Jianfeng Xu
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Professor
Also affiliated: Hebei Agricultural University (2005–2025); Beth Israel Deaconess Medical Center (2005–2013); Shanghai Medical College of Fudan University (2008–2013); Endeavor Health (2016–2020); Harvard University (2005–2013); Nanjing Normal University (2005); Harbin Medical University (2008); Xiamen University (2014–2015); Chinese Academy of Sciences (1998); Chinese Academy of Medical Sciences & Peking Union Medical College (2025); Huazhong Agricultural University (2024); Cornell University (2009); Fudan University (2008–2016); Dalian University of Technology (1998); Wenzhou Medical University (2020); Massachusetts General Hospital (2013); Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (2020); Ohio University (2000–2011); Zhongshan Hospital of Xiamen University (2014); Zhongshan Hospital (2008–2015); Institute of Process Engineering (1998); Cancer Hospital of Chinese Academy of Medical Sciences (2025); Affiliated Zhongshan Hospital of Dalian University (2025); Ministry of Agriculture and Rural Affairs (2019); Arkansas Biosciences Institute (2008–2025); Lilly (China) (2015–2019); Chinese Research Academy of Environmental Sciences (2021); Huashan Hospital (2016); State Key Laboratory of Genetic Engineering (2008–2016); Shanghai Ocean University (2018–2025); University of Bath (2019); China Jiliang University (2015); Liverpool John Moores University (2019)
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Jianfeng Xu's research focuses on plant bioengineering and its applications in medicine and biotechnology. He has received federal funding for projects related to engineering plant cells to produce recombinant proteins for therapeutic use. One grant, totaling $395,242 from the NIH/National Institute of Diabetes and Digestive and Kidney Diseases, supports his work on engineering novel designer biologics in plant cells for the oral treatment of ulcerative colitis. Another NSF-funded project, for which he is PI, received $394,063 to engineer GPI-anchored proteins in plant cells for enhanced protein production and applications.
His scholarly work includes publications on diverse topics such as the development of cell-free protein-producing gels, high-yield production of pharmaceutical proteins using plant cell suspension cultures, and the use of genetically transformed roots as biotechnological resources. He has also investigated the conversion of plant biomass to ethanol and explored the therapeutic potential of mesenchymal stem cell-based gene therapy for acute lung injury in mice. Xu is a member of the ARA Academy and has been recognized as a highly cited researcher.
Xu's research network includes collaborators at Arkansas State University, such as Paula Perez Sanchez, Shekoofeh Sadravi, and Jacqueline Vargas Ulloa, with whom he has co-authored multiple publications. His academic contributions are reflected in his h-index of 36 and over 4,800 citations across 135 publications.
Metrics
- h-index: 35
- Publications: 127
- Citations: 4,660
Positions
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Professor 2020–presentArkansas State University Arkansas Biosciences Institute ORCID
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Associate Professor 2013–2020Arkansas State University Arkansas Biosciences Institute ORCID
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Assistant Professor 2008–2013Arkansas State University Arkansas Biosciences Institute ORCID
Selected Publications
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Advances in promoter engineering strategies for enhanced recombinant protein expression in plants (2026)
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Morphology and bioproduction potential of DCB-induced cell wall-deficient tobacco BY-2 cells and transcriptomic analysis (2025)
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Unlocking the full potential of plant cell-based production for valuable proteins: Challenges and innovative strategies (2025)
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Acidothermus cellulolyticus E1 endoglucanase expressed in planta undergoes extensive hydroxyproline-O-glycosylation and exhibits enhanced impact on biomass digestibility (2024)
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Abstract 2377 Thermophilic E1 endoglucanase from Acidothermus cellulolyticus undergoes extensive hydroxyproline-O-glycosylation when expressed in planta (2024)
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Harnessing the Power of Plants: A Green Factory for Bioactive Compounds (2023)
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Intracellular trafficking and glycosylation of hydroxyproline-O-glycosylation module in tobacco BY-2 cells is dependent on medium composition and transcriptome analysis (2023)
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Arabinogalactan Structures of Repetitive Serine-Hydroxyproline Glycomodule Expressed by Arabidopsis Cell Suspension Cultures (2023)
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Plants as Biofactories for Therapeutic Proteins and Antiviral Compounds to Combat COVID-19 (2023)
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CAP1 (cyclase-associated protein 1) mediates the cyclic AMP signals that activate Rap1 in stimulating matrix adhesion of colon cancer cells (2023)
ARA Academy 2023 ARA Fellow
Dr. Xu holds a PhD in Biochemical Engineering from Dalian University of Technology and joined A-State's faculty in 2008 after serving as Senior Research Associate at Cornell University. His research focuses on genetically engineering plants for biofuel and therapeutic benefits.
Policy Impact
Engineers plants for biofuel and therapeutic applications at Arkansas State University, creating potential new revenue streams for Arkansas agriculture and biomanufacturing.
Growth Areas
['Food Production & Integrative Health', 'Precision Agriculture']
Federal Grants 3 $1,403,716 total
Engineering novel designer biologics in plant cells for oral treatment of ulcerative colitis
Engineering GPI-anchored Proteins in Plant Cells for Enhanced Protein Production and Applications
Collaboration Network
Top Collaborators
- Towards high-yield production of pharmaceutical proteins with plant cell suspension cultures
- Growing Lemna minor in agricultural wastewater and converting the duckweed biomass to ethanol
- Bioethanol and biodiesel: Alternative liquid fuels for future generations
- Cell-Free Protein Expression under Macromolecular Crowding Conditions
- Bioethanol production from dedicated energy crops and residues in Arkansas, USA
Showing 5 of 11 shared publications
- Cellular engineering of plant cells for improved therapeutic protein production
- Engineering ‘designer’ glycomodules for boosting recombinant protein secretion in tobacco hairy root culture and studying hydroxyproline‐O‐glycosylation process in plants
- Plants as Biofactories for Therapeutic Proteins and Antiviral Compounds to Combat COVID-19
- Plant cell-secreted stem cell factor stimulates expansion and differentiation of hematopoietic stem cells
- Dynamic Phosphorylation and Dephosphorylation of Cyclase-Associated Protein 1 by Antagonistic Signaling through Cyclin-Dependent Kinase 5 and cAMP Are Critical for the Protein Functions in Actin Filament Disassembly and Cell Adhesion
Showing 5 of 8 shared publications
- Green factory: Plants as bioproduction platforms for recombinant proteins
- Bench to batch: advances in plant cell culture for producing useful products
- Bioethanol and biodiesel: Alternative liquid fuels for future generations
- Integrated green algal technology for bioremediation and biofuel
- Ettlia oleoabundans growth and oil production on agricultural anaerobic waste effluents
Showing 5 of 7 shared publications
- In Vitro Biocompatibility of Decellularized Cultured Plant Cell-Derived Matrices
- Engineering ‘designer’ glycomodules for boosting recombinant protein secretion in tobacco hairy root culture and studying hydroxyproline‐O‐glycosylation process in plants
- Enhanced secretion of human α1-antitrypsin expressed with a novel glycosylation module in tobacco BY-2 cell culture
- Production of thermostable endo-1,5-α-l-arabinanase in Pichia pastoris for enzymatically releasing functional oligosaccharides from sugar beet pulp
- High yield secretion of human erythropoietin from tobacco cells for ex vivo differentiation of hematopoietic stem cells towards red blood cells
Showing 5 of 6 shared publications
- Human growth hormone expressed in tobacco cells as an arabinogalactan-protein fusion glycoprotein has a prolonged serum life
- Enhanced accumulation of secreted human growth hormone by transgenic tobacco cells correlates with the introduction of an N-glycosylation site
- A Novel Plant Cell Bioproduction Platform for High-Yield Secretion of Recombinant Proteins
- Arabinogalactan Structures of Repetitive Serine-Hydroxyproline Glycomodule Expressed by Arabidopsis Cell Suspension Cultures
- Towards high-yield production of pharmaceutical proteins with plant cell suspension cultures
- Green factory: Plants as bioproduction platforms for recombinant proteins
- Dramatic secretion of recombinant protein expressed in tobacco cells with a designer glycopeptide tag is highly impacted by medium composition
- Hydroxyproline-O-glycosylated peptide tags enhance recombinant protein yields in tobacco transient expression
- Engineering ‘designer’ glycomodules for boosting recombinant protein secretion in tobacco hairy root culture and studying hydroxyproline‐O‐glycosylation process in plants
- High‐yield secretion of recombinant proteins expressed in tobacco cell culture with a designer glycopeptide tag: Process development
- Ethanol fermentation of energy beets by self-flocculating and non-flocculating yeasts
- Production of thermostable endo-1,5-α-l-arabinanase in Pichia pastoris for enzymatically releasing functional oligosaccharides from sugar beet pulp
- Engineering ‘designer’ glycomodules for boosting recombinant protein secretion in tobacco hairy root culture and studying hydroxyproline‐O‐glycosylation process in plants
- Enhanced secretion of human α1-antitrypsin expressed with a novel glycosylation module in tobacco BY-2 cell culture
- Dramatic secretion of recombinant protein expressed in tobacco cells with a designer glycopeptide tag is highly impacted by medium composition
- Intracellular trafficking and glycosylation of hydroxyproline-O-glycosylation module in tobacco BY-2 cells is dependent on medium composition and transcriptome analysis
- Green factory: Plants as bioproduction platforms for recombinant proteins
- Protein targeting
- Hydroxyproline-O-glycosylated peptide tags enhance recombinant protein yields in tobacco transient expression
- Growing Lemna minor in agricultural wastewater and converting the duckweed biomass to ethanol
- Eastern gamagrass as an alternative cellulosic feedstock for bioethanol production
- Poplar (Populus deltoides L.): The Effect of Washing Pretreated Biomass on Enzymatic Hydrolysis and Fermentation to Ethanol
- Growing Lemna minor in agricultural wastewater and converting the duckweed biomass to ethanol
- Bioethanol production from dedicated energy crops and residues in Arkansas, USA
- Dramatic secretion of recombinant protein expressed in tobacco cells with a designer glycopeptide tag is highly impacted by medium composition
- Bioethanol and biodiesel: Alternative liquid fuels for future generations
- Bioethanol production from dedicated energy crops and residues in Arkansas, USA
- Eastern gamagrass as an alternative cellulosic feedstock for bioethanol production
- Cell-Free Protein Expression under Macromolecular Crowding Conditions
- DNA nanomedicine: Engineering DNA as a polymer for therapeutic and diagnostic applications
- High-yield cell-free protein production from P-gel
- Effects of fungicides on the yeast-like symbiotes and their host, Nilaparvata lugens Stål (Hemiptera: Delphacidae)
- Improved antibiotic production and silent gene activation in Streptomyces diastatochromogenes by ribosome engineering
- Transcriptome Sequencing and Gene Expression Analysis of Trichoderma brevicompactum under Different Culture Conditions
- Bench to batch: advances in plant cell culture for producing useful products
- Platforms for Plant-Based Protein Production
- Platforms for Plant-Based Protein Production