Yuan Le Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

Researcher

National Center for Toxicological Research

faculty

13 h-index 30 pubs 372 cited

Research Areas

Carcinogens and Genotoxicity Assessment Pharmacological Effects and Toxicity Studies Gut microbiota and health Immune Response and Inflammation Metabolism and Genetic Disorders Phytochemicals and Antioxidant Activities Meta-analysis and systematic reviews Behavioral Health and Interventions

Links

ORCID Lab Website

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OverviewAI-generated summary

Yuan Le investigates the genotoxicity and mutagenicity of various chemical compounds, with a focus on nitrosamine impurities and natural botanical active ingredients. Their research utilizes in vitro assays with human lymphoblastoid TK6 cells and HepaRG cell cultures, including advanced techniques like high-throughput micronucleus assays and error-corrected next-generation sequencing. Le's work also explores the role of intestinal microbiota in regulating immunity and inflammation, particularly in the context of ischemic stroke and its potential modulation by dietary components. Recent publications also touch upon the effects of probiotics on postoperative cognitive dysfunction and the relationship between gut dysbiosis, vitamin B6 metabolism, and stress-related behaviors. Le has collaborated with several researchers at the National Center for Toxicological Research, including Nan Mei, Robert H. Heflich, Xilin Li, and Mugimane G. Manjanatha.

Metrics

h-index: 13
Publications: 30
Citations: 372

Selected Publications

Review of black cohosh-induced toxicity and adverse clinical effects (2025) DOI
Characterizing the Pulmonary Toxicity and Potential Mutagenicity of Formaldehyde Fumes in a Human Bronchial Epithelial Tissue Model (2025) DOI
Mutagenicity and genotoxicity evaluation of 15 nitrosamine drug substance-related impurities in human TK6 cells (2024) DOI
Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations (2024) DOI
Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing (2024) DOI
Evaluation of weak genotoxicity of hydroxychloroquine in human TK6 cells (2024) DOI
Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays (2023) DOI
High-throughput micronucleus assay using three-dimensional HepaRG spheroids for in vitro genotoxicity testing (2023) DOI
Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s (2022) DOI
Actein contributes to black cohosh extract‐induced genotoxicity in human TK6 cells (2022) DOI
Activation of activator protein-1-fibroblast growth factor 21 signaling attenuates Cisplatin hepatotoxicity (2021) DOI
The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells (2021) DOI