A
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
A.C.W. Pike's research focuses on determining the three-dimensional structures of medically relevant proteins and protein complexes using X-ray crystallography. This work provides insights into molecular mechanisms, identifies potential drug binding sites, and informs the development of inhibitors. Recent publications have elucidated the structural basis for the function and inhibition of human ceramide synthases, human urea transporters (UT-A and UT-B), the lysosomal two-pore channel TPC2, and the sphingosine-1-phosphate exporter SPNS2. Additionally, research has investigated the structure and function of the SIT1 proline transporter in complex with ACE2, the receptor for SARS-CoV-2, and the structural basis of fatty acid elongation by ELOVL elongases. Another area of study involves the extracellular modulation of TREK-2 channel activity with nanobodies.
Pike has published 266 papers with 11,372 citations, achieving an h-index of 42. This work has been recognized with a "high-impact researcher (highly cited)" designation. Key collaborators at the University of Arkansas for Medical Sciences include Tatiana Wolfe, Clint Kilts, Sienna Colonese, and Laura B. Dunn.
Metrics
- h-index: 42
- Publications: 265
- Citations: 11,427
Selected Publications
-
511 Functional link between myelination integrity in the connectome of the cingulum bundle and information processing speed in RRMS (2025)
-
423 Innovation in MS Patient Care: Linking Cognitive Health and Myelin Integrity (2024)
Collaboration Network
Top Collaborators
N. Burgess-Brown
University of Oxford (GB)
11 shared publications
- The structural basis of fatty acid elongation by the ELOVL elongases
- Structural characterization of human urea transporters UT-A and UT-B and their inhibition
- Structural basis for inhibition of the lysosomal two-pore channel TPC2 by a small molecule antagonist
- Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2
- Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2
Showing 5 of 11 shared publications
Elisabeth P. Carpenter
11 shared publications
- The structural basis of fatty acid elongation by the ELOVL elongases
- Structural basis of the mechanism and inhibition of a human ceramide synthase
- Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation
- Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2
- Structural basis of the mechanism and inhibition of a human ceramide synthase
Showing 5 of 11 shared publications
Shubhashish Mukhopadhyay
University of Oxford (GB)
10 shared publications
- The structural basis of fatty acid elongation by the ELOVL elongases
- Structural characterization of human urea transporters UT-A and UT-B and their inhibition
- Structural basis for inhibition of the lysosomal two-pore channel TPC2 by a small molecule antagonist
- Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2
- Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2
Showing 5 of 10 shared publications
Gamma Chi
University of Oxford (GB)
9 shared publications
- Structural basis of the mechanism and inhibition of a human ceramide synthase
- Structural characterization of human urea transporters UT-A and UT-B and their inhibition
- Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2
- Structural basis for inhibition of the lysosomal two-pore channel TPC2 by a small molecule antagonist
- Structural basis of the mechanism and inhibition of a human ceramide synthase
Showing 5 of 9 shared publications
Simon R. Bushell
University of Oxford (GB)
8 shared publications
- The structural basis of fatty acid elongation by the ELOVL elongases
- Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation
- Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2
- Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation
- Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2
Showing 5 of 8 shared publications
David B. Sauer
University of Oxford (GB)
8 shared publications
- Structural basis of the mechanism and inhibition of a human ceramide synthase
- Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2
- Structural basis of the mechanism and inhibition of a human ceramide synthase
- Structures of the human adult muscle-type nicotinic receptor in resting and desensitized states
- Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2
Showing 5 of 8 shared publications
Tomas C. Pascoa
6 shared publications
- The structural basis of fatty acid elongation by the ELOVL elongases
- Structural basis of the mechanism and inhibition of a human ceramide synthase
- Structural basis of the mechanism and inhibition of a human ceramide synthase
- Major facilitator superfamily domain-containing protein 10 (MFSD10) A Target Enabling Package (TEP)
- Major facilitator superfamily domain-containing protein 10 (MFSD10) A Target Enabling Package (TEP)
Showing 5 of 6 shared publications
Andrew Quigley
University of Oxford (GB)
6 shared publications
- The structural basis of fatty acid elongation by the ELOVL elongases
- Structural basis of the mechanism and inhibition of a human ceramide synthase
- Structural basis of the mechanism and inhibition of a human ceramide synthase
- Major facilitator superfamily domain-containing protein 10 (MFSD10) A Target Enabling Package (TEP)
- Major facilitator superfamily domain-containing protein 10 (MFSD10) A Target Enabling Package (TEP)
Showing 5 of 6 shared publications
R. Chalk
University of Oxford (GB)
5 shared publications
- Structural basis of the mechanism and inhibition of a human ceramide synthase
- Structural characterization of human urea transporters UT-A and UT-B and their inhibition
- Structural basis of the mechanism and inhibition of a human ceramide synthase
- Cryo-EM structure of human TMEM45A
- Structure of Wild-Type Human Potassium Chloride Transporter KCC3 in NaCl (LMNG/CHS)
Huanyu Li
University of Oxford (GB)
5 shared publications
- Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2
- Structural basis for inhibition of the lysosomal two-pore channel TPC2 by a small molecule antagonist
- Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2
- Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2
- Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2
Dong Wang
University of Oxford (GB)
5 shared publications
- Structural characterization of human urea transporters UT-A and UT-B and their inhibition
- Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2
- Structural basis for inhibition of the lysosomal two-pore channel TPC2 by a small molecule antagonist
- Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2
- Amino acid and viral binding by the high-affinity Cationic Amino acidTransporter 1 (CAT1) from Mus musculus
G. McKinley
University of Oxford (GB)
4 shared publications
- Structural characterization of human urea transporters UT-A and UT-B and their inhibition
- Structural basis for inhibition of the lysosomal two-pore channel TPC2 by a small molecule antagonist
- Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2
- Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2
Saša Štefanić
University of Zurich (CH)
4 shared publications
- Structural basis of the mechanism and inhibition of a human ceramide synthase
- Structural basis of the mechanism and inhibition of a human ceramide synthase
- Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2
- Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2
C. Moreau
University of Oxford (GB)
3 shared publications
- Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2
- Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2
- Structure of Wild-Type Human Potassium Chloride Transporter KCC3 in NaCl (LMNG/CHS)
Karin E. J. Rödström
University of Oxford (GB)
3 shared publications
- Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation
- Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation
- Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2
Similar Researchers
Based on overlapping research topics
Oshadi Edirisinghe
University of Arkansas at Fayetteville
Protein Structure and Dynamics
Disease Mechanisms Research
Metabolism and Genetic Disorders
Rowland, Matthew
University of Arkansas for Medical Sciences
Protein Structure and Dynamics
Disease Mechanisms Research
Metabolism and Genetic Disorders
Sheryl Davide-Ureta
University of Arkansas for Medical Sciences
Disease Mechanisms Research
Metabolism and Genetic Disorders
Drug Transport and Resistance Mechanisms
Isabelle Racine Miousse
University of Arkansas for Medical Sciences
Protein Structure and Dynamics
Disease Mechanisms Research
Receptor Mechanisms and Signaling
Patience Okoto
University of Arkansas at Fayetteville
Protein Structure and Dynamics
Metabolism and Genetic Disorders
Receptor Mechanisms and Signaling
Joseph Williamson
University of Arkansas at Fayetteville
Protein Structure and Dynamics
Disease Mechanisms Research
Cellular transport and secretion