M
Mugimane G. Manjanatha Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
High Impact
Deputy Director, Supervisory Research Microbiologist
faculty
28 h-index
98 pubs
2,603 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Mugimane G. Manjanatha leads a research group focused on understanding genotoxicity and its mechanisms. His work investigates how various agents, including nanomaterials and pharmaceutical compounds, can induce DNA damage. Manjanatha has published extensively on methodologies for assessing genotoxicity, such as the comet assay, and has adapted these techniques for specific applications, including the evaluation of nanomaterials in vivo.
His research also explores the impact of external factors on DNA repair and damage. This includes studies on the effects of circadian dysregulation, such as night shift work, on DNA repair genes and overall DNA damage levels in humans. Manjanatha collaborates with researchers at the National Center for Toxicological Research, including Nan Mei, Xiaoqing Guo, Yuan Le, and Ji‐Eun Seo, with whom he has co-authored multiple publications.
Manjanatha's scholarship metrics include an h-index of 28, with 99 total publications and 2,575 total citations. He is recognized as a high-impact researcher due to his high citation count. His recent work also includes investigations into the genotoxicity of specific compounds like black cohosh extract and hydroxychloroquine, as well as the biodistribution and toxic potential of silver nanoparticles in animal models.
Metrics
- h-index: 28
- Publications: 98
- Citations: 2,603
Selected Publications
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Review of black cohosh-induced toxicity and adverse clinical effects (2025)
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Development of a TK6-derived cell line expressing four human cytochrome P450s for genotoxicity testing (2025)
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Biodistribution and toxic potential of silver nanoparticles when introduced to the female rat reproductive tract (2024)
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Evaluation of weak genotoxicity of hydroxychloroquine in human TK6 cells (2024)
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Measuring DNA modifications with the comet assay: a compendium of protocols (2023)
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0025 Circadian Dysregulation of Human DNA Repair Genes and Elevated DNA Damage in Simulated Night Shift Schedule (2022)
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In vivo Mammalian Alkaline Comet Assay: Method Adapted for Genotoxicity Assessment of Nanomaterials (2022)
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Common Considerations for Genotoxicity Assessment of Nanomaterials (2022)
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Actein contributes to black cohosh extract‐induced genotoxicity in human TK6 cells (2022)
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Appropriate in vivo follow-up assays to an in vitro bacterial reverse mutation (Ames) test positive investigational drug candidate (active pharmaceutical ingredient), drug-related metabolite, or drug-related impurity (2021)
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Mechanistic Evaluation of Black Cohosh Extract-Induced Genotoxicity in Human Cells (2021)
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Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans (2021)
Collaboration Network
Top Collaborators
Nan Mei
National Center for Toxicological Research
6 shared publications
In database
- Appropriate in vivo follow-up assays to an in vitro bacterial reverse mutation (Ames) test positive investigational drug candidate (active pharmaceutical ingredient), drug-related metabolite, or drug-related impurity
- Mechanistic Evaluation of Black Cohosh Extract-Induced Genotoxicity in Human Cells
- Evaluation of weak genotoxicity of hydroxychloroquine in human TK6 cells
- Actein contributes to black cohosh extract‐induced genotoxicity in human TK6 cells
- Review of black cohosh-induced toxicity and adverse clinical effects
Showing 5 of 6 shared publications
Xiaoqing Guo
National Center for Toxicological Research
4 shared publications
In database
- Mechanistic Evaluation of Black Cohosh Extract-Induced Genotoxicity in Human Cells
- Actein contributes to black cohosh extract‐induced genotoxicity in human TK6 cells
- Review of black cohosh-induced toxicity and adverse clinical effects
- Development of a TK6-derived cell line expressing four human cytochrome P450s for genotoxicity testing
Rosalie K. Elespuru
Center for Devices and Radiological Health (US)
3 shared publications
- Common Considerations for Genotoxicity Assessment of Nanomaterials
- Appropriate in vivo follow-up assays to an in vitro bacterial reverse mutation (Ames) test positive investigational drug candidate (active pharmaceutical ingredient), drug-related metabolite, or drug-related impurity
- In vivo Mammalian Alkaline Comet Assay: Method Adapted for Genotoxicity Assessment of Nanomaterials
Yuan Le
National Center for Toxicological Research
3 shared publications
In database
- Evaluation of weak genotoxicity of hydroxychloroquine in human TK6 cells
- Actein contributes to black cohosh extract‐induced genotoxicity in human TK6 cells
- Review of black cohosh-induced toxicity and adverse clinical effects
Andrew Collins
University of Oslo (NO)
3 shared publications
- Measuring DNA modifications with the comet assay: a compendium of protocols
- Common Considerations for Genotoxicity Assessment of Nanomaterials
- In vivo Mammalian Alkaline Comet Assay: Method Adapted for Genotoxicity Assessment of Nanomaterials
Mária Dušinská
NILU (NO)
3 shared publications
- Measuring DNA modifications with the comet assay: a compendium of protocols
- Common Considerations for Genotoxicity Assessment of Nanomaterials
- In vivo Mammalian Alkaline Comet Assay: Method Adapted for Genotoxicity Assessment of Nanomaterials
Bala S. C. Koritala
Cincinnati Children's Hospital Medical Center (US)
2 shared publications
- Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans
- 0025 Circadian Dysregulation of Human DNA Repair Genes and Elevated DNA Damage in Simulated Night Shift Schedule
Osama A. Arshad
Pacific Northwest National Laboratory (US)
2 shared publications
- Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans
- 0025 Circadian Dysregulation of Human DNA Repair Genes and Elevated DNA Damage in Simulated Night Shift Schedule
Rajendra P. Gajula
Washington State University (US)
2 shared publications
- Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans
- 0025 Circadian Dysregulation of Human DNA Repair Genes and Elevated DNA Damage in Simulated Night Shift Schedule
Hugh Mitchell
Pacific Northwest National Laboratory (US)
2 shared publications
- Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans
- 0025 Circadian Dysregulation of Human DNA Repair Genes and Elevated DNA Damage in Simulated Night Shift Schedule
Tarana Arman
Washington State University (US)
2 shared publications
- Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans
- 0025 Circadian Dysregulation of Human DNA Repair Genes and Elevated DNA Damage in Simulated Night Shift Schedule
Justin Teeguarden
Pacific Northwest National Laboratory (US)
2 shared publications
- Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans
- 0025 Circadian Dysregulation of Human DNA Repair Genes and Elevated DNA Damage in Simulated Night Shift Schedule
Jason McDermott
Pacific Northwest National Laboratory (US)
2 shared publications
- Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans
- 0025 Circadian Dysregulation of Human DNA Repair Genes and Elevated DNA Damage in Simulated Night Shift Schedule
Shobhan Gaddameedhi
North Carolina State University (US)
2 shared publications
- Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans
- 0025 Circadian Dysregulation of Human DNA Repair Genes and Elevated DNA Damage in Simulated Night Shift Schedule
Xilin Li
National Center for Toxicological Research (US)
2 shared publications
- Evaluation of weak genotoxicity of hydroxychloroquine in human TK6 cells
- Actein contributes to black cohosh extract‐induced genotoxicity in human TK6 cells
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