A.C.W. Pike

OverviewAI-generated summary

A.C.W. Pike's research focuses on elucidating the molecular mechanisms underlying biological processes, particularly through the application of structural biology techniques. Pike has published extensively on the structure and function of various protein complexes, including those involved in cellular signaling and transport. Recent work has investigated the structural basis for the activation and inhibition of estrogen receptors, exploring how these proteins interact with ligands and mediate cellular responses. This research has contributed to understanding the molecular basis of agonism and antagonism in these critical signaling pathways.

Further investigations have delved into the structures of ion channels and transporters. Pike's group has determined the structures of K2P channel complexes, revealing insights into their gating mechanisms, and has also studied the structures of ATP-binding cassette transporters, providing a molecular understanding of their function in cellular transport. Additionally, research has examined the structural basis of protein assembly in E3 ubiquitin ligase complexes, shedding light on the mechanisms of protein degradation and cellular regulation.

Pike's scholarship is characterized by a significant publication record, with 265 total publications and over 11,500 citations, reflected in an h-index of 42. Pike leads an active research group at the University of Arkansas for Medical Sciences and collaborates with several colleagues, including Tatiana Wolfe, G. Andrew James, and Clint Kilts.

Metrics

• h-index: 42
• Publications: 265
• Citations: 11,532