Dylan Girodat Data-verified

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

Assistant Professor

University of Arkansas

Last publication 2025 Last refreshed 2026-04-01

faculty

9 h-index 33 pubs 590 cited

Research Areas

Links

ORCID Lab Website

OverviewAI-generated summary

Dylan Girodat's research focuses on understanding the molecular mechanisms of protein synthesis, particularly the role of ribosomes and transfer RNA (tRNA) in this process. His work utilizes molecular dynamics simulations to investigate the conformational changes of ribosomes during translation elongation and translocation. Girodat has published research examining the geometric alignment of aminoacyl-tRNA relative to ribosomal catalytic centers, which underpins accurate messenger RNA decoding. He has also investigated the role of specific tRNA movements, such as hyper-swivel head domain motions, in ribosome resetting and translocation. His investigations extend to human protein synthesis, exploring the necessity of tRNA pivoting during proofreading and studying the impact of mutations in ribosomal proteins, such as uL18, on structural dynamics. Girodat collaborates with researchers at the University of Arkansas at Fayetteville, including Anuradha Chowdhury and Divya Sapkota, with whom he has co-authored multiple publications. His scholarship metrics include an h-index of 9, with 33 total publications and 590 total citations.

Metrics

h-index: 9
Publications: 33
Citations: 590

Selected Publications

Human protein synthesis requires aminoacyl-tRNA pivoting during proofreading (2025)

1 citation DOI OpenAlex
Solution Structure Determination and Biophysical Studies of 7SK RNP and 7SL SRP RNAs (2025)

DOI OpenAlex
Human Protein Synthesis Requires aminoacyl-tRNA Pivoting During Proofreading (2025)

DOI OpenAlex
BPS2025 - Human aminoacyl-tRNA pivots during accommodation (2025)

DOI OpenAlex
BPS2025 - Diamond-Blackfan anemia-associated mutations perturb uL5 helix stability and conformational ensemble (2025)

DOI OpenAlex
BPS2025 - Measurement of nucleotide triphosphate hydrolysis rates and inorganic phosphate release using a coumarin-labeled phosphate binding protein (2025)

DOI OpenAlex
Alternate conformational trajectories in ribosome translocation (2024)

1 citation DOI OpenAlex
Implementing Cryo-EM Manual Plunger Techniques in University Workshops and Teaching Laboratories (2024)

DOI OpenAlex
Alternate conformational trajectories in protein synthesis (2024)

DOI OpenAlex
Conformational changes of ribosomes during translation elongation resolved by molecular dynamics simulations (2024)

4 citations DOI OpenAlex
Divergent pathways of ribosomal motions during protein synthesis (2024)

DOI OpenAlex
Development of a non-radioactive based assay to measure GTP and ATP hydrolysis rates (2024)

DOI OpenAlex
Impact of Diamond-Blackfan anemia associated mutations on structural dynamics of ribosomal protein uL5 (2024)

DOI OpenAlex
Geometric alignment of aminoacyl-tRNA relative to catalytic centers of the ribosome underpins accurate mRNA decoding (2023)

16 citations DOI OpenAlex
Ribosome hyper-swivel head domain motions are required for translocation and resetting (2023)

DOI OpenAlex