Joseph H. Holthoff
Assistant Professor
University of Arkansas for Medical Sciences
faculty
Internal Med, College of Medicine
Research Areas
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Biography and Research Information
OverviewAI-generated summary
Joseph H. Holthoff's research focuses on understanding and improving outcomes for patients with acute kidney injury (AKI), particularly following cardiothoracic surgery. His work investigates potential biomarkers for predicting adverse outcomes in these patients, including urinary complement C3 and vitamin D-binding protein. Holthoff also studies the role of specific proteins, such as SOD1 and IGFBP-1, as prognostic indicators for AKI. Additionally, his publications address less common but significant renal conditions, including a case report on a new mutation associated with Polycystic Kidney Disease Type I and treatment strategies for refractory membranous nephropathy. His research extends to the pathophysiology of diabetic kidney disease, examining the role of ESM-1. Holthoff has collaborated with researchers Nithin Karakala, Luis A. Juncos, Manisha Singh, and Fatima Ayub, all from the University of Arkansas for Medical Sciences, on multiple publications.
Metrics
- h-index: 7
- Publications: 37
- Citations: 772
Selected Publications
- Perfusion Under Pressure: Reversing Anuric AKI with Targeted Intra-Abdominal Pressure (IAP) Reduction (2025) DOI
- The Second Slice Tells the Story: Evolving Cryoglobulinemia in Mesangial Glomerulonephritis (2025) DOI
- Dialysate Sodium (2025) DOI
- SGLT2 Inhibitors as a Therapeutic Option for Both Acute and Chronic Refractory Hypomagnesemia in Diabetic and Nondiabetic Patients: A Multicenter Case Series (2025) DOI
- Plasma Cell–Directed Rescue With Bortezomib in Refractory Antiphospholipase A2 Receptor–Positive Membranous Nephropathy (2025) DOI
- The role of IGFBP-1 in the clinical prognosis and pathophysiology of acute kidney injury (2025) DOI
- Breaking Barriers: Unconventional Therapy Treats a Challenging Case of Primary Membranous Nephropathy (2024) DOI
- New Mutation Associated with Polycystic Kidney Disease Type I: A Case Report (2024) DOI
- Urine Chemistry: A Valuable Link Binding Kidney Physiology to Patient Care (2024) DOI
- New Mutation Associated with Polycystic Kidney Disease Type I: A Case Report (2024) DOI
- I Am the Lucky Third: Spontaneous Resolution of High-Risk Membranous Nephropathy (2023) DOI
- The Drug that Keeps Giving: Hypomagnesemia Fixed by SGLT2 Inhibitor (2023) DOI
- SOD1 is a novel prognostic biomarker of acute kidney injury following cardiothoracic surgery (2023) DOI
- SAT145 Familial Renal Glycosuria - A Differential Diagnosis For Hypoglycemia (2023) DOI
- Hemodialysis Is More Effective Than Continuous Venovenous Hemodialysis for Treatment of Hypermagnesemia due to Epsom Salt Ingestion (2022) DOI
Grants & Funding
- Investigating the mechanism of protection of IGFBP-1 in a murine model of acute kidney injury Dialysis Clinic, Inc. Principal Investigator
- Preclinical evaluation of resveratrol in sepsis-induced renal injury NIH Principal Investigator
- Investigating the mechanism of protection of IGFBP-1 in a murine model of acute kidney injury Dialysis Clinic, Inc. Principal Investigator
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