Steven R. Post
Vice Chair for Research
University of Arkansas for Medical Sciences
faculty
Pathology, College of Medicine
Research Areas
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Biography and Research Information
OverviewAI-generated summary
Steven R. Post is a researcher at the University of Arkansas for Medical Sciences, where he serves as Vice Chair for Research in the Department of Pathology. His research focuses on the intersection of viral infections, oncogenesis, and potential therapeutic strategies. He has investigated the role of SARS-CoV-2 proteins and antiviral drugs in reactivating oncogenic viruses, such as herpesviruses, and explored this as a potential threat in the postpandemic era. His work also examines the therapeutic potential of repurposed agents and novel oncolytic viruses for various cancers.
Dr. Post's research group has characterized Morreton virus as a potential oncolytic virotherapy platform for liver cancers and explored echinomycin as a therapeutic agent against Kaposi's sarcoma herpesvirus (KSHV)-related malignancies. Additionally, his lab has investigated the repurposing of the live attenuated trivalent MMR vaccine as a cancer immunotherapy and the enhancement of immune response in hepatocellular carcinoma using oncolytic Jurona virus in combination with immune checkpoint blockade. He is also the Principal Investigator on an NIH/National Cancer Institute grant studying how periodontal bacteria enhance oral KSHV pathogenesis and Kaposi's Sarcoma development in HIV+ patients.
With a career marked by significant scholarly output, Dr. Post has authored 129 publications, accumulating over 4,509 citations and an h-index of 33. He is recognized as a highly cited researcher. His collaborations include extensive work with Martin J. Cannon and Bolni Marius Nagalo at the University of Arkansas for Medical Sciences, and Alexei G. Basnakian at Arkansas State University.
Metrics
- h-index: 33
- Publications: 129
- Citations: 4,509
Selected Publications
- Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models (2025) DOI
- Multimodal reprogramming of the tumor microenvironment by MMR and dual checkpoint blockade in hepatocellular carcinoma models (2025) DOI
- Pancreatic tumor microenvironment reprogramming via alloantigen-expressing virotherapy elicits tumor rejection and improves immunotherapy response (2025) DOI
- Impact of New Hematopoietic Progenitor Cell Collection Goals on Apheresis and Cell Therapy Laboratory Services (2025) DOI
- Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model (2025) DOI
- Isolation of mitochondrial mutation-specific T cell receptors (2025) DOI
- Abstract 2987: Role of EIF4G1 network in non-small cell lung cancers (NSCLC) pathogenesis and development of targeted therapy (2025) DOI
- Abstract 945: Live attenuated MMR vaccines modulate tumor immune cell infiltration and synergize with standard of care to prolong survival in preclinical HCC models (2025) DOI
- Abstract 947: Engineering a synthetic oncolytic virus to overcome apoptotic resistance and induce immunogenic cell death in pancreatic ductal adenocarcinoma (2025) DOI
- Monensin and Its Analogs Offer a Multi-Targeted Approach to Enhancing Metastatic Breast Cancer Immunogenicity and Cell Death (Abstract ID: 163059) (2025) DOI
- 474 Repositioning monensin: Enhancing anti-cancer activity and immune modulation in breast cancer cells (2025) DOI
- Alterations in Cellular Gene Expression Due to Co‐Infection With Kaposi's Sarcoma‐Associated Herpesvirus and SARS‐CoV‐2: Implications for Disease Severity (2024) DOI
- Enhancing immune response and survival in hepatocellular carcinoma with novel oncolytic Jurona virus and immune checkpoint blockade (2024) DOI
- Enhancing Neoadjuvant Virotherapy’s Effectiveness by Targeting Stroma to Improve Resectability in Pancreatic Cancer (2024) DOI
- Abstract 5004: Oncolytic Jurona-driven systemic and intratumoral immunotherapy combined with immune checkpoint blockade boost immune response and survival in hepatocellular carcinoma models (2024) DOI
Federal Grants 1 $324,563 total
Research Interests
The goal of our research is to better understand the key role that macrophages play in the development and progression of chronic inflammatory diseases including cardiovascular disease and cancer. Our studies indicate that a specific macrophage receptor, the class A macrophage scavenger receptor (SR-A), may differentially function to enhance or diminish inflammation. Our ongoing studies seek to provide mechanistic details regarding the functional interactions between SR-A and inflammatory signaling pathways. Results of these studies will advance understanding of the pathologic role of macrophages in cardiovascular disease and cancer, and may indicate novel therapeutic approaches targeting the inflammatory responses in these disease.
Grants & Funding
- No FP attached UAMS Internal Research Awards Principal Investigator
- Impact of hemodynamics on efferocytosis in endothelial cells NIH/Nat. Heart, Lung & Blood Institute Co-Investigator
- No FP attached UAMS Executive Breast Committee Principal Investigator
- Diabetes Medicine Adherence in Marshallese Patients UAMS College of Medicine Principal Investigator
- Periodontal bacteria enhance oral KSHV pathogenesis and Kaposi's Sarcoma development in HIV + patients - Continuation NIH/Nat. Cancer Institute Co-Investigator
- Fibroblast-macrophage interactions induce a tumor-promoting microenvironment NIH/National Institutes of Health Principal Investigator
- Regulation of Ras Signaling by Rlf in Hypertrophy NIH/Nat. Heart, Lung & Blood Institute Principal Investigator
- Periodontal bacteria enhance oral KSHV pathogenesis and Kaposi's Sarcoma development in HIV + patients - Continuation NIH/Nat. Cancer Institute Principal Investigator
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