Match tier
Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-08-20
Matthew A. Jorgenson
Federal Grant PI
Assistant Professor
Also affiliated: University of Iowa (2014–2015)
Faculty Researcher
Microbiology & Immunology, College of Medicine
10 h-index
25 pubs
924 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Matthew A. Jorgenson's research focuses on the cell envelope of bacteria, particularly *Escherichia coli*. His work investigates the synthesis and assembly of cell wall components, such as peptidoglycan and polysaccharides, and how these processes are regulated. He has published studies on the biosynthesis of the Enterobacterial Common Antigen (ECA) and colanic acid, examining the stepwise formation of these complex glycans and the role of specific enzymes like the DigH glycosyl hydrolase in cell division and daughter cell separation.
His federally funded research, supported by a $370,397 grant from the NIH/National Institute of General Medical Sciences, aims to manipulate undecaprenyl phosphate (Und-P) levels to understand competing cell envelope assembly pathways in *E. coli*. This work has led to engineering *E. coli* for increased Und-P availability, resulting in improvements in glycan expression technology. Jorgenson also studies other bacterial species, including *Staphylococcus aureus* and *Bacteroides fragilis*, characterizing their surface polysaccharides and the mechanisms of their assembly.
Jorgenson's scholarship metrics include an h-index of 10 and 911 total citations across 25 publications. He collaborates with researchers at the University of Arkansas for Medical Sciences, including Joseph C. Bryant and Emily J. Robbs.
Metrics
- h-index: 10
- Publications: 25
- Citations: 924
Selected Publications
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Stepwise Assembly of the <i>Bacteroides fragilis</i> Capsular Polysaccharide A Repeating Unit in <i>Escherichia coli</i> (2026)
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Dysregulation of a nucleotidyltransferase induces division and surface glycan defects in <i>Escherichia coli</i> by altering related metabolite levels (2026)
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Pardon the interruption: how Und-P sequestration has reshaped our understanding of the bacterial cell envelope (2025)
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The DigH glycosyl hydrolase is conditionally required for daughter cell separation in <i>Escherichia coli</i> (2025)
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Characterization of Ssc, an <i>N</i> -acetylgalactosamine-containing <i>Staphylococcus aureus</i> surface polysaccharide (2024)
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Engineering Escherichia coli for increased Und-P availability leads to material improvements in glycan expression technology (2024)
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Tracking Colanic Acid Repeat Unit Formation from Stepwise Biosynthesis Inactivation in <i>Escherichia coli</i> (2021)
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Making the Enterobacterial Common Antigen Glycan and Measuring Its Substrate Sequestration (2021)
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A genetic screen to identify factors affected by undecaprenyl phosphate recycling uncovers novel connections to morphogenesis in <i>Escherichia coli</i> (2020)
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A genetic screen to identify factors affected by undecaprenyl phosphate recycling uncovers novel connections to morphogenesis in <i>Escherichia coli</i> (2020)
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Faculty Opinions recommendation of Regulation of the peptidoglycan polymerase activity of pbp1b by antagonist actions of the core divisome proteins ftsblq and ftsn. (2019)
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Simultaneously inhibiting undecaprenyl phosphate production and peptidoglycan synthases promotes rapid lysis in <i>Escherichia coli</i> (2019)
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Faculty Opinions recommendation of Mycobacterial cell wall synthesis inhibitors cause lethal ATP burst. (2018)
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Faculty Opinions recommendation of Comprehensive analysis of central carbon metabolism illuminates connections between nutrient availability, growth rate, and cell morphology in Escherichia coli. (2018)
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YtfB, an OapA Domain-Containing Protein, Is a New Cell Division Protein in Escherichia coli (2018)
Federal Grants 1 $370,397 total
NIH
Contact PI
Jun 2024 - Apr 2029
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- Composition and characteristics of cell poles as a measure of bacterial growth history US Department of the Army Co-Investigator
- Bacterial cell wall synthesis, shape and septation NIH Co-Investigator
- In vitro and cellular tools for complex polysaccharide biosynthesis NIH Co-Investigator
- Center for Microbial Pathogenesis and Host Inflammatory Responses NIH Co-Investigator
Collaboration Network
Top Collaborators
Jerry M. Troutman
University of North Carolina at Charlotte (US)
4 shared publications
- Making the Enterobacterial Common Antigen Glycan and Measuring Its Substrate Sequestration
- Tracking Colanic Acid Repeat Unit Formation from Stepwise Biosynthesis Inactivation in <i>Escherichia coli</i>
- Engineering Escherichia coli for increased Und-P availability leads to material improvements in glycan expression technology
- Stepwise Assembly of the <i>Bacteroides fragilis</i> Capsular Polysaccharide A Repeating Unit in <i>Escherichia coli</i>
Amanda J. Reid
University of North Carolina at Charlotte (US)
3 shared publications
- Making the Enterobacterial Common Antigen Glycan and Measuring Its Substrate Sequestration
- Tracking Colanic Acid Repeat Unit Formation from Stepwise Biosynthesis Inactivation in <i>Escherichia coli</i>
- Engineering Escherichia coli for increased Und-P availability leads to material improvements in glycan expression technology
Joseph C. Bryant
University of Arkansas for Medical Sciences
3 shared publications
In database
- Engineering Escherichia coli for increased Und-P availability leads to material improvements in glycan expression technology
- The DigH glycosyl hydrolase is conditionally required for daughter cell separation in <i>Escherichia coli</i>
- Dysregulation of a nucleotidyltransferase induces division and surface glycan defects in <i>Escherichia coli</i> by altering related metabolite levels
Colleen R. Eade
University of North Carolina at Charlotte (US)
2 shared publications
- Making the Enterobacterial Common Antigen Glycan and Measuring Its Substrate Sequestration
- Tracking Colanic Acid Repeat Unit Formation from Stepwise Biosynthesis Inactivation in <i>Escherichia coli</i>
Beth A. Scarbrough
University of North Carolina at Charlotte (US)
2 shared publications
- Making the Enterobacterial Common Antigen Glycan and Measuring Its Substrate Sequestration
- Stepwise Assembly of the <i>Bacteroides fragilis</i> Capsular Polysaccharide A Repeating Unit in <i>Escherichia coli</i>
Manoj K. Dooda
University of North Carolina at Charlotte (US)
2 shared publications
- Engineering Escherichia coli for increased Und-P availability leads to material improvements in glycan expression technology
- Stepwise Assembly of the <i>Bacteroides fragilis</i> Capsular Polysaccharide A Repeating Unit in <i>Escherichia coli</i>
Emily J. Robbs
University of Arkansas for Medical Sciences
2 shared publications
In database
- Characterization of Ssc, an <i>N</i> -acetylgalactosamine-containing <i>Staphylococcus aureus</i> surface polysaccharide
- The DigH glycosyl hydrolase is conditionally required for daughter cell separation in <i>Escherichia coli</i>
Timothy W. Wallen
University of North Carolina at Charlotte (US)
1 shared publication
- Making the Enterobacterial Common Antigen Glycan and Measuring Its Substrate Sequestration
Claire E. Gates
University of North Carolina at Charlotte (US)
1 shared publication
- Making the Enterobacterial Common Antigen Glycan and Measuring Its Substrate Sequestration
Cassidy L. Oliverio
University of North Carolina at Charlotte (US)
1 shared publication
- Making the Enterobacterial Common Antigen Glycan and Measuring Its Substrate Sequestration
Kevin D. Young
University of Arkansas for Medical Sciences
1 shared publication
In database
- Making the Enterobacterial Common Antigen Glycan and Measuring Its Substrate Sequestration
Kyle J. Jones
University of North Carolina at Charlotte (US)
1 shared publication
- Tracking Colanic Acid Repeat Unit Formation from Stepwise Biosynthesis Inactivation in <i>Escherichia coli</i>
Emily J. Kay
London School of Hygiene & Tropical Medicine (GB)
1 shared publication
- Engineering Escherichia coli for increased Und-P availability leads to material improvements in glycan expression technology
Brendan W. Wren
London School of Hygiene & Tropical Medicine (GB)
1 shared publication
- Engineering Escherichia coli for increased Und-P availability leads to material improvements in glycan expression technology
Mei G. Lei
University of Arkansas for Medical Sciences
1 shared publication
In database
- Characterization of Ssc, an <i>N</i> -acetylgalactosamine-containing <i>Staphylococcus aureus</i> surface polysaccharide
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