Nithin Karakala
Professor
Also affiliated: Emory University (2017); Medical University of South Carolina (2011–2016); University of Arkansas Medical Center (2017–2026); University of Arkansas System (2022–2023); Central Arkansas Veterans Healthcare System (2016–2021); Duke Medical Center (2013); Ralph H. Johnson VA Medical Center (2012); Durham VA Medical Center (2013); John L. McClellan Memorial Veterans Hospital (2021)
Internal Med, College of Medicine
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Dr. Nithin Karakala investigates biomarkers associated with renal disease, with a particular focus on acute kidney injury (AKI). His clinical interests include continuous renal replacement therapy, early prognostic markers for AKI, and volume management in AKI. His research has explored the utility of urinary biomarkers, such as neutrophil gelatinase-associated lipocalin (NGAL) and angiotensinogen, in diagnosing and predicting outcomes for patients with AKI, including those with cirrhosis.
Dr. Karakala has also examined the misclassification of AKI as hepatorenal syndrome using point-of-care echocardiography and has contributed to reviews on best practices for continuous renal replacement therapy in critically ill patients. His work has been published in peer-reviewed journals, and he has a citation count of 690 with an h-index of 13 across his 45 publications. He collaborates with researchers at the University of Arkansas for Medical Sciences, including Joseph H. Holthoff and Luis A. Juncos.
Research Overview
Dr. Karakala is an Assistant Professor of Medicine in the Division of Nephrology, Department of Internal Medicine. He received his medical degree from Deccan College of Medical Sciences in India. He completed his internal medicine residency at Greater Baltimore Medical Center in Maryland and his nephrology fellowship training at Medical University of South Carolina. He served as the Chief Nephrology Fellow at MUSC as well. Dr. Karakala was on the faculty at MUSC for two years before coming to UAMS. Dr. Karakala is board certified in internal medicine and nephrology. His clinical interests are continuous renal replacement therapy, early prognostic markers of acute kidney injury, and volume management in acute kidney injury. His research interests include biomarkers in renal disease.
Metrics
- h-index: 13
- Publications: 46
- Citations: 693
Positions
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Professor 2015–presentUniversity of Arkansas for Medical Sciences Internal Med, College of Medicine Institutional directory
Selected Publications
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Diabetic kidney disease within the framework of cardio-kidney-metabolic health: a paradigm shift (2026)
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Response to Letter to the Editor “Gastrointestinal Mucosal Cell Injury Caused by Sevelamer” (2026)
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Perfusion Under Pressure: Reversing Anuric AKI with Targeted Intra-Abdominal Pressure (IAP) Reduction (2025)
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Protective Phosphorus Ranges for Major Adverse Cardiovascular Events in CKD: Insights from Spline-Based Survival Models (2025)
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Calculated Preemptive Strike: Solving Overcorrection of Hyponatremia with Math and Medicine (2025)
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Hypophosphatemia as a Marker for Immune Effector Cell-Associated Neurotoxicity Syndrome in Chimeric Antigen Receptor T Cell Recipients (2025)
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SGLT2 Inhibitors as a Therapeutic Option for Both Acute and Chronic Refractory Hypomagnesemia in Diabetic and Nondiabetic Patients: A Multicenter Case Series (2025)
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The role of IGFBP-1 in the clinical prognosis and pathophysiology of acute kidney injury (2025)
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Gastrointestinal Mucosal Cell Injury Caused by Sevelamer Crystals: Case Series and Literature Review (2025)
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Urine Chemistry: A Valuable Link Binding Kidney Physiology to Patient Care (2024)
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Stepwise Teamwork Approach Saves Patients Extensive Work-Up (2024)
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Urinary Complement C3 and Vitamin D-Binding Protein Predict Adverse Outcomes in Patients with Acute Kidney Injury after Cardiac Surgery (2024)
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I Am in a Crystal Bind! A Case that Gave Us Ulcers (2023)
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The Drug that Keeps Giving: Hypomagnesemia Fixed by SGLT2 Inhibitor (2023)
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SOD1 is a novel prognostic biomarker of acute kidney injury following cardiothoracic surgery (2023)
Grants & Funding
As listed on this researcher's institutional profile.
- Clinical Scientist Award UAMS Principal Investigator
- Targeting Abdominal Perfusion Pressure in Septic Shock (The MAP APP Study) IRB 228252 Potrero Medical via Biomedical Research Foundation - Arkansas Principal Investigator
Collaboration Network
Top Collaborators
- Urinary NGAL as a Diagnostic and Prognostic Marker for Acute Kidney Injury in Cirrhosis: A Prospective Study
- Terlipressin and the Treatment of Hepatorenal Syndrome: How the CONFIRM Trial Moves the Story Forward
- Vascular access, membranes and circuit for CRRT
- Point-of-Care Ultrasound in Acute Care Nephrology
- Providing Continuous Renal Replacement Therapy in Patients on Extracorporeal Membrane Oxygenation
Showing 5 of 9 shared publications
- An integrated pathology and ultrasonography-based simulation for training in performing kidney biopsy
- Vancomycin-Associated Acute Kidney Injury with a Steep Rise in Serum Creatinine
- Proteomic Analysis for Identification of Biomarkers that Predict Severe Acute Kidney Injury
- SOD1 is a novel prognostic biomarker of acute kidney injury following cardiothoracic surgery
- Urinary Complement C3 and Vitamin D-Binding Protein Predict Adverse Outcomes in Patients with Acute Kidney Injury after Cardiac Surgery
Showing 5 of 8 shared publications
- SOD1 is a novel prognostic biomarker of acute kidney injury following cardiothoracic surgery
- Urinary Complement C3 and Vitamin D-Binding Protein Predict Adverse Outcomes in Patients with Acute Kidney Injury after Cardiac Surgery
- The role of IGFBP-1 in the clinical prognosis and pathophysiology of acute kidney injury
- The Drug that Keeps Giving: Hypomagnesemia Fixed by SGLT2 Inhibitor
- Urine Chemistry: A Valuable Link Binding Kidney Physiology to Patient Care
Showing 5 of 7 shared publications
- An integrated pathology and ultrasonography-based simulation for training in performing kidney biopsy
- Long-term Adverse Events Associated With Acute Kidney Injury
- Gastrointestinal Mucosal Cell Injury Caused by Sevelamer Crystals: Case Series and Literature Review
- Peritoneal Dialysis Catheter−Fallopian Tube Fistula
- SGLT2 Inhibitors as a Therapeutic Option for Both Acute and Chronic Refractory Hypomagnesemia in Diabetic and Nondiabetic Patients: A Multicenter Case Series
Showing 5 of 6 shared publications
- Urinary NGAL as a Diagnostic and Prognostic Marker for Acute Kidney Injury in Cirrhosis: A Prospective Study
- Point-of-Care Echocardiography Unveils Misclassification of Acute Kidney Injury as Hepatorenal Syndrome
- Terlipressin and the Treatment of Hepatorenal Syndrome: How the CONFIRM Trial Moves the Story Forward
- Responsiveness to Vasoconstrictor Therapy in Hepatorenal Syndrome Type 1
- An integrated pathology and ultrasonography-based simulation for training in performing kidney biopsy
Showing 5 of 6 shared publications
- Gastrointestinal Mucosal Cell Injury Caused by Sevelamer Crystals: Case Series and Literature Review
- The Drug that Keeps Giving: Hypomagnesemia Fixed by SGLT2 Inhibitor
- I Am in a Crystal Bind! A Case that Gave Us Ulcers
- Response to Letter to the Editor “Gastrointestinal Mucosal Cell Injury Caused by Sevelamer”
- Urinary NGAL as a Diagnostic and Prognostic Marker for Acute Kidney Injury in Cirrhosis: A Prospective Study
- Terlipressin and the Treatment of Hepatorenal Syndrome: How the CONFIRM Trial Moves the Story Forward
- Responsiveness to Vasoconstrictor Therapy in Hepatorenal Syndrome Type 1
- Urinary NGAL as a Diagnostic and Prognostic Marker for Acute Kidney Injury in Cirrhosis: A Prospective Study
- Terlipressin and the Treatment of Hepatorenal Syndrome: How the CONFIRM Trial Moves the Story Forward
- Responsiveness to Vasoconstrictor Therapy in Hepatorenal Syndrome Type 1
- Urinary NGAL as a Diagnostic and Prognostic Marker for Acute Kidney Injury in Cirrhosis: A Prospective Study
- Terlipressin and the Treatment of Hepatorenal Syndrome: How the CONFIRM Trial Moves the Story Forward
- Responsiveness to Vasoconstrictor Therapy in Hepatorenal Syndrome Type 1
- The Drug that Keeps Giving: Hypomagnesemia Fixed by SGLT2 Inhibitor
- I Am in a Crystal Bind! A Case that Gave Us Ulcers
- Stepwise Teamwork Approach Saves Patients Extensive Work-Up
- Calculated Preemptive Strike: Solving Overcorrection of Hyponatremia with Math and Medicine
- Protective Phosphorus Ranges for Major Adverse Cardiovascular Events in CKD: Insights from Spline-Based Survival Models
- Perfusion Under Pressure: Reversing Anuric AKI with Targeted Intra-Abdominal Pressure (IAP) Reduction
- Calculated Preemptive Strike: Solving Overcorrection of Hyponatremia with Math and Medicine
- Protective Phosphorus Ranges for Major Adverse Cardiovascular Events in CKD: Insights from Spline-Based Survival Models
- Perfusion Under Pressure: Reversing Anuric AKI with Targeted Intra-Abdominal Pressure (IAP) Reduction
- Timing of Renal Replacement Therapy for Acute Kidney Injury
- We Use Heparin as the Anticoagulant for CRRT
- Peritoneal Dialysis Catheter−Fallopian Tube Fistula
- A Case of Sevelamer-Induced Colon Perforation
- Vascular access, membranes and circuit for CRRT
- Point-of-Care Ultrasound in Acute Care Nephrology
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