S
Srihari Shankar
Principal Scientific Associate
unknown
4 h-index
8 pubs
43 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Srihari Shankar's research focuses on understanding the molecular mechanisms underlying cellular processes, including replication, cargo trafficking, and protein allostery. His work investigates the molecular biology of cancer and other disease states. Shankar has published on the structural basis for the regulation of Rho inactivation by p50RhoGAP, the enzymatic activity of the HACE1 HECT-type E3 ligase, and a novel allosteric site in human kidney-type glutaminase. His recent publications also explore the regulation of CHIP E3 ligase-mediated ubiquitination and the distinct roles of specific amino acid residues in the BCH domain of yeast p50RhoGAP. Additionally, he has contributed to structural studies of the GINS tetramer from *Saccharolobus solfataricus*.
Metrics
- h-index: 4
- Publications: 8
- Citations: 43
Selected Publications
-
Structure of the <i>Saccharolobus solfataricus</i> GINS tetramer (2025)
Collaboration Network
Top Collaborators
J. Sivaraman
National University of Singapore (SG)
5 shared publications
- Structural basis for p50RhoGAP BCH domain–mediated regulation of Rho inactivation
- Structural Basis for the Enzymatic Activity of the HACE1 HECT‐Type E3 Ligase Through N‐Terminal Helix Dimerization
- A novel allosteric site employs a conserved inhibition mechanism in human kidney‐type glutaminase
- Structural basis for the distinct roles of non-conserved Pro116 and conserved Tyr124 of BCH domain of yeast p50RhoGAP
- Insights into the regulation of CHIP E3 ligase-mediated ubiquitination of neuronal protein BNIP-H
Boon Chuan Low
National University of Singapore (SG)
3 shared publications
- Structural basis for p50RhoGAP BCH domain–mediated regulation of Rho inactivation
- Structural basis for the distinct roles of non-conserved Pro116 and conserved Tyr124 of BCH domain of yeast p50RhoGAP
- Insights into the regulation of CHIP E3 ligase-mediated ubiquitination of neuronal protein BNIP-H
Nikhil Kumar Tulsian
National University of Singapore (SG)
3 shared publications
- Structural Basis for the Enzymatic Activity of the HACE1 HECT‐Type E3 Ligase Through N‐Terminal Helix Dimerization
- A novel allosteric site employs a conserved inhibition mechanism in human kidney‐type glutaminase
- Insights into the regulation of CHIP E3 ligase-mediated ubiquitination of neuronal protein BNIP-H
Vishnu Priyanka Reddy Chichili
National University of Singapore (SG)
2 shared publications
- Structural basis for p50RhoGAP BCH domain–mediated regulation of Rho inactivation
- Structural basis for the distinct roles of non-conserved Pro116 and conserved Tyr124 of BCH domain of yeast p50RhoGAP
Ti Weng Chew
National University of Singapore (SG)
2 shared publications
- Structural basis for p50RhoGAP BCH domain–mediated regulation of Rho inactivation
- Structural basis for the distinct roles of non-conserved Pro116 and conserved Tyr124 of BCH domain of yeast p50RhoGAP
Chacko Jobichen
National University Cancer Institute, Singapore (SG)
2 shared publications
- Structural basis for p50RhoGAP BCH domain–mediated regulation of Rho inactivation
- A novel allosteric site employs a conserved inhibition mechanism in human kidney‐type glutaminase
Yaochen Liu
National University of Singapore (SG)
2 shared publications
- Structural Basis for the Enzymatic Activity of the HACE1 HECT‐Type E3 Ligase Through N‐Terminal Helix Dimerization
- Insights into the regulation of CHIP E3 ligase-mediated ubiquitination of neuronal protein BNIP-H
Shi Yin Er
National University of Singapore (SG)
1 shared publication
- Structural basis for p50RhoGAP BCH domain–mediated regulation of Rho inactivation
Cheen Fei Chin
National University of Singapore (SG)
1 shared publication
- Structural basis for p50RhoGAP BCH domain–mediated regulation of Rho inactivation
Catherine Pan
National University of Singapore (SG)
1 shared publication
- Structural basis for p50RhoGAP BCH domain–mediated regulation of Rho inactivation
Yi Zhou
National University of Singapore (SG)
1 shared publication
- Structural basis for p50RhoGAP BCH domain–mediated regulation of Rho inactivation
Foong May Yeong
National University of Singapore (SG)
1 shared publication
- Structural basis for p50RhoGAP BCH domain–mediated regulation of Rho inactivation
Sarath Ramachandran
National University of Singapore (SG)
1 shared publication
- A novel allosteric site employs a conserved inhibition mechanism in human kidney‐type glutaminase
R. Sridhar
National University Cancer Institute, Singapore (SG)
1 shared publication
- A novel allosteric site employs a conserved inhibition mechanism in human kidney‐type glutaminase
Sunil Singh
National University of Singapore (SG)
1 shared publication
- Structural Basis for the Enzymatic Activity of the HACE1 HECT‐Type E3 Ligase Through N‐Terminal Helix Dimerization
Similar Researchers
Based on overlapping research topics
Herbert Fendley
University of Arkansas for Medical Sciences
Cancer-related molecular mechanisms research
Molecular Biology Techniques and Applications
Metabolism and Genetic Disorders
Shi‐Ming Tu
University of Arkansas for Medical Sciences
Cancer-related molecular mechanisms research
Protein Structure and Dynamics
Molecular Biology Techniques and Applications
J. G. Stephens
University of Arkansas at Fayetteville
Protein Structure and Dynamics
Molecular Biology Techniques and Applications
Metabolism and Genetic Disorders
Christophe Bobda
University of Arkansas for Medical Sciences
Cancer-related molecular mechanisms research
Molecular Biology Techniques and Applications
Metabolism and Genetic Disorders
Amanda Costa
University of Arkansas for Medical Sciences
Cancer-related molecular mechanisms research
Molecular Biology Techniques and Applications
Metabolism and Genetic Disorders
Leonard Ferdman
Arkansas State University
Cancer-related molecular mechanisms research
Molecular Biology Techniques and Applications
Genomics and Phylogenetic Studies