Jerry Ware

High Impact

Professor

UAMS

Faculty Researcher

Physiology & Cell Biology, College of Medicine

60 h-index 220 pubs 13,312 cited

Research Areas

Biomedical Subjects

Links

ORCID Google Scholar Lab Website Research Group UAMS TRI Profile

OverviewAI-generated summary

Jerry Ware's research primarily investigates the role of platelets in various disease states, with a particular focus on chronic kidney disease (CKD) and liver disease. His work explores how platelet function and count are altered in patients with advanced CKD and how these changes contribute to inflammation and disease progression. Ware has published studies examining the inflammatory dysregulation associated with CKD and comparing the effects of different antiplatelet medications, such as ticagrelor and clopidogrel, on platelet aggregation and inflammatory markers in these patients.

Beyond CKD, Ware's research extends to other conditions, including NASH (non-alcoholic steatohepatitis) and liver cancer, where platelets and specific platelet glycoproteins like GPIbα are implicated as mediators and potential therapeutic targets. He also studies the involvement of platelet-GPVI in the axis driving systemic sclerosis. His laboratory utilizes murine models, including genetically modified mice, to investigate these complex biological processes. Ware has received significant funding for his research, including a substantial NIH grant focused on partnerships for biomedical research in Arkansas and another for studying platelets in radiation-induced immune dysregulation. His scholarly output is marked by a high citation count and an h-index of 60 across over 200 publications.

Metrics

h-index: 60
Publications: 220
Citations: 13,312

Selected Publications

Platelet glycoprotein <scp>VI</scp> modulates leukocyte characteristics in sepsis‐induced systemic inflammatory response in male mice (2026)

DOI OpenAlex
Identification and Characterization of Platelet Surface-membrane-derived Microparticles before and after Total-body Irradiation (2025)

DOI OpenAlex
Contrasting Effects of Platelet GPVI Deletion Versus Syk Inhibition on Mouse Jugular Vein Puncture Wound Structure (2025)

International Journal of Molecular Sciences 2 citations DOI OpenAlex
A GPVI-platelet-neutrophil-NET axis drives systemic sclerosis (2025)

bioRxiv (Cold Spring Harbor Laboratory) 3 citations DOI OpenAlex
OC 10.3 Platelets Mediate Intracranial Aneurysm Formation and Rupture in Mice (2023)

DOI OpenAlex
Platelet Count and Platelet Volume in Patients with CKD (2023)

Journal of the American Society of Nephrology 7 citations DOI OpenAlex
438 Platelets, Inflammation and Thrombosis in Chronic Kidney Disease (2023)

DOI OpenAlex
Ticagrelor inhibits platelet aggregation and reduces inflammatory burden more than clopidogrel in patients with stages 4 or 5 chronic kidney disease (2023)

Vascular Pharmacology 12 citations DOI OpenAlex
Platelet-Dependent Inflammatory Dysregulation in Patients with Stages 4 or 5 Chronic Kidney Disease: A Mechanistic Clinical Study (2022)

Kidney360 13 citations DOI OpenAlex
Murine models of glycoprotein Ib-IX (2022)

Platelets 3 citations DOI OpenAlex
Author Correction: Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer (2022)

Nature Medicine 7 citations DOI OpenAlex
Platelet glycoprotein Ibα provides radiation protection (2021)

Radiotherapy and Oncology 4 citations DOI OpenAlex
Role of Platelets in Chronic Kidney Disease (2021)

Journal of the American Society of Nephrology 47 citations DOI OpenAlex
Calcium Ion Chelation Preserves Platelet Function During Cold Storage (2020)

Arteriosclerosis Thrombosis and Vascular Biology 18 citations DOI OpenAlex
Hemostasis vs. homeostasis: Platelets are essential for preserving vascular barrier function in the absence of injury or inflammation (2020)

Proceedings of the National Academy of Sciences 85 citations DOI OpenAlex

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Federal Grants 2 $4,674,158 total

NIH Co-PI Jul 2022 - May 2027

Platelets in radiation-induced immune dysregulation

NIH Office of the Director $636,257 U01

NIH Co-PI Sep 2001 - Apr 2031

Partnerships for Biomedical Research in Arkansas

National Institute of General Medical Sciences $4,037,901 P20

Grants & Funding

As listed on this researcher's institutional profile. Federal awards with verified records are shown above.

Leukocyte-platelet modulation of the systemic inflammatory response NIH Principal Investigator
Transgenic analysis of platelet receptor expression NIH Principal Investigator
Murine Hemostatic Properties of Thrombosomes DHHS - Biomedical Advanced Research and Development Authority via Cellphire, Inc. Principal Investigator
In vivo, noninvasive, ultrasensitive photoacoustic detection of early breast cancer metastasis in bone US Department of the Army Principal Investigator
Characterization and Analysis of Platelet Septins NIH Principal Investigator
Platelet-leukocyte regulation of inflammatory responses- Resubmission- Resubmission American Heart Association Co-Investigator
Platelet glycoprotein Ib-IX and malignancy US Department of the Army Principal Investigator
Resubmission: Structure/Function Determinants of Puncture Wound Thrombus Formation NIH Co-Investigator