Match tier
Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-07
M
Melinda G. Gunnell
Research Program Manager
Also affiliated: InterveXion Therapeutics (United States) (2025)
13 h-index
29 pubs
542 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Melinda G. Gunnell's research focuses on developing therapeutic monoclonal antibodies for substance abuse treatment, particularly for methamphetamine and phencyclidine. Her work involves hapten design to create effective immunogens for antibody production and has explored the synthesis of specific haptens to improve epitope density on conjugate vaccines. Gunnell has investigated the effects of these antibodies on drug self-administration and behavioral impairment in animal models, including Sprague-Dawley rats and mice. Her research has also examined sexual dimorphism in phencyclidine metabolism and pharmacokinetics in rats. Gunnell has published 28 papers, with an h-index of 13 and over 500 citations. She has collaborated with researchers at the University of Arkansas for Medical Sciences, including Michael D. Berquist and W. Brooks Gentry.
Metrics
- h-index: 13
- Publications: 29
- Citations: 542
Positions
-
Research Program Manager publications 1988–2026University of Arkansas for Medical Sciences Institution web page
Selected Publications
-
Comparison between a chimeric anti-methamphetamine monoclonal antibody and humanized antibodies on pharmacological effects of methamphetamine (2025)
-
Identifying a Lead Candidate Anti-methamphetamine Monoclonal Antibody for IND-enabling Studies: Cross-reactivity and Locomotor Activity (2024)
-
Limited bedding and nesting increases ethanol drinking in female rats (2024)
-
Pharmacokinetics of α-Pyrrolidinovalerophenone in Male Rats with and without Vaccination with an α-Pyrrolidinovalerophenone Vaccine (2021)
-
Active vaccination reduces reinforcing effects of MDPV in male Sprague-Dawley rats trained to self-administer cocaine (2020)
-
Design, synthesis and biological evaluation of a bi-specific vaccine against α-pyrrolidinovalerophenone (α-PVP) and 3,4-methylenedioxypyrovalerone (MDPV) in rats (2019)
-
Antibody production and pharmacokinetics of METH in rats following vaccination with the METH vaccine, IXT-v100, adjuvanted with GLA-SE (2019)
-
Effect of Bile Duct Ligation-induced Liver Dysfunction on Methamphetamine Pharmacokinetics and Locomotor Activity in Rats (2019)
-
Cardiovascular effects of 3,4-methylenedioxypyrovalerone (MDPV) in male and female Sprague-Dawley rats (2019)
-
Organ Distribution and Clearance of (3,4)‐Methylenedioxypyrovalerone (MDPV) Enantiomers in Female and Male Rats after Intravenous Administration of Racemic MDPV (2018)
-
Development and Preclinical Testing of a Vaccine for 3,4‐Methylenedioxypyrovalerone (( R,S )‐MDPV) Substance Use Disorders (2018)
-
The pharmacokinetics of racemic MDPV and its (R) and (S) enantiomers in female and male rats (2017)
-
Chronic treatment of (+)-methamphetamine-induced locomotor effects in rats using one or a combination of two high affinity anti-methamphetamine monoclonal antibodies (2016)
-
Optimization of a methamphetamine conjugate vaccine for antibody production in mice (2016)
-
Discovery and Development of an Anti-methamphetamine Monoclonal Antibody for Use in Treating Methamphetamine Abuse (2015)
Collaboration Network
Top Collaborators
S. Michael Owens
University of Arkansas for Medical Sciences
18 shared publications
In database
- Vaccination protects rats from methamphetamine-induced impairment of behavioral responding for food
- Synthesis of Mercapto-(+)-methamphetamine Haptens and Their Use for Obtaining Improved Epitope Density on (+)-Methamphetamine Conjugate Vaccines
- The Synthesis of Haptens and Their Use for the Development of Monoclonal Antibodies for Treating Methamphetamine Abuse
- Optimization of a methamphetamine conjugate vaccine for antibody production in mice
- The pharmacokinetics of racemic MDPV and its (R) and (S) enantiomers in female and male rats
Showing 5 of 18 shared publications
Michael D. Hambuchen
University of Arkansas for Medical Sciences (US)
9 shared publications
- The pharmacokinetics of racemic MDPV and its (R) and (S) enantiomers in female and male rats
- Cardiovascular effects of 3,4-methylenedioxypyrovalerone (MDPV) in male and female Sprague-Dawley rats
- Chronic treatment of (+)-methamphetamine-induced locomotor effects in rats using one or a combination of two high affinity anti-methamphetamine monoclonal antibodies
- Simple Radiometric Method for Accurately Quantitating Epitope Densities of Hapten–Protein Conjugates with Sulfhydryl Linkages
- Effect of Bile Duct Ligation-induced Liver Dysfunction on Methamphetamine Pharmacokinetics and Locomotor Activity in Rats
Showing 5 of 9 shared publications
Samantha J. McClenahan
University of Arkansas for Medical Sciences (US)
7 shared publications
- The pharmacokinetics of racemic MDPV and its (R) and (S) enantiomers in female and male rats
- Cardiovascular effects of 3,4-methylenedioxypyrovalerone (MDPV) in male and female Sprague-Dawley rats
- Design, synthesis and biological evaluation of a bi-specific vaccine against α-pyrrolidinovalerophenone (α-PVP) and 3,4-methylenedioxypyrovalerone (MDPV) in rats
- Active vaccination reduces reinforcing effects of MDPV in male Sprague-Dawley rats trained to self-administer cocaine
- Pharmacokinetics of α-Pyrrolidinovalerophenone in Male Rats with and without Vaccination with an α-Pyrrolidinovalerophenone Vaccine
Showing 5 of 7 shared publications
Michael D. Berquist
University of Arkansas for Medical Sciences
6 shared publications
In database
- The pharmacokinetics of racemic MDPV and its (R) and (S) enantiomers in female and male rats
- Cardiovascular effects of 3,4-methylenedioxypyrovalerone (MDPV) in male and female Sprague-Dawley rats
- Limited bedding and nesting increases ethanol drinking in female rats
- Effect of Bile Duct Ligation-induced Liver Dysfunction on Methamphetamine Pharmacokinetics and Locomotor Activity in Rats
- Identifying a Lead Candidate Anti-methamphetamine Monoclonal Antibody for IND-enabling Studies: Cross-reactivity and Locomotor Activity
Showing 5 of 6 shared publications
Misty W. Stevens
InterveXion Therapeutics (United States) (US)
5 shared publications
- Optimization of a methamphetamine conjugate vaccine for antibody production in mice
- Antibody production and pharmacokinetics of METH in rats following vaccination with the METH vaccine, IXT-v100, adjuvanted with GLA-SE
- Discovery and Development of an Anti-methamphetamine Monoclonal Antibody for Use in Treating Methamphetamine Abuse
- Identifying a Lead Candidate Anti-methamphetamine Monoclonal Antibody for IND-enabling Studies: Cross-reactivity and Locomotor Activity
- Comparison between a chimeric anti-methamphetamine monoclonal antibody and humanized antibodies on pharmacological effects of methamphetamine
Bruce E. Blough
RTI International (US)
4 shared publications
- Vaccination protects rats from methamphetamine-induced impairment of behavioral responding for food
- Synthesis of Mercapto-(+)-methamphetamine Haptens and Their Use for Obtaining Improved Epitope Density on (+)-Methamphetamine Conjugate Vaccines
- The Synthesis of Haptens and Their Use for the Development of Monoclonal Antibodies for Treating Methamphetamine Abuse
- Simple Radiometric Method for Accurately Quantitating Epitope Densities of Hapten–Protein Conjugates with Sulfhydryl Linkages
Eric C. Peterson
University of Arkansas for Medical Sciences (US)
4 shared publications
- Synthesis of Mercapto-(+)-methamphetamine Haptens and Their Use for Obtaining Improved Epitope Density on (+)-Methamphetamine Conjugate Vaccines
- The Synthesis of Haptens and Their Use for the Development of Monoclonal Antibodies for Treating Methamphetamine Abuse
- Simple Radiometric Method for Accurately Quantitating Epitope Densities of Hapten–Protein Conjugates with Sulfhydryl Linkages
- Design, synthesis and biological evaluation of a bi-specific vaccine against α-pyrrolidinovalerophenone (α-PVP) and 3,4-methylenedioxypyrovalerone (MDPV) in rats
Howard P. Hendrickson
University of Arkansas for Medical Sciences (US)
4 shared publications
- The pharmacokinetics of racemic MDPV and its (R) and (S) enantiomers in female and male rats
- Chronic treatment of (+)-methamphetamine-induced locomotor effects in rats using one or a combination of two high affinity anti-methamphetamine monoclonal antibodies
- Effect of Bile Duct Ligation-induced Liver Dysfunction on Methamphetamine Pharmacokinetics and Locomotor Activity in Rats
- Organ Distribution and Clearance of (3,4)‐Methylenedioxypyrovalerone (MDPV) Enantiomers in Female and Male Rats after Intravenous Administration of Racemic MDPV
F. Ivy Carroll
RTI International (US)
3 shared publications
- Vaccination protects rats from methamphetamine-induced impairment of behavioral responding for food
- Synthesis of Mercapto-(+)-methamphetamine Haptens and Their Use for Obtaining Improved Epitope Density on (+)-Methamphetamine Conjugate Vaccines
- The Synthesis of Haptens and Their Use for the Development of Monoclonal Antibodies for Treating Methamphetamine Abuse
Jackson O. Lay
University of Arkansas at Fayetteville (US)
3 shared publications
- Synthesis of Mercapto-(+)-methamphetamine Haptens and Their Use for Obtaining Improved Epitope Density on (+)-Methamphetamine Conjugate Vaccines
- The Synthesis of Haptens and Their Use for the Development of Monoclonal Antibodies for Treating Methamphetamine Abuse
- Simple Radiometric Method for Accurately Quantitating Epitope Densities of Hapten–Protein Conjugates with Sulfhydryl Linkages
Rachel Tawney
InterveXion Therapeutics (United States)
3 shared publications
In database
- Optimization of a methamphetamine conjugate vaccine for antibody production in mice
- Simple Radiometric Method for Accurately Quantitating Epitope Densities of Hapten–Protein Conjugates with Sulfhydryl Linkages
- Antibody production and pharmacokinetics of METH in rats following vaccination with the METH vaccine, IXT-v100, adjuvanted with GLA-SE
Daniela Rüedi‐Bettschen
University of Arkansas for Medical Sciences (US)
3 shared publications
- Vaccination protects rats from methamphetamine-induced impairment of behavioral responding for food
- Chronic treatment of (+)-methamphetamine-induced locomotor effects in rats using one or a combination of two high affinity anti-methamphetamine monoclonal antibodies
- Antibody production and pharmacokinetics of METH in rats following vaccination with the METH vaccine, IXT-v100, adjuvanted with GLA-SE
W. Brooks Gentry
InterveXion Therapeutics (United States)
3 shared publications
In database
- Discovery and Development of an Anti-methamphetamine Monoclonal Antibody for Use in Treating Methamphetamine Abuse
- Identifying a Lead Candidate Anti-methamphetamine Monoclonal Antibody for IND-enabling Studies: Cross-reactivity and Locomotor Activity
- Comparison between a chimeric anti-methamphetamine monoclonal antibody and humanized antibodies on pharmacological effects of methamphetamine
Philip Abraham
RTI International (US)
2 shared publications
- Synthesis of Mercapto-(+)-methamphetamine Haptens and Their Use for Obtaining Improved Epitope Density on (+)-Methamphetamine Conjugate Vaccines
- The Synthesis of Haptens and Their Use for the Development of Monoclonal Antibodies for Treating Methamphetamine Abuse
Paul K. Gong
RTI International (US)
2 shared publications
- Synthesis of Mercapto-(+)-methamphetamine Haptens and Their Use for Obtaining Improved Epitope Density on (+)-Methamphetamine Conjugate Vaccines
- The Synthesis of Haptens and Their Use for the Development of Monoclonal Antibodies for Treating Methamphetamine Abuse
Similar Researchers
Based on overlapping research topics
William Brooks Gentry
University of Arkansas for Medical Sciences
Substance Abuse Treatment and Outcomes
Monoclonal and Polyclonal Antibodies Research
Pharmacological Effects and Toxicity Studies
Amy R. Pearce
Arkansas State University
Substance Abuse Treatment and Outcomes
Pharmacological Effects and Toxicity Studies
Animal Behavior and Welfare Studies
Brenda M. Gannon
University of Arkansas for Medical Sciences
Substance Abuse Treatment and Outcomes
Pharmacological Effects and Toxicity Studies
Animal Behavior and Welfare Studies
Michael D. Berquist
University of Arkansas for Medical Sciences
Substance Abuse Treatment and Outcomes
Pharmacological Effects and Toxicity Studies
Animal Behavior and Welfare Studies
Catheryn D. Wilson
University of Arkansas for Medical Sciences
Substance Abuse Treatment and Outcomes
Pharmacological Effects and Toxicity Studies
Animal Behavior and Welfare Studies
John T. Striednig
University of Arkansas for Medical Sciences
Substance Abuse Treatment and Outcomes
Pharmacological Effects and Toxicity Studies
Animal Behavior and Welfare Studies