Mugimane G. Manjanatha Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

High Impact

Deputy Director, Supervisory Research Microbiologist

National Center for Toxicological Research

faculty

28 h-index 99 pubs 2,535 cited

Research Areas

Carcinogens and Genotoxicity Assessment DNA Repair Mechanisms Molecular Biology Techniques and Applications Pharmacological Effects and Toxicity Studies Epigenetics and DNA Methylation Nanomaterials: synthesis and applications Mitochondrial Function and Pathology

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ORCID Research Group

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OverviewAI-generated summary

Mugimane G. Manjanatha is a Supervisory Research Microbiologist at the National Center for Toxicological Research, where he also serves as Deputy Director. His research group focuses on understanding the mechanisms of genotoxicity and DNA damage, particularly in relation to environmental exposures and pharmaceutical agents.

Dr. Manjanatha's work involves the development and application of various assay methodologies, including the comet assay, for assessing DNA modifications and genotoxicity. He has investigated the genotoxic potential of nanomaterials, herbal extracts like black cohosh, and pharmaceutical compounds such as hydroxychloroquine. His research also explores the impact of lifestyle factors, such as night shift work, on circadian regulation of DNA repair genes and overall DNA damage in humans.

With a career marked by significant contributions to toxicology and molecular biology, Dr. Manjanatha has published extensively in peer-reviewed journals, amassing a total of 99 publications and over 2,500 citations, with an h-index of 28. He has collaborated with researchers within the National Center for Toxicological Research, including Nan Mei, Yuan Le, Xilin Li, and Volodymyr Tryndyak.

Metrics

  • h-index: 28
  • Publications: 99
  • Citations: 2,535

Selected Publications

  • Review of black cohosh-induced toxicity and adverse clinical effects (2025) DOI
  • Development of a TK6-derived cell line expressing four human cytochrome P450s for genotoxicity testing (2025) DOI
  • Biodistribution and toxic potential of silver nanoparticles when introduced to the female rat reproductive tract (2024) DOI
  • Evaluation of weak genotoxicity of hydroxychloroquine in human TK6 cells (2024) DOI
  • Measuring DNA modifications with the comet assay: a compendium of protocols (2023) DOI
  • 0025 Circadian Dysregulation of Human DNA Repair Genes and Elevated DNA Damage in Simulated Night Shift Schedule (2022) DOI
  • In vivo Mammalian Alkaline Comet Assay: Method Adapted for Genotoxicity Assessment of Nanomaterials (2022) DOI
  • Common Considerations for Genotoxicity Assessment of Nanomaterials (2022) DOI
  • Actein contributes to black cohosh extract‐induced genotoxicity in human TK6 cells (2022) DOI
  • Appropriate in vivo follow-up assays to an in vitro bacterial reverse mutation (Ames) test positive investigational drug candidate (active pharmaceutical ingredient), drug-related metabolite, or drug-related impurity (2021) DOI
  • Mechanistic Evaluation of Black Cohosh Extract-Induced Genotoxicity in Human Cells (2021) DOI
  • Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans (2021) DOI

Collaborators

Researchers in the database who share publications

Nan Mei National Center for Toxicological Research 5 shared publications Yuan Le National Center for Toxicological Research 3 shared publications Xilin Li National Center for Toxicological Research 2 shared publications Volodymyr Tryndyak National Center for Toxicological Research 1 shared publication Dayton M. Petibone National Center for Toxicological Research 1 shared publication Sharon D. Shelton National Center for Toxicological Research 1 shared publication Ji‐Eun Seo National Center for Toxicological Research 1 shared publication Anil K. Patri National Center for Toxicological Research 1 shared publication

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