Marcelo Puppo Bigarella

Sourced from institutional research profiles (UAMS TRI or ARA).

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UAMS UA Little Rock University of Arkansas primary

Also affiliated: University of Wisconsin System (2024); University of Wisconsin–Madison (2023–2026); Universidade de São Paulo (2022)

2 h-index 22 pubs 18 cited

Research Areas

Biomedical Subjects

Links

ORCID Research Group UAMS TRI Profile

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OverviewAI-generated summary

Marcelo Bigarella's research focuses on the molecular mechanisms and diagnostic approaches for prostate cancer. He has developed multiplex assays to assess activated histone modifiers, specifically p300/CBP, in circulating tumor cells, aiming to improve the understanding and detection of advanced prostate cancer, including castration-resistant forms. His work also investigates the impact of therapeutic agents, such as 5α-reductase inhibitors, on prostate cancer characteristics as observed through multiparametric MRI. Bigarella has explored the role of PSA kinetics in men with negative MRI-targeted prostate biopsies and examined treatment considerations for prostate cancer patients with neurogenic bladders.

His publications also extend to broader cancer biology principles, including the stem cell origin of cancer and strategies for chemoprevention and maintenance therapy. Bigarella collaborates with researchers at the University of Arkansas for Medical Sciences, including Shi-Ming Tu, Jaskirat Sethi, Sunny Singh, and Yusra B. Medik, with whom he has co-authored publications.

Metrics

h-index: 2
Publications: 22
Citations: 18

Selected Publications

Addition of 18F-DCFPyL PSMA PET to MRI to avoid unnecessary biopsy in men on active surveillance: Final results from a phase II diagnostic trial (PROMPT). (2026)

Journal of Clinical Oncology 1 citation DOI OpenAlex
Pathologic findings and clinical outcomes after immune checkpoint blockade in renal cell carcinoma patients undergoing deferred consolidative nephrectomy. (2026)

Journal of Clinical Oncology DOI OpenAlex
Stem Cell Origin of Cancer: Biological Principles and Clinical Strategies for Chemoprevention and Maintenance Therapy in Cancer Care (2025)

Cancers 2 citations DOI OpenAlex
Multidisciplinary management of nonmetastatic locally advanced prostate cancer (T3-4N0M0) (2025)

Surgical Oncology Insight DOI OpenAlex