R
Reza Hakkak
High Impact
Associate Dean for Research
faculty
Dietetics and Nutrition, College of Health Profession
24 h-index
210 pubs
1,875 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Reza Hakkak's research program investigates the influence of nutrition on health outcomes, with a particular focus on the links between obesity, diet, and cancer promotion. His work also explores the efficacy of nutritional interventions for conditions such as non-alcoholic fatty liver steatosis.
Dr. Hakkak's recent studies utilize rodent models, specifically Zucker rats, to examine the effects of dietary components like soy protein concentrate and isoflavones on metabolic status, liver steatosis, and inflammation. These investigations also assess the impact of pharmacological agents, such as metformin, on these physiological processes. His research has been supported by funding from the Susan G. Komen Foundation, the USDA, and the Arkansas Biosciences Institute. Dr. Hakkak has authored over 65 research articles and presented more than 220 abstracts and presentations, with a h-index of 24 and over 1,800 citations, indicating significant contributions to his field.
In addition to his research, Dr. Hakkak holds leadership positions at the University of Arkansas for Medical Sciences, serving as Associate Dean for Research in the College of Health Professions, and as Professor and Chairman of the Department of Dietetics and Nutrition. He also holds professorships in the College of Medicine and the College of Public Health.
Metrics
- h-index: 24
- Publications: 210
- Citations: 1,875
Selected Publications
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Metformin Attenuates Oxidative Stress and Inflammatory Responses in Obesity-Associated Nonalcoholic Fatty Liver Disease (NAFLD) (2025)
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The effect of obesity and dietary soy protein with different isoflavone levels on fecal microbial composition in lean and obese Zucker rats over 9- and 18-week periods (2025)
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Obesity-Associated NAFLD Coexists with a Chronic Inflammatory Kidney Condition That Is Partially Mitigated by Short-Term Oral Metformin (2025)
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Obesity and Dietary Soy Protein With Different Isoflavone Levels Alter Fecal Microbial Composition in Zucker Rats Over 9- and 18-Week Periods (2025)
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Unrecognized Effects of Metformin to Reduce Proteasomal Stress and Macrophage Infiltration in Kidneys of Obese Rats with NAFLD (Abstract ID: 166383) (2025)
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Dietary soy protein reverses obesity-induced liver steatosis and alters fecal microbial composition independent of isoflavone level (2024)
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Soy Protein Concentrate With Low and High Isoflavones Can Reverse Non-alcoholic Fatty Liver Disease Caused by Obesity and Alter Gut Microbial Composition (2024)
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Soy Protein Concentrate Diets Reduce Liver Lipopolysaccharide-Binding Protein Expression and Liver Inflammation in Obese Zucker Rats With Liver Steatosis (2024)
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Soy Protein Concentrate Diets Inversely Affect LPS-Binding Protein Expression in Colon and Liver, Reduce Liver Inflammation, and Increase Fecal LPS Excretion in Obese Zucker Rats (2024)
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Abstract 759: Soy protein diet changes metabolic profile in liver of 7,12-dimethylbenz(<i>α</i>)anthracene (DMBA)-induced mammary tumors in obese zucker rats (2024)
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Feeding soy protein concentrates with low or high isoflavone decreases liver inflammation by reducing lipopolysaccharide translocation (2023)
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Long-Term Feeding Soy Protein Concentrates Protect Against Hepatic Steatosis Independent of Isoflavone Levels (2023)
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Effect of Metformin Treatment on Serum Metabolic Profile Changes in Lean and Obese Zucker Rat Model for Fatty Liver Disease (2023)
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Feeding Soy Protein Concentrates with Low and High Isoflavones Alters 9 and 18 Weeks Serum Isoflavones and Inflammatory Protein Levels in Lean and Obese Zucker Rats (2023)
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Diet Containing Soy Protein Concentrate With Low and High Isoflavones for 9 Weeks Protects Against Non-alcoholic Fatty Liver Steatosis Using Obese Zucker Rats (2022)
Grants & Funding
- No FP attached UAMS ACHRI Flow Through Principal Investigator
Collaboration Network
Top Collaborators
Soheila Korourian
University of Arkansas for Medical Sciences
10 shared publications
In database
- Diet Containing Soy Protein Concentrate With Low and High Isoflavones for 9 Weeks Protects Against Non-alcoholic Fatty Liver Steatosis Using Obese Zucker Rats
- Effects of obesity and 10 weeks metformin treatment on liver steatosis
- Long-Term Feeding Soy Protein Concentrates Protect Against Hepatic Steatosis Independent of Isoflavone Levels
- Dietary soy protein reverses obesity-induced liver steatosis and alters fecal microbial composition independent of isoflavone level
- Effects of Obesity and Low and High Isoflavones in Soy Protein Concentrate Diet on Liver Steatosis
Showing 5 of 10 shared publications
Beverly J. Spray
Arkansas Children's Hospital (US)
9 shared publications
- Diet Containing Soy Protein Concentrate With Low and High Isoflavones for 9 Weeks Protects Against Non-alcoholic Fatty Liver Steatosis Using Obese Zucker Rats
- Feeding Soy Protein Concentrates with Low and High Isoflavones Alters 9 and 18 Weeks Serum Isoflavones and Inflammatory Protein Levels in Lean and Obese Zucker Rats
- Effects of obesity and 10 weeks metformin treatment on liver steatosis
- Long-Term Feeding Soy Protein Concentrates Protect Against Hepatic Steatosis Independent of Isoflavone Levels
- Dietary soy protein reverses obesity-induced liver steatosis and alters fecal microbial composition independent of isoflavone level
Showing 5 of 9 shared publications
Melisa Kozaczek
University of Arkansas for Medical Sciences
7 shared publications
In database
- Effects of obesity and 10 weeks metformin treatment on liver steatosis
- A Comparison of Short- and Long-Term Soy Protein Isolate Intake and Its Ability to Reduce Liver Steatosis in Obese Zucker Rats Through Modifications of Genes Involved in Inflammation and Lipid Transport
- Effects of Short- and Long-Term Soy Protein Feeding on Hepatic Cytochrome P450 Expression in Obese Nonalcoholic Fatty Liver Disease Rat Model
- Hepatic Proteomics Analysis of Nonalcoholic Fatty Liver Disease Obese Rat Model After Short- and Long-Term Soy Protein Isolate Feeding
- Liver Proteomics Analysis After Short- and Long-Term Soy Protein Isolate Feeding Using Obese Zucker Rat Model
Showing 5 of 7 shared publications
Wei Li
University of Arkansas for Medical Sciences (US)
6 shared publications
- Feeding Soy Protein Concentrates with Low and High Isoflavones Alters 9 and 18 Weeks Serum Isoflavones and Inflammatory Protein Levels in Lean and Obese Zucker Rats
- Soy Protein Concentrate Diets Inversely Affect LPS-Binding Protein Expression in Colon and Liver, Reduce Liver Inflammation, and Increase Fecal LPS Excretion in Obese Zucker Rats
- Long-Term Feeding Soy Protein Concentrates Protect Against Hepatic Steatosis Independent of Isoflavone Levels
- Feeding Obese Zucker Rats With Soy Protein Concentrate With High Isoflavones Compared to Low Isoflavones Leads to a Significant Reduction of Serum Tumor Necrosis Factor-α
- P03-051-23 Long-Term Feeding Soy Protein Concentrates With Low and High Isoflavones Reduces Liver Inflammation in Obese Zucker Rats
Showing 5 of 6 shared publications
Walter Bottje
University of Arkansas System (US)
5 shared publications
- A Comparison of Short- and Long-Term Soy Protein Isolate Intake and Its Ability to Reduce Liver Steatosis in Obese Zucker Rats Through Modifications of Genes Involved in Inflammation and Lipid Transport
- Effects of Short- and Long-Term Soy Protein Feeding on Hepatic Cytochrome P450 Expression in Obese Nonalcoholic Fatty Liver Disease Rat Model
- Hepatic Proteomics Analysis of Nonalcoholic Fatty Liver Disease Obese Rat Model After Short- and Long-Term Soy Protein Isolate Feeding
- Liver Proteomics Analysis After Short- and Long-Term Soy Protein Isolate Feeding Using Obese Zucker Rat Model
- Effects of Short and Long-Term Soy Protein Isolate Intake on Hepatic Cytochrome P450 Expression in Obese Zucker Rats
Michael S. Robeson
University of Arkansas for Medical Sciences
5 shared publications
In database
- Short-Term Metformin Treatment Enriches Bacteroides dorei in an Obese Liver Steatosis Zucker Rat Model
- Dietary soy protein reverses obesity-induced liver steatosis and alters fecal microbial composition independent of isoflavone level
- Effects of Short-Term Metformin Treatment on Gut Microbiota Profile Using Female Obese Zucker Rat Model
- Soy Protein Concentrate With Low and High Isoflavones Can Reverse Non-alcoholic Fatty Liver Disease Caused by Obesity and Alter Gut Microbial Composition
- The effect of obesity and dietary soy protein with different isoflavone levels on fecal microbial composition in lean and obese Zucker rats over 9- and 18-week periods
David M. Irby
5 shared publications
- Diet Containing Soy Protein Concentrate with Low and High Isoflavones for 18 Weeks Protects Against Non-alcoholic Fatty Liver Diseases
- Effects of 8 Weeks Feeding Diet with Low and High Isoflavones Soy Protein Concentrate on Serum Isoflavones in Non-alcoholic Fatty Liver Disease (NAFLD) Rat Model
- Feeding Obese Zucker Rats With Soy Protein Concentrate With High Isoflavones Compared to Low Isoflavones Leads to a Significant Reduction of Serum Tumor Necrosis Factor-α
- P31-022-23 Feeding Soy Protein Concentrate With Low and High Isoflavones Can Reverse Non-Alcoholic Fatty Liver Disease Caused by Obesity in Obese Zucker Rat Model
- Soy Protein Concentrate With Low and High Isoflavones Can Reverse Non-alcoholic Fatty Liver Disease Caused by Obesity and Alter Gut Microbial Composition
Lisa T. Jansen
5 shared publications
In database
- A Pilot Study Protocol: Glycemic Patterns in Obese Pregnancies Without Diabetes – Identifying Susceptible Periods for Intervention
- P14-054-23 Increased Polyunsaturated Fatty Acid (PUFA) Intake Is Not Associated With Lower HbA1c Levels in U.S. Adults With Non-Insulin Dependent Diabetes Ages 19–50
- P08-005-23 The Effect of Adding a Registered Dietitian to the Interdisciplinary Team on Malnutrition Diagnosis and Nutrition Care in Long-Term Care Residents
- P04-009-23 Impact of a PharmD, MSCN Guided Educational Intervention on Knowledge of Nutrition & Dietary Supplement Use in Baseball and Softball Athletes at an NCAA Division II Program
- P04-009-23 Impact of a PharmD, MSCN Guided Educational Intervention on Knowledge of Nutrition & Dietary Supplement Use in Baseball and Softball Athletes at an NCAA Division II Program
Wei Li
5 shared publications
- Feeding soy protein concentrates with low or high isoflavone decreases liver inflammation by reducing lipopolysaccharide translocation
- P03-053-23 The Effect of Long-Term Feeding Soy Protein Concentrates With Low and High Isoflavones to Lean and Obese Rats on Liver microRNAs Linked to Nonalcoholic Fatty Liver Disease
- P14-054-23 Increased Polyunsaturated Fatty Acid (PUFA) Intake Is Not Associated With Lower HbA1c Levels in U.S. Adults With Non-Insulin Dependent Diabetes Ages 19–50
- Soy Protein Concentrate Diets Reduce Liver Lipopolysaccharide-Binding Protein Expression and Liver Inflammation in Obese Zucker Rats With Liver Steatosis
- Lipopolysaccharide-Binding Protein Colonic Expression Inversely Associates With Liver Inflammation With Its Level in Feces Altered by Obesity and Dietary Soy Protein
Elisabet Børsheim
Arkansas Children's Hospital
4 shared publications
In database
- Diet Containing Soy Protein Concentrate With Low and High Isoflavones for 9 Weeks Protects Against Non-alcoholic Fatty Liver Steatosis Using Obese Zucker Rats
- Long-Term Feeding Soy Protein Concentrates Protect Against Hepatic Steatosis Independent of Isoflavone Levels
- Dietary soy protein reverses obesity-induced liver steatosis and alters fecal microbial composition independent of isoflavone level
- A Pilot Study Protocol: Glycemic Patterns in Obese Pregnancies Without Diabetes – Identifying Susceptible Periods for Intervention
Wei Li
University of Arkansas for Medical Sciences (US)
4 shared publications
- Dietary soy protein reverses obesity-induced liver steatosis and alters fecal microbial composition independent of isoflavone level
- Obesity and Dietary Soy Protein With Different Isoflavone Levels Alter Fecal Microbial Composition in Zucker Rats Over 9- and 18-Week Periods
- Soy Protein and Its Influence on Hepatic Inflammation in Non-Alcoholic Fatty Liver Disease (NAFLD)
- The effect of obesity and dietary soy protein with different isoflavone levels on fecal microbial composition in lean and obese Zucker rats over 9- and 18-week periods
Josh Phelps
3 shared publications
- Examining weight gain: A retrospective study on preterm newborn growth on a diet exclusively of fortified donor breast milk
- P08-020-23 Interruptions for Enteral Nutrition Provision in Critically Ill Patients
- P04-006-23 Rate and Accuracy of Coded Malnutrition Diagnosis Among Hospitalized Adult Patients Following Implementation of a Malnutrition Quality Improvement Initiative Program
Stepan Melnyk
3 shared publications
In database
- Metabolic Status of Lean and Obese Zucker Rats Based on Untargeted and Targeted Metabolomics Analysis of Serum
- Abstract 740: Obesity promotes liver pro-oxidative and DNA damage in mammary tumor of Zucker rats
- Abstract 759: Soy protein diet changes metabolic profile in liver of 7,12-dimethylbenz(<i>α</i>)anthracene (DMBA)-induced mammary tumors in obese zucker rats
Nathan C. Twaddle
United States Food and Drug Administration
3 shared publications
In database
- Feeding Soy Protein Concentrates with Low and High Isoflavones Alters 9 and 18 Weeks Serum Isoflavones and Inflammatory Protein Levels in Lean and Obese Zucker Rats
- Dietary soy protein reverses obesity-induced liver steatosis and alters fecal microbial composition independent of isoflavone level
- Effects of 8 Weeks Feeding Diet with Low and High Isoflavones Soy Protein Concentrate on Serum Isoflavones in Non-alcoholic Fatty Liver Disease (NAFLD) Rat Model
Christopher E. Randolph
Arkansas Children's Hospital
3 shared publications
In database
- Dietary soy protein reverses obesity-induced liver steatosis and alters fecal microbial composition independent of isoflavone level
- Obesity and Dietary Soy Protein With Different Isoflavone Levels Alter Fecal Microbial Composition in Zucker Rats Over 9- and 18-Week Periods
- The effect of obesity and dietary soy protein with different isoflavone levels on fecal microbial composition in lean and obese Zucker rats over 9- and 18-week periods
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