Matthew A. Jorgenson
Federal Grant PI
Assistant Professor
faculty
Microbiology & Immunology, College of Medicine
10 h-index
25 pubs
905 cited
Research Areas
Biography and Research Information
OverviewAI-generated summary
Matthew A. Jorgenson, an Assistant Professor in Microbiology & Immunology at the University of Arkansas for Medical Sciences, focuses his research on bacterial cell envelope assembly and function, particularly in *Escherichia coli*. His work investigates the intricate biochemical pathways involved in synthesizing and transporting essential cell surface molecules, such as peptidoglycan and polysaccharides.
Jorgenson is the Principal Investigator on a $376,625 grant from the NIH/National Institute of General Medical Sciences aimed at manipulating undecaprenyl phosphate levels to decipher mechanisms of competing cell envelope assembly pathways in *Escherichia coli*. His recent publications explore topics including the biosynthesis of the Enterobacterial Common Antigen and colanic acid, the role of specific glycosyl hydrolases in cell division, and the engineering of *E. coli* for improved glycan expression. He also collaborates with researchers at the University of Arkansas for Medical Sciences, including Joseph C. Bryant, with whom he has co-authored three publications.
His research group's investigations contribute to a deeper understanding of bacterial cell wall dynamics, which has implications for fields ranging from infectious disease to biotechnology. Jorgenson's scholarship metrics include an h-index of 10 across 24 publications with 892 total citations, and he is noted as recently active with his most recent publication in 2026.
Metrics
- h-index: 10
- Publications: 25
- Citations: 905
Selected Publications
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Stepwise Assembly of the <i>Bacteroides fragilis</i> Capsular Polysaccharide A Repeating Unit in <i>Escherichia coli</i> (2026)
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Dysregulation of a nucleotidyltransferase induces division and surface glycan defects in <i>Escherichia coli</i> by altering related metabolite levels (2026)
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Pardon the interruption: how Und-P sequestration has reshaped our understanding of the bacterial cell envelope (2025)
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The DigH glycosyl hydrolase is conditionally required for daughter cell separation in <i>Escherichia coli</i> (2025)
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Characterization of Ssc, an <i>N</i> -acetylgalactosamine-containing <i>Staphylococcus aureus</i> surface polysaccharide (2024)
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Engineering Escherichia coli for increased Und-P availability leads to material improvements in glycan expression technology (2024)
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Tracking Colanic Acid Repeat Unit Formation from Stepwise Biosynthesis Inactivation in <i>Escherichia coli</i> (2021)
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Making the Enterobacterial Common Antigen Glycan and Measuring Its Substrate Sequestration (2021)
Federal Grants 1 $370,397 total
NIH/National Institute of General Medical Sciences
Contact PI
Jun 2024 - Apr 2029
Grants & Funding
- Composition and characteristics of cell poles as a measure of bacterial growth history US Department of the Army Co-Investigator
- Bacterial cell wall synthesis, shape and septation NIH Co-Investigator
- In vitro and cellular tools for complex polysaccharide biosynthesis NIH Co-Investigator
- Center for Microbial Pathogenesis and Host Inflammatory Responses NIH Co-Investigator
- Center for Microbial Pathogenesis and Host Inflammatory Responses NIH Co-Investigator
- Manipulating undecaprenyl phosphate levels to decipher mechanisms of competing cell envelope assembly pathways in Escherichia coli NIH/Nat. Inst. of General Medical Sciences Principal Investigator
Collaboration Network
Top Collaborators
Jerry M. Troutman
University of North Carolina at Charlotte (US)
4 shared publications
- Making the Enterobacterial Common Antigen Glycan and Measuring Its Substrate Sequestration
- Tracking Colanic Acid Repeat Unit Formation from Stepwise Biosynthesis Inactivation in <i>Escherichia coli</i>
- Engineering Escherichia coli for increased Und-P availability leads to material improvements in glycan expression technology
- Stepwise Assembly of the <i>Bacteroides fragilis</i> Capsular Polysaccharide A Repeating Unit in <i>Escherichia coli</i>
Amanda J. Reid
University of North Carolina at Charlotte (US)
3 shared publications
- Making the Enterobacterial Common Antigen Glycan and Measuring Its Substrate Sequestration
- Tracking Colanic Acid Repeat Unit Formation from Stepwise Biosynthesis Inactivation in <i>Escherichia coli</i>
- Engineering Escherichia coli for increased Und-P availability leads to material improvements in glycan expression technology
Joseph C. Bryant
University of Arkansas for Medical Sciences
3 shared publications
In database
- Engineering Escherichia coli for increased Und-P availability leads to material improvements in glycan expression technology
- The DigH glycosyl hydrolase is conditionally required for daughter cell separation in <i>Escherichia coli</i>
- Dysregulation of a nucleotidyltransferase induces division and surface glycan defects in <i>Escherichia coli</i> by altering related metabolite levels
Colleen R. Eade
University of North Carolina at Charlotte (US)
2 shared publications
- Making the Enterobacterial Common Antigen Glycan and Measuring Its Substrate Sequestration
- Tracking Colanic Acid Repeat Unit Formation from Stepwise Biosynthesis Inactivation in <i>Escherichia coli</i>
Beth A. Scarbrough
University of North Carolina at Charlotte (US)
2 shared publications
- Making the Enterobacterial Common Antigen Glycan and Measuring Its Substrate Sequestration
- Stepwise Assembly of the <i>Bacteroides fragilis</i> Capsular Polysaccharide A Repeating Unit in <i>Escherichia coli</i>
Manoj K. Dooda
University of North Carolina at Charlotte (US)
2 shared publications
- Engineering Escherichia coli for increased Und-P availability leads to material improvements in glycan expression technology
- Stepwise Assembly of the <i>Bacteroides fragilis</i> Capsular Polysaccharide A Repeating Unit in <i>Escherichia coli</i>
Emily J. Robbs
University of Arkansas for Medical Sciences
2 shared publications
In database
- Characterization of Ssc, an <i>N</i> -acetylgalactosamine-containing <i>Staphylococcus aureus</i> surface polysaccharide
- The DigH glycosyl hydrolase is conditionally required for daughter cell separation in <i>Escherichia coli</i>
Timothy W. Wallen
University of North Carolina at Charlotte (US)
1 shared publication
- Making the Enterobacterial Common Antigen Glycan and Measuring Its Substrate Sequestration
Claire E. Gates
University of North Carolina at Charlotte (US)
1 shared publication
- Making the Enterobacterial Common Antigen Glycan and Measuring Its Substrate Sequestration
Cassidy L. Oliverio
University of North Carolina at Charlotte (US)
1 shared publication
- Making the Enterobacterial Common Antigen Glycan and Measuring Its Substrate Sequestration
Kevin D. Young
University of Arkansas for Medical Sciences (US)
1 shared publication
- Making the Enterobacterial Common Antigen Glycan and Measuring Its Substrate Sequestration
Kyle J. Jones
University of North Carolina at Charlotte (US)
1 shared publication
- Tracking Colanic Acid Repeat Unit Formation from Stepwise Biosynthesis Inactivation in <i>Escherichia coli</i>
Emily J. Kay
London School of Hygiene & Tropical Medicine (GB)
1 shared publication
- Engineering Escherichia coli for increased Und-P availability leads to material improvements in glycan expression technology
Brendan W. Wren
London School of Hygiene & Tropical Medicine (GB)
1 shared publication
- Engineering Escherichia coli for increased Und-P availability leads to material improvements in glycan expression technology
Mei G. Lei
University of Arkansas for Medical Sciences (US)
1 shared publication
- Characterization of Ssc, an <i>N</i> -acetylgalactosamine-containing <i>Staphylococcus aureus</i> surface polysaccharide
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