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Biography and Research Information
OverviewAI-generated summary
Mara J. Campbell's research focuses on understanding and combating Staphylococcus aureus infections, particularly osteomyelitis. Her work investigates the bacterial factors that contribute to virulence and the development of effective prevention and treatment strategies. Recent publications explore the role of bacterial proteases, such as aureolysin and staphopain A, and regulatory elements like the <i>sarA</i> gene in the pathogenesis of osteomyelitis. Campbell has also evaluated the efficacy of bone filler scaffolds for local antibiotic delivery and examined biofilm formation inhibitors. Her investigations utilize animal models, specifically murine models, to study disease progression and test therapeutic interventions. Campbell collaborates with researchers at the University of Arkansas for Medical Sciences, including Mark S. Smeltzer and Karen E. Beenken, with whom she has co-authored multiple publications. Her research contributes to the fields of microbial infections and bone health.
Metrics
- h-index: 6
- Publications: 12
- Citations: 102
Selected Publications
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Staphylococcus aureus Proteins Implicated in the Reduced Virulence of sarA and sarA/agr Mutants in Osteomyelitis (2025)
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The ability of <i>sarA</i> to limit protease production plays a key role in the pathogenesis of <i>Staphylococcus aureus</i> osteomyelitis irrespective of the functional status of <i>agr</i> (2024)
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RANKL-mediated osteoclast formation is required for bone loss in a murine model of Staphylococcus aureus osteomyelitis (2024)
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Increased production of aureolysin and staphopain A is a primary determinant of the reduced virulence of <i>Staphylococcus aureus sarA</i> mutants in osteomyelitis (2024)
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Comparative evaluation of small molecules reported to be inhibitors of <i>Staphylococcus aureus</i> biofilm formation (2023)
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The major role of <i>sarA</i> in limiting <i>Staphylococcus aureus</i> extracellular protease production <i>in vitro</i> is correlated with decreased virulence in diverse clinical isolates in osteomyelitis (2023)
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The major role of <i>sarA</i> in limiting <i>Staphylococcus aureus</i> extracellular protease production is correlated with decreased virulence in diverse clinical isolates in osteomyelitis (2022)
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Evaluation of a bone filler scaffold for local antibiotic delivery to prevent Staphylococcus aureus infection in a contaminated bone defect (2021)
Collaboration Network
Top Collaborators
Mark S. Smeltzer
University of Arkansas for Medical Sciences
10 shared publications
In database
- Evaluation of a bone filler scaffold for local antibiotic delivery to prevent Staphylococcus aureus infection in a contaminated bone defect
- RANKL-mediated osteoclast formation is required for bone loss in a murine model of Staphylococcus aureus osteomyelitis
- The major role of <i>sarA</i> in limiting <i>Staphylococcus aureus</i> extracellular protease production <i>in vitro</i> is correlated with decreased virulence in diverse clinical isolates in osteomyelitis
- Increased production of aureolysin and staphopain A is a primary determinant of the reduced virulence of <i>Staphylococcus aureus sarA</i> mutants in osteomyelitis
- The ability of <i>sarA</i> to limit protease production plays a key role in the pathogenesis of <i>Staphylococcus aureus</i> osteomyelitis irrespective of the functional status of <i>agr</i>
Showing 5 of 10 shared publications
Karen E. Beenken
University of Arkansas for Medical Sciences
9 shared publications
In database
- Evaluation of a bone filler scaffold for local antibiotic delivery to prevent Staphylococcus aureus infection in a contaminated bone defect
- RANKL-mediated osteoclast formation is required for bone loss in a murine model of Staphylococcus aureus osteomyelitis
- The major role of <i>sarA</i> in limiting <i>Staphylococcus aureus</i> extracellular protease production <i>in vitro</i> is correlated with decreased virulence in diverse clinical isolates in osteomyelitis
- Increased production of aureolysin and staphopain A is a primary determinant of the reduced virulence of <i>Staphylococcus aureus sarA</i> mutants in osteomyelitis
- The ability of <i>sarA</i> to limit protease production plays a key role in the pathogenesis of <i>Staphylococcus aureus</i> osteomyelitis irrespective of the functional status of <i>agr</i>
Showing 5 of 9 shared publications
Aura M. Ramírez
5 shared publications
- Evaluation of a bone filler scaffold for local antibiotic delivery to prevent Staphylococcus aureus infection in a contaminated bone defect
- The major role of <i>sarA</i> in limiting <i>Staphylococcus aureus</i> extracellular protease production <i>in vitro</i> is correlated with decreased virulence in diverse clinical isolates in osteomyelitis
- Increased production of aureolysin and staphopain A is a primary determinant of the reduced virulence of <i>Staphylococcus aureus sarA</i> mutants in osteomyelitis
- The major role of <i>sarA</i> in limiting <i>Staphylococcus aureus</i> extracellular protease production is correlated with decreased virulence in diverse clinical isolates in osteomyelitis
- The major role of <i>sarA</i> in limiting <i>Staphylococcus aureus</i> extracellular protease production <i>in vitro</i> is correlated with decreased virulence in diverse clinical isolates in osteomyelitis
Karrar M. Alghazali
University of Arkansas at Little Rock (US)
1 shared publication
- Evaluation of a bone filler scaffold for local antibiotic delivery to prevent Staphylococcus aureus infection in a contaminated bone defect
Christopher M. Walker
University of Arkansas for Medical Sciences (US)
1 shared publication
- Evaluation of a bone filler scaffold for local antibiotic delivery to prevent Staphylococcus aureus infection in a contaminated bone defect
Bailey K. Jackson
University of Arkansas at Little Rock
1 shared publication
In database
- Evaluation of a bone filler scaffold for local antibiotic delivery to prevent Staphylococcus aureus infection in a contaminated bone defect
Christopher Griffin
University of Arkansas at Little Rock (US)
1 shared publication
- Evaluation of a bone filler scaffold for local antibiotic delivery to prevent Staphylococcus aureus infection in a contaminated bone defect
William King
University of Arkansas at Little Rock
1 shared publication
In database
- Evaluation of a bone filler scaffold for local antibiotic delivery to prevent Staphylococcus aureus infection in a contaminated bone defect
Shawn E. Bourdo
University of Arkansas at Little Rock
1 shared publication
In database
- Evaluation of a bone filler scaffold for local antibiotic delivery to prevent Staphylococcus aureus infection in a contaminated bone defect
Rebecca E. Rifkin
University of Tennessee at Knoxville (US)
1 shared publication
- Evaluation of a bone filler scaffold for local antibiotic delivery to prevent Staphylococcus aureus infection in a contaminated bone defect
Silke Hecht
University of Tennessee at Knoxville (US)
1 shared publication
- Evaluation of a bone filler scaffold for local antibiotic delivery to prevent Staphylococcus aureus infection in a contaminated bone defect
Daniel G. Meeker
University of Arkansas for Medical Sciences (US)
1 shared publication
- Evaluation of a bone filler scaffold for local antibiotic delivery to prevent Staphylococcus aureus infection in a contaminated bone defect
David E. Anderson
University of Tennessee at Knoxville (US)
1 shared publication
- Evaluation of a bone filler scaffold for local antibiotic delivery to prevent Staphylococcus aureus infection in a contaminated bone defect
Alexandru S. Biris
University of Arkansas at Little Rock
1 shared publication
In database
- Evaluation of a bone filler scaffold for local antibiotic delivery to prevent Staphylococcus aureus infection in a contaminated bone defect
Firuze Soltani-Kordshuli
University of Arkansas at Fayetteville
1 shared publication
In database
- Cartilage-inspired surface textures for improved tribological performance of orthopedic implants
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