Matthew A. Jorgenson

Federal Grant PI

Assistant Professor

University of Arkansas for Medical Sciences

faculty

Microbiology & Immunology, College of Medicine

10 h-index 24 pubs 882 cited

Research Areas

Links

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OverviewAI-generated summary

Matthew A. Jorgenson is an Assistant Professor in the Department of Microbiology & Immunology at the University of Arkansas for Medical Sciences. His research focuses on the biosynthesis and function of bacterial cell envelope glycans, particularly those in Gram-negative bacteria like *Escherichia coli* and Gram-positive bacteria such as *Staphylococcus aureus*. He investigates the stepwise assembly of these complex carbohydrate structures and their roles in bacterial physiology and pathogenesis.

Dr. Jorgenson's work involves understanding how specific enzymes and metabolic pathways contribute to glycan production. He has explored the regulation of these processes, including how disruptions in nucleotide sugar metabolism can lead to defects in cell division and surface polysaccharide expression. His research also examines the substrate sequestration properties of these glycans and their impact on the bacterial cell envelope. He is currently funded by the National Institute of General Medical Sciences (NIH/NIGMS) for a project aimed at manipulating undecaprenyl phosphate levels to decipher mechanisms of competing cell envelope assembly pathways in *Escherichia coli*.

His scholarship metrics include an h-index of 10, with 24 total publications and 882 total citations. Dr. Jorgenson collaborates with researchers at the University of Arkansas for Medical Sciences, including Joseph C. Bryant, Chia Y. Lee, and Alongkorn Kurilung.

Metrics

h-index: 10
Publications: 24
Citations: 882

Selected Publications

Dysregulation of a nucleotidyltransferase induces division and surface glycan defects in Escherichia coli by altering related metabolite levels (2026) DOI
Pardon the interruption: how Und-P sequestration has reshaped our understanding of the bacterial cell envelope (2025) DOI
The DigH glycosyl hydrolase is conditionally required for daughter cell separation in Escherichia coli (2025) DOI
Characterization of Ssc, an N -acetylgalactosamine-containing Staphylococcus aureus surface polysaccharide (2024) DOI
Engineering Escherichia coli for increased Und-P availability leads to material improvements in glycan expression technology (2024) DOI
Tracking Colanic Acid Repeat Unit Formation from Stepwise Biosynthesis Inactivation in Escherichia coli (2021) DOI
Making the Enterobacterial Common Antigen Glycan and Measuring Its Substrate Sequestration (2021) DOI

Federal Grants 1 $376,625 total

NIH/National Institute of General Medical Sciences Contact PI Jun 2024 - Apr 2029

Manipulating undecaprenyl phosphate levels to decipher mechanisms of competing cell envelope assembly pathways in Escherichia coli

National Institute of General Medical Sciences $376,625 R35

Grants & Funding

Composition and characteristics of cell poles as a measure of bacterial growth history US Department of the Army Co-Investigator
Bacterial cell wall synthesis, shape and septation NIH Co-Investigator
In vitro and cellular tools for complex polysaccharide biosynthesis NIH Co-Investigator
Center for Microbial Pathogenesis and Host Inflammatory Responses NIH Co-Investigator
Center for Microbial Pathogenesis and Host Inflammatory Responses NIH Co-Investigator
Manipulating undecaprenyl phosphate levels to decipher mechanisms of competing cell envelope assembly pathways in Escherichia coli NIH/Nat. Inst. of General Medical Sciences Principal Investigator