A
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Alison Simmons' research focuses on the molecular and cellular mechanisms underlying intestinal diseases, particularly inflammatory bowel disease (IBD) and colitis. Her work investigates the role of specific genes and signaling pathways in regulating epithelial cell function, repair, and immune responses within the gut. She has studied the function of GSDMB in IBD, examining its impact on epithelial restitution and its independence from pyroptosis. Additionally, her research has explored the therapeutic potential of targeting interferon-gamma-producing CD8+ tissue-resident memory T cells in immune checkpoint inhibitor-induced colitis.
Simmons' research also extends to broader applications of single-cell analysis and atlas development for human tissues. She has contributed to projects focused on spatiotemporal analysis of human intestinal development at single-cell resolution and the creation of a roadmap for the human gut cell atlas. Her work has also touched upon the interaction between the gut microbiota, specifically *Akkermansia muciniphila*, and the intestinal mucus barrier, as well as the role of the bone morphogenetic protein pathway in intestinal regeneration. Her scholarship metrics include an h-index of 45 and over 15,000 citations across 169 publications.
Metrics
- h-index: 45
- Publications: 168
- Citations: 15,438
Selected Publications
-
Enhancing Maternal Confidence in the Neonatal Intensive Care Unit: A Pilot Study on Multimodal, Occupation-Based Education for First-Time Mothers (2025)
Collaboration Network
Top Collaborators
Agne Antanaviciute
MRC Weatherall Institute of Molecular Medicine (GB)
25 shared publications
- Spatiotemporal analysis of human intestinal development at single-cell resolution
- GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis
- Multi-Modal Characterization of Monocytes in Idiopathic Pulmonary Fibrosis Reveals a Primed Type I Interferon Immune Phenotype
- Bone Morphogenetic Protein Pathway Antagonism by Grem1 Regulates Epithelial Cell Fate in Intestinal Regeneration
- Intelectin-1 binds and alters the localization of the mucus barrier–modifying bacterium <i>Akkermansia muciniphila</i>
Showing 5 of 25 shared publications
Chloe H. Lee
MRC Weatherall Institute of Molecular Medicine (GB)
13 shared publications
- Evaluating performance of existing computational models in predicting CD8+ T cell pathogenic epitopes and cancer neoantigens
- HLA‐dependent variation in SARS‐CoV‐2 CD8 <sup>+</sup> T cell cross‐reactivity with human coronaviruses
- Tracking in situ checkpoint inhibitor-bound target T cells in patients with checkpoint-induced colitis
- A robust deep learning workflow to predict CD8 + T-cell epitopes
- To what extent does MHC binding translate to immunogenicity in humans?
Showing 5 of 13 shared publications
Hashem Koohy
University of Oxford (GB)
11 shared publications
- Spatiotemporal analysis of human intestinal development at single-cell resolution
- Evaluating performance of existing computational models in predicting CD8+ T cell pathogenic epitopes and cancer neoantigens
- HLA‐dependent variation in SARS‐CoV‐2 CD8 <sup>+</sup> T cell cross‐reactivity with human coronaviruses
- Dual RNA sequencing reveals dendritic cell reprogramming in response to typhoidal Salmonella invasion
- A robust deep learning workflow to predict CD8 + T-cell epitopes
Showing 5 of 11 shared publications
Paul Buckley
MRC Weatherall Institute of Molecular Medicine (GB)
8 shared publications
- Evaluating performance of existing computational models in predicting CD8+ T cell pathogenic epitopes and cancer neoantigens
- HLA‐dependent variation in SARS‐CoV‐2 CD8 <sup>+</sup> T cell cross‐reactivity with human coronaviruses
- A robust deep learning workflow to predict CD8 + T-cell epitopes
- To what extent does MHC binding translate to immunogenicity in humans?
- HLA-dependent variation in SARS-CoV-2 CD8+ T cell cross-reactivity with human coronaviruses
Showing 5 of 8 shared publications
David Fawkner-Corbett
Nuffield Orthopaedic Centre (GB)
7 shared publications
- Spatiotemporal analysis of human intestinal development at single-cell resolution
- Tracking in situ checkpoint inhibitor-bound target T cells in patients with checkpoint-induced colitis
- Mutational order and epistasis determine the consequences of FBXW7 mutations during colorectal cancer evolution
- Common heritage of fibroblasts
- Spatial fibroblast niches define Crohn’s fistulae
Showing 5 of 7 shared publications
Anna Aulicino
MRC Weatherall Institute of Molecular Medicine (GB)
7 shared publications
- Tracking in situ checkpoint inhibitor-bound target T cells in patients with checkpoint-induced colitis
- Dual RNA sequencing reveals dendritic cell reprogramming in response to typhoidal Salmonella invasion
- Spatial fibroblast niches define Crohn’s fistulae
- P298 Checkpoint inhibitor colitis: insights from bench and bedside
- P097 Spatially resolved insights into fistulating Crohn's disease pathogenesis: Unveiling molecular heterogeneity
Showing 5 of 7 shared publications
Marta Jagielowicz
MRC Weatherall Institute of Molecular Medicine (GB)
6 shared publications
- Spatiotemporal analysis of human intestinal development at single-cell resolution
- Tracking in situ checkpoint inhibitor-bound target T cells in patients with checkpoint-induced colitis
- Dual RNA sequencing reveals dendritic cell reprogramming in response to typhoidal Salmonella invasion
- IL-6 effector function of group 2 innate lymphoid cells (ILC2) is NOD2 dependent
- Spatial fibroblast niches define Crohn’s fistulae
Showing 5 of 6 shared publications
Tarun Gupta
John Radcliffe Hospital (GB)
6 shared publications
- Spatiotemporal analysis of human intestinal development at single-cell resolution
- Interferon-Gamma–Producing CD8+ Tissue Resident Memory T Cells Are a Targetable Hallmark of Immune Checkpoint Inhibitor–Colitis
- Tracking in situ checkpoint inhibitor-bound target T cells in patients with checkpoint-induced colitis
- P93 Faecal microbiota transplant for refractory checkpoint inhibitor immunotherapy-related colitis
- P298 Checkpoint inhibitor colitis: insights from bench and bedside
Showing 5 of 6 shared publications
Jeongmin Woo
MRC Weatherall Institute of Molecular Medicine (GB)
6 shared publications
- Evaluating performance of existing computational models in predicting CD8+ T cell pathogenic epitopes and cancer neoantigens
- HLA‐dependent variation in SARS‐CoV‐2 CD8 <sup>+</sup> T cell cross‐reactivity with human coronaviruses
- HLA-dependent variation in SARS-CoV-2 CD8+ T cell cross-reactivity with human coronaviruses
- Spatial fibroblast niches define Crohn’s fistulae
- Type I IFN-activated lung monocytes and macrophages as initiators and drivers of fibrosis at the alveolar barrier in IPF
Showing 5 of 6 shared publications
Megat Abd Hamid
6 shared publications
- Data from Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8<sup>+</sup> Tumor-Infiltrating T Lymphocyte Responses
- Data from Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8<sup>+</sup> Tumor-Infiltrating T Lymphocyte Responses
- Supplemental File For Publication from Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8<sup>+</sup> Tumor-Infiltrating T Lymphocyte Responses
- Supplementary Fig S1-7, Sup Table 1 from Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8<sup>+</sup> Tumor-Infiltrating T Lymphocyte Responses
- Supplementary Fig S1-7, Sup Table 1 from Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8<sup>+</sup> Tumor-Infiltrating T Lymphocyte Responses
Showing 5 of 6 shared publications
Ruozheng Wang
6 shared publications
- Data from Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8<sup>+</sup> Tumor-Infiltrating T Lymphocyte Responses
- Data from Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8<sup>+</sup> Tumor-Infiltrating T Lymphocyte Responses
- Supplemental File For Publication from Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8<sup>+</sup> Tumor-Infiltrating T Lymphocyte Responses
- Supplementary Fig S1-7, Sup Table 1 from Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8<sup>+</sup> Tumor-Infiltrating T Lymphocyte Responses
- Supplementary Fig S1-7, Sup Table 1 from Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8<sup>+</sup> Tumor-Infiltrating T Lymphocyte Responses
Showing 5 of 6 shared publications
Xuan Yao
6 shared publications
- Data from Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8<sup>+</sup> Tumor-Infiltrating T Lymphocyte Responses
- Data from Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8<sup>+</sup> Tumor-Infiltrating T Lymphocyte Responses
- Supplemental File For Publication from Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8<sup>+</sup> Tumor-Infiltrating T Lymphocyte Responses
- Supplementary Fig S1-7, Sup Table 1 from Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8<sup>+</sup> Tumor-Infiltrating T Lymphocyte Responses
- Supplementary Fig S1-7, Sup Table 1 from Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8<sup>+</sup> Tumor-Infiltrating T Lymphocyte Responses
Showing 5 of 6 shared publications
Peiwen Fan
6 shared publications
- Data from Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8<sup>+</sup> Tumor-Infiltrating T Lymphocyte Responses
- Data from Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8<sup>+</sup> Tumor-Infiltrating T Lymphocyte Responses
- Supplemental File For Publication from Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8<sup>+</sup> Tumor-Infiltrating T Lymphocyte Responses
- Supplementary Fig S1-7, Sup Table 1 from Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8<sup>+</sup> Tumor-Infiltrating T Lymphocyte Responses
- Supplementary Fig S1-7, Sup Table 1 from Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8<sup>+</sup> Tumor-Infiltrating T Lymphocyte Responses
Showing 5 of 6 shared publications
Xi Li
6 shared publications
- Data from Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8<sup>+</sup> Tumor-Infiltrating T Lymphocyte Responses
- Data from Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8<sup>+</sup> Tumor-Infiltrating T Lymphocyte Responses
- Supplemental File For Publication from Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8<sup>+</sup> Tumor-Infiltrating T Lymphocyte Responses
- Supplementary Fig S1-7, Sup Table 1 from Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8<sup>+</sup> Tumor-Infiltrating T Lymphocyte Responses
- Supplementary Fig S1-7, Sup Table 1 from Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8<sup>+</sup> Tumor-Infiltrating T Lymphocyte Responses
Showing 5 of 6 shared publications
Xue-Mei Chang
6 shared publications
- Data from Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8<sup>+</sup> Tumor-Infiltrating T Lymphocyte Responses
- Data from Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8<sup>+</sup> Tumor-Infiltrating T Lymphocyte Responses
- Supplemental File For Publication from Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8<sup>+</sup> Tumor-Infiltrating T Lymphocyte Responses
- Supplementary Fig S1-7, Sup Table 1 from Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8<sup>+</sup> Tumor-Infiltrating T Lymphocyte Responses
- Supplementary Fig S1-7, Sup Table 1 from Enriched HLA-E and CD94/NKG2A Interaction Limits Antitumor CD8<sup>+</sup> Tumor-Infiltrating T Lymphocyte Responses
Showing 5 of 6 shared publications
Similar Researchers
Based on overlapping research topics
Andreea M. Bujor
University of Arkansas for Medical Sciences
Immune Response and Inflammation
Disease Mechanisms Research
Molecular Biology Techniques and Applications
Supriya Jambhekar
University of Arkansas for Medical Sciences
Gut microbiota and health
Immune Response and Inflammation
Disease Mechanisms Research
Shelley Crary
University of Arkansas for Medical Sciences
Disease Mechanisms Research
Molecular Biology Techniques and Applications
Cellular transport and secretion
Dr. Stephanie Byrum
University of Arkansas for Medical Sciences
Disease Mechanisms Research
Molecular Biology Techniques and Applications
Cellular transport and secretion
Carlon Q Gragg
University of Arkansas for Medical Sciences
Immune Response and Inflammation
Disease Mechanisms Research
Molecular Biology Techniques and Applications
Hamza Khan
University of Arkansas for Medical Sciences
Inflammatory Bowel Disease
Gut microbiota and health
Disease Mechanisms Research