Match tier
Listed
Presence
Current · Arkansas
Last published
2024
Sources
OpenAlex · ORCID
Refreshed
2026-10-08
Chia Y. Lee
Federal Grant PI
High Impact
Professor
Also affiliated: University of Nebraska–Lincoln (2010); Tufts University (2010); University of Kansas (1997); University of Arkansas Medical Center (2010); University of Kansas Medical Center (1991–2005); New York University (2015); University of Nebraska Medical Center (2010)
Microbiology & Immunology, College of Medicine
37 h-index
63 pubs
4,951 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Chia Y. Lee's research focuses on the molecular mechanisms underlying *Staphylococcus aureus* infections, particularly the regulation of virulence factors and the formation of bacterial biofilms. Lee has received federal funding from the National Institute of Allergy and Infectious Diseases (NIAID) for two grant awards totaling $457,500. One award supports research into the characterization of a novel *S. aureus* biofilm polysaccharide, while the other investigates the modulation of the Agr system by the ClpC chaperone in *S. aureus*.
Published work includes studies on the characterization of an *N*-acetylgalactosamine-containing surface polysaccharide in *S. aureus*, the development of a rat model for orthopedic implant-associated infections to identify staphylococcal biofilm proteins, and the regulation of the staphylococcal capsule by SarZ, which was found to be SigA-dependent. Lee's scholarship metrics include an h-index of 37, with 63 total publications and over 4,855 citations. Key collaborators at the University of Arkansas for Medical Sciences include Mei G. Lei, Ravi Kr. Gupta, Matthew A. Jorgenson, and Emily J. Robbs.
Metrics
- h-index: 37
- Publications: 63
- Citations: 4,951
Positions
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Professor 2004–presentUniversity of Arkansas for Medical Sciences Microbiology & Immunology, College of Medicine Institutional directory
Selected Publications
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Characterization of Ssc, an N -acetylgalactosamine-containing Staphylococcus aureus surface polysaccharide (2024)
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Regulation of Staphylococcal Capsule by SarZ is SigA-Dependent (2022)
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A Rat Model of Orthopedic Implant-Associated Infection for Identification of Staphylococcal Biofilm Proteins (2021)
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MgrA Activates Staphylococcal Capsule via SigA-Dependent Promoter (2020)
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MgrA Negatively Impacts Staphylococcus aureus Invasion by Regulating Capsule and FnbA (2019)
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Contribution of hla Regulation by SaeR to Staphylococcus aureus USA300 Pathogenesis (2019)
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Repression of Capsule Production by XdrA and CodY in Staphylococcus aureus (2018)
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Proteomics of Staphylococcus aureus biofilm matrix in a rat model of orthopedic implant-associated infection (2017)
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Minimum Information about a Biosynthetic Gene cluster (2015)
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RNAIII of the Staphylococcus aureus agr system activates global regulator MgrA by stabilizing mRNA (2015)
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Comparative impact of diverse regulatory loci on Staphylococcus aureus biofilm formation (2015)
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SaeRS-Dependent Inhibition of Biofilm Formation in Staphylococcus aureus Newman (2015)
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Recombination-mediated remodelling of host–pathogen interactions during Staphylococcus aureus niche adaptation (2015)
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RbsR Activates Capsule but Represses the rbsUDK Operon in Staphylococcus aureus (2015)
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Trapping and Identification of Cellular Substrates of the Staphylococcus aureus ClpC Chaperone (2014)
Federal Grants 2 $457,500 total
NIH
Contact PI
Mar 2023 - Feb 2027
NIH
Contact PI
Mar 2021 - Feb 2024
Characterization of a novel S. aureus biofilm polysaccharide
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- Regulation of biofilm formation in clinical isolates of Staphylococcus aureus NIH Co-Investigator
- Proteomic analysis of S aureus biofilm in vivo NIH Principal Investigator
- STAPHYLOCOCCAL CAPSULE AND VIRULENCE NIH Principal Investigator
- Global regulation by mgr in S. aureus NIH Principal Investigator
- Virulence gene regulation in Staphylococcus aureus NIH Select
- Capsule regulatory network in S. aureus pathogenesis NIH Principal Investigator
- Regulation of Staphylococcus aureus biofilm by Rbf NIH Principal Investigator
Collaboration Network
Top Collaborators
Mei G. Lei
University of Arkansas for Medical Sciences
19 shared publications
In database
- Genetic regulation of the intercellular adhesion locus in staphylococci
- Rbf Promotes Biofilm Formation by Staphylococcus aureus via Repression of icaR , a Negative Regulator of icaADBC
- Tricarboxylic Acid Cycle-Dependent Attenuation of Staphylococcus aureus In Vivo Virulence by Selective Inhibition of Amino Acid Transport
- SaeRS-Dependent Inhibition of Biofilm Formation in Staphylococcus aureus Newman
- Rsp Inhibits Attachment and Biofilm Formation by Repressing fnbA in Staphylococcus aureus MW2
Showing 5 of 19 shared publications
Thanh T. Luong
University of Arkansas for Medical Sciences (US)
16 shared publications
- Transcription Profiling of the mgrA Regulon in Staphylococcus aureus
- Direct Targets of CodY in Staphylococcus aureus
- RNAIII of the Staphylococcus aureus agr system activates global regulator MgrA by stabilizing mRNA
- Rbf Promotes Biofilm Formation by Staphylococcus aureus via Repression of icaR , a Negative Regulator of icaADBC
- Defining the Strain-Dependent Impact of the Staphylococcal Accessory Regulator ( sarA ) on the Alpha-Toxin Phenotype of Staphylococcus aureus
Showing 5 of 16 shared publications
Mark S. Smeltzer
University of Arkansas for Medical Sciences
8 shared publications
In database
- Investigation of Biofilm Formation in Clinical Isolates of Staphylococcus aureus
- Defining the Strain-Dependent Impact of the Staphylococcal Accessory Regulator ( sarA ) on the Alpha-Toxin Phenotype of Staphylococcus aureus
- saeRS and sarA Act Synergistically to Repress Protease Production and Promote Biofilm Formation in Staphylococcus aureus
- SaeRS-Dependent Inhibition of Biofilm Formation in Staphylococcus aureus Newman
- Comparative impact of diverse regulatory loci on Staphylococcus aureus biofilm formation
Showing 5 of 8 shared publications
Paul M. Dunman
University of Nebraska–Lincoln (US)
7 shared publications
- Transcription Profiling of the mgrA Regulon in Staphylococcus aureus
- Direct Targets of CodY in Staphylococcus aureus
- Rbf Promotes Biofilm Formation by Staphylococcus aureus via Repression of icaR , a Negative Regulator of icaADBC
- Characterizing the effects of inorganic acid and alkaline shock on theStaphylococcus aureustranscriptome and messenger RNA turnover
- Staphylococcus aureus ClpC Divergently Regulates Capsule via sae and codY in Strain Newman but Activates Capsule via codY in Strain UAMS-1 and in Strain Newman with Repaired saeS
Showing 5 of 7 shared publications
David Cue
University of Arkansas for Medical Sciences (US)
6 shared publications
- Genetic regulation of the intercellular adhesion locus in staphylococci
- Rbf Promotes Biofilm Formation by Staphylococcus aureus via Repression of icaR , a Negative Regulator of icaADBC
- SaeRS-Dependent Inhibition of Biofilm Formation in Staphylococcus aureus Newman
- Rsp Inhibits Attachment and Biofilm Formation by Repressing fnbA in Staphylococcus aureus MW2
- Activation of sarX by Rbf Is Required for Biofilm Formation and icaADBC Expression in Staphylococcus aureus
Showing 5 of 6 shared publications
Ravi Gupta
University of Arkansas for Medical Sciences (US)
5 shared publications
- RNAIII of the Staphylococcus aureus agr system activates global regulator MgrA by stabilizing mRNA
- Comparative impact of diverse regulatory loci on Staphylococcus aureus biofilm formation
- Recombination-mediated remodelling of host–pathogen interactions during Staphylococcus aureus niche adaptation
- MgrA Activates Expression of Capsule Genes, but Not the α-Toxin Gene in Experimental Staphylococcus aureus Endocarditis
- Proteomics of Staphylococcus aureus biofilm matrix in a rat model of orthopedic implant-associated infection
Marat R. Sadykov
University of Nebraska–Lincoln (US)
5 shared publications
- Direct Targets of CodY in Staphylococcus aureus
- Tricarboxylic Acid Cycle-Dependent Attenuation of Staphylococcus aureus In Vivo Virulence by Selective Inhibition of Amino Acid Transport
- Tricarboxylic Acid Cycle-Dependent Synthesis of Staphylococcus aureus Type 5 and 8 Capsular Polysaccharides
- RpiR Homologues May Link Staphylococcus aureus RNAIII Synthesis and Pentose Phosphate Pathway Regulation
- Direct Targets of CodY in Staphylococcus aureus
Greg A. Somerville
University of Nebraska–Lincoln (US)
5 shared publications
- Direct Targets of CodY in Staphylococcus aureus
- Tricarboxylic Acid Cycle-Dependent Attenuation of Staphylococcus aureus In Vivo Virulence by Selective Inhibition of Amino Acid Transport
- Tricarboxylic Acid Cycle-Dependent Synthesis of Staphylococcus aureus Type 5 and 8 Capsular Polysaccharides
- RpiR Homologues May Link Staphylococcus aureus RNAIII Synthesis and Pentose Phosphate Pathway Regulation
- Direct Targets of CodY in Staphylococcus aureus
Karen E. Beenken
University of Arkansas for Medical Sciences
4 shared publications
In database
- Defining the Strain-Dependent Impact of the Staphylococcal Accessory Regulator ( sarA ) on the Alpha-Toxin Phenotype of Staphylococcus aureus
- saeRS and sarA Act Synergistically to Repress Protease Production and Promote Biofilm Formation in Staphylococcus aureus
- Comparative impact of diverse regulatory loci on Staphylococcus aureus biofilm formation
- Impact of the functional status of saeRS on in vivo phenotypes of S taphylococcus aureus sarA mutants
Christelle M. Roux
University of Nebraska Medical Center (US)
3 shared publications
- Characterizing the effects of inorganic acid and alkaline shock on theStaphylococcus aureustranscriptome and messenger RNA turnover
- Staphylococcus aureus ClpC Divergently Regulates Capsule via sae and codY in Strain Newman but Activates Capsule via codY in Strain UAMS-1 and in Strain Newman with Repaired saeS
- Rsp Inhibits Attachment and Biofilm Formation by Repressing fnbA in Staphylococcus aureus MW2
Lara N. Mrak
University of Arkansas for Medical Sciences (US)
3 shared publications
- Defining the Strain-Dependent Impact of the Staphylococcal Accessory Regulator ( sarA ) on the Alpha-Toxin Phenotype of Staphylococcus aureus
- saeRS and sarA Act Synergistically to Repress Protease Production and Promote Biofilm Formation in Staphylococcus aureus
- Impact of the functional status of saeRS on in vivo phenotypes of S taphylococcus aureus sarA mutants
A. Zielińska
University of Arkansas for Medical Sciences (US)
3 shared publications
- Defining the Strain-Dependent Impact of the Staphylococcal Accessory Regulator ( sarA ) on the Alpha-Toxin Phenotype of Staphylococcus aureus
- saeRS and sarA Act Synergistically to Repress Protease Production and Promote Biofilm Formation in Staphylococcus aureus
- Impact of the functional status of saeRS on in vivo phenotypes of S taphylococcus aureus sarA mutants
Danielle N. Atwood
University of Arkansas for Medical Sciences (US)
3 shared publications
- saeRS and sarA Act Synergistically to Repress Protease Production and Promote Biofilm Formation in Staphylococcus aureus
- Comparative impact of diverse regulatory loci on Staphylococcus aureus biofilm formation
- Impact of the functional status of saeRS on in vivo phenotypes of S taphylococcus aureus sarA mutants
Linda M. Griffin
University of Arkansas for Medical Sciences (US)
3 shared publications
- Defining the Strain-Dependent Impact of the Staphylococcal Accessory Regulator ( sarA ) on the Alpha-Toxin Phenotype of Staphylococcus aureus
- saeRS and sarA Act Synergistically to Repress Protease Production and Promote Biofilm Formation in Staphylococcus aureus
- Impact of the functional status of saeRS on in vivo phenotypes of S taphylococcus aureus sarA mutants
Justin W. Graham
University of Arkansas for Medical Sciences (US)
3 shared publications
- Trapping and Identification of Cellular Substrates of the Staphylococcus aureus ClpC Chaperone
- A single copy integration vector that integrates at an engineered site on the Staphylococcus aureus chromosome
- Trapping and Identification of Cellular Substrates of the Staphylococcus aureus ClpC Chaperone
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