Match tier
Confirmed
Presence
Current · Arkansas
Last published
2025
Sources
OpenAlex · ORCID
Refreshed
2026-08-15
M
Mugimane G. Manjanatha
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
High Impact
Deputy Director, Supervisory Research Microbiologist
Also affiliated: United States Food and Drug Administration (2003–2025); Iowa State University (1990–1992); Dalian Medical University (2014); Thomas Jefferson National Accelerator Facility (2002–2011); Food and Drug Administration (2008–2013)
Faculty Researcher
29 h-index
98 pubs
2,652 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Mugimane G. Manjanatha's research focuses on genotoxicity assessment and the mechanisms of DNA damage and repair. He has investigated the genotoxic potential of various substances, including investigational drugs, drug-related metabolites, and impurities, utilizing in vitro and in vivo mammalian assays such as the comet assay and the Ames test. His work also extends to evaluating the genotoxicity of nanomaterials and specific compounds like black cohosh extract and hydroxychloroquine in human cell lines and animal models.
Manjanatha has explored the impact of environmental factors and lifestyle choices on DNA integrity, including circadian dysregulation caused by night shift work, which has been shown to affect DNA repair genes and elevate DNA damage in humans. His research group, comprising collaborators such as Nan Mei, Xiaoqing Guo, Yuan Le, and Ji-Eun Seo, all at the National Center for Toxicological Research, has published extensively on these topics. With an h-index of 28 and over 2,600 citations across nearly 100 publications, Manjanatha is recognized as a highly cited researcher.
Metrics
- h-index: 29
- Publications: 98
- Citations: 2,652
Selected Publications
-
Review of black cohosh-induced toxicity and adverse clinical effects (2025)
-
Development of a TK6-derived cell line expressing four human cytochrome P450s for genotoxicity testing (2025)
-
Biodistribution and toxic potential of silver nanoparticles when introduced to the female rat reproductive tract (2024)
-
Evaluation of weak genotoxicity of hydroxychloroquine in human TK6 cells (2024)
-
Measuring DNA modifications with the comet assay: a compendium of protocols (2023)
-
0025 Circadian Dysregulation of Human DNA Repair Genes and Elevated DNA Damage in Simulated Night Shift Schedule (2022)
-
In vivo Mammalian Alkaline Comet Assay: Method Adapted for Genotoxicity Assessment of Nanomaterials (2022)
-
Common Considerations for Genotoxicity Assessment of Nanomaterials (2022)
-
Actein contributes to black cohosh extract‐induced genotoxicity in human TK6 cells (2022)
-
Appropriate in vivo follow-up assays to an in vitro bacterial reverse mutation (Ames) test positive investigational drug candidate (active pharmaceutical ingredient), drug-related metabolite, or drug-related impurity (2021)
-
Mechanistic Evaluation of Black Cohosh Extract-Induced Genotoxicity in Human Cells (2021)
-
Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans (2021)
-
Evaluation of pyrrolizidine alkaloid-induced genotoxicity using metabolically competent TK6 cell lines (2020)
-
0025 Circadian Dysregulation of DNA Repair and Increased Endogenous and Exogenous Sensitivity to DNA Damage Precipitate Elevated Cancer Risk Associated with Night Shift Work (2020)
-
Performance of high-throughput CometChip assay using primary human hepatocytes: a comparison of DNA damage responses with in vitro human hepatoma cell lines (2020)
Collaboration Network
Top Collaborators
Nan Mei
National Center for Toxicological Research
6 shared publications
In database
- Appropriate in vivo follow-up assays to an in vitro bacterial reverse mutation (Ames) test positive investigational drug candidate (active pharmaceutical ingredient), drug-related metabolite, or drug-related impurity
- Mechanistic Evaluation of Black Cohosh Extract-Induced Genotoxicity in Human Cells
- Evaluation of weak genotoxicity of hydroxychloroquine in human TK6 cells
- Actein contributes to black cohosh extract‐induced genotoxicity in human TK6 cells
- Review of black cohosh-induced toxicity and adverse clinical effects
Showing 5 of 6 shared publications
Xiaoqing Guo
National Center for Toxicological Research
4 shared publications
In database
- Mechanistic Evaluation of Black Cohosh Extract-Induced Genotoxicity in Human Cells
- Actein contributes to black cohosh extract‐induced genotoxicity in human TK6 cells
- Review of black cohosh-induced toxicity and adverse clinical effects
- Development of a TK6-derived cell line expressing four human cytochrome P450s for genotoxicity testing
Rosalie K. Elespuru
Center for Devices and Radiological Health (US)
3 shared publications
- Common Considerations for Genotoxicity Assessment of Nanomaterials
- Appropriate in vivo follow-up assays to an in vitro bacterial reverse mutation (Ames) test positive investigational drug candidate (active pharmaceutical ingredient), drug-related metabolite, or drug-related impurity
- In vivo Mammalian Alkaline Comet Assay: Method Adapted for Genotoxicity Assessment of Nanomaterials
Yuan Le
National Center for Toxicological Research
3 shared publications
In database
- Evaluation of weak genotoxicity of hydroxychloroquine in human TK6 cells
- Actein contributes to black cohosh extract‐induced genotoxicity in human TK6 cells
- Review of black cohosh-induced toxicity and adverse clinical effects
Andrew Collins
University of Oslo (NO)
3 shared publications
- Measuring DNA modifications with the comet assay: a compendium of protocols
- Common Considerations for Genotoxicity Assessment of Nanomaterials
- In vivo Mammalian Alkaline Comet Assay: Method Adapted for Genotoxicity Assessment of Nanomaterials
Mária Dušinská
NILU (NO)
3 shared publications
- Measuring DNA modifications with the comet assay: a compendium of protocols
- Common Considerations for Genotoxicity Assessment of Nanomaterials
- In vivo Mammalian Alkaline Comet Assay: Method Adapted for Genotoxicity Assessment of Nanomaterials
Bala S. C. Koritala
Cincinnati Children's Hospital Medical Center (US)
2 shared publications
- Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans
- 0025 Circadian Dysregulation of Human DNA Repair Genes and Elevated DNA Damage in Simulated Night Shift Schedule
Osama A. Arshad
Pacific Northwest National Laboratory (US)
2 shared publications
- Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans
- 0025 Circadian Dysregulation of Human DNA Repair Genes and Elevated DNA Damage in Simulated Night Shift Schedule
Rajendra P. Gajula
Washington State University (US)
2 shared publications
- Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans
- 0025 Circadian Dysregulation of Human DNA Repair Genes and Elevated DNA Damage in Simulated Night Shift Schedule
Hugh Mitchell
Pacific Northwest National Laboratory (US)
2 shared publications
- Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans
- 0025 Circadian Dysregulation of Human DNA Repair Genes and Elevated DNA Damage in Simulated Night Shift Schedule
Tarana Arman
Washington State University (US)
2 shared publications
- Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans
- 0025 Circadian Dysregulation of Human DNA Repair Genes and Elevated DNA Damage in Simulated Night Shift Schedule
Justin Teeguarden
Pacific Northwest National Laboratory (US)
2 shared publications
- Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans
- 0025 Circadian Dysregulation of Human DNA Repair Genes and Elevated DNA Damage in Simulated Night Shift Schedule
Jason McDermott
Pacific Northwest National Laboratory (US)
2 shared publications
- Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans
- 0025 Circadian Dysregulation of Human DNA Repair Genes and Elevated DNA Damage in Simulated Night Shift Schedule
Shobhan Gaddameedhi
North Carolina State University (US)
2 shared publications
- Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans
- 0025 Circadian Dysregulation of Human DNA Repair Genes and Elevated DNA Damage in Simulated Night Shift Schedule
Xilin Li
National Center for Toxicological Research
2 shared publications
In database
- Evaluation of weak genotoxicity of hydroxychloroquine in human TK6 cells
- Actein contributes to black cohosh extract‐induced genotoxicity in human TK6 cells
Similar Researchers
Based on overlapping research topics
Michelle E. Bishop
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Molecular Biology Techniques and Applications
Pharmacological Effects and Toxicity Studies
S A Montoya Guerrero
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Molecular Biology Techniques and Applications
Pharmacological Effects and Toxicity Studies
R. A. Donley
University of Arkansas at Fayetteville
Carcinogens and Genotoxicity Assessment
Molecular Biology Techniques and Applications
Pharmacological Effects and Toxicity Studies
Page B. McKinzie
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
DNA Repair Mechanisms
Molecular Biology Techniques and Applications
Audrey M Sims
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Molecular Biology Techniques and Applications
Pharmacological Effects and Toxicity Studies
Nyosha Moore
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Molecular Biology Techniques and Applications
Pharmacological Effects and Toxicity Studies