Jack Hinson
Distinguished Professor Emeritus
Also affiliated: National Institutes of Health (1974–2008); Arkansas Children's Hospital (2006–2017); United States Food and Drug Administration (1991); University of Arizona (2003); University of South Carolina (1969); University of California, San Francisco (2009); Baylor College of Medicine (1981); Vanderbilt University (1972–1975); Medical College of Wisconsin (2009–2010); University of Arkansas Medical Center (1998–2022); University of California San Diego (2009); National Heart, Lung, and Blood Institute (1974–2008); PAREXEL International (United States) (2012); Eunice Kennedy Shriver National Institute of Child Health and Human Development (1977–1979); National Institute of Mental Health (1996); Arkansas Children's Research Institute (2006–2012); The University of Texas Southwestern Medical Center (2009)
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Jack Hinson's research focuses on the metabolic pathways and mechanisms of drug-induced liver injury, particularly involving acetaminophen. He investigates the role of reactive intermediates and oxidative stress in the pathogenesis of this condition. His work also explores the function of various transporters and enzymes, such as organic cation transporters (OCTs) and catechol-O-methyl transferase (COMT), in xenobiotic metabolism. Hinson's publications contribute to understanding the fundamental processes of drug metabolism, including first-pass effects and conjugation reactions, which are critical for drug discovery and development.
With a substantial publication record and a high citation count, Hinson is recognized as a highly cited researcher. He leads a research group at the University of Arkansas for Medical Sciences, where he contributes to the advancement of knowledge in toxicology and pharmacology. His research has implications for understanding how the body processes drugs and the potential for toxicity, particularly in the liver.
Metrics
- h-index: 51
- Publications: 369
- Citations: 9,396
Positions
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Distinguished Professor Emeritus publications 1988–2024University of Arkansas for Medical Sciences Institution web page
Selected Publications
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Development of clinical assays for determination of acetaminophen protein adducts (2024)
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15 Amino Acid Conjugation (2022)
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158 Organic Cation Transporters (Octs) (2022)
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36 Catechol-O-Methyl Transferase (Comt) (2022)
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191 Reactive Intermediates (2022)
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45 Cysteine-S-Conjugate Β-Lyase (C-S Lyase) (2022)
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228 Ultra-Rapid Metabolizer (2022)
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190 Reaction Phenotyping (2022)
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28 Bioequivalence (2022)
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58 Disulfiram Reaction (2022)
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34 Catabolism (2022)
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17 Anabolism (2022)
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49 Dealkylation (2022)
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192 Reactive Metabolites (2022)
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205 Saturation Kinetics (2022)
Collaboration Network
Top Collaborators
- Glossary and tutorial of xenobiotic metabolism terms used during small molecule drug discovery and development (IUPAC Technical Report)
- 191 Reactive Intermediates
- 20 Aromatic Hydrocarbon Receptor (Ahr)
- 36 Catechol-O-Methyl Transferase (Comt)
- 158 Organic Cation Transporters (Octs)
Showing 5 of 54 shared publications
- Glossary and tutorial of xenobiotic metabolism terms used during small molecule drug discovery and development (IUPAC Technical Report)
- 191 Reactive Intermediates
- 20 Aromatic Hydrocarbon Receptor (Ahr)
- 36 Catechol-O-Methyl Transferase (Comt)
- 158 Organic Cation Transporters (Octs)
Showing 5 of 54 shared publications
- Glossary and tutorial of xenobiotic metabolism terms used during small molecule drug discovery and development (IUPAC Technical Report)
- 191 Reactive Intermediates
- 20 Aromatic Hydrocarbon Receptor (Ahr)
- 36 Catechol-O-Methyl Transferase (Comt)
- 158 Organic Cation Transporters (Octs)
Showing 5 of 54 shared publications
- Glossary and tutorial of xenobiotic metabolism terms used during small molecule drug discovery and development (IUPAC Technical Report)
- 191 Reactive Intermediates
- 20 Aromatic Hydrocarbon Receptor (Ahr)
- 36 Catechol-O-Methyl Transferase (Comt)
- 158 Organic Cation Transporters (Octs)
Showing 5 of 54 shared publications
- Glossary and tutorial of xenobiotic metabolism terms used during small molecule drug discovery and development (IUPAC Technical Report)
- 191 Reactive Intermediates
- 20 Aromatic Hydrocarbon Receptor (Ahr)
- 36 Catechol-O-Methyl Transferase (Comt)
- 158 Organic Cation Transporters (Octs)
Showing 5 of 54 shared publications
- Glossary and tutorial of xenobiotic metabolism terms used during small molecule drug discovery and development (IUPAC Technical Report)
- 191 Reactive Intermediates
- 20 Aromatic Hydrocarbon Receptor (Ahr)
- 36 Catechol-O-Methyl Transferase (Comt)
- 158 Organic Cation Transporters (Octs)
Showing 5 of 54 shared publications
- Glossary and tutorial of xenobiotic metabolism terms used during small molecule drug discovery and development (IUPAC Technical Report)
- 191 Reactive Intermediates
- 20 Aromatic Hydrocarbon Receptor (Ahr)
- 36 Catechol-O-Methyl Transferase (Comt)
- 158 Organic Cation Transporters (Octs)
Showing 5 of 54 shared publications
- Glossary and tutorial of xenobiotic metabolism terms used during small molecule drug discovery and development (IUPAC Technical Report)
- 191 Reactive Intermediates
- 20 Aromatic Hydrocarbon Receptor (Ahr)
- 36 Catechol-O-Methyl Transferase (Comt)
- 158 Organic Cation Transporters (Octs)
Showing 5 of 54 shared publications
- Glossary and tutorial of xenobiotic metabolism terms used during small molecule drug discovery and development (IUPAC Technical Report)
- 191 Reactive Intermediates
- 20 Aromatic Hydrocarbon Receptor (Ahr)
- 36 Catechol-O-Methyl Transferase (Comt)
- 158 Organic Cation Transporters (Octs)
Showing 5 of 54 shared publications
- Glossary and tutorial of xenobiotic metabolism terms used during small molecule drug discovery and development (IUPAC Technical Report)
- 191 Reactive Intermediates
- 20 Aromatic Hydrocarbon Receptor (Ahr)
- 36 Catechol-O-Methyl Transferase (Comt)
- 158 Organic Cation Transporters (Octs)
Showing 5 of 54 shared publications
- Glossary and tutorial of xenobiotic metabolism terms used during small molecule drug discovery and development (IUPAC Technical Report)
- 191 Reactive Intermediates
- 20 Aromatic Hydrocarbon Receptor (Ahr)
- 36 Catechol-O-Methyl Transferase (Comt)
- 158 Organic Cation Transporters (Octs)
Showing 5 of 54 shared publications
- Glossary and tutorial of xenobiotic metabolism terms used during small molecule drug discovery and development (IUPAC Technical Report)
- 191 Reactive Intermediates
- 20 Aromatic Hydrocarbon Receptor (Ahr)
- 36 Catechol-O-Methyl Transferase (Comt)
- 158 Organic Cation Transporters (Octs)
Showing 5 of 54 shared publications
- Glossary and tutorial of xenobiotic metabolism terms used during small molecule drug discovery and development (IUPAC Technical Report)
- 191 Reactive Intermediates
- 20 Aromatic Hydrocarbon Receptor (Ahr)
- 36 Catechol-O-Methyl Transferase (Comt)
- 158 Organic Cation Transporters (Octs)
Showing 5 of 54 shared publications
- Glossary and tutorial of xenobiotic metabolism terms used during small molecule drug discovery and development (IUPAC Technical Report)
- 191 Reactive Intermediates
- 20 Aromatic Hydrocarbon Receptor (Ahr)
- 36 Catechol-O-Methyl Transferase (Comt)
- 158 Organic Cation Transporters (Octs)
Showing 5 of 54 shared publications
- Glossary and tutorial of xenobiotic metabolism terms used during small molecule drug discovery and development (IUPAC Technical Report)
- 191 Reactive Intermediates
- 20 Aromatic Hydrocarbon Receptor (Ahr)
- 36 Catechol-O-Methyl Transferase (Comt)
- 158 Organic Cation Transporters (Octs)
Showing 5 of 54 shared publications
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