F
Fen Xia
Federal Grant PI
High Impact
Department Chairperson
faculty
Department Chairs, College of Medicine
40 h-index
176 pubs
6,459 cited
Research Areas
Biography and Research Information
OverviewAI-generated summary
Fen Xia's research investigates the role of Sirtuin 2 (SIRT2) in regulating transcription-associated DNA damage repair, with a focus on its implications in cancer treatment and the prevention of cisplatin-induced peripheral neuropathy. This work has been supported by a $326,880 grant from the NIH/National Cancer Institute, where Xia serves as PI. The research group explores how targeting DNA damage response and repair mechanisms can enhance the therapeutic index of cancer treatments, particularly those involving cisplatin.
Additional research interests include the development of novel materials, such as antioxidant high-conductivity copper pastes for flexible printed electronics and magnesium phosphate cement-based emulsified asphalt mortar. Xia also investigates the scalability of parallel machine learning training algorithms and the application of advanced neural networks, including transformers, for tasks such as deepfake video detection.
With an h-index of 40 and over 6,400 citations across 176 publications, Xia is recognized as a highly cited researcher. Key collaborators include Faraz Kalantari, Forouh Kalantari, Mumtaz Patel, and Mausam Patel, all from the University of Arkansas for Medical Sciences, with whom Xia has co-authored six publications each.
Metrics
- h-index: 40
- Publications: 176
- Citations: 6,459
Selected Publications
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SIRT2 mitigates radiation-induced oral mucositis by promoting homologous recombination-mediated DNA double-strand break repair in epithelial stem cells (2026)
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Spatially Fractionated Radiotherapy GRID for Bulky Tumor: A Large Single Institution Experience (2024)
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A Prospective Study Measuring Resident and Faculty Contour Concordance: A Potential Tool for Quantitative Assessment of Residents’ Performance in Contouring and Target Delineation in Radiation Oncology Residency (2023)
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A Prospective Study Measuring Resident/Faculty Contour Concordance: A Potential Tool for Quantitative Assessment of Residents’ Performance in Contouring and Target Delineation (2023)
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Discovery of a Novel Driver of Radioresistance in Pancreatic Cancer (PC) Using Genome-Wide RNA-Seq (2022)
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Analysis of Resident/Faculty Contour Concordance: A Potential Tool for Quantitative Assessment of Residents’ Performance in Target Volume Delineation (2022)
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Measuring resident/faculty contour concordance as a potential tool for quantitative assessment of residents' performance in target volume delineation: a feasibility study (2022)
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A phantom-based study and clinical implementation of brainlab’s treatment planning system for radiosurgical treatments of arteriovenous malformations (2022)
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Nicotinamide riboside alleviates cisplatin-induced peripheral neuropathy via SIRT2 activation (2022)
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#Brachytherapy: Physicians As Influencers on Instagram (2022)
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A dosimetric comparative analysis of Brainlab elements and Eclipse RapidArc for spine SBRT treatment planning (2022)
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Targeting DNA Damage Response and Repair to Enhance Therapeutic Index in Cisplatin-Based Cancer Treatment (2021)
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SIRT2 promotes murine melanoma progression through natural killer cell inhibition (2021)
Federal Grants 2 $955,860 total
NIH/National Cancer Institute
Contact PI
May 2026 - Apr 2031
Exploring host GSK3β-53BP1 axis in immune control of solid tumor progression
NIH/National Cancer Institute
Contact PI
Apr 2020 - Sep 2026
The novel role of Sirtuin 2 in regulation of transcription-associated DNA damage repair
Grants & Funding
- A Prospective Trial of Stereotactic Adaptive Radiation Therapy for Borderline Resectable/Locally Advanced Pancreatic Cancer: An Individualized Approach to Minimizing Gastrointestinal Toxicity (ARTIA-Pancreas) Varian Medical Systems Principal Investigator
- Novel functions of Pyruvate kinase M2 in DNA double-strand break repair NIH/NCI Principal Investigator
- The novel role of Sirtuin 2 in regulation of transcription-associated DNA damage repair NIH/Nat. Cancer Institute Principal Investigator
- GSK3b mediates radiation-induced cytotoxicity in hippocampal neurons NIH Principal Investigator
- Center for Musculoskeletal Disease Research (CMDR) NIH/Nat. Inst. of General Medical Sciences Co-Investigator
- Center for Molecular Interactions in Cancer (CMIC) NIH Co-Investigator
- GSK3b mediates radiation-induced cytotoxicity in hippocampal neurons NIH Principal Investigator
- The novel role of Sirtuin 2 in regulation of transcription-associated DNA damage repair NIH/Nat. Cancer Institute Principal Investigator
Collaboration Network
Top Collaborators
Eddy S. Yang
22 shared publications
- Data from Targeting BRCA1 Localization to Augment Breast Tumor Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition
- Supplementary Figure 2A from Erlotinib Attenuates Homologous Recombinational Repair of Chromosomal Breaks in Human Breast Cancer Cells
- Supplementary Figure 1 from Erlotinib Attenuates Homologous Recombinational Repair of Chromosomal Breaks in Human Breast Cancer Cells
- Supplementary Figure Legends 1-2 from Erlotinib Attenuates Homologous Recombinational Repair of Chromosomal Breaks in Human Breast Cancer Cells
- Supplementary Figure 2B from Erlotinib Attenuates Homologous Recombinational Repair of Chromosomal Breaks in Human Breast Cancer Cells
Showing 5 of 22 shared publications
Somaira Nowsheen
15 shared publications
- Data from Targeting BRCA1 Localization to Augment Breast Tumor Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition
- Supplementary Methods and Materials, Figures 1-5 from p53-Dependent BRCA1 Nuclear Export Controls Cellular Susceptibility to DNA Damage
- Supplementary Methods from Targeting BRCA1 Localization to Augment Breast Tumor Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition
- Supplementary Figure Legends 1-4 from Targeting BRCA1 Localization to Augment Breast Tumor Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition
- Supplementary Figure 1 from Targeting BRCA1 Localization to Augment Breast Tumor Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition
Showing 5 of 15 shared publications
Rebecca S. Cook
13 shared publications
- Data from Targeting BRCA1 Localization to Augment Breast Tumor Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition
- Supplementary Methods from Targeting BRCA1 Localization to Augment Breast Tumor Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition
- Supplementary Figure Legends 1-4 from Targeting BRCA1 Localization to Augment Breast Tumor Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition
- Supplementary Figure 1 from Targeting BRCA1 Localization to Augment Breast Tumor Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition
- Supplementary Figure 4 from Targeting BRCA1 Localization to Augment Breast Tumor Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition
Showing 5 of 13 shared publications
Mohammad Azizur Rahman
9 shared publications
- Data from Targeting BRCA1 Localization to Augment Breast Tumor Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition
- Supplementary Figure Legends 1-4 from Targeting BRCA1 Localization to Augment Breast Tumor Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition
- Supplementary Figure 1 from Targeting BRCA1 Localization to Augment Breast Tumor Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition
- Supplementary Figure 4 from Targeting BRCA1 Localization to Augment Breast Tumor Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition
- Supplementary Figure 3 from Targeting BRCA1 Localization to Augment Breast Tumor Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition
Showing 5 of 9 shared publications
Carlos L. Arteaga
7 shared publications
- Supplementary Figure 2A from Erlotinib Attenuates Homologous Recombinational Repair of Chromosomal Breaks in Human Breast Cancer Cells
- Supplementary Figure 1 from Erlotinib Attenuates Homologous Recombinational Repair of Chromosomal Breaks in Human Breast Cancer Cells
- Supplementary Figure Legends 1-2 from Erlotinib Attenuates Homologous Recombinational Repair of Chromosomal Breaks in Human Breast Cancer Cells
- Supplementary Figure 2B from Erlotinib Attenuates Homologous Recombinational Repair of Chromosomal Breaks in Human Breast Cancer Cells
- Supplementary Figure Legends 1-2 from Erlotinib Attenuates Homologous Recombinational Repair of Chromosomal Breaks in Human Breast Cancer Cells
Showing 5 of 7 shared publications
Jun Yan
6 shared publications
- Data from The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response
- Supplementary Figures 1-2 from The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response
- Data from The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response
- Supplementary Methods and Materials, Figure Legends 1-2 from The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response
- Supplementary Methods and Materials, Figure Legends 1-2 from The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response
Showing 5 of 6 shared publications
Yong‐Sik Kim
6 shared publications
- Data from The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response
- Supplementary Figures 1-2 from The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response
- Data from The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response
- Supplementary Methods and Materials, Figure Legends 1-2 from The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response
- Supplementary Methods and Materials, Figure Legends 1-2 from The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response
Showing 5 of 6 shared publications
Xiaoping Yang
6 shared publications
- Data from The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response
- Supplementary Figures 1-2 from The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response
- Data from The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response
- Supplementary Methods and Materials, Figure Legends 1-2 from The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response
- Supplementary Methods and Materials, Figure Legends 1-2 from The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response
Showing 5 of 6 shared publications
Grace Liao
6 shared publications
- Data from The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response
- Supplementary Figures 1-2 from The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response
- Data from The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response
- Supplementary Methods and Materials, Figure Legends 1-2 from The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response
- Supplementary Methods and Materials, Figure Legends 1-2 from The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response
Showing 5 of 6 shared publications
Anton M. Jetten
6 shared publications
- Data from The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response
- Supplementary Figures 1-2 from The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response
- Data from The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response
- Supplementary Methods and Materials, Figure Legends 1-2 from The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response
- Supplementary Methods and Materials, Figure Legends 1-2 from The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response
Showing 5 of 6 shared publications
Arpan V. Prabhu
University of Arkansas for Medical Sciences (US)
5 shared publications
- Pulsed reduced dose-rate radiotherapy for previously irradiated tumors in the brain and spine
- A Prospective Study Measuring Resident and Faculty Contour Concordance: A Potential Tool for Quantitative Assessment of Residents’ Performance in Contouring and Target Delineation in Radiation Oncology Residency
- #Brachytherapy: Physicians As Influencers on Instagram
- Measuring resident/faculty contour concordance as a potential tool for quantitative assessment of residents' performance in target volume delineation: a feasibility study
- A Prospective Study Measuring Resident/Faculty Contour Concordance: A Potential Tool for Quantitative Assessment of Residents’ Performance in Contouring and Target Delineation
Faraz Kalantari
University of Arkansas for Medical Sciences (US)
5 shared publications
- A Prospective Study Measuring Resident and Faculty Contour Concordance: A Potential Tool for Quantitative Assessment of Residents’ Performance in Contouring and Target Delineation in Radiation Oncology Residency
- A dosimetric comparative analysis of Brainlab elements and Eclipse RapidArc for spine SBRT treatment planning
- Measuring resident/faculty contour concordance as a potential tool for quantitative assessment of residents' performance in target volume delineation: a feasibility study
- A Prospective Study Measuring Resident/Faculty Contour Concordance: A Potential Tool for Quantitative Assessment of Residents’ Performance in Contouring and Target Delineation
- A phantom-based study and clinical implementation of brainlab’s treatment planning system for radiosurgical treatments of arteriovenous malformations
Mausam Patel
University of Arkansas for Medical Sciences (US)
5 shared publications
- A Prospective Study Measuring Resident and Faculty Contour Concordance: A Potential Tool for Quantitative Assessment of Residents’ Performance in Contouring and Target Delineation in Radiation Oncology Residency
- #Brachytherapy: Physicians As Influencers on Instagram
- Measuring resident/faculty contour concordance as a potential tool for quantitative assessment of residents' performance in target volume delineation: a feasibility study
- The effect of anticonvulsants on survival among patients with GBM brain tumors undergoing radiation: A SEER-Medicare analysis
- A Prospective Study Measuring Resident/Faculty Contour Concordance: A Potential Tool for Quantitative Assessment of Residents’ Performance in Contouring and Target Delineation
Liping Li
5 shared publications
- Data from The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response
- Supplementary Figures 1-2 from The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response
- Data from The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response
- Supplementary Methods and Materials, Figure Legends 1-2 from The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response
- Supplementary Figures 1-2 from The Ubiquitin-Interacting Motif–Containing Protein RAP80 Interacts with BRCA1 and Functions in DNA Damage Repair Response
Scarlett Acklin
University of Arkansas for Medical Sciences (US)
4 shared publications
- Targeting DNA Damage Response and Repair to Enhance Therapeutic Index in Cisplatin-Based Cancer Treatment
- The Role of Nucleotide Excision Repair in Cisplatin-Induced Peripheral Neuropathy: Mechanism, Prevention, and Treatment
- SIRT2 promotes murine melanoma progression through natural killer cell inhibition
- Nicotinamide riboside alleviates cisplatin-induced peripheral neuropathy via SIRT2 activation
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