Laura James

Sourced from institutional research profiles (UAMS TRI or ARA).

◆ ARA Academy Federal Grant PI

Professor

UAMS

Faculty Researcher

Peds Pediatrics, College of Medicine

Research Areas

Links

ORCID Lab Website UAMS TRI Profile

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OverviewAI-generated summary

Laura James is a Professor in the Department of Pediatrics at the University of Arkansas for Medical Sciences, where she also serves as the Director of the Translational Research Institute. Her research focuses on the translational studies of acetaminophen toxicity. In collaboration with other researchers, she has developed novel methods for quantifying acetaminophen protein adducts in peripheral blood samples. Dr. James also leads clinical trials in pediatric populations aimed at establishing safe and effective drug dosing strategies for various diseases.

Prior to her work at UAMS, Dr. James completed her PhD, focusing on behavioral ecology and the molecular mechanisms underlying behavioral phenotypes in agricultural environments, using bees as a model species. Her doctoral research investigated the molecular effects of chronic pesticide exposure on bumblebee learning and memory. This work integrated ecotoxicology, entomology, behavior, and molecular biology, utilizing techniques such as RNA sequencing to analyze gene expression differences.

Research Overview

Dr. James is the Director of the Translational Research Institute at the University of Arkansas for Medical Sciences. Her research interest is in translational studies of acetaminophen toxicity. She and her collaborators developed novel approaches for the quantitation of acetaminophen protein adducts in peripheral blood samples. She also directs clinical trials in children to develop safe and effective drug dosing strategies in a number of disease areas.

ARA Academy 2015 ARA Fellow

Dr. James has served as a pediatrician and UAMS faculty member since 1994. Her research training focused on pediatric pharmacology studies in children, supported by the NIH through the Pediatric Pharmacology Research Unit Network, with emphasis on guiding the dosing of a number of pediatric therapeutics. She now leads the Translational Research Institute at UAMS.

Policy Impact

Leads the UAMS Translational Research Institute, accelerating the translation of laboratory discoveries into clinical treatments that benefit patients across Arkansas.

Growth Areas

['Population Health Innovations & Clinical Research']

Resources

Discovery Economics Article Project Scope Video Additional Video Video ARA Academy Profile

Grants & Funding

As listed on this researcher's institutional profile.

Adduct Dipstick for Diagnosis of Acetaminophen Toxicity NIH/NIDDK Principal Investigator
Engaging Cooperative Sites for Trial Acceleration, Trust, Innovation, and Capability (ECSTATIC) NIH/National Center for Advancing Translational Sciences via Vanderbilt University Principal Investigator
Synthetic Cannabinoid Toxicity: Role of Biotransformation NIH Co-Investigator
AcetaSTAT Rapid Assay for Acetaminophen Liver Injury NIH Principal Investigator
COVID-19 PREVENT (Partnership for Rapid Engagement to enhance Vaccine uptake for Everyone: Neighbors working Together) Project NIH/Nat. Heart, Lung & Blood Institute via Westat Principal Investigator
Identification of new mechanistic biomarkers of adverse responses to acetaminophe NIH Principal Investigator
Primary Care HEART-NET (Health Equity through Access and Research in Transformative Networks) in the Deep South NIH Co-Principal Investigator
Primary Care HEART-NET (Health Equity through Access and Research in Transformative Networks) in the Deep South NIH/Office of the Director via University of Alabama at Birmingham Principal Investigator

Arkansas Center for Advancing Pediatric Therapeutics NIH Principal Investigator
Expanding Translational Science in Arkansas NIH/National Center for Advancing Translational Sciences Principal Investigator
Dipstick Assay for Detection of Acetaminophen Protein Adducts NIH Principal Investigator
Expanding Translational Science in Arkansas NIH Principal Investigator
HIF-1alpha and VEGF in Acetaminophen Toxicity and Repair NIH Principal Investigator
NOVEL THERAPIES FOR ACETAMINOPHEN TOXICITY NIH Principal Investigator
ABI C. OBrien NIH COBRE FY26 Y4 State of Arkansas Principal Investigator
Arkansas Center for Clinical Translational Research NIH Co-Principal Investigator
Community Engagement Research Alliance (CEAL) 2023-2024 Renewal NIH/Nat. Heart, Lung & Blood Institute via Westat Co-Principal Investigator
Arkansas Center for Clinical & Translational Research NIH/National Center for Advancing Translational Sciences Principal Investigator
Expanding Translational Research in Arkansas NIH Principal Investigator
Pediatric Pharmacology Research Unit Network NIH Principal Investigator
Arkansas ECHO ISPCTN Site (AREIS) NIH Co-Principal Investigator
AcetaSTAT Validation and Commercialization NIH Principal Investigator
Arkansas Center for Advancing Pediatric Therapeutics (ArCAPT) NIH Co-Principal Investigator
AcetaSTAT Validation and Commercialization NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases via Acetaminophen Toxicity Diagnostics, LLC Principal Investigator
Evaluation of a Biomarker for Acetaminophen Toxicity NIH Principal Investigator
Arkansas Center for Clinical and Translational Research NIH Co-Principal Investigator
FOOD AS MEDICINE: ADDRESSING SOCIAL DETERMINANTS OF HEALTH (FOOD INSECURITY) TO EFFECT CLINICAL OUTCOMES (CEAL) Westat via Westat Principal Investigator