Drug Transport And Resistance Mechanisms

Researchers investigate how drugs move into, through, and out of cells and organisms. This work explores the molecular and cellular mechanisms that govern drug absorption, distribution, metabolism, and excretion. A significant focus is on understanding how cells and pathogens develop resistance to therapeutic agents, including antibiotics and chemotherapies. Studies employ a range of techniques, from biochemical assays and cell culture to animal models and computational simulations, to identify targets for overcoming drug resistance and improving drug efficacy.

This research holds direct relevance for Arkansas’s agricultural sector, particularly in developing strategies to combat antimicrobial resistance in livestock and poultry. Understanding drug transport and resistance is also crucial for addressing public health challenges, such as the opioid crisis and the prevalence of infectious diseases within the state. Furthermore, insights gained can inform the development of new pest management strategies and contribute to the safety of food production systems.

This area draws upon and contributes to diverse fields including pharmacology, toxicology, microbiology, molecular biology, and genetics. Engagement spans multiple Arkansas institutions, fostering a broad base of expertise and collaborative opportunities.