Match tier
Listed
Presence
Current · Arkansas
Last published
2024
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
L
Lisa K. Brents
Assistant Professor
Also affiliated: Texas A&M Health Science Center (2012); Arkansas Children's Hospital (2012); University of Michigan (2012); Cayman Chemical (United States) (2012); Michigan Medicine (2012); Arkansas State Crime Laboratory (2012); Arkansas Biosciences Institute (2011); Arkansas Department of Health (2012); Texas A&M University (2012)
18 h-index
53 pubs
1,597 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Lisa K. Brents' research focuses on the pharmacological effects and metabolism of synthetic cannabinoids, particularly those found in products marketed as herbal incense. Her work has investigated the affinity and activity of these compounds and their metabolites at cannabinoid receptors, specifically the CB1 receptor. Brents has also explored the role of cytochrome P450 enzymes in the metabolism of synthetic cannabinoids and identified novel ligands. Her publications include studies on the interaction of synthetic cannabinoids with opioid receptors and the impact of marijuana and the endocannabinoid system on the female reproductive system. She has also investigated the role of cannabinoid receptors in breast cancer.
Metrics
- h-index: 18
- Publications: 53
- Citations: 1,597
Positions
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Assistant Professor 2019–presentUniversity of Arkansas for Medical Sciences Department of Pharmacology and Toxicology Institutional directory
Selected Publications
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Deuterated Buprenorphine Mitigates Fentanyl Effects in Pregnant Rats (2024)
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Limited bedding and nesting increases ethanol drinking in female rats (2024)
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Interaction between buprenorphine and norbuprenorphine in neonatal opioid withdrawal syndrome (2023)
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Deuterated buprenorphine retains pharmacodynamic properties of buprenorphine and resists metabolism to the active metabolite norbuprenorphine in rats (2023)
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Effects of a two-hit model of early life adversity on oral ethanol self-administration and adrenergic receptor expression in adolescent rats (2023)
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481 Interactions between buprenorphine and norbuprenorphine in neonatal opioid withdrawal syndrome (2023)
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Response to article – alternative interpretation of “there is reduced immunohistochemical staining of placental aromatase in severe neonatal opioid withdrawal syndrome” (2023)
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Interaction between buprenorphine and norbuprenorphine in neonatal opioid withdrawal syndrome. (2022)
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Deuterated buprenorphine retains pharmacodynamic properties of buprenorphine and resists metabolism to the active metabolite norbuprenorphine in rats (2022)
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Qualitative content analysis of public responses to an FDA inquiry on the impact of scheduling changes to kratom (2022)
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Effects of prenatal opioid exposure and early life adversity on opioid‐induced antinociception (2022)
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384 Motives for kratom self-medication: contents of public comments solicited by the FDA (2022)
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Automated quantification of opioid withdrawal in neonatal rat pups using Ethovision® XT software (2021)
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Automated Quantification of Opioid Withdrawal Severity in Neonatal Rat Pups Using Ethovision® XT Software (2020)
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The Effects of P‐glycoprotein Inhibition on Norbuprenorphine‐induced Neonatal Abstinence Syndrome (NAS) (2019)
Grants & Funding
As listed on this researcher's institutional profile.
- Fellow-to-Faculty Award UAMS Tobacco
- Post Doc Support UAMS
- No FP attached (Funded by: UAMS Intramural Grant (CTSA))
- Translational Training in Addiction NIH
- The Metabolic and Pharmacodynamic Profile of Deuterated Buprenorphine UAMS CTSA
- The Role of Norbuprenorphine in the Development of Neonatal Abstinence Syndrome UAMS College of Medicine
- RSPGACH 17-DN-10 UAMS College of Medicine
- Use of precision deuteration to determine the contribution of norbuprenorphine to buprenorphine-associated neonatal abstinence syndrome NIH
Collaboration Network
Top Collaborators
Paul L. Prather
University of Arkansas for Medical Sciences
18 shared publications
In database
- Phase I Hydroxylated Metabolites of the K2 Synthetic Cannabinoid JWH-018 Retain In Vitro and In Vivo Cannabinoid 1 Receptor Affinity and Activity
- Cytochrome P450-Mediated Oxidative Metabolism of Abused Synthetic Cannabinoids Found in K2/Spice: Identification of Novel Cannabinoid Receptor Ligands
- Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity
- The K2/Spice Phenomenon: emergence, identification, legislation and metabolic characterization of synthetic cannabinoids in herbal incense products
- AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: Implications for opioid/cannabinoid interaction studies
Showing 5 of 18 shared publications
Jeffery H. Moran
University of Arkansas for Medical Sciences
11 shared publications
In database
- Phase I Hydroxylated Metabolites of the K2 Synthetic Cannabinoid JWH-018 Retain In Vitro and In Vivo Cannabinoid 1 Receptor Affinity and Activity
- Cytochrome P450-Mediated Oxidative Metabolism of Abused Synthetic Cannabinoids Found in K2/Spice: Identification of Novel Cannabinoid Receptor Ligands
- Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity
- Human metabolites of synthetic cannabinoids JWH-018 and JWH-073 bind with high affinity and act as potent agonists at cannabinoid type-2 receptors
- A Major Glucuronidated Metabolite of JWH-018 Is a Neutral Antagonist at CB1 Receptors
Showing 5 of 11 shared publications
Brian J. Parks
University of Applied Management Studies
11 shared publications
In database
- Qualitative content analysis of public responses to an FDA inquiry on the impact of scheduling changes to kratom
- Limited bedding and nesting increases ethanol drinking in female rats
- Deuterated buprenorphine retains pharmacodynamic properties of buprenorphine and resists metabolism to the active metabolite norbuprenorphine in rats
- Interaction between buprenorphine and norbuprenorphine in neonatal opioid withdrawal syndrome
- 384 Motives for kratom self-medication: contents of public comments solicited by the FDA
Showing 5 of 11 shared publications
Julia Tobacyk
University of Arkansas for Medical Sciences
10 shared publications
In database
- Qualitative content analysis of public responses to an FDA inquiry on the impact of scheduling changes to kratom
- Limited bedding and nesting increases ethanol drinking in female rats
- Interaction between buprenorphine and norbuprenorphine in neonatal opioid withdrawal syndrome
- 384 Motives for kratom self-medication: contents of public comments solicited by the FDA
- Effects of prenatal opioid exposure and early life adversity on opioid‐induced antinociception
Showing 5 of 10 shared publications
William E. Fantegrossi
University of Arkansas for Medical Sciences
9 shared publications
In database
- Phase I Hydroxylated Metabolites of the K2 Synthetic Cannabinoid JWH-018 Retain In Vitro and In Vivo Cannabinoid 1 Receptor Affinity and Activity
- Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity
- AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: Implications for opioid/cannabinoid interaction studies
- In vivo effects of synthetic cannabinoids JWH-018 and JWH-073 and phytocannabinoid Δ9-THC in mice: Inhalation versus intraperitoneal injection
- Differential Drug–Drug Interactions of the Synthetic Cannabinoids JWH-018 and JWH-073: Implications for Drug Abuse Liability and Pain Therapy
Showing 5 of 9 shared publications
Paloma Salazar
University of Arkansas for Medical Sciences (US)
8 shared publications
- Limited bedding and nesting increases ethanol drinking in female rats
- Deuterated buprenorphine retains pharmacodynamic properties of buprenorphine and resists metabolism to the active metabolite norbuprenorphine in rats
- Interaction between buprenorphine and norbuprenorphine in neonatal opioid withdrawal syndrome
- The Effects of P‐glycoprotein Inhibition on Norbuprenorphine‐induced Neonatal Abstinence Syndrome (NAS)
- Effects of prenatal opioid exposure and early life adversity on opioid‐induced antinociception
Showing 5 of 8 shared publications
Michael D. Berquist
University of Applied Management Studies
7 shared publications
In database
- Limited bedding and nesting increases ethanol drinking in female rats
- Interaction between buprenorphine and norbuprenorphine in neonatal opioid withdrawal syndrome
- Effects of prenatal opioid exposure and early life adversity on opioid‐induced antinociception
- Interaction between buprenorphine and norbuprenorphine in neonatal opioid withdrawal syndrome.
- 481 Interactions between buprenorphine and norbuprenorphine in neonatal opioid withdrawal syndrome
Showing 5 of 7 shared publications
Kathryn A. Seely
Arkansas Children's Hospital (US)
5 shared publications
- Cytochrome P450-Mediated Oxidative Metabolism of Abused Synthetic Cannabinoids Found in K2/Spice: Identification of Novel Cannabinoid Receptor Ligands
- AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: Implications for opioid/cannabinoid interaction studies
- A Major Glucuronidated Metabolite of JWH-018 Is a Neutral Antagonist at CB1 Receptors
- Natural prenylated resveratrol analogs arachidin-1 and -3 demonstrate improved glucuronidation profiles and have affinity for cannabinoid receptors
- Effects of the β‐agonist, isoprenaline, on the down‐regulation, functional responsiveness and trafficking of β2‐adrenergic receptors with N‐terminal polymorphisms
J. A. Young
University of Arkansas for Medical Sciences (US)
5 shared publications
- The role of childhood maltreatment in the altered trait and global expression of personality in cocaine addiction
- Perceived social support and socioeconomic status predict maternal delay discounting behavior and neural function in healthy postpartum women
- Cocaine dependence and childhood maltreatment are associated with altered configurations of personality traits
- Maternal Delay and Social Discounting Behavior Predicts Impaired Mother‐Infant Bonding, Maternal Stress, and Paternal Involvement
- Perceived Social Support and Socioeconomic Status Predict Maternal Delay Discounting Behavior and Neural Function in Healthy Postpartum Women
G. Andrew James
University of Arkansas for Medical Sciences
5 shared publications
In database
- The role of childhood maltreatment in the altered trait and global expression of personality in cocaine addiction
- Personality variables modify the relationship between childhood maltreatment history and poor functional outcomes
- Perceived social support and socioeconomic status predict maternal delay discounting behavior and neural function in healthy postpartum women
- Cocaine dependence and childhood maltreatment are associated with altered configurations of personality traits
- Perceived Social Support and Socioeconomic Status Predict Maternal Delay Discounting Behavior and Neural Function in Healthy Postpartum Women
Gregory S. Gorman
Samford University (US)
5 shared publications
- Deuterated buprenorphine retains pharmacodynamic properties of buprenorphine and resists metabolism to the active metabolite norbuprenorphine in rats
- Interaction between buprenorphine and norbuprenorphine in neonatal opioid withdrawal syndrome
- Deuterated buprenorphine retains pharmacodynamic properties of buprenorphine and resists metabolism to the active metabolite norbuprenorphine in rats
- Interaction between buprenorphine and norbuprenorphine in neonatal opioid withdrawal syndrome.
- 481 Interactions between buprenorphine and norbuprenorphine in neonatal opioid withdrawal syndrome
Lirit N. Franks
University of Arkansas for Medical Sciences
4 shared publications
In database
- AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: Implications for opioid/cannabinoid interaction studies
- Human metabolites of synthetic cannabinoids JWH-018 and JWH-073 bind with high affinity and act as potent agonists at cannabinoid type-2 receptors
- Repeated administration of phytocannabinoid Δ9-THC or synthetic cannabinoids JWH-018 and JWH-073 induces tolerance to hypothermia but not locomotor suppression in mice, and reduces CB1 receptor expression and function in a brain region-specific manner
- The omega and omega‐1 monohydroxyl metabolites of the abused K2/Spice synthetic cannabinoids JWH‐018 and JWH‐ 073 bind with high affinity and act as agonists at human cannabinoid 2 receptors (hCB2s)
Anna Radomińska‐Pandya
Arkansas Children's Hospital
4 shared publications
In database
- Cytochrome P450-Mediated Oxidative Metabolism of Abused Synthetic Cannabinoids Found in K2/Spice: Identification of Novel Cannabinoid Receptor Ligands
- Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity
- A Major Glucuronidated Metabolite of JWH-018 Is a Neutral Antagonist at CB1 Receptors
- Natural prenylated resveratrol analogs arachidin-1 and -3 demonstrate improved glucuronidation profiles and have affinity for cannabinoid receptors
Zachary N. Stowe
University of Arkansas for Medical Sciences (US)
4 shared publications
- Perceived social support and socioeconomic status predict maternal delay discounting behavior and neural function in healthy postpartum women
- Maternal Delay and Social Discounting Behavior Predicts Impaired Mother‐Infant Bonding, Maternal Stress, and Paternal Involvement
- Perceived Social Support and Socioeconomic Status Predict Maternal Delay Discounting Behavior and Neural Function in Healthy Postpartum Women
- The Role of Norbuprenorphine in Buprenorphine‐Induced Neonatal Abstinence Syndrome: A Pilot Study
Alexander W. Alund
4 shared publications
In database
- In Utero Exposure to Norbuprenorphine, a Major Metabolite of Buprenorphine, Induces Fetal Opioid Dependence and Leads to Neonatal Opioid Withdrawal Syndrome
- Deuterated buprenorphine retains pharmacodynamic properties of buprenorphine and resists metabolism to the active metabolite norbuprenorphine in rats
- 2421 Development and validation of a translational rat model of neonatal abstinence syndrome
- Deuterated buprenorphine retains pharmacodynamic properties of buprenorphine and resists metabolism to the active metabolite norbuprenorphine in rats
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