Andrew N. J. McKenzie Source Confirmed
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Programme Leader
University of Arkansas at Fayetteville
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Biography and Research Information
OverviewAI-generated summary
Andrew N. J. McKenzie's research program focuses on the role of innate lymphoid cells (ILCs) and other immune cells in the development and progression of cancer, as well as in tissue regeneration. His work has investigated how these cells influence the tumor microenvironment and impact patient outcomes.
Recent publications from his laboratory have explored the blockade of PD-1 to unleash ILC2-dependent antitumor immunity in melanoma, and the role of RORα in T cell and ILC2 commitment. His group has also studied how SREBP1-induced fatty acid synthesis affects macrophage antioxidant defenses and contributes to their alternative activation. Further investigations have examined an innate IL-25–ILC2–MDSC axis in promoting intestinal tumorigenesis and the protective role of Type 2 Innate Lymphoid Cells against colorectal cancer progression, linking their presence to improved patient survival.
McKenzie's research also extends to the function of eosinophils in thymus regeneration and the modulation of immune responses during vaccination. His scholarship metrics include an h-index of 113 and over 45,000 citations across more than 350 publications, recognizing him as a highly cited researcher.
Metrics
- h-index: 113
- Publications: 350
- Citations: 45,743
Selected Publications
- Strategic Hedging Approaches for Grain and Oilseed Producers (2025) DOI
- Effective Risk Management for Grain and Oilseed End Users (2025) DOI
- Final Thoughts (2025) DOI
- Basis, Futures, and Cash (2025) DOI
- Building and Managing a Position (2025) DOI
- Processing Margins (2025) DOI
- Introduction (2025) DOI
- USDA and Market Report Summary (2025) DOI
- Practical Applications of Factor Model Index for Commodity Investment (2022) DOI
Collaboration Network
Top Collaborators
- RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus
- SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defences to promote their alternative activation
- An innate IL-25–ILC2–MDSC axis creates a cancer-permissive microenvironment for <i>Apc</i> mutation–driven intestinal tumorigenesis
- Eosinophils are an essential element of a type 2 immune axis that controls thymus regeneration
- An αvβ3 integrin checkpoint is critical for efficient TH2 cell cytokine polarization and potentiation of antigen-specific immunity
Showing 5 of 12 shared publications
- RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus
- An innate IL-25–ILC2–MDSC axis creates a cancer-permissive microenvironment for <i>Apc</i> mutation–driven intestinal tumorigenesis
- An αvβ3 integrin checkpoint is critical for efficient TH2 cell cytokine polarization and potentiation of antigen-specific immunity
- Mef2d potentiates type-2 immune responses and allergic lung inflammation
- Neuroprotective protein ADNP-dependent histone remodeling complex promotes T helper 2 immune cell differentiation
Showing 5 of 8 shared publications
- RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus
- An αvβ3 integrin checkpoint is critical for efficient TH2 cell cytokine polarization and potentiation of antigen-specific immunity
- Mef2d potentiates type-2 immune responses and allergic lung inflammation
- Neuroprotective protein ADNP-dependent histone remodeling complex promotes T helper 2 immune cell differentiation
- ILC2-derived LIF licences progress from tissue to systemic immunity
Showing 5 of 7 shared publications
- An innate IL-25–ILC2–MDSC axis creates a cancer-permissive microenvironment for <i>Apc</i> mutation–driven intestinal tumorigenesis
- Group 2 Innate Lymphoid Cells: Team Players in Regulating Asthma
- ILC2-derived LIF licences progress from tissue to systemic immunity
- Identification of aceNKPs, a committed common progenitor population of the ILC1 and NK cell continuum
- Emerging roles for IL-25 and IL-33 in colorectal cancer tumorigenesis
Showing 5 of 6 shared publications
- RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus
- An αvβ3 integrin checkpoint is critical for efficient TH2 cell cytokine polarization and potentiation of antigen-specific immunity
- Mef2d potentiates type-2 immune responses and allergic lung inflammation
- Neuroprotective protein ADNP-dependent histone remodeling complex promotes T helper 2 immune cell differentiation
- Molecular mechanisms regulating T helper 2 cell differentiation and function
- RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus
- An αvβ3 integrin checkpoint is critical for efficient TH2 cell cytokine polarization and potentiation of antigen-specific immunity
- Mef2d potentiates type-2 immune responses and allergic lung inflammation
- ILC2-derived LIF licences progress from tissue to systemic immunity
- Identification of aceNKPs, a committed common progenitor population of the ILC1 and NK cell continuum
- RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus
- Mapping Rora expression in resting and activated CD4+ T cells
- Identification of aceNKPs, a committed common progenitor population of the ILC1 and NK cell continuum
- Group 2 Innate Lymphoid Cells Exhibit Tissue-Specific Dynamic Behaviour During Type 2 Immune Responses
- Recipient tissue microenvironment determines developmental path of intestinal innate lymphoid progenitors
- RORα is a critical checkpoint for T cell and ILC2 commitment in the embryonic thymus
- An αvβ3 integrin checkpoint is critical for efficient TH2 cell cytokine polarization and potentiation of antigen-specific immunity
- Neuroprotective protein ADNP-dependent histone remodeling complex promotes T helper 2 immune cell differentiation
- Identification of aceNKPs, a committed common progenitor population of the ILC1 and NK cell continuum
- Recipient tissue microenvironment determines developmental path of intestinal innate lymphoid progenitors
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