Xuefei Cao Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

Researcher

National Center for Toxicological Research

faculty

19 h-index 52 pubs 967 cited

Research Areas

Pharmacological Effects and Toxicity Studies Carcinogens and Genotoxicity Assessment Tracheal and airway disorders Molecular Biology Techniques and Applications Health and Medical Research Impacts

Links

ORCID Lab Website

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OverviewAI-generated summary

Xuefei Cao's research focuses on investigating the toxicity of various substances, particularly in human in vitro airway tissue models. Cao has studied the sub-acute toxicity of formaldehyde and glutaraldehyde fumes, as well as the toxicity of ortho-phthalaldehyde aerosols in these models. Cao also investigates methods for genetic toxicity testing, including assessing DNA damage with the CometChip and using Duplex Sequencing to detect mutagenesis. Further research involves integrating transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity and developing quantitative in vitro to in vivo extrapolation methods for genotoxicity data to provide protective estimates of in vivo dose. Cao has published 52 papers, with an h-index of 19 and 967 citations. Key collaborators include Robert H. Heflich, Qiangen Wu, Rebecca Wynne, and Roberta A. Mittelstaedt, all from the National Center for Toxicological Research.

Metrics

  • h-index: 19
  • Publications: 52
  • Citations: 967

Selected Publications

  • Characterizing the Pulmonary Toxicity and Potential Mutagenicity of Formaldehyde Fumes in a Human Bronchial Epithelial Tissue Model (2025) DOI
  • Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations (2024) DOI
  • Key Challenges and Recommendations for <i>In Vitro</i> Testing of Tobacco Products for Regulatory Applications: Consideration of Test Materials and Exposure Parameters (2023) DOI
  • Quantitative in vitro to in vivo extrapolation of genotoxicity data provides protective estimates of in vivo dose (2022) DOI
  • Subacute Pulmonary Toxicity of Glutaraldehyde Aerosols in a Human In Vitro Airway Tissue Model (2022) DOI
  • Ciliary Beat Frequency: Proceedings and Recommendations from a Multi-laboratory Ring Trial Using 3-D Reconstituted Human Airway Epithelium to Model Mucociliary Clearance (2022) DOI
  • Evaluating the Sub-Acute Toxicity of Formaldehyde Fumes in an In Vitro Human Airway Epithelial Tissue Model (2022) DOI
  • Effect of life stage and target tissue on dose–response assessment of ethyl methane sulfonate‐induced genotoxicity (2021) DOI
  • Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing <scp>DNA</scp> damage with the <scp>CometChip</scp> and mutagenesis by Duplex Sequencing (2021) DOI
  • Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model (2021) DOI
  • Transcriptome analysis reveals lung-specific miRNAs associated with impaired mucociliary clearance induced by cigarette smoke in an in vitro human airway tissue model (2021) DOI
  • Toxicity of Ortho-phthalaldehyde Aerosols in a Human <i>In Vitro</i> Airway Tissue Model (2021) DOI

Collaborators

Researchers in the database who share publications

Robert H. Heflich National Center for Toxicological Research 5 shared publications Qiangen Wu National Center for Toxicological Research 5 shared publications Rebecca Wynne National Center for Toxicological Research 4 shared publications Roberta A. Mittelstaedt National Center for Toxicological Research 3 shared publications Matthew Bryant National Center for Toxicological Research 3 shared publications Baiping Ren National Center for Toxicological Research 3 shared publications Yuan Le National Center for Toxicological Research 2 shared publications Nan Mei National Center for Toxicological Research 1 shared publication

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