C

Clara M. Stiefel

Researcher

UAMS

Last publication 2024 Last refreshed 2026-05-16

unknown

4 h-index 5 pubs 137 cited

Research Areas

OverviewAI-generated summary

Clara M. Stiefel's research investigates the molecular mechanisms underlying DNA double-strand break repair and the consequences of genomic instability, particularly in the context of trisomy syndromes. Her work has identified the APE2 nuclease as essential for microhomology-mediated end joining, a critical pathway for repairing DNA breaks. Additionally, her studies explore how genotoxic stress in constitutive trisomies triggers cellular responses like autophagy and the innate immune system through the cGAS-STING pathway. She also examines the functional impact of genetic variations, such as a rare SNP in the HELB gene that interferes with RPA interaction and cellular function. Stiefel collaborates with researchers at the University of Arkansas for Medical Sciences, including Maroof K. Zafar, Eric J. Enemark, Alicia K. Byrd, and Matthew D. Thompson. Her scholarly contributions are reflected in a h-index of 4, with 5 publications and 133 citations.

Metrics

h-index: 4
Publications: 5
Citations: 137

Selected Publications

Rare SNP in the <i>HELB</i> gene interferes with RPA interaction and cellular function of HELB (2024)

DOI OpenAlex
Consequences of chromosome gain: A new view on trisomy syndromes (2022)

39 citations DOI OpenAlex
The APE2 nuclease is essential for DNA double strand break repair by microhomology-mediated end-joining (2022)

5 citations DOI OpenAlex

View all publications on OpenAlex →

Collaboration Network

32 Collaborators 10 Institutions 3 Countries

Top Collaborators

Justin Leung The University of Texas Health Science Center at San Antonio (US) 3 shared publications

Maria Krivega Heidelberg University (DE) 2 shared publications

Zuzana Štorchová University of Kaiserslautern (DE) 2 shared publications

Hubert Fleury University of Colorado Boulder (US) 2 shared publications

Myles K. MacEachern University of Colorado Boulder (US) 2 shared publications

Roopesh Anand The Francis Crick Institute (GB) 2 shared publications

Colin Sempeck University of Colorado Boulder (US) 2 shared publications

Benjamin Nebenfuehr University of Colorado Boulder (US) 2 shared publications

Benjamin Dodd University of Colorado Boulder (US) 2 shared publications

Erin Taylor University of Colorado Boulder (US) 2 shared publications

Djelika Dansoko University of Colorado Boulder (US) 2 shared publications

Raquel Ortega University of Colorado Boulder (US) 2 shared publications

Simon J. Boulton The Francis Crick Institute (GB) 2 shared publications

Nausica Arnoult University of Colorado Boulder (US) 2 shared publications

Sahar Karbassi University of Kaiserslautern (DE) 1 shared publication

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