Andrea A. Duina
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Researcher
Formerly Arkansas Affiliated with Hendrix College through 2024; recent publications list Centre for Quantum Technologies, National University of Singapore.
Faculty Researcher
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Andrea A. Duina's research focuses on the molecular mechanisms of gene transcription and chromatin regulation, primarily utilizing the model organism *Saccharomyces cerevisiae* (budding yeast). Her recent work investigates the impact of specific histone mutations on gene expression and the interaction of transcription machinery with DNA. This includes studying how mutations in histone H3, such as H3-L61R, affect the recruitment and function of proteins like Spt16 and the yeast FACT complex (yFACT) at gene loci.
Duina also examines the influence of DNA sequences at the 3' end of genes on the occupancy of yFACT, RNA polymerase II, and nucleosomes. Her research contributes to understanding the fundamental processes of transcription elongation, chromatin structure, and how genetic alterations can disrupt these processes. She has received funding from the National Science Foundation (NSF) for a conference aimed at broadening research opportunities within South Central EPSCoR states, serving as Principal Investigator for this $83,387 award. Duina has a h-index of 13, with 29 publications and 996 citations, and actively collaborates with colleagues at Hendrix College, including Elijah G. Dilday, Alex Pablo-Kaiser, McKenzie G. Tucker, and Avery G. Olmstead.
Metrics
- h-index: 13
- Publications: 29
- Citations: 996
Selected Publications
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Trapping of yFACT at 3’ ends of genes is not a universal characteristic of yeast versions of Bryant-Li-Bhoj syndrome histone H3 mutants (2024)
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Assessing contributions of DNA sequences at the 3’ end of a yeast gene on yFACT, RNA polymerase II, and nucleosome occupancy (2024)
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Dominant effects of the histone mutant H3-L61R on Spt16-gene interactions in budding yeast (2022)
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Evidence that dissociation of Spt16 from transcribed genes is partially dependent on RNA Polymerase II termination (2019)
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Targeted <em>in Situ</em> Mutagenesis of Histone Genes in Budding Yeast (2017)
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Charged residues on the side of the nucleosome contribute to normal Spt16-gene interactions in budding yeast (2017)
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Targeted <em>in Situ</em> Mutagenesis of Histone Genes in Budding Yeast (2017)
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A Systematic Mutational Analysis of a Histone H3 Residue in Budding Yeast Provides Insights into Chromatin Dynamics (2015)
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Budding Yeast for Budding Geneticists: A Primer on the <i>Saccharomyces cerevisiae</i> Model System (2014)
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A Nucleosomal Region Important for Ensuring Proper Interactions Between the Transcription Elongation Factor Spt16 and Transcribed Genes in<i>Saccharomyces cerevisiae</i> (2013)
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New Roles for Old Characters: An Educational Primer for Use with “Vps Factors Are Required for Efficient Transcription Elongation in Budding Yeast” (2013)
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Identification of a nucleosomal region required for the proper distribution of the transcription elongation factor Spt16 across transcribed genes in Saccharomyces cerevisiae (2012)
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Genetic evidence for an involvement of the TOR complex 1 in the process of transcription elongation in Saccharomyces cerevisiae (2012)
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Histone Chaperones Spt6 and FACT: Similarities and Differences in Modes of Action at Transcribed Genes (2011)
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Mutant Versions of the S. cerevisiae Transcription Elongation Factor Spt16 Define Regions of Spt16 That Functionally Interact with Histone H3 (2011)
Federal Grants 1 $83,387 total
Conference: Broadening Access to Research Opportunities in South Central EPSCoR States
Collaboration Network
Top Collaborators
- Dominant effects of the histone mutant H3-L61R on Spt16-gene interactions in budding yeast
- Trapping of yFACT at 3’ ends of genes is not a universal characteristic of yeast versions of Bryant-Li-Bhoj syndrome histone H3 mutants
- Dominant effects of the histone mutant H3-L61R on Spt16-gene interactions in budding yeast
- Dominant effects of the histone mutant H3-L61R on Spt16-gene interactions in budding yeast
- Dominant effects of the histone mutant H3-L61R on Spt16-gene interactions in budding yeast
- Dominant effects of the histone mutant H3-L61R on Spt16-gene interactions in budding yeast
- Dominant effects of the histone mutant H3-L61R on Spt16-gene interactions in budding yeast
- Assessing contributions of DNA sequences at the 3’ end of a yeast gene on yFACT, RNA polymerase II, and nucleosome occupancy
- Assessing contributions of DNA sequences at the 3’ end of a yeast gene on yFACT, RNA polymerase II, and nucleosome occupancy
- Assessing contributions of DNA sequences at the 3’ end of a yeast gene on yFACT, RNA polymerase II, and nucleosome occupancy
- Assessing contributions of DNA sequences at the 3’ end of a yeast gene on yFACT, RNA polymerase II, and nucleosome occupancy
- Assessing contributions of DNA sequences at the 3’ end of a yeast gene on yFACT, RNA polymerase II, and nucleosome occupancy
- Assessing contributions of DNA sequences at the 3’ end of a yeast gene on yFACT, RNA polymerase II, and nucleosome occupancy
- Assessing contributions of DNA sequences at the 3’ end of a yeast gene on yFACT, RNA polymerase II, and nucleosome occupancy
- Assessing contributions of DNA sequences at the 3’ end of a yeast gene on yFACT, RNA polymerase II, and nucleosome occupancy
- Assessing contributions of DNA sequences at the 3’ end of a yeast gene on yFACT, RNA polymerase II, and nucleosome occupancy
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