Lydia M. Bilinsky Source Confirmed

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Researcher

National Center for Toxicological Research

unknown

4 h-index 8 pubs 66 cited

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Biography and Research Information

OverviewAI-generated summary

Lydia M. Bilinsky's research focuses on the development and application of computational models to understand biological processes, particularly concerning cellular metabolism and oxidative stress. Her recent work includes a 2024 publication detailing a computational model of endogenous hydrogen peroxide metabolism in hepatocytes, highlighting the role of glutathione (GSH). She has also published on a computational model that predicts intracellular H₂O₂ concentration and cell death during oxidative stress, with applications to PBPK/PD modeling of trivalent arsenical DMA<sup>III</sup>. This research provides insights into the critical role of GSH depletion in apoptosis and the regulation of intracellular H₂O₂ concentration. Bilinsky's investigations extend to the kinetic and thermodynamic regulation of mitochondrial energy metabolism and reactive oxygen species (ROS) production, as explored in her 2022 publication. Her scholarly contributions are reflected in a h-index of 4 across 8 publications, with a total of 66 citations.

Metrics

  • h-index: 4
  • Publications: 8
  • Citations: 66

Selected Publications

  • A computational model of endogenous hydrogen peroxide metabolism in hepatocytes, featuring a critical role for GSH (2024) DOI
  • A Computational Model of Hydrogen Peroxide Production in Liver and its Removal by Catalase and GSH-reliant Enzymes that Can Predict Intracellular H <sub>2</sub> O <sub>2</sub> Concentration and Cell Death During Incidents of Extreme Oxidative Stress: (1) Applications to PBPK/PD Modeling of the Trivalent Arsenical DMA <i> <sup>III</sup> </i> , (2) Insights Obtained into (a) the Role of Critical GSH Depletion in Apoptosis and (b) How Intracellular H <sub>2</sub> O <sub>2</sub> Concentration is So Tightly Regulated (2023) DOI

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