Jack Hinson

High Impact

Researcher

University of Arkansas for Medical Sciences

faculty

51 h-index 368 pubs 9,279 cited

Research Areas

Pharmacological Effects and Toxicity Studies Diet and metabolism studies Drug Transport and Resistance Mechanisms Metabolomics and Mass Spectrometry Studies Carcinogens and Genotoxicity Assessment Receptor Mechanisms and Signaling Computational Drug Discovery Methods

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OverviewAI-generated summary

Jack Hinson's research focuses on the study of xenobiotic metabolism, particularly as it relates to small molecule drug discovery and development. His work investigates the complex processes by which the body processes foreign compounds, including the identification and characterization of reactive intermediates, amino acid conjugation pathways, and the role of various transporter proteins such as Organic Cation Transporters (OCTs).

He has contributed to the understanding of key enzymes involved in xenobiotic metabolism, including Catechol-O-Methyl Transferase (COMT) and the Aromatic Hydrocarbon Receptor (AHR). Hinson's research also explores the 'first-pass effect,' a critical concept in pharmacokinetics describing the initial metabolism of orally administered drugs as they pass through the liver and intestinal wall. His scholarly output includes a significant number of publications, with a high h-index of 51 and over 9,000 citations, reflecting a highly cited researcher designation. He leads a research group, indicating ongoing and active research endeavors in this field.

Metrics

  • h-index: 51
  • Publications: 368
  • Citations: 9,279

Selected Publications

  • 15 Amino Acid Conjugation (2022) DOI
  • 158 Organic Cation Transporters (Octs) (2022) DOI
  • 36 Catechol-O-Methyl Transferase (Comt) (2022) DOI
  • 191 Reactive Intermediates (2022) DOI
  • 226 Transferase (2022) DOI
  • 81 First Pass Effect/Metabolism (Pseudo-First Pass Effect) (2022) DOI
  • 170 Pharmacokinetics (Pk) (2022) DOI
  • 12 Aldehyde Oxidase (Ao) (2022) DOI
  • 47 Cytochrome P-450 Enzymes (Cyps) (2022) DOI
  • 48 Deacetylation (2022) DOI
  • 20 Aromatic Hydrocarbon Receptor (Ahr) (2022) DOI
  • 69 Elimination (2022) DOI
  • 57 Diamine Oxidases (Dao) (2022) DOI
  • 87 Glucocorticoid Responsive Element (Gre) (2022) DOI
  • 177 Polyamine Oxidase (Pao) (2022) DOI

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