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Current · Arkansas
Last published
2025
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OpenAlex · ORCID
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2026-10-06
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Xuefei Cao
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
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Also affiliated: University of Southern California (2007–2023); United States Food and Drug Administration (2011–2025); Tianjin University of Science and Technology (2013); Nanjing Tech University (2021–2023); Beijing Forestry University (2024); Xi'an Honghui Hospital (2025); USC Norris Comprehensive Cancer Center (2011); Heilongjiang Provincial Hospital (2022); First Affiliated Hospital of Harbin Medical University (2017); State Key Laboratory of Pulp and Paper Engineering (2014); University of Cincinnati (2001–2003); Xi'an Jiaotong University (2025); South China University of Technology (2014)
19 h-index
52 pubs
1,053 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Xuefei Cao's research focuses on evaluating the toxicity of various substances using in vitro human airway tissue models. This work investigates the potential for DNA damage and mutagenicity caused by inhaled chemicals, such as formaldehyde and glutaraldehyde fumes, and cigarette smoke. Cao employs advanced techniques like the CometChip assay and Duplex Sequencing to assess genotoxicity. Additional research explores the integration of transcriptome analysis with pathophysiological endpoints to understand chemical toxicity more comprehensively. Cao has published 52 papers, accumulating over 1,000 citations, and holds an h-index of 19. Collaborations include Robert H. Heflich, Qiangen Wu, Rebecca Wynne, and Roberta A. Mittelstaedt, all at the National Center for Toxicological Research.
Metrics
- h-index: 19
- Publications: 52
- Citations: 1,053
Selected Publications
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Comparative genotoxicity assessment of ortho-phthalaldehyde using human in vitro organotypic airway epithelial cultures and standard in vitro genotoxicity assays (2026)
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Characterizing the Pulmonary Toxicity and Potential Mutagenicity of Formaldehyde Fumes in a Human Bronchial Epithelial Tissue Model (2025)
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Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations (2024)
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Key Challenges and Recommendations for In Vitro Testing of Tobacco Products for Regulatory Applications: Consideration of Test Materials and Exposure Parameters (2023)
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Quantitative in vitro to in vivo extrapolation of genotoxicity data provides protective estimates of in vivo dose (2022)
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Subacute Pulmonary Toxicity of Glutaraldehyde Aerosols in a Human In Vitro Airway Tissue Model (2022)
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Ciliary Beat Frequency: Proceedings and Recommendations from a Multi-laboratory Ring Trial Using 3-D Reconstituted Human Airway Epithelium to Model Mucociliary Clearance (2022)
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Evaluating the Sub-Acute Toxicity of Formaldehyde Fumes in an In Vitro Human Airway Epithelial Tissue Model (2022)
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Effect of life stage and target tissue on dose–response assessment of ethyl methane sulfonate‐induced genotoxicity (2021)
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Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing DNA damage with the CometChip and mutagenesis by Duplex Sequencing (2021)
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Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model (2021)
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Transcriptome analysis reveals lung-specific miRNAs associated with impaired mucociliary clearance induced by cigarette smoke in an in vitro human airway tissue model (2021)
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Toxicity of Ortho-phthalaldehyde Aerosols in a Human In Vitro Airway Tissue Model (2021)
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Detection of Pig-a Mutant Erythrocytes in the Peripheral Blood of Rats and Mice (2020)
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In vitro dosimetry analyses for acrolein exposure in normal human lung epithelial cells and human lung cancer cells (2020)
Collaboration Network
Top Collaborators
Robert H. Heflich
National Center for Toxicological Research
17 shared publications
In database
- Invited review: human air-liquid-interface organotypic airway tissue models derived from primary tracheobronchial epithelial cells—overview and perspectives
- Tight junction disruption by cadmium in an in vitro human airway tissue model
- Report on stage III Pig‐a mutation assays using N‐ethyl‐N‐nitrosourea – comparison with other in vivo genotoxicity endpoints
- Report on stage IIIPig‐amutation assays using benzo[a]pyrene
- Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing DNA damage with the CometChip and mutagenesis by Duplex Sequencing
Showing 5 of 17 shared publications
Levan Muskhelishvili
13 shared publications
- Tight junction disruption by cadmium in an in vitro human airway tissue model
- Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing DNA damage with the CometChip and mutagenesis by Duplex Sequencing
- Cigarette whole smoke solutions disturb mucin homeostasis in a human in vitro airway tissue model
- Disease-related responses induced by cadmium in an in vitro human airway tissue model
- Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model
Showing 5 of 13 shared publications
Kelly J. Davis
10 shared publications
In database
- Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing DNA damage with the CometChip and mutagenesis by Duplex Sequencing
- Cigarette whole smoke solutions disturb mucin homeostasis in a human in vitro airway tissue model
- Disease-related responses induced by cadmium in an in vitro human airway tissue model
- Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model
- Evaluating the Sub-Acute Toxicity of Formaldehyde Fumes in an In Vitro Human Airway Epithelial Tissue Model
Showing 5 of 10 shared publications
Qiangen Wu
National Center for Toxicological Research
9 shared publications
In database
- Disease-related responses induced by cadmium in an in vitro human airway tissue model
- Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model
- Evaluating the Sub-Acute Toxicity of Formaldehyde Fumes in an In Vitro Human Airway Epithelial Tissue Model
- Subacute Pulmonary Toxicity of Glutaraldehyde Aerosols in a Human In Vitro Airway Tissue Model
- Assessing the respiratory toxicity of dihydroxyacetone using an in vitro human airway epithelial tissue model
Showing 5 of 9 shared publications
Matthew Bryant
National Center for Toxicological Research
7 shared publications
In database
- Disease-related responses induced by cadmium in an in vitro human airway tissue model
- Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model
- Assessing the respiratory toxicity of dihydroxyacetone using an in vitro human airway epithelial tissue model
- In vitro dosimetry analyses for acrolein exposure in normal human lung epithelial cells and human lung cancer cells
- Toxicity of Ortho-phthalaldehyde Aerosols in a Human In Vitro Airway Tissue Model
Showing 5 of 7 shared publications
Roberta A. Mittelstaedt
National Center for Toxicological Research
5 shared publications
In database
- Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing DNA damage with the CometChip and mutagenesis by Duplex Sequencing
- Quantitative dose–response analysis of ethyl methanesulfonate genotoxicity in adult gpt‐delta transgenic mice
- In Vivo cII, gpt, and Spi− Gene Mutation Assays in Transgenic Mice and Rats
- Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations
- Effect of life stage and target tissue on dose–response assessment of ethyl methane sulfonate‐induced genotoxicity
Yiying Wang
National Center for Toxicological Research (US)
5 shared publications
- Invited review: human air-liquid-interface organotypic airway tissue models derived from primary tracheobronchial epithelial cells—overview and perspectives
- Cigarette whole smoke solutions disturb mucin homeostasis in a human in vitro airway tissue model
- Subacute Pulmonary Toxicity of Glutaraldehyde Aerosols in a Human In Vitro Airway Tissue Model
- Toxicity of Ortho-phthalaldehyde Aerosols in a Human In Vitro Airway Tissue Model
- Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations
Rui Xiong
National Center for Toxicological Research (US)
5 shared publications
- Invited review: human air-liquid-interface organotypic airway tissue models derived from primary tracheobronchial epithelial cells—overview and perspectives
- Cigarette whole smoke solutions disturb mucin homeostasis in a human in vitro airway tissue model
- Disease-related responses induced by cadmium in an in vitro human airway tissue model
- In vitro dosimetry analyses for acrolein exposure in normal human lung epithelial cells and human lung cancer cells
- Dr. Daniel Acosta and In Vitro toxicology at the U.S. Food and Drug Administration's National Center for Toxicological Research
Rebecca Wynne
National Center for Toxicological Research
5 shared publications
In database
- Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing DNA damage with the CometChip and mutagenesis by Duplex Sequencing
- Subacute Pulmonary Toxicity of Glutaraldehyde Aerosols in a Human In Vitro Airway Tissue Model
- Toxicity of Ortho-phthalaldehyde Aerosols in a Human In Vitro Airway Tissue Model
- Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations
- Comparative genotoxicity assessment of ortho-phthalaldehyde using human in vitro organotypic airway epithelial cultures and standard in vitro genotoxicity assays
Mason G. Pearce
National Center for Toxicological Research
4 shared publications
In database
- Report on stage III Pig‐a mutation assays using N‐ethyl‐N‐nitrosourea – comparison with other in vivo genotoxicity endpoints
- Report on stage IIIPig‐amutation assays using benzo[a]pyrene
- Quantitative dose–response analysis of ethyl methanesulfonate genotoxicity in adult gpt‐delta transgenic mice
- Effect of life stage and target tissue on dose–response assessment of ethyl methane sulfonate‐induced genotoxicity
Javed A. Bhalli
Covance (United States)
4 shared publications
In database
- Report on stage III Pig‐a mutation assays using N‐ethyl‐N‐nitrosourea – comparison with other in vivo genotoxicity endpoints
- Report on stage IIIPig‐amutation assays using benzo[a]pyrene
- Detection of Pig-a Mutant Erythrocytes in the Peripheral Blood of Rats and Mice
- Detection of Pig-a Mutant Erythrocytes in the Peripheral Blood of Rats and Mice
Vasily N. Dobrovolsky
National Center for Toxicological Research
4 shared publications
In database
- Report on stage III Pig‐a mutation assays using N‐ethyl‐N‐nitrosourea – comparison with other in vivo genotoxicity endpoints
- Report on stage IIIPig‐amutation assays using benzo[a]pyrene
- Detection of Pig-a Mutant Erythrocytes in the Peripheral Blood of Rats and Mice
- Detection of Pig-a Mutant Erythrocytes in the Peripheral Blood of Rats and Mice
Patricia Richter
United States Food and Drug Administration (US)
4 shared publications
- Tight junction disruption by cadmium in an in vitro human airway tissue model
- Cigarette whole smoke solutions disturb mucin homeostasis in a human in vitro airway tissue model
- Disease-related responses induced by cadmium in an in vitro human airway tissue model
- Evaluating the Toxicity of Cigarette Whole Smoke Solutions in an Air-liquid-interface Human in vitro Airway Tissue Model
Yiying Wang
National Center for Toxicological Research
4 shared publications
In database
- Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing DNA damage with the CometChip and mutagenesis by Duplex Sequencing
- Assessing the respiratory toxicity of dihydroxyacetone using an in vitro human airway epithelial tissue model
- Effects of cellular differentiation in human primary bronchial epithelial cells: Metabolism of 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone
- Characterizing the Pulmonary Toxicity and Potential Mutagenicity of Formaldehyde Fumes in a Human Bronchial Epithelial Tissue Model
Hans Rosenfeldt
United States Food and Drug Administration (US)
4 shared publications
- Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model
- In vitro dosimetry analyses for acrolein exposure in normal human lung epithelial cells and human lung cancer cells
- Effects of cellular differentiation in human primary bronchial epithelial cells: Metabolism of 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone
- Transcriptome analysis reveals lung-specific miRNAs associated with impaired mucociliary clearance induced by cigarette smoke in an in vitro human airway tissue model
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