Z. Ryan Tian
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Professor
Also affiliated: Hebei Medical University (2021); Jiangsu University (2019–2020); Uppsala University (2007–2012); Uppsala University Hospital (2012); University of Connecticut (1996–1999); Emory University (2020); Xinjiang Medical University (2013–2023); Shenyang University of Technology (2025); Chiba University (2018–2021); Tianjin University (2011); University of St Andrews (2017); University of New Mexico (2006–2007); Lehigh University (2014–2019); Jilin University (2006); Chinese Academy of Medical Sciences & Peking Union Medical College (2020–2022); Changchun Normal University (2025); Missouri University of Science and Technology (2013); Hubei University of Chinese Medicine (2025); Beijing Jiaotong University (2026); University of Arkansas System (2023); China-Japan Friendship Hospital (2020–2022); First Affiliated Hospital of Xinjiang Medical University (2013–2023); University of California San Diego (2020); Third Hospital of Hebei Medical University (2021); Chinese Academy of Inspection and Quarantine (2019–2021); Sandia National Laboratories (2006); Ningxia Medical University (2025); Ningxia Medical University General Hospital (2025); Institute of Hematology & Blood Diseases Hospital (2020); Center for Forensic Mental Health, Chiba University (2018–2021); Winship Cancer Institute (2020); State Key Laboratory of Optoelectronic Materials and Technology (2006); State Key Laboratory of Inorganic Synthesis and Preparative Chemistry (2006); Institute of Spacecraft System Engineering (2023); East China Normal University (2022–2024); Tsinghua University (2006–2007)
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Z. Ryan Tian's research interests include the development and application of nanomaterials for various biomedical purposes. His work has explored the synthesis of complex nanostructures, such as branched ZnO crystallites and multifunctional nanowire bioscaffolds on titanium. A significant portion of his research has focused on the neuroprotective potential of nanomaterials, including studies on how chronic nanoparticle treatment can exacerbate hyperthermia-induced blood-brain barrier breakdown and cognitive dysfunction in rats, and the potential of nanowired-antioxidant compounds to mitigate these effects.
Dr. Tian has also investigated porous manganese oxide materials and their electrical resistivity properties. In addition to his work in nanomaterials and neuroscience, he has explored other areas, including a review of porous manganese oxide materials and a model for tooth wear with implications for microwear formation and diet reconstruction. He is also a principal investigator on an NSF I-Corps grant focused on the commercialization of a real-time, palm-size, low-cost, and wireless SARS-COV-II detector.
With an h-index of 31, over 250 publications, and more than 4,300 citations, Dr. Tian has a substantial publication record. His collaborations include research with Mark Lanoue, Asya Ozkızılcık, Parker Cole, and Savannah Thornburgh, all from the University of Arkansas at Fayetteville.
Metrics
- h-index: 31
- Publications: 225
- Citations: 4,206
Positions
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Professor 2023–presentUniversity of Arkansas Department of Chemistry and Biochemistry ORCID
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Associate Professor/ Assistant Professor 2004–2016University of Arkansas Fayetteville Chemistry and Biochemistry ORCID
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Post Doctoral Fellow 2002–2004Sandia National Laboratories Nanomaterial and Interfacial Science ORCID
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Manager 2000–2001AXT Inc. R&D/Production/Tech-Transfer ORCID
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Post Doc. Researcher 1998–2000University of California Davis Chemical Engineering and Materials Science ORCID
Selected Publications
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Retraction Note: Cerebrolysin Attenuates Exacerbation of Neuropathic Pain, Blood-Spinal Cord Barrier Breakdown and Cord Pathology Following Chronic Intoxication of Engineered Ag, Cu or Al (50–60 nm) Nanoparticles (2026)
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Retraction Note to: Timed Release of Cerebrolysin Using Drug-Loaded Titanate Nanospheres Reduces Brain Pathology and Improves Behavioral Functions in Parkinson’s Disease (2026)
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Retraction Note to: Nanowired Delivery of Growth Hormone Attenuates Pathophysiology of Spinal Cord Injury and Enhances Insulin-Like Growth Factor-1 Concentration in the Plasma and the Spinal Cord (2026)
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Surface properties and in-vitro bioactivity studies of TiO2 nanowire doped transition metal (M=Fe, Co, and Mn) (2026)
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Novel Nanomaterials for Developing Bone Scaffolds and Tissue Regeneration (2025)
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Hydrothermally doping valve metal Nb into Titanate nanofibers structure for potentially engineering bone tissue (2024)
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Efficient Photocatalytic Core–Shell Synthesis of Titanate Nanowire/rGO (2024)
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Mo-doped titanate nanofibers from hydrothermal syntheses for improving bone scaffold (2024)
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Hydrothermal synthesis of valve metal Ta-doped titanate nanofibers for potentially engineering bone tissue (2024)
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Hydrothermal synthesis of valve metal Zr-doped titanate nanofibers for bone tissue engineering (2023)
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Spinal cord injury induced exacerbation of Alzheimer's disease like pathophysiology is reduced by topical application of nanowired cerebrolysin with monoclonal antibodies to amyloid beta peptide, p-tau and tumor necrosis factor alpha (2023)
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Co-administration of dl-3-n-butylphthalide and neprilysin is neuroprotective in Alzheimer disease associated with mild traumatic brain injury (2023)
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Nicotine neurotoxicity exacerbation following engineered Ag and Cu (50–60 nm) nanoparticles intoxication. Neuroprotection with nanowired delivery of antioxidant compound H-290/51 together with serotonin 5-HT3 receptor antagonist ondansetron (2023)
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Sleep deprivation enhances amyloid beta peptide, p-tau and serotonin in the brain: Neuroprotective effects of nanowired delivery of cerebrolysin with monoclonal antibodies to amyloid beta peptide, p-tau and serotonin (2023)
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Nanowired delivery of antibodies to tau and neuronal nitric oxide synthase together with cerebrolysin attenuates traumatic brain injury induced exacerbation of brain pathology in Parkinson’s disease (2023)
Federal Grants 1 $50,000 total
I-Corps: Commercialization of a real-time, palm-size, low-cost, and wireless SARS-COV-II detector
Collaboration Network
Top Collaborators
- RETRACTED ARTICLE: Sleep Deprivation-Induced Blood-Brain Barrier Breakdown and Brain Dysfunction are Exacerbated by Size-Related Exposure to Ag and Cu Nanoparticles. Neuroprotective Effects of a 5-HT3 Receptor Antagonist Ondansetron
- Pathophysiology of blood-brain barrier in brain tumor. Novel therapeutic advances using nanomedicine
- RETRACTED ARTICLE: Co-Administration of TiO2 Nanowired Mesenchymal Stem Cells with Cerebrolysin Potentiates Neprilysin Level and Reduces Brain Pathology in Alzheimer’s Disease
- RETRACTED ARTICLE: Cold Environment Exacerbates Brain Pathology and Oxidative Stress Following Traumatic Brain Injuries: Potential Therapeutic Effects of Nanowired Antioxidant Compound H-290/51
- REMOVED: Nanowired delivery of cerebrolysin with neprilysin and p-Tau antibodies induces superior neuroprotection in Alzheimer's disease
Showing 5 of 51 shared publications
- Drug Delivery to the Spinal Cord Tagged with Nanowire Enhances Neuroprotective Efficacy and Functional Recovery following Trauma to the Rat Spinal Cord
- RETRACTED ARTICLE: Sleep Deprivation-Induced Blood-Brain Barrier Breakdown and Brain Dysfunction are Exacerbated by Size-Related Exposure to Ag and Cu Nanoparticles. Neuroprotective Effects of a 5-HT3 Receptor Antagonist Ondansetron
- Pathophysiology of blood-brain barrier in brain tumor. Novel therapeutic advances using nanomedicine
- RETRACTED ARTICLE: Co-Administration of TiO2 Nanowired Mesenchymal Stem Cells with Cerebrolysin Potentiates Neprilysin Level and Reduces Brain Pathology in Alzheimer’s Disease
- RETRACTED ARTICLE: Cold Environment Exacerbates Brain Pathology and Oxidative Stress Following Traumatic Brain Injuries: Potential Therapeutic Effects of Nanowired Antioxidant Compound H-290/51
Showing 5 of 48 shared publications
- RETRACTED ARTICLE: Sleep Deprivation-Induced Blood-Brain Barrier Breakdown and Brain Dysfunction are Exacerbated by Size-Related Exposure to Ag and Cu Nanoparticles. Neuroprotective Effects of a 5-HT3 Receptor Antagonist Ondansetron
- Pathophysiology of blood-brain barrier in brain tumor. Novel therapeutic advances using nanomedicine
- RETRACTED ARTICLE: Co-Administration of TiO2 Nanowired Mesenchymal Stem Cells with Cerebrolysin Potentiates Neprilysin Level and Reduces Brain Pathology in Alzheimer’s Disease
- RETRACTED ARTICLE: Cold Environment Exacerbates Brain Pathology and Oxidative Stress Following Traumatic Brain Injuries: Potential Therapeutic Effects of Nanowired Antioxidant Compound H-290/51
- REMOVED: Nanowired delivery of cerebrolysin with neprilysin and p-Tau antibodies induces superior neuroprotection in Alzheimer's disease
Showing 5 of 48 shared publications
- Drug Delivery to the Spinal Cord Tagged with Nanowire Enhances Neuroprotective Efficacy and Functional Recovery following Trauma to the Rat Spinal Cord
- RETRACTED ARTICLE: Sleep Deprivation-Induced Blood-Brain Barrier Breakdown and Brain Dysfunction are Exacerbated by Size-Related Exposure to Ag and Cu Nanoparticles. Neuroprotective Effects of a 5-HT3 Receptor Antagonist Ondansetron
- Pathophysiology of blood-brain barrier in brain tumor. Novel therapeutic advances using nanomedicine
- RETRACTED ARTICLE: Co-Administration of TiO2 Nanowired Mesenchymal Stem Cells with Cerebrolysin Potentiates Neprilysin Level and Reduces Brain Pathology in Alzheimer’s Disease
- RETRACTED ARTICLE: Cold Environment Exacerbates Brain Pathology and Oxidative Stress Following Traumatic Brain Injuries: Potential Therapeutic Effects of Nanowired Antioxidant Compound H-290/51
Showing 5 of 46 shared publications
- Pathophysiology of blood-brain barrier in brain tumor. Novel therapeutic advances using nanomedicine
- REMOVED: Nanowired delivery of cerebrolysin with neprilysin and p-Tau antibodies induces superior neuroprotection in Alzheimer's disease
- REMOVED: Nanodelivery of cerebrolysin reduces pathophysiology of Parkinson's disease
- REMOVED: Histamine H3 and H4 receptors modulate Parkinson's disease induced brain pathology. Neuroprotective effects of nanowired BF-2649 and clobenpropit with anti-histamine-antibody therapy
- Manganese nanoparticles induce blood-brain barrier disruption, cerebral blood flow reduction, edema formation and brain pathology associated with cognitive and motor dysfunctions
Showing 5 of 38 shared publications
- RETRACTED ARTICLE: Sleep Deprivation-Induced Blood-Brain Barrier Breakdown and Brain Dysfunction are Exacerbated by Size-Related Exposure to Ag and Cu Nanoparticles. Neuroprotective Effects of a 5-HT3 Receptor Antagonist Ondansetron
- Pathophysiology of blood-brain barrier in brain tumor. Novel therapeutic advances using nanomedicine
- REMOVED: Histamine H3 and H4 receptors modulate Parkinson's disease induced brain pathology. Neuroprotective effects of nanowired BF-2649 and clobenpropit with anti-histamine-antibody therapy
- Manganese nanoparticles induce blood-brain barrier disruption, cerebral blood flow reduction, edema formation and brain pathology associated with cognitive and motor dysfunctions
- REMOVED: Mild traumatic brain injury exacerbates Parkinson's disease induced hemeoxygenase-2 expression and brain pathology: Neuroprotective effects of co-administration of TiO2 nanowired mesenchymal stem cells and cerebrolysin
Showing 5 of 30 shared publications
- Pathophysiology of blood-brain barrier in brain tumor. Novel therapeutic advances using nanomedicine
- REMOVED: Histamine H3 and H4 receptors modulate Parkinson's disease induced brain pathology. Neuroprotective effects of nanowired BF-2649 and clobenpropit with anti-histamine-antibody therapy
- Manganese nanoparticles induce blood-brain barrier disruption, cerebral blood flow reduction, edema formation and brain pathology associated with cognitive and motor dysfunctions
- REMOVED: Mild traumatic brain injury exacerbates Parkinson's disease induced hemeoxygenase-2 expression and brain pathology: Neuroprotective effects of co-administration of TiO2 nanowired mesenchymal stem cells and cerebrolysin
- REMOVED: Cerebrolysin enhances spinal cord conduction and reduces blood-spinal cord barrier breakdown, edema formation, immediate early gene expression and cord pathology after injury
Showing 5 of 24 shared publications
- RETRACTED ARTICLE: Sleep Deprivation-Induced Blood-Brain Barrier Breakdown and Brain Dysfunction are Exacerbated by Size-Related Exposure to Ag and Cu Nanoparticles. Neuroprotective Effects of a 5-HT3 Receptor Antagonist Ondansetron
- Pathophysiology of blood-brain barrier in brain tumor. Novel therapeutic advances using nanomedicine
- RETRACTED ARTICLE: Co-Administration of TiO2 Nanowired Mesenchymal Stem Cells with Cerebrolysin Potentiates Neprilysin Level and Reduces Brain Pathology in Alzheimer’s Disease
- RETRACTED ARTICLE: Cold Environment Exacerbates Brain Pathology and Oxidative Stress Following Traumatic Brain Injuries: Potential Therapeutic Effects of Nanowired Antioxidant Compound H-290/51
- RETRACTED ARTICLE: Nanowired Delivery of Growth Hormone Attenuates Pathophysiology of Spinal Cord Injury and Enhances Insulin-Like Growth Factor-1 Concentration in the Plasma and the Spinal Cord
Showing 5 of 22 shared publications
- Pathophysiology of blood-brain barrier in brain tumor. Novel therapeutic advances using nanomedicine
- REMOVED: Histamine H3 and H4 receptors modulate Parkinson's disease induced brain pathology. Neuroprotective effects of nanowired BF-2649 and clobenpropit with anti-histamine-antibody therapy
- Manganese nanoparticles induce blood-brain barrier disruption, cerebral blood flow reduction, edema formation and brain pathology associated with cognitive and motor dysfunctions
- Potentiation of spinal cord conduction and neuroprotection following nanodelivery of DL-3-n-butylphthalide in titanium implanted nanomaterial in a focal spinal cord injury induced functional outcome, blood-spinal cord barrier breakdown and edema formation
- REMOVED: Mild traumatic brain injury exacerbates Parkinson's disease induced hemeoxygenase-2 expression and brain pathology: Neuroprotective effects of co-administration of TiO2 nanowired mesenchymal stem cells and cerebrolysin
Showing 5 of 19 shared publications
- RETRACTED ARTICLE: Co-Administration of TiO2 Nanowired Mesenchymal Stem Cells with Cerebrolysin Potentiates Neprilysin Level and Reduces Brain Pathology in Alzheimer’s Disease
- RETRACTED ARTICLE: Cold Environment Exacerbates Brain Pathology and Oxidative Stress Following Traumatic Brain Injuries: Potential Therapeutic Effects of Nanowired Antioxidant Compound H-290/51
- REMOVED: Nanowired delivery of cerebrolysin with neprilysin and p-Tau antibodies induces superior neuroprotection in Alzheimer's disease
- RETRACTED ARTICLE: TiO2-Nanowired Delivery of DL-3-n-butylphthalide (DL-NBP) Attenuates Blood-Brain Barrier Disruption, Brain Edema Formation, and Neuronal Damages Following Concussive Head Injury
- REMOVED: Nanodelivery of cerebrolysin reduces pathophysiology of Parkinson's disease
Showing 5 of 17 shared publications
- RETRACTED ARTICLE: TiO2-Nanowired Delivery of DL-3-n-butylphthalide (DL-NBP) Attenuates Blood-Brain Barrier Disruption, Brain Edema Formation, and Neuronal Damages Following Concussive Head Injury
- Manganese nanoparticles induce blood-brain barrier disruption, cerebral blood flow reduction, edema formation and brain pathology associated with cognitive and motor dysfunctions
- Potentiation of spinal cord conduction and neuroprotection following nanodelivery of DL-3-n-butylphthalide in titanium implanted nanomaterial in a focal spinal cord injury induced functional outcome, blood-spinal cord barrier breakdown and edema formation
- REMOVED: Nanowired delivery of DL-3-n-butylphthalide induces superior neuroprotection in concussive head injury
- REMOVED: Co-administration of TiO2-nanowired dl-3-n-butylphthalide (dl-NBP) and mesenchymal stem cells enhanced neuroprotection in Parkinson's disease exacerbated by concussive head injury
Showing 5 of 13 shared publications
- Site-Specific Nucleation and Growth Kinetics in Hierarchical Nanosyntheses of Branched ZnO Crystallites
- Multifunctional Nanowire Bioscaffolds on Titanium
- Multifunctional, Catalytic Nanowire Membranes and the Membrane-Based 3D Devices
- Drug Delivery to the Spinal Cord Tagged with Nanowire Enhances Neuroprotective Efficacy and Functional Recovery following Trauma to the Rat Spinal Cord
- Future Approaches of Nanomedicine in Clinical Science
Showing 5 of 10 shared publications
- Co-administration of Nanowired Oxiracetam and Neprilysin with Monoclonal Antibodies to Amyloid Beta Peptide and p-Tau Thwarted Exacerbation of Brain Pathology in Concussive Head Injury at Hot Environment
- TiO2-Nanowired Delivery of Chinese Extract of Ginkgo biloba EGb-761 and Bilobalide BN-52021 Enhanced Neuroprotective Effects of Cerebrolysin Following Spinal Cord Injury at Cold Environment
- Nanowired delivery of antibodies to tau and neuronal nitric oxide synthase together with cerebrolysin attenuates traumatic brain injury induced exacerbation of brain pathology in Parkinson’s disease
- Sleep deprivation enhances amyloid beta peptide, p-tau and serotonin in the brain: Neuroprotective effects of nanowired delivery of cerebrolysin with monoclonal antibodies to amyloid beta peptide, p-tau and serotonin
- Co-administration of dl-3-n-butylphthalide and neprilysin is neuroprotective in Alzheimer disease associated with mild traumatic brain injury
Showing 5 of 10 shared publications
- REMOVED: Novel Treatment Strategies Using TiO2-Nanowired Delivery of Histaminergic Drugs and Antibodies to Tau With Cerebrolysin for Superior Neuroprotection in the Pathophysiology of Alzheimer's Disease
- REMOVED: Histamine H3 and H4 receptors modulate Parkinson's disease induced brain pathology. Neuroprotective effects of nanowired BF-2649 and clobenpropit with anti-histamine-antibody therapy
- Development ofin vivodrug-induced neurotoxicity models
- REMOVED: Cerebrolysin enhances spinal cord conduction and reduces blood-spinal cord barrier breakdown, edema formation, immediate early gene expression and cord pathology after injury
- REMOVED: Alzheimer's disease neuropathology is exacerbated following traumatic brain injury. Neuroprotection by co-administration of nanowired mesenchymal stem cells and cerebrolysin with monoclonal antibodies to amyloid beta peptide
Showing 5 of 9 shared publications
- Synthesis and characterization of manganese(III) and high-valent manganese-oxo complexes and their roles in conversion of alkenes to cyclic carbonates
- Second-Harmonic Whispering-Gallery Modes in ZnO Nanotetrapod
- Reversed crystal growth of ZnO microdisks
- Improving the cycling stability of Na3V2(PO4)3 nanoparticle in aqueous sodium ion batteries by introducing carbon support
- Recent advances in multistep solution nanosynthesis of nanostructured three-dimensional complexes of semiconductive materials
Showing 5 of 9 shared publications
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