Match tier
Confirmed
Presence
Current · Arkansas
Last published
2025
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
M
Mugimane G. Manjanatha
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
High Impact
Deputy Director, Supervisory Research Microbiologist
Also affiliated: United States Food and Drug Administration (1996–2025); Iowa State University (1990–1992); Dalian Medical University (2014); The University of Texas at Austin (2014)
29 h-index
96 pubs
2,693 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Mugimane G. Manjanatha's research focuses on understanding the mechanisms of genotoxicity and mutagenicity, particularly in relation to human health and aging. His work investigates how various agents, including nanomaterials and environmental chemicals like acrylamide, can cause DNA damage and mutations. Manjanatha has explored the application and refinement of genotoxicity assessment methods, such as the comet assay, to evaluate potential hazards.
His research extends to the study of aging processes, examining the accumulation of point mutations in mitochondrial DNA in aging mice. Manjanatha also investigates the impact of lifestyle factors, such as night shift work, on circadian regulation of DNA repair genes and overall DNA damage in humans. He leads a research group and has a substantial publication record, with 98 publications and a citation count of 2,684, contributing to the field of toxicology and molecular biology.
Metrics
- h-index: 29
- Publications: 96
- Citations: 2,693
Positions
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Deputy Director, Supervisory Research Microbiologist 1993–presentNational Center for Toxicological Research Division of Genetic and Molecular Toxicology ORCID
Selected Publications
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Review of black cohosh-induced toxicity and adverse clinical effects (2025)
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Development of a TK6-derived cell line expressing four human cytochrome P450s for genotoxicity testing (2025)
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Biodistribution and toxic potential of silver nanoparticles when introduced to the female rat reproductive tract (2024)
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Evaluation of weak genotoxicity of hydroxychloroquine in human TK6 cells (2024)
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Measuring DNA modifications with the comet assay: a compendium of protocols (2023)
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0025 Circadian Dysregulation of Human DNA Repair Genes and Elevated DNA Damage in Simulated Night Shift Schedule (2022)
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In vivo Mammalian Alkaline Comet Assay: Method Adapted for Genotoxicity Assessment of Nanomaterials (2022)
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Common Considerations for Genotoxicity Assessment of Nanomaterials (2022)
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Actein contributes to black cohosh extract‐induced genotoxicity in human TK6 cells (2022)
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Appropriate in vivo follow-up assays to an in vitro bacterial reverse mutation (Ames) test positive investigational drug candidate (active pharmaceutical ingredient), drug-related metabolite, or drug-related impurity (2021)
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Mechanistic Evaluation of Black Cohosh Extract-Induced Genotoxicity in Human Cells (2021)
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Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans (2021)
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Evaluation of pyrrolizidine alkaloid-induced genotoxicity using metabolically competent TK6 cell lines (2020)
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0025 Circadian Dysregulation of DNA Repair and Increased Endogenous and Exogenous Sensitivity to DNA Damage Precipitate Elevated Cancer Risk Associated with Night Shift Work (2020)
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Performance of high-throughput CometChip assay using primary human hepatocytes: a comparison of DNA damage responses with in vitro human hepatoma cell lines (2020)
Collaboration Network
Top Collaborators
Sharon D. Shelton
National Center for Toxicological Research
26 shared publications
In database
- Genotoxicity of acrylamide and its metabolite glycidamide administered in drinking water to male and female Big Blue mice
- Mutagenicity and carcinogenicity in relation to DNA adduct formation in rats fed leucomalachite green
- Mutagenicity of Acrylamide and Glycidamide in the Testes of Big Blue Mice
- Comparison of in vivo mutagenesis in the endogenous Hprt gene and the lacI transgene of Big Blue® rats treated with 7,12-dimethylbenz[a]anthracene
- Acrylamide‐induced carcinogenicity in mouse lung involves mutagenicity: cII gene mutations in the lung of big blue mice exposed to acrylamide and glycidamide for up to 4 weeks
Showing 5 of 26 shared publications
Robert H. Heflich
National Center for Toxicological Research
19 shared publications
In database
- Accumulation of point mutations in mitochondrial DNA of aging mice
- Transgenic Animal Models in Toxicology: Historical Perspectives and Future Outlook
- Mutagenicity and carcinogenicity in relation to DNA adduct formation in rats fed leucomalachite green
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Flow cytometric detection of Pig‐A mutant red blood cells using an erythroid‐specific antibody: Application of the method for evaluating the in vivo genotoxicity of methylphenidate in adolescent rats
Showing 5 of 19 shared publications
Anane Aidoo
National Center for Toxicological Research (US)
18 shared publications
- Accumulation of point mutations in mitochondrial DNA of aging mice
- Genotoxicity of acrylamide and its metabolite glycidamide administered in drinking water to male and female Big Blue mice
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Comparison of in vivo mutagenesis in the endogenous Hprt gene and the lacI transgene of Big Blue® rats treated with 7,12-dimethylbenz[a]anthracene
- Methyleugenol Genotoxicity in the Fischer 344 Rat Using the Comet Assay and Pathway-Focused Gene Expression Profiling
Showing 5 of 18 shared publications
Nan Mei
National Center for Toxicological Research
17 shared publications
In database
- In vivo genotoxicity testing strategies: Report from the 7th International workshop on genotoxicity testing (IWGT)
- Mutagenicity of Acrylamide and Glycidamide in the Testes of Big Blue Mice
- Mechanistic Evaluation of Ginkgo biloba Leaf Extract-Induced Genotoxicity in L5178Y Cells
- Gene expression changes associated with xenobiotic metabolism pathways in mice exposed to acrylamide
- Performance of high-throughput CometChip assay using primary human hepatocytes: a comparison of DNA damage responses with in vitro human hepatoma cell lines
Showing 5 of 17 shared publications
Lascelles E. Lyn‐Cook
National Center for Toxicological Research
14 shared publications
In database
- Genotoxicity of acrylamide and its metabolite glycidamide administered in drinking water to male and female Big Blue mice
- Comparison of in vivo mutagenesis in the endogenous Hprt gene and the lacI transgene of Big Blue® rats treated with 7,12-dimethylbenz[a]anthracene
- Comparison of the types of mutations induced by 7,12-dimethylbenz[a]anthracene in thelacI andhprt genes of Big Blue® rats
- DNA sequence analysis of hprt mutations in lymphocytes from Sprague-Dawley rats treated with 7,12-dimethylbenz[a]anthracene
- Comparison of mutant frequencies and types of mutations induced by thiotepa in the endogenous Hprt gene and transgenic lacI gene of Big Blue® rats
Showing 5 of 14 shared publications
Michelle E. Bishop
National Center for Toxicological Research
13 shared publications
In database
- Genotoxicity of acrylamide and its metabolite glycidamide administered in drinking water to male and female Big Blue mice
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Flow cytometric detection of Pig‐A mutant red blood cells using an erythroid‐specific antibody: Application of the method for evaluating the in vivo genotoxicity of methylphenidate in adolescent rats
- Methyleugenol Genotoxicity in the Fischer 344 Rat Using the Comet Assay and Pathway-Focused Gene Expression Profiling
- Genotoxicity of doxorubicin in F344 rats by combining the comet assay, flow‐cytometric peripheral blood micronucleus test, and pathway‐focused gene expression profiling
Showing 5 of 13 shared publications
Roberta A. Mittelstaedt
12 shared publications
In database
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Comparison of the types of mutations induced by 7,12-dimethylbenz[a]anthracene in thelacI andhprt genes of Big Blue® rats
- Evaluation of Macaca mulatta as a model for genotoxicity studies
- DNA sequence analysis of hprt mutations in lymphocytes from Sprague-Dawley rats treated with 7,12-dimethylbenz[a]anthracene
- Comparison of mutant frequencies and types of mutations induced by thiotepa in the endogenous Hprt gene and transgenic lacI gene of Big Blue® rats
Showing 5 of 12 shared publications
Suzanne M. Morris
National Center for Toxicological Research (US)
8 shared publications
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Evaluation of Macaca mulatta as a model for genotoxicity studies
- Pharmacokinetics, dose‐range, and mutagenicity studies of methylphenidate hydrochloride in B6C3F1 mice
- The genetic toxicology of methylphenidate hydrochloride in non-human primates
- A role for apoptosis in the toxicity and mutagenicity of bleomycin in AHH-1 tk human lymphoblastoid cells
Showing 5 of 8 shared publications
Daniel A. Casciano
National Center for Toxicological Research (US)
8 shared publications
- Comparison of in vivo mutagenesis in the endogenous Hprt gene and the lacI transgene of Big Blue® rats treated with 7,12-dimethylbenz[a]anthracene
- Comparison of the types of mutations induced by 7,12-dimethylbenz[a]anthracene in thelacI andhprt genes of Big Blue® rats
- Molecular analysis of lacI mutations in Rat2TM cells exposed to 7,12-dimethylbenz[a]anthracene: evidence for DNA sequence and DNA strand biases for mutation
- Comparison of mutant frequencies and types of mutations induced by thiotepa in the endogenous Hprt gene and transgenic lacI gene of Big Blue® rats
- Hprt mutant frequency and molecular analysis of Hprt mutations in rats treated with mutagenic carcinogens
Showing 5 of 8 shared publications
Daniel R. Doerge
National Center for Toxicological Research
7 shared publications
In database
- Genotoxicity of acrylamide and its metabolite glycidamide administered in drinking water to male and female Big Blue mice
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Mutagenicity of Acrylamide and Glycidamide in the Testes of Big Blue Mice
- Acrylamide‐induced carcinogenicity in mouse lung involves mutagenicity: cII gene mutations in the lung of big blue mice exposed to acrylamide and glycidamide for up to 4 weeks
- Flow cytometric detection of Pig‐A mutant red blood cells using an erythroid‐specific antibody: Application of the method for evaluating the in vivo genotoxicity of methylphenidate in adolescent rats
Showing 5 of 7 shared publications
Xiaoqing Guo
National Center for Toxicological Research
7 shared publications
In database
- Mechanistic Evaluation of Ginkgo biloba Leaf Extract-Induced Genotoxicity in L5178Y Cells
- Performance of high-throughput CometChip assay using primary human hepatocytes: a comparison of DNA damage responses with in vitro human hepatoma cell lines
- Evaluation of pyrrolizidine alkaloid-induced genotoxicity using metabolically competent TK6 cell lines
- Mechanistic Evaluation of Black Cohosh Extract-Induced Genotoxicity in Human Cells
- Actein contributes to black cohosh extract‐induced genotoxicity in human TK6 cells
Showing 5 of 7 shared publications
Vasily N. Dobrovolsky
National Center for Toxicological Research
6 shared publications
In database
- Flow cytometric detection of Pig‐A mutant red blood cells using an erythroid‐specific antibody: Application of the method for evaluating the in vivo genotoxicity of methylphenidate in adolescent rats
- Evaluation of Macaca mulatta as a model for genotoxicity studies
- Pharmacokinetics, dose‐range, and mutagenicity studies of methylphenidate hydrochloride in B6C3F1 mice
- The genetic toxicology of methylphenidate hydrochloride in non-human primates
- Evaluation of mutagenic mode of action in Big Blue mice fed methylphenidate for 24 weeks
Showing 5 of 6 shared publications
Joseph G. Shaddock
National Center for Toxicological Research
6 shared publications
In database
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Evaluation of Macaca mulatta as a model for genotoxicity studies
- Molecular analysis of lacI mutations in Rat2TM cells exposed to 7,12-dimethylbenz[a]anthracene: evidence for DNA sequence and DNA strand biases for mutation
- Pharmacokinetics, dose‐range, and mutagenicity studies of methylphenidate hydrochloride in B6C3F1 mice
- The genetic toxicology of methylphenidate hydrochloride in non-human primates
Showing 5 of 6 shared publications
Martha M. Moore
National Center for Toxicological Research (US)
6 shared publications
- Genotoxicity Assessment of Nanomaterials: Recommendations on Best Practices, Assays, and Methods
- Mechanistic Evaluation of Ginkgo biloba Leaf Extract-Induced Genotoxicity in L5178Y Cells
- Temporal Changes in K-ras Mutant Fraction in Lung Tissue of Big Blue B6C3F1 Mice Exposed to Ethylene Oxide
- Evaluation of cII mutations in lung of male Big Blue mice exposed by inhalation to vanadium pentoxide for up to 8 weeks
- Dose and temporal evaluation of ethylene oxide‐induced mutagenicity in the lungs of male big blue mice following inhalation exposure to carcinogenic concentrations
Showing 5 of 6 shared publications
Wei Ding
United States Food and Drug Administration (US)
5 shared publications
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Genotoxicity of doxorubicin in F344 rats by combining the comet assay, flow‐cytometric peripheral blood micronucleus test, and pathway‐focused gene expression profiling
- Appropriate in vivo follow-up assays to an in vitro bacterial reverse mutation (Ames) test positive investigational drug candidate (active pharmaceutical ingredient), drug-related metabolite, or drug-related impurity
- In vivo genotoxicity of estragole in male F 344 rats
- Sex-specific dose-response analysis of genotoxicity in cyproterone acetate-treated F344 rats
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Alexander W. Alund
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Roberta A. Mittelstaedt
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Robert H. Heflich
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