Match tier
Listed
Presence
Current · Arkansas
Last published
2025
Sources
OpenAlex · ORCID
Refreshed
2026-10-08
J
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Jingwei Shao's research focuses on targeted protein degradation, particularly through the development and application of Proteolysis-Targeting Chimeras (PROTACs). Shao has investigated novel PROTAC designs, including O'PROTACs, which utilize programmable oligonucleotides to direct protein degradation. Publications highlight the destruction of DNA-binding proteins like LEF1 and ERG using these methods. Further work explores the mechanisms of PROTAC delivery, such as CD36-mediated endocytosis. Shao also studies related molecular processes, including the role of inositol as an inhibitor of mitochondrial fission and its interaction with AMPK. Collaborations at the University of Arkansas for Medical Sciences include work with Anupreet Kharbanda and Phuc Tran. Shao's scholarship metrics include an h-index of 8 and 11 total publications.
Metrics
- h-index: 8
- Publications: 9
- Citations: 386
Selected Publications
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CD36-mediated endocytosis of proteolysis-targeting chimeras (2025)
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Feasible Column Chromatography-Free, Multi-Gram Scale Synthetic Process of VH032 Amine, Which Could Enable Rapid PROTAC Library Construction (2022)
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3-Aminophthalic acid, a new cereblon ligand for targeted protein degradation by O’PROTAC (2022)
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Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK (2021)
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Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG (2021)
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Microwave-Assisted Copper Catalysis of α-Difluorinated gem-Diol toward Difluoroalkyl Radical for Hydrodifluoroalkylation of para-Quinone Methides (2020)
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A concise and unexpected one-pot methodology for the synthesis of pyrazinone-fused pyridones (2020)
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An acid-catalyzed 1,4-addition isocyanide-based multicomponent reaction in neat water (2020)
Collaboration Network
Top Collaborators
Hongyu Li
The University of Texas at San Antonio Health Science Center (US)
7 shared publications
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG
- Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK
- CD36-mediated endocytosis of proteolysis-targeting chimeras
- 3-Aminophthalic acid, a new cereblon ligand for targeted protein degradation by O’PROTAC
- A concise and unexpected one-pot methodology for the synthesis of pyrazinone-fused pyridones
Showing 5 of 7 shared publications
Wei Yan
The University of Texas at San Antonio Health Science Center (US)
5 shared publications
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG
- Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK
- CD36-mediated endocytosis of proteolysis-targeting chimeras
- 3-Aminophthalic acid, a new cereblon ligand for targeted protein degradation by O’PROTAC
- Feasible Column Chromatography-Free, Multi-Gram Scale Synthetic Process of VH032 Amine, Which Could Enable Rapid PROTAC Library Construction
Zhong‐Zhu Chen
Chongqing University of Arts and Sciences (CN)
4 shared publications
- Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK
- An acid-catalyzed 1,4-addition isocyanide-based multicomponent reaction in neat water
- A concise and unexpected one-pot methodology for the synthesis of pyrazinone-fused pyridones
- Microwave-Assisted Copper Catalysis of α-Difluorinated gem-Diol toward Difluoroalkyl Radical for Hydrodifluoroalkylation of para-Quinone Methides
Zhigang Xu
Chongqing University of Arts and Sciences (CN)
4 shared publications
- Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK
- An acid-catalyzed 1,4-addition isocyanide-based multicomponent reaction in neat water
- A concise and unexpected one-pot methodology for the synthesis of pyrazinone-fused pyridones
- Microwave-Assisted Copper Catalysis of α-Difluorinated gem-Diol toward Difluoroalkyl Radical for Hydrodifluoroalkylation of para-Quinone Methides
Dianyong Tang
Chongqing University of Arts and Sciences (CN)
3 shared publications
- An acid-catalyzed 1,4-addition isocyanide-based multicomponent reaction in neat water
- A concise and unexpected one-pot methodology for the synthesis of pyrazinone-fused pyridones
- Microwave-Assisted Copper Catalysis of α-Difluorinated gem-Diol toward Difluoroalkyl Radical for Hydrodifluoroalkylation of para-Quinone Methides
Bo‐Syong Pan
Wake Forest University (US)
3 shared publications
- Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK
- CD36-mediated endocytosis of proteolysis-targeting chimeras
- Feasible Column Chromatography-Free, Multi-Gram Scale Synthetic Process of VH032 Amine, Which Could Enable Rapid PROTAC Library Construction
Jie Lei
Target (United States) (US)
2 shared publications
- An acid-catalyzed 1,4-addition isocyanide-based multicomponent reaction in neat water
- A concise and unexpected one-pot methodology for the synthesis of pyrazinone-fused pyridones
Jia Xu
Target (United States) (US)
2 shared publications
- An acid-catalyzed 1,4-addition isocyanide-based multicomponent reaction in neat water
- A concise and unexpected one-pot methodology for the synthesis of pyrazinone-fused pyridones
Yuqian Yan
Mayo Clinic (US)
2 shared publications
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG
- 3-Aminophthalic acid, a new cereblon ligand for targeted protein degradation by O’PROTAC
Donglin Ding
Mayo Clinic (US)
2 shared publications
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG
- 3-Aminophthalic acid, a new cereblon ligand for targeted protein degradation by O’PROTAC
Yunqian Pan
Mayo Clinic (US)
2 shared publications
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG
- 3-Aminophthalic acid, a new cereblon ligand for targeted protein degradation by O’PROTAC
Haojie Huang
Mayo Clinic (US)
2 shared publications
- Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG
- 3-Aminophthalic acid, a new cereblon ligand for targeted protein degradation by O’PROTAC
Che-Chia Hsu
Wake Forest University (US)
2 shared publications
- Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK
- CD36-mediated endocytosis of proteolysis-targeting chimeras
Rajesh Manne
Wake Forest University (US)
2 shared publications
- Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK
- CD36-mediated endocytosis of proteolysis-targeting chimeras
Hui‐Kuan Lin
Duke University (US)
2 shared publications
- Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK
- CD36-mediated endocytosis of proteolysis-targeting chimeras
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