism in the male Fischer 344 rat
- The Physiologic, Neurologic, and Behavioral Effects of Caloric Restriction Related to Aging, Disease, and Environmental Factors
- Role of Glucocorticoids and “Caloric Stress” in Modulating the Effects of Caloric Restriction in Rodentsa
- FDA Points-to-Consider Documents: The Need for Dietary Control for the Reduction of Experimental Variability within Animal Assays and the Use of Dietary Restriction to Achieve Dietary Control
Showing 5 of 11 shared publications
William T. Allaben
National Center for Toxicological Research (US)
10 shared publications
- Effect of (+)-usnic acid on mitochondrial functions as measured by mitochondria-specific oligonucleotide microarray in liver of B6C3F1 mice
- FDA Points-to-Consider Documents: The Need for Dietary Control for the Reduction of Experimental Variability within Animal Assays and the Use of Dietary Restriction to Achieve Dietary Control
- Dietary controlled carcinogenicity study of chloral hydrate in male B6C3F1 mice
- Modulation of Chemical Toxicity by Modification of Caloric Intake
- Body weight considerations in the B6C3F1 mouse and the use of dietary control to standardize background tumor incidence in chronic bioassays
Showing 5 of 10 shared publications
John E. Seng
National Center for Toxicological Research
9 shared publications
In database
- Purification and characterization of an amidase from an acrylamide-degrading Rhodococcus sp
- Effects of caloric restriction on rodent drug and carcinogen metabolizing enzymes: implications for mutagenesis and cancer
- FDA Points-to-Consider Documents: The Need for Dietary Control for the Reduction of Experimental Variability within Animal Assays and the Use of Dietary Restriction to Achieve Dietary Control
- Effects of Caloric Restriction on Expression of Testicular Cytochrome P450 Enzymes Associated with the Metabolic Activation of Carcinogens
- Dietary controlled carcinogenicity study of chloral hydrate in male B6C3F1 mice
Showing 5 of 9 shared publications
Sherry M. Lewis
National Center for Toxicological Research
8 shared publications
In database
- Review of Usnic Acid and Usnea Barbata Toxicity
- Effect of (+)-usnic acid on mitochondrial functions as measured by mitochondria-specific oligonucleotide microarray in liver of B6C3F1 mice
- Nucleoside reverse transcriptase inhibitors (NRTIs)-induced expression profile of mitochondria-related genes in the mouse liver
- Dietary restriction in humans: report on the Little Rock Conference on the value, feasibility, and parameters of a proposed study
- Oral glucosamine increases expression of transforming growth factor β1 (TGFβ1) and connective tissue growth factor (CTGF) mRNA in rat cartilage and kidney: Implications for human efficacy and toxicity
Showing 5 of 8 shared publications
R HART
National Center for Toxicological Research (US)
5 shared publications
- Effect of chronic caloric restriction on physiological variables related to energy metabolism in the male Fischer 344 rat
- Effect of chronic caloric restriction on hepatic enzymes of intermediary metabolism in the male Fischer 344 rat
- Effects of aging and caloric restriction on hepatic drug metabolizing enzymes in the Fischer 344 rat. I: The cytochrome P-450 dependent monooxygenase system
- Effects of aging and caloric restriction on hepatic drug metabolizing enzymes in the fischer 344 rat II: Effects on conjugating enzymes
- Effects of Caloric Restriction on Expression of Testicular Cytochrome P450 Enzymes Associated with the Metabolic Activation of Carcinogens
Daniel A. Casciano
National Center for Toxicological Research (US)
4 shared publications
- Differential stability of drug-metabolizing enzyme activities in primary rat hepatocytes, cultured in the absence or presence of dexamethasone
- The use of transgenic cell lines for evaluating toxic metabolites of carbamazepine
- Modifications in Regulation of Intermediary Metabolism by Caloric Restriction in Rodents
- P48: A novel nuclear protein possibly associated with aging and mortality
Akhtar A. Ali
National Center for Toxicological Research (US)
4 shared publications
- Review of Usnic Acid and Usnea Barbata Toxicity
- Effect of (+)-usnic acid on mitochondrial functions as measured by mitochondria-specific oligonucleotide microarray in liver of B6C3F1 mice
- Oral glucosamine increases expression of transforming growth factor β1 (TGFβ1) and connective tissue growth factor (CTGF) mRNA in rat cartilage and kidney: Implications for human efficacy and toxicity
- Modifying a displacement pump for oral gavage dosing of solution and suspension preparations to adult and neonatal mice
Varsha G. Desai
National Center for Toxicological Research
4 shared publications
In database
- Effect of (+)-usnic acid on mitochondrial functions as measured by mitochondria-specific oligonucleotide microarray in liver of B6C3F1 mice
- Nucleoside reverse transcriptase inhibitors (NRTIs)-induced expression profile of mitochondria-related genes in the mouse liver
- Development of mitochondria-specific mouse oligonucleotide microarray and validation of data by real-time PCR
- Evaluation of Hepatic Mitochondria and Hematological Parameters in Zidovudine-Treated B6C3F1 Mice
Taewon Lee
Korea University (KR)
4 shared publications
- Effect of (+)-usnic acid on mitochondrial functions as measured by mitochondria-specific oligonucleotide microarray in liver of B6C3F1 mice
- Nucleoside reverse transcriptase inhibitors (NRTIs)-induced expression profile of mitochondria-related genes in the mouse liver
- Development of mitochondria-specific mouse oligonucleotide microarray and validation of data by real-time PCR
- Evaluation of Hepatic Mitochondria and Hematological Parameters in Zidovudine-Treated B6C3F1 Mice
Carrie L. Moland
National Center for Toxicological Research
4 shared publications
In database
- Effect of (+)-usnic acid on mitochondrial functions as measured by mitochondria-specific oligonucleotide microarray in liver of B6C3F1 mice
- Nucleoside reverse transcriptase inhibitors (NRTIs)-induced expression profile of mitochondria-related genes in the mouse liver
- Development of mitochondria-specific mouse oligonucleotide microarray and validation of data by real-time PCR
- Evaluation of Hepatic Mitochondria and Hematological Parameters in Zidovudine-Treated B6C3F1 Mice
William S. Branham
National Center for Toxicological Research (US)
4 shared publications
- Effect of (+)-usnic acid on mitochondrial functions as measured by mitochondria-specific oligonucleotide microarray in liver of B6C3F1 mice
- Nucleoside reverse transcriptase inhibitors (NRTIs)-induced expression profile of mitochondria-related genes in the mouse liver
- Development of mitochondria-specific mouse oligonucleotide microarray and validation of data by real-time PCR
- Evaluation of Hepatic Mitochondria and Hematological Parameters in Zidovudine-Treated B6C3F1 Mice
James C. Fuscoe
National Center for Toxicological Research
4 shared publications
In database
- Effect of (+)-usnic acid on mitochondrial functions as measured by mitochondria-specific oligonucleotide microarray in liver of B6C3F1 mice
- Nucleoside reverse transcriptase inhibitors (NRTIs)-induced expression profile of mitochondria-related genes in the mouse liver
- Development of mitochondria-specific mouse oligonucleotide microarray and validation of data by real-time PCR
- Evaluation of Hepatic Mitochondria and Hematological Parameters in Zidovudine-Treated B6C3F1 Mice
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