Mohammad Abrar Alam
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Professor
Also affiliated: University of Minnesota (2011); University of Minnesota, Duluth (2011–2018); Arkansas Biosciences Institute (2024–2025); Ottawa Heart Institute (2011); Rowan University (2013–2016); Indian Institute of Technology Kanpur (2008)
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Mohammad A. Alam's research focuses on the design, synthesis, and evaluation of novel chemical compounds, particularly pyrazole derivatives, as potential therapeutic agents. His work investigates the antibacterial properties of these compounds against a range of pathogens, including resistant strains like *Staphylococcus aureus* and *Acinetobacter baumannii*. Alam has published extensively on the structure-activity relationships of these molecules, aiming to develop potent inhibitors of bacterial processes such as fatty acid biosynthesis.
His research also extends to the broader application of privileged scaffolds like pyrazoles and thiazoles in drug discovery, exploring their utility in creating antimicrobial agents. Alam has secured significant federal funding, including grants from the NIH and NSF, to support his research endeavors. He has served as PI on projects involving functional genomics of oral pathogens and the acquisition of advanced analytical instrumentation, such as X-ray diffractometers and NMR spectrometers, to enhance research capabilities at Arkansas State University. His scholarly contributions are recognized by a high h-index of 22 and over 1,000 citations, positioning him as a highly cited researcher.
Metrics
- h-index: 22
- Publications: 75
- Citations: 1,164
Positions
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Professor 2024–presentArkansas State University Chemistry and Physics ORCID
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Associate Professor 2019–2024Arkansas State University ORCID
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Assistant Professor 2015–2019Arkansas State University Chemistry and Physics ORCID
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Visiting Assistant Professor 2014–2015Arkansas State University Chemistry and Physics ORCID
Selected Publications
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Genomic instability and biofilm determinants in Streptococcus mutans : insights from a sequence-defined arrayed transposon library (2026)
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Genomic instability and biofilm determinants in Streptococcus mutans : insights from a sequence-defined arrayed transposon library (2026)
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Late-Stage Functionalization of the Rifamycin Core via Click Chemistry Toward New Antibacterial Derivatives (2026)
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Design, Synthesis, and Development of 4-[2-[3,5-Bis(trifluoromethyl)anilino]thiazolo-4-yl]phenol as a Dual Inhibitor of Fatty Acid Biosynthesis (FASII) to Clear MRSA Infection (2026)
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High-level production of antibacterial pentacyclic triterpenoids from hairy root cultures of Bixa orellana via abiotic elicitation (2026)
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Correction: Thiazole-fused androstenone and ethisterone derivatives: potent β- and γ-actin cytoskeleton inhibitors to treat melanoma tumors (2025)
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Enhanced Production of Anti-Inflammatory and Antibacterial Prenylated Isoflavonoids in Pigeon Pea (Cajanus cajan) Hairy Root Cultures (2025)
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Production of Malheuran A, a Geranylated Flavonoid with Antimicrobial and Anti-Inflammatory Activities, in Hairy Root Cultures of Dalea purpurea (2025)
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Thiazole-fused androstenone and ethisterone derivatives: potent β- and γ-actin cytoskeleton inhibitors to treat melanoma tumors (2024)
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Synthesis of Thiazole‐Fused Diosgenin Derivatives as Potential Therapeutic Agents (2024)
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Editorial: Five-membered heterocycles: synthesis and applications (2024)
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Efficient Synthesis of Thiazole-Fused Bisnoralcohol Derivatives as Potential Therapeutic Agents (2024)
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Domino Reaction Protocol to Synthesize Benzothiophene-Derived Chemical Entities as Potential Therapeutic Agents (2024)
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Construction of an arrayed CRISPRi library as a resource for essential gene function studies in Streptococcus mutans (2023)
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Pyrazole: an Emerging Privileged Scaffold in Drug Discovery (2023)
Federal Grants 3 $1,379,507 total
Systematic Functional Genomics Analysis of the Oral Pathogen Streptococcus Mutans
Collaboration Network
Top Collaborators
- Synthesis and Antimicrobial Studies of Coumarin-Substituted Pyrazole Derivatives as Potent Anti-Staphylococcus aureus Agents
- Synthesis and antimicrobial studies of novel derivatives of 4-(4-formyl-3-phenyl-1H-pyrazol-1-yl)benzoic acid as potent anti-Acinetobacter baumannii agents
- Synthesis and antimicrobial studies of hydrazone derivatives of 4-[3-(2,4-difluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic acid and 4-[3-(3,4-difluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic acid
- Design, synthesis, and antibacterial activity of N -(trifluoromethyl)phenyl substituted pyrazole derivatives
- Synthesis and Antimicrobial Studies of 4-[3-(3-Fluorophenyl)-4-formyl-1 H -pyrazol-1-yl]benzoic Acid and 4-[3-(4-Fluorophenyl)-4-formyl-1 H -pyrazol-1-yl]benzoic Acid as Potent Growth Inhibitors of Drug-Resistant Bacteria
Showing 5 of 15 shared publications
- Design, synthesis, and antibacterial activity of N -(trifluoromethyl)phenyl substituted pyrazole derivatives
- Benign synthesis of fused-thiazoles with enone-based natural products and drugs for lead discovery
- Development and Antibacterial Properties of 4-[4-(Anilinomethyl)-3-phenylpyrazol-1-yl]benzoic Acid Derivatives as Fatty Acid Biosynthesis Inhibitors
- Domino Reaction Protocol to Synthesize Benzothiophene-Derived Chemical Entities as Potential Therapeutic Agents
- Synthesis of 3,5-Bis(trifluoromethyl)phenyl-Substituted Pyrazole Derivatives as Potent Growth Inhibitors of Drug-Resistant Bacteria
Showing 5 of 10 shared publications
- Synthesis and Antimicrobial Studies of Coumarin-Substituted Pyrazole Derivatives as Potent Anti-Staphylococcus aureus Agents
- Design, synthesis, and antibacterial activity of N -(trifluoromethyl)phenyl substituted pyrazole derivatives
- Design and synthesis of 4-[4-formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic acid derivatives as potent growth inhibitors of drug-resistant Staphylococcus aureus
- Synthesis of 4,4′-(4-Formyl-1H-pyrazole-1,3-diyl)dibenzoic Acid Derivatives as Narrow Spectrum Antibiotics for the Potential Treatment of Acinetobacter Baumannii Infections
- Development and Antibacterial Properties of 4-[4-(Anilinomethyl)-3-phenylpyrazol-1-yl]benzoic Acid Derivatives as Fatty Acid Biosynthesis Inhibitors
Showing 5 of 9 shared publications
- Development and Antibacterial Properties of 4-[4-(Anilinomethyl)-3-phenylpyrazol-1-yl]benzoic Acid Derivatives as Fatty Acid Biosynthesis Inhibitors
- Construction of an arrayed CRISPRi library as a resource for essential gene function studies in Streptococcus mutans
- Enhanced Production of Anti-Inflammatory and Antibacterial Prenylated Isoflavonoids in Pigeon Pea (Cajanus cajan) Hairy Root Cultures
- Production of Malheuran A, a Geranylated Flavonoid with Antimicrobial and Anti-Inflammatory Activities, in Hairy Root Cultures of Dalea purpurea
- Design, Synthesis, and Development of 4-[2-[3,5-Bis(trifluoromethyl)anilino]thiazolo-4-yl]phenol as a Dual Inhibitor of Fatty Acid Biosynthesis (FASII) to Clear MRSA Infection
Showing 5 of 9 shared publications
- Synthesis and Antimicrobial Studies of 4-[3-(3-Fluorophenyl)-4-formyl-1 H -pyrazol-1-yl]benzoic Acid and 4-[3-(4-Fluorophenyl)-4-formyl-1 H -pyrazol-1-yl]benzoic Acid as Potent Growth Inhibitors of Drug-Resistant Bacteria
- Benign Synthesis of Thiazolo-androstenone Derivatives as Potent Anticancer Agents
- Hexafluoroisopropanol mediated benign synthesis of 2 H -pyrido[1,2- a ]pyrimidin-2-ones by using a domino protocol
- Benign synthesis of fused-thiazoles with enone-based natural products and drugs for lead discovery
- Hexafluoroisopropanol-Mediated Domino Reaction for the Synthesis of Thiazolo-androstenones: Potent Anticancer Agents
Showing 5 of 8 shared publications
- Synthesis and Antimicrobial Studies of Coumarin-Substituted Pyrazole Derivatives as Potent Anti-Staphylococcus aureus Agents
- Synthesis and antimicrobial studies of hydrazone derivatives of 4-[3-(2,4-difluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic acid and 4-[3-(3,4-difluorophenyl)-4-formyl-1H-pyrazol-1-yl]benzoic acid
- Synthesis and Antimicrobial Studies of 4-[3-(3-Fluorophenyl)-4-formyl-1 H -pyrazol-1-yl]benzoic Acid and 4-[3-(4-Fluorophenyl)-4-formyl-1 H -pyrazol-1-yl]benzoic Acid as Potent Growth Inhibitors of Drug-Resistant Bacteria
- Synthesis of Hydrazone Derivatives of 4-[4-Formyl-3-(2-oxochromen-3-yl)pyrazol-1-yl]benzoic acid as Potent Growth Inhibitors of Antibiotic-resistant Staphylococcus aureus and Acinetobacter baumannii
- Benign Synthesis of Thiazolo-androstenone Derivatives as Potent Anticancer Agents
Showing 5 of 7 shared publications
- Synthesis and Antimicrobial Studies of Coumarin-Substituted Pyrazole Derivatives as Potent Anti-Staphylococcus aureus Agents
- Synthesis and Antimicrobial Studies of 4-[3-(3-Fluorophenyl)-4-formyl-1 H -pyrazol-1-yl]benzoic Acid and 4-[3-(4-Fluorophenyl)-4-formyl-1 H -pyrazol-1-yl]benzoic Acid as Potent Growth Inhibitors of Drug-Resistant Bacteria
- Synthesis of Hydrazone Derivatives of 4-[4-Formyl-3-(2-oxochromen-3-yl)pyrazol-1-yl]benzoic acid as Potent Growth Inhibitors of Antibiotic-resistant Staphylococcus aureus and Acinetobacter baumannii
- Benign Synthesis of Thiazolo-androstenone Derivatives as Potent Anticancer Agents
- Design and synthesis of 4-[4-formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic acid derivatives as potent growth inhibitors of drug-resistant Staphylococcus aureus
Showing 5 of 7 shared publications
- 4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents
- Synthesis of Hydrazone Derivatives of 4-[4-Formyl-3-(2-oxochromen-3-yl)pyrazol-1-yl]benzoic acid as Potent Growth Inhibitors of Antibiotic-resistant Staphylococcus aureus and Acinetobacter baumannii
- Synthesis of 4,4′-(4-Formyl-1H-pyrazole-1,3-diyl)dibenzoic Acid Derivatives as Narrow Spectrum Antibiotics for the Potential Treatment of Acinetobacter Baumannii Infections
- Antimelanoma activities of chimeric thiazole–androstenone derivatives
- Thiazole-fused androstenone and ethisterone derivatives: potent β- and γ-actin cytoskeleton inhibitors to treat melanoma tumors
Showing 5 of 7 shared publications
- Synthesis and antimicrobial studies of novel derivatives of 4-(4-formyl-3-phenyl-1H-pyrazol-1-yl)benzoic acid as potent anti-Acinetobacter baumannii agents
- Modular synthesis of thiazoline and thiazole derivatives by using a cascade protocol
- Hexafluoroisopropyl alcohol mediated synthesis of 2,3-dihydro-4H-pyrido[1,2-a]pyrimidin-4-ones
- Benign Synthesis of Thiazolo-androstenone Derivatives as Potent Anticancer Agents
- Hexafluoroisopropanol mediated benign synthesis of 2 H -pyrido[1,2- a ]pyrimidin-2-ones by using a domino protocol
Showing 5 of 6 shared publications
- Domino Reaction Protocol to Synthesize Benzothiophene-Derived Chemical Entities as Potential Therapeutic Agents
- Synthesis of Thiazole‐Fused Diosgenin Derivatives as Potential Therapeutic Agents
- Thiazole-fused androstenone and ethisterone derivatives: potent β- and γ-actin cytoskeleton inhibitors to treat melanoma tumors
- Design, Synthesis, and Development of 4-[2-[3,5-Bis(trifluoromethyl)anilino]thiazolo-4-yl]phenol as a Dual Inhibitor of Fatty Acid Biosynthesis (FASII) to Clear MRSA Infection
- Correction: Thiazole-fused androstenone and ethisterone derivatives: potent β- and γ-actin cytoskeleton inhibitors to treat melanoma tumors
Showing 5 of 6 shared publications
- Synthesis and antimicrobial studies of novel derivatives of 4-(4-formyl-3-phenyl-1H-pyrazol-1-yl)benzoic acid as potent anti-Acinetobacter baumannii agents
- Synthesis and antimicrobial studies of azomethine and N-arylamine derivatives of 4-(4-formyl-3-phenyl-1H-pyrazol-1-yl)benzoic acid as potent anti-methicillin-resistant Staphylococcus aureus agents
- Hexafluoroisopropyl alcohol mediated synthesis of 2,3-dihydro-4H-pyrido[1,2-a]pyrimidin-4-ones
- Hexafluoroisopropanol mediated benign synthesis of 2 H -pyrido[1,2- a ]pyrimidin-2-ones by using a domino protocol
- Synthesis of 4,4′-(4-Formyl-1H-pyrazole-1,3-diyl)dibenzoic Acid Derivatives as Narrow Spectrum Antibiotics for the Potential Treatment of Acinetobacter Baumannii Infections
- Synthesis and Antimicrobial Studies of Coumarin-Substituted Pyrazole Derivatives as Potent Anti-Staphylococcus aureus Agents
- Synthesis of Hydrazone Derivatives of 4-[4-Formyl-3-(2-oxochromen-3-yl)pyrazol-1-yl]benzoic acid as Potent Growth Inhibitors of Antibiotic-resistant Staphylococcus aureus and Acinetobacter baumannii
- Synthesis of Chimeric Thiazolo‐Nootkatone Derivatives as Potent Antimicrobial Agents
- Design and synthesis of 4-[4-formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic acid derivatives as potent growth inhibitors of drug-resistant Staphylococcus aureus
- Benign synthesis of fused-thiazoles with enone-based natural products and drugs for lead discovery
- Synthesis of Chimeric Thiazolo‐Nootkatone Derivatives as Potent Antimicrobial Agents
- Benign synthesis of fused-thiazoles with enone-based natural products and drugs for lead discovery
- Novel Pyrazoles As Potent Growth Inhibitors of Staphylococci, Enterococci and Acinetobacter Baumannii Bacteria
- Synthesis of 3,5-Bis(trifluoromethyl)phenyl-Substituted Pyrazole Derivatives as Potent Growth Inhibitors of Drug-Resistant Bacteria
- In Vitro Antimelanoma Properties of Verbena officinalis Fractions
- Efficient Synthesis of Thiazole-Fused Bisnoralcohol Derivatives as Potential Therapeutic Agents
- Thiazole-fused androstenone and ethisterone derivatives: potent β- and γ-actin cytoskeleton inhibitors to treat melanoma tumors
- Correction: Thiazole-fused androstenone and ethisterone derivatives: potent β- and γ-actin cytoskeleton inhibitors to treat melanoma tumors
- Enhanced Production of Anti-Inflammatory and Antibacterial Prenylated Isoflavonoids in Pigeon Pea (Cajanus cajan) Hairy Root Cultures
- Production of Malheuran A, a Geranylated Flavonoid with Antimicrobial and Anti-Inflammatory Activities, in Hairy Root Cultures of Dalea purpurea
- Design, Synthesis, and Development of 4-[2-[3,5-Bis(trifluoromethyl)anilino]thiazolo-4-yl]phenol as a Dual Inhibitor of Fatty Acid Biosynthesis (FASII) to Clear MRSA Infection
- High-level production of antibacterial pentacyclic triterpenoids from hairy root cultures of Bixa orellana via abiotic elicitation
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