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Biography and Research Information
OverviewAI-generated summary
Cassie M. Chandler's research program investigates the neurobiological mechanisms underlying substance use disorders and their developmental consequences. Her work often utilizes rodent models to examine the effects of adolescent alcohol exposure on adult behaviors, including alcohol intake and self-administration. This research has explored factors such as social isolation, oral gavage administration, and the role of specific neurochemical systems, including glucocorticoid receptors and adrenergic receptors.
Chandler's publications also address the neuroinflammatory processes associated with adolescent alcohol drinking, particularly the involvement of microglia. Additionally, her research extends to the effects of other substances, such as fentanyl and methamphetamine, and investigates potential pharmacological countermeasures. She has a recent publication in 2024 on targeting adrenergic receptors for fentanyl-induced depression and another in 2024 on a vesicular monoamine transporter-2 inhibitor for methamphetamine toxicity and self-administration. Her scholarly output includes 18 publications with 140 citations and an h-index of 7.
Metrics
- h-index: 8
- Publications: 18
- Citations: 144
Selected Publications
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Vesicular monoamine transporter-2 inhibitor JPC-141 prevents methamphetamine-induced dopamine toxicity and blocks methamphetamine self-administration in rats (2024)
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The effect of bethanechol on tracheobronchomalacia in infants: A retrospective cohort study (2023)
Collaboration Network
Top Collaborators
Michael T. Bardo
University of Kentucky (US)
9 shared publications
- Primed for addiction: A critical review of the role of microglia in the neurodevelopmental consequences of adolescent alcohol drinking
- Effect of the glucocorticoid receptor antagonist PT150 on acquisition and escalation of fentanyl self-administration following early-life stress.
- Effects of voluntary adolescent intermittent alcohol exposure and social isolation on adult alcohol intake in male rats
- Adolescent Intermittent Ethanol Drives Modest Neuroinflammation but Does Not Escalate Drinking in Male Rats
- Effects of adolescent alcohol exposure via oral gavage on adult alcohol drinking and co-use of alcohol and nicotine in Sprague Dawley rats
Showing 5 of 9 shared publications
Kimberly Nixon
Austin College (US)
5 shared publications
- Primed for addiction: A critical review of the role of microglia in the neurodevelopmental consequences of adolescent alcohol drinking
- Effects of voluntary adolescent intermittent alcohol exposure and social isolation on adult alcohol intake in male rats
- Adolescent Intermittent Ethanol Drives Modest Neuroinflammation but Does Not Escalate Drinking in Male Rats
- Effects of adolescent alcohol exposure via oral gavage on adult alcohol drinking and co-use of alcohol and nicotine in Sprague Dawley rats
- Effects of isolation stress and voluntary ethanol exposure during adolescence on ethanol and nicotine co-use in adulthood using male rats
James R. Pauly
University of Kentucky (US)
4 shared publications
- Primed for addiction: A critical review of the role of microglia in the neurodevelopmental consequences of adolescent alcohol drinking
- Effects of voluntary adolescent intermittent alcohol exposure and social isolation on adult alcohol intake in male rats
- Effects of adolescent alcohol exposure via oral gavage on adult alcohol drinking and co-use of alcohol and nicotine in Sprague Dawley rats
- Effects of isolation stress and voluntary ethanol exposure during adolescence on ethanol and nicotine co-use in adulthood using male rats
Jakob D. Shaykin
University of Kentucky (US)
4 shared publications
- Effects of voluntary adolescent intermittent alcohol exposure and social isolation on adult alcohol intake in male rats
- Targeting α1- and α2-adrenergic receptors as a countermeasure for fentanyl-induced locomotor and ventilatory depression
- ALPHA 1 AND 2 NORADRENERGIC RECEPTORS AS TARGETS FOR REVERSING FENTANYL-INDUCED RESPIRATORY DEPRESSION
- Effects of isolation stress and voluntary ethanol exposure during adolescence on ethanol and nicotine co-use in adulthood using male rats
Hui Peng
University of Kentucky (US)
3 shared publications
- Primed for addiction: A critical review of the role of microglia in the neurodevelopmental consequences of adolescent alcohol drinking
- Effects of voluntary adolescent intermittent alcohol exposure and social isolation on adult alcohol intake in male rats
- Effects of adolescent alcohol exposure via oral gavage on adult alcohol drinking and co-use of alcohol and nicotine in Sprague Dawley rats
Emily D. Denehy
University of Kentucky (US)
3 shared publications
- Effect of the glucocorticoid receptor antagonist PT150 on acquisition and escalation of fentanyl self-administration following early-life stress.
- Targeting α1- and α2-adrenergic receptors as a countermeasure for fentanyl-induced locomotor and ventilatory depression
- ALPHA 1 AND 2 NORADRENERGIC RECEPTORS AS TARGETS FOR REVERSING FENTANYL-INDUCED RESPIRATORY DEPRESSION
Jennifer K. Melbourne
The University of Texas at Austin (US)
2 shared publications
- Primed for addiction: A critical review of the role of microglia in the neurodevelopmental consequences of adolescent alcohol drinking
- Adolescent Intermittent Ethanol Drives Modest Neuroinflammation but Does Not Escalate Drinking in Male Rats
Catherine E Van Doorn
University of Kentucky (US)
2 shared publications
- Primed for addiction: A critical review of the role of microglia in the neurodevelopmental consequences of adolescent alcohol drinking
- Effects of isolation stress and voluntary ethanol exposure during adolescence on ethanol and nicotine co-use in adulthood using male rats
Joshua S. Beckmann
University of Kentucky (US)
2 shared publications
- Effects of adolescent alcohol exposure via oral gavage on adult alcohol drinking and co-use of alcohol and nicotine in Sprague Dawley rats
- Effects of isolation stress and voluntary ethanol exposure during adolescence on ethanol and nicotine co-use in adulthood using male rats
Jocelyn Martin
University of Kentucky (US)
2 shared publications
- Targeting α1- and α2-adrenergic receptors as a countermeasure for fentanyl-induced locomotor and ventilatory depression
- ALPHA 1 AND 2 NORADRENERGIC RECEPTORS AS TARGETS FOR REVERSING FENTANYL-INDUCED RESPIRATORY DEPRESSION
Jill Turner
University of Kentucky (US)
2 shared publications
- Targeting α1- and α2-adrenergic receptors as a countermeasure for fentanyl-induced locomotor and ventilatory depression
- ALPHA 1 AND 2 NORADRENERGIC RECEPTORS AS TARGETS FOR REVERSING FENTANYL-INDUCED RESPIRATORY DEPRESSION
Warren J. Alilain
University of Kentucky (US)
2 shared publications
- Targeting α1- and α2-adrenergic receptors as a countermeasure for fentanyl-induced locomotor and ventilatory depression
- ALPHA 1 AND 2 NORADRENERGIC RECEPTORS AS TARGETS FOR REVERSING FENTANYL-INDUCED RESPIRATORY DEPRESSION
Thomas E. Prisinzano
University of Kentucky (US)
2 shared publications
- Targeting α1- and α2-adrenergic receptors as a countermeasure for fentanyl-induced locomotor and ventilatory depression
- ALPHA 1 AND 2 NORADRENERGIC RECEPTORS AS TARGETS FOR REVERSING FENTANYL-INDUCED RESPIRATORY DEPRESSION
Jaren A. Reeves-Darby
University of Mississippi Medical Center (US)
1 shared publication
- Modulation of relapse-like drinking in male Sprague-Dawley rats by ligands targeting the α5GABAA receptor
Sherman A. Jones
University of Mississippi Medical Center (US)
1 shared publication
- Modulation of relapse-like drinking in male Sprague-Dawley rats by ligands targeting the α5GABAA receptor
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