Match tier
Confirmed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-08-20
R
Reham S. Sewilam
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Federal Grant PI
Researcher
Unknown Researcher
1 h-index
4 pubs
4 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Reham S. Sewilam's research focuses on understanding the mechanisms of DNA replication and damage tolerance, particularly in the context of cancer. Her work investigates the roles of specific DNA polymerases, such as DNA polymerase kappa (Pol k), and accessory proteins like REV1 and DHX36, in promoting cell survival and potentially contributing to drug resistance in hard-to-treat cancers like glioblastoma.
Her publications explore how these proteins interact to facilitate replication fork progression, suppress replication gaps, and tolerate challenging DNA structures such as G-quadruplexes. Sewilam has received a $3,000 NIH/National Cancer Institute grant as Principal Investigator for her work on replication gap suppression by translesion synthesis and its promotion of drug resistance in cancers. She collaborates with researchers at the University of Arkansas for Medical Sciences, including Robert L. Eoff and Megan R. Reed, and with Julie Gunderson at Hendrix College.
Metrics
- h-index: 1
- Publications: 4
- Citations: 4
Selected Publications
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Human REV1 interacts with DHX36 to promote replication and tolerance of G-quadruplex DNA (2026)
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Abstract 1488: DNA polymerase kappa slows replication fork speed by promoting fork reversal in glioblastoma (2025)
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Abstract 1333 DNA polymerase kappa (Pol k) promotes replication gap suppression by preventing PrimPol mediated repriming and safeguards genomic stability in Glioblastoma Multiforme (GBM) (2024)
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Conservation of the insert-2 motif confers Rev1 from different species with an ability to disrupt G-quadruplexes and stimulate translesion DNA synthesis (2023)
Federal Grants 1 $3,000 total
NIH
Contact PI
May 2026 - Jul 2027
Collaboration Network
Top Collaborators
Robert L. Eoff
University of Arkansas for Medical Sciences
4 shared publications
In database
- Conservation of the insert-2 motif confers Rev1 from different species with an ability to disrupt G-quadruplexes and stimulate translesion DNA synthesis
- Abstract 1488: DNA polymerase kappa slows replication fork speed by promoting fork reversal in glioblastoma
- Abstract 1333 DNA polymerase kappa (Pol k) promotes replication gap suppression by preventing PrimPol mediated repriming and safeguards genomic stability in Glioblastoma Multiforme (GBM)
- Human REV1 interacts with DHX36 to promote replication and tolerance of G-quadruplex DNA
Bethany C. Paxton
University of Arkansas for Medical Sciences
2 shared publications
In database
- Conservation of the insert-2 motif confers Rev1 from different species with an ability to disrupt G-quadruplexes and stimulate translesion DNA synthesis
- Human REV1 interacts with DHX36 to promote replication and tolerance of G-quadruplex DNA
Megan R. Reed
University of Arkansas for Medical Sciences
2 shared publications
In database
- Abstract 1488: DNA polymerase kappa slows replication fork speed by promoting fork reversal in glioblastoma
- Abstract 1333 DNA polymerase kappa (Pol k) promotes replication gap suppression by preventing PrimPol mediated repriming and safeguards genomic stability in Glioblastoma Multiforme (GBM)
Amit Ketkar
University of Arkansas for Medical Sciences
1 shared publication
In database
- Conservation of the insert-2 motif confers Rev1 from different species with an ability to disrupt G-quadruplexes and stimulate translesion DNA synthesis
Mason McCrury
University of Arkansas for Medical Sciences
1 shared publication
In database
- Conservation of the insert-2 motif confers Rev1 from different species with an ability to disrupt G-quadruplexes and stimulate translesion DNA synthesis
Ashtyn Bell
University of Arkansas for Medical Sciences
1 shared publication
In database
- Conservation of the insert-2 motif confers Rev1 from different species with an ability to disrupt G-quadruplexes and stimulate translesion DNA synthesis
Shreyam Tripathi
1 shared publication
- Conservation of the insert-2 motif confers Rev1 from different species with an ability to disrupt G-quadruplexes and stimulate translesion DNA synthesis
Julie Gunderson
Hendrix College
1 shared publication
In database
- Conservation of the insert-2 motif confers Rev1 from different species with an ability to disrupt G-quadruplexes and stimulate translesion DNA synthesis
Amit Ketkar
University of Arkansas for Medical Sciences
1 shared publication
In database
- Human REV1 interacts with DHX36 to promote replication and tolerance of G-quadruplex DNA
Oscar E Zuniga
University of Arkansas for Medical Sciences (US)
1 shared publication
- Human REV1 interacts with DHX36 to promote replication and tolerance of G-quadruplex DNA
Martin Morales
University of Arkansas for Medical Sciences
1 shared publication
In database
- Human REV1 interacts with DHX36 to promote replication and tolerance of G-quadruplex DNA
John Schaller
University of Arkansas for Medical Sciences
1 shared publication
In database
- Human REV1 interacts with DHX36 to promote replication and tolerance of G-quadruplex DNA
Rowan J McCollum
University of Arkansas for Medical Sciences
1 shared publication
In database
- Human REV1 interacts with DHX36 to promote replication and tolerance of G-quadruplex DNA
Kathleen E Jackson
University of Arkansas for Medical Sciences
1 shared publication
In database
- Human REV1 interacts with DHX36 to promote replication and tolerance of G-quadruplex DNA
Kaitlin Lowran
Oakland University (US)
1 shared publication
- Human REV1 interacts with DHX36 to promote replication and tolerance of G-quadruplex DNA
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