Match tier Listed
Presence Formerly Arkansas
Last published 2026
Sources OpenAlex · ORCID
Refreshed 2026-10-04

Clara M. Stiefel

Role not yet determined Is this you? Add your title

UAMS

Also affiliated: University of Kaiserslautern (2021); The University of Texas at San Antonio Health Science Center (2023)

Formerly Arkansas Affiliated with UAMS through 2024; recent publications list The University of Texas at San Antonio Health Science Center.

4 h-index 5 pubs 146 cited

Research Areas

Biomedical Subjects

  • DNA Damage
  • Humans
  • Trisomy
  • DNA Repair
  • DNA Breaks, Double-Stranded
  • Homologous Recombination
  • Down Syndrome
  • Tumor Suppressor p53-Binding Protein 1
  • Chromatin
  • Histones
  • Ubiquitination
  • R-Loop Structures
  • DNA Helicases
  • Transcription, Genetic
  • BRCA2 Protein

OverviewAI-generated summary

Clara M. Stiefel's research investigates DNA damage and repair mechanisms, particularly in the context of chromosomal abnormalities. Her work examines how constitutive trisomies, such as Down syndrome, influence cellular responses to genotoxic stress, including the activation of autophagy and the innate immune system via the cGAS-STING pathway. Stiefel also studies the role of specific nucleases, like APE2, in DNA double-strand break repair pathways, including microhomology-mediated end joining. Additionally, her research explores the regulation of proteins like 53BP1 at damaged chromatin and how histone modifications impact DNA repair processes. She has published findings on the consequences of chromosome gain in trisomy syndromes and the mechanisms by which complexes like HELZ-BRCA2 resolve R-loops to facilitate homologous recombination. Stiefel collaborates with researchers at the University of Arkansas for Medical Sciences, including Maroof K. Zafar, Eric J. Enemark, Alicia K. Byrd, and Matthew D. Thompson.

Metrics

  • h-index: 4
  • Publications: 5
  • Citations: 146

Selected Publications

  • Rare SNP in the HELB gene interferes with RPA interaction and cellular function of HELB (2024)
    bioRxiv (Cold Spring Harbor Laboratory) DOI OpenAlex
  • Consequences of chromosome gain: A new view on trisomy syndromes (2022)
    The American Journal of Human Genetics 43 citations DOI OpenAlex
  • The APE2 nuclease is essential for DNA double strand break repair by microhomology-mediated end-joining (2022)
    bioRxiv (Cold Spring Harbor Laboratory) 5 citations DOI OpenAlex

View all publications on OpenAlex →

Collaboration Network

22 Collaborators 9 Institutions 3 Countries

Top Collaborators

Similar Researchers

Based on overlapping research topics

April C.L. Bostian University of Arkansas for Medical Sciences
DNA Repair Mechanisms Metabolism and Genetic Disorders Disease Mechanisms Research
Good match 4 shared topics
Kirk L. West University of Arkansas for Medical Sciences
DNA Repair Mechanisms Genomics and Chromatin Dynamics Disease Mechanisms Research
Good match 4 shared topics
Leena Maddukuri University of Arkansas for Medical Sciences
DNA Repair Mechanisms Carcinogens and Genotoxicity Assessment Disease Mechanisms Research
Good match 4 shared topics
John Gillenwater University of Arkansas for Medical Sciences
Metabolism and Genetic Disorders Disease Mechanisms Research Cancer-related molecular mechanisms research
Good match 4 shared topics
Heba Allam University of Arkansas for Medical Sciences
DNA Repair Mechanisms Disease Mechanisms Research Cancer-related molecular mechanisms research
Good match 4 shared topics
Andrew J. Pierce Ouachita Baptist University
DNA Repair Mechanisms Metabolism and Genetic Disorders Disease Mechanisms Research
Good match 4 shared topics