Reza Hakkak

High Impact

Associate Dean for Research

University of Arkansas for Medical Sciences

faculty

Dietetics and Nutrition, College of Health Profession

24 h-index 213 pubs 1,860 cited

Research Areas

Diet and metabolism studies Cancer-related molecular mechanisms research Obesity Phytochemicals and Antioxidant Activities Gut microbiota and health Liver Disease Diagnosis and Treatment Health Sciences Research and Education

Links

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OverviewAI-generated summary

Reza Hakkak's research focuses on the influence of nutrition on cancer prevention and promotion, with a particular emphasis on the links between obesity and breast cancer. His work also investigates the impact of diet on liver steatosis and the broader effects of nutrition on chemical carcinogenesis.

Dr. Hakkak's laboratory studies have explored the role of soy protein concentrates with varying isoflavone levels in mitigating non-alcoholic fatty liver steatosis in obese Zucker rats. His research has also examined the metabolic status of lean and obese Zucker rats through metabolomics analysis, and investigated how metformin treatment affects liver steatosis and the gut microbiota in these models. He has received funding for his research from the Susan G. Komen Foundation, the USDA, and the Arkansas Biosciences Institute.

With over 65 research articles and more than 220 abstracts and presentations, Dr. Hakkak has a significant publication record. His scholarly metrics include an h-index of 24, with 213 total publications and 1,860 citations. He holds multiple professorial appointments at the University of Arkansas for Medical Sciences, serving as Professor and Chairman of the Department of Dietetics and Nutrition, Associate Dean for Research in the College of Health Professions, Professor of Pediatrics in the College of Medicine, and Professor in the Department of Health Policy and Management in the College of Public Health.

Metrics

  • h-index: 24
  • Publications: 213
  • Citations: 1,860

Selected Publications

  • Metformin Attenuates Oxidative Stress and Inflammatory Responses in Obesity-Associated Nonalcoholic Fatty Liver Disease (NAFLD) (2025) DOI
  • The effect of obesity and dietary soy protein with different isoflavone levels on fecal microbial composition in lean and obese Zucker rats over 9- and 18-week periods (2025) DOI
  • Obesity-Associated NAFLD Coexists with a Chronic Inflammatory Kidney Condition That Is Partially Mitigated by Short-Term Oral Metformin (2025) DOI
  • Unrecognized Effects of Metformin to Reduce Proteasomal Stress and Macrophage Infiltration in Kidneys of Obese Rats with NAFLD (Abstract ID: 166383) (2025) DOI
  • Dietary soy protein reverses obesity-induced liver steatosis and alters fecal microbial composition independent of isoflavone level (2024) DOI
  • Soy Protein Concentrate With Low and High Isoflavones Can Reverse Non-alcoholic Fatty Liver Disease Caused by Obesity and Alter Gut Microbial Composition (2024) DOI
  • Soy Protein Concentrate Diets Reduce Liver Lipopolysaccharide-Binding Protein Expression and Liver Inflammation in Obese Zucker Rats With Liver Steatosis (2024) DOI
  • Soy Protein Concentrate Diets Inversely Affect LPS-Binding Protein Expression in Colon and Liver, Reduce Liver Inflammation, and Increase Fecal LPS Excretion in Obese Zucker Rats (2024) DOI
  • Abstract 759: Soy protein diet changes metabolic profile in liver of 7,12-dimethylbenz(<i>α</i>)anthracene (DMBA)-induced mammary tumors in obese zucker rats (2024) DOI
  • Feeding soy protein concentrates with low or high isoflavone decreases liver inflammation by reducing lipopolysaccharide translocation (2023) DOI
  • Long-Term Feeding Soy Protein Concentrates Protect Against Hepatic Steatosis Independent of Isoflavone Levels (2023) DOI
  • Effect of Metformin Treatment on Serum Metabolic Profile Changes in Lean and Obese Zucker Rat Model for Fatty Liver Disease (2023) DOI
  • Feeding Soy Protein Concentrates with Low and High Isoflavones Alters 9 and 18 Weeks Serum Isoflavones and Inflammatory Protein Levels in Lean and Obese Zucker Rats (2023) DOI
  • Diet Containing Soy Protein Concentrate With Low and High Isoflavones for 9 Weeks Protects Against Non-alcoholic Fatty Liver Steatosis Using Obese Zucker Rats (2022) DOI
  • Abstract 740: Obesity promotes liver pro-oxidative and DNA damage in mammary tumor of Zucker rats (2022) DOI

Grants & Funding

  • No FP attached UAMS ACHRI Flow Through Principal Investigator

Collaborators

Researchers in the database who share publications

Soheila Korourian University of Arkansas for Medical Sciences 10 shared publications Melisa Kozaczek University of Arkansas for Medical Sciences 7 shared publications Michael Scott Robeson University of Arkansas for Medical Sciences 5 shared publications Elisabet Børsheim University of Arkansas for Medical Sciences 4 shared publications Lisa T. Jansen University of Arkansas for Medical Sciences 4 shared publications Nirmala Parajuli University of Arkansas for Medical Sciences 3 shared publications Nathan C. Twaddle National Center for Toxicological Research 3 shared publications Christopher E. Randolph University of Arkansas for Medical Sciences 3 shared publications

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