Jia‐Long Fang

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NCTR

Also affiliated: Jiangnan University (2023–2025); United States Food and Drug Administration (2000–2026); University of South Florida (2002–2004); Karolinska Institutet (1995–1999); Moffitt Cancer Center (2002–2004); University of Illinois Chicago (2013); State Key Laboratory of Food Science and Technology (2023); Penn State Cancer Institute (2006)

30 h-index 63 pubs 3,238 cited

Research Areas

Biomedical Subjects

Links

ORCID Lab Website

OverviewAI-generated summary

Jia-Long Fang investigates the toxicological effects and biological mechanisms of various chemical compounds, with a focus on potential carcinogenicity, metabolic disorders, and cellular responses. His research has examined the carcinogenicity of dyes such as gentian violet and malachite green, and the toxicity of polyethylene glycols in animal models. Fang has also explored the role of specific molecular pathways, including the thromboxane A2/thromboxane A2 receptor axis, in the development of hepatic insulin resistance and steatosis associated with non-alcoholic fatty liver disease. This work has led to the investigation of natural compounds like piperlongumine and ginkgolide B as potential therapeutic agents for ameliorating these conditions by targeting these pathways.

Further research by Fang delves into the metabolic transformations of compounds, such as the oxidation of 7-hydroxycannabidiol to a reactive metabolite by NAD(P)+-dependent alcohol oxidoreductases. His work also encompasses the impact of microbial metabolites, like indole-3-lactic acid produced by Lactiplantibacillus plantarum, on mitigating oxidative stress and intestinal aging. Fang's research network includes consistent collaborations with researchers at the National Center for Toxicological Research, including Frederick A. Beland, Mackean P. Maisha, Michelle M. Vanlandingham, and Robert P. Felton. With an h-index of 30 and over 3,187 citations across 65 publications, Fang is recognized as a highly cited researcher.

Metrics

h-index: 30
Publications: 63
Citations: 3,238

Selected Publications

Contribution of cytochrome P450-mediated metabolism to clavulanic acid-induced cytotoxicity in TK6-derived cytochrome P450-overexpressing cell lines (2026)

Scientific Reports DOI OpenAlex
NAD(P)+-dependent alcohol oxidoreductases oxidize 7-hydroxycannabidiol to a reactive formyl metabolite (2025)

Archives of Toxicology 2 citations DOI OpenAlex
Flow cytometric analysis of the SARS coronavirus 2 antibodies in human plasma (2025)

Scientific Reports DOI OpenAlex
Two-year dermal carcinogenicity bioassay of triclosan in B6C3F1 mice (2023)

Archives of Toxicology 1 citation DOI OpenAlex
Evaluation of association of anti-PEG antibodies with anaphylaxis after mRNA COVID-19 vaccination (2023)

Vaccine 29 citations DOI OpenAlex
Evaluation of association of anti-PEG antibodies with anaphylaxis after mRNA COVID-19 vaccination (2023)

medRxiv DOI OpenAlex
Toxicity of high-molecular-weight polyethylene glycols in Sprague Dawley rats (2022)

Toxicology Letters 23 citations DOI OpenAlex
Flow cytometry analysis of anti-polyethylene glycol antibodies in human plasma (2020)

Toxicology Reports 38 citations DOI OpenAlex
Apoptosis contributes to the cytotoxicity induced by amodiaquine and its major metabolite N-desethylamodiaquine in hepatic cells (2019)

Toxicology in Vitro 10 citations DOI OpenAlex
Role of peroxisome proliferator-activated receptor alpha (PPARα) and PPARα-mediated species differences in triclosan-induced liver toxicity (2018)

Archives of Toxicology 25 citations DOI OpenAlex
Effects of human sulfotransferases on the cytotoxicity of 12-hydroxynevirapine (2018)

Biochemical Pharmacology 7 citations DOI OpenAlex
Cytochrome P450-mediated metabolism of triclosan attenuates its cytotoxicity in hepatic cells (2016)

Archives of Toxicology 49 citations DOI OpenAlex
Effect of triclosan, triclocarban, 2,2′,4,4′-tetrabromodiphenyl ether, and bisphenol A on the iodide uptake, thyroid peroxidase activity, and expression of genes involved in thyroid hormone synthesis (2016)

Toxicology in Vitro 121 citations DOI OpenAlex
Human Sulfotransferases Enhance the Cytotoxicity of Tolvaptan (2015)

Toxicological Sciences 17 citations DOI OpenAlex
Mechanisms of tolvaptan-induced toxicity in HepG2 cells (2015)

Biochemical Pharmacology 41 citations DOI OpenAlex