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Presence
Current · Arkansas
Last published
2024
Sources
OpenAlex · ORCID
Refreshed
2026-10-07
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Nathan A. Koonce
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Also affiliated: United States Food and Drug Administration (2017–2020)
14 h-index
29 pubs
973 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Nathan A. Koonce's research focuses on the application of nanoparticles and combined therapeutic modalities for cancer treatment. His work investigates the potential of gold nanoparticles conjugated with tumor necrosis factor-alpha (TNF-α) as a multimodal cancer therapy, demonstrating synergistic antitumor responses in murine models when combined with radiation therapy. Koonce has also studied the effects of nanoparticles, specifically titanium dioxide, on DNA methylation in human cell lines. His research also explores indirect tumor cell death mechanisms following high-dose hypofractionated irradiation, with implications for stereotactic body radiation therapy and stereotactic radiation surgery. Additionally, he has investigated the protective effects of antioxidants, such as N-acetyl-cysteine, against acute radiation-induced death in mice. Koonce's publications include work on tumor-endothelial cell spheroids to enhance radiation and drug therapeutics, and the alteration of vascular architecture and tumor oxygenation by microbeam radiation therapy.
Metrics
- h-index: 14
- Publications: 29
- Citations: 973
Selected Publications
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Biodistribution and toxic potential of silver nanoparticles when introduced to the female rat reproductive tract (2024)
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Effect of titanium dioxide nanoparticles on DNA methylation in multiple human cell lines (2020)
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Galectin-1 Inhibitor OTX008 Induces Tumor Vessel Normalization and Tumor Growth Inhibition in Human Head and Neck Squamous Cell Carcinoma Models (2017)
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Real-time monitoring of circulating tumor cell (CTC) release after nanodrug or tumor radiotherapy using in vivo flow cytometry (2017)
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Combination of Gold Nanoparticle-Conjugated Tumor Necrosis Factor-α and Radiation Therapy Results in a Synergistic Antitumor Response in Murine Carcinoma Models (2015)
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Indirect Tumor Cell Death After High-Dose Hypofractionated Irradiation: Implications for Stereotactic Body Radiation Therapy and Stereotactic Radiation Surgery (2015)
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Targeting Artificial Tumor Stromal Targets for Molecular Imaging of Tumor Vascular Hypoxia (2015)
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PET AND MRI-GUIDED FOCUSED ULTRASOUND SURGERY FOR HYPOXIC-TISSUE ABLATION COMBINED WITH RADIOTHERAPY IN SOLID TUMORS (2015)
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A34 Session 10: Adjunctive Therapeutic Approaches (2014)
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Photothermal nanodrugs: potential of TNF-gold nanospheres for cancer theranostics (2013)
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Hyperthermia-enhanced indocyanine green delivery for laser-induced thermal ablation of carcinomas (2013)
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Nanoparticle Delivered Vascular Disrupting Agents (VDAs): Use of TNF-Alpha Conjugated Gold Nanoparticles for Multimodal Cancer Therapy (2013)
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10. Nanoparticle delivered vascular disrupting agents (VDAs): a new opportunity in multimodal cancer treatment (2013)
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Abstract 4644: A novel strategy for targeted drug delivery to the tumor vasculature by radiation-induced receptor expression on endothelial cells (2012)
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Radiation-induced galectin-1 by endothelial cells: a promising molecular target for preferential drug delivery to the tumor vasculature (2012)
Collaboration Network
Top Collaborators
Robert J. Griffin
University of Arkansas for Medical Sciences
21 shared publications
In database
- Indirect Tumor Cell Death After High-Dose Hypofractionated Irradiation: Implications for Stereotactic Body Radiation Therapy and Stereotactic Radiation Surgery
- Photothermal nanodrugs: potential of TNF-gold nanospheres for cancer theranostics
- Nanoparticle Delivered Vascular Disrupting Agents (VDAs): Use of TNF-Alpha Conjugated Gold Nanoparticles for Multimodal Cancer Therapy
- Tumor-Endothelial Cell Three-dimensional Spheroids: New Aspects to Enhance Radiation and Drug Therapeutics
- Microbeam Radiation Therapy Alters Vascular Architecture and Tumor Oxygenation and is Enhanced by a Galectin-1 Targeted Anti-Angiogenic Peptide
Showing 5 of 21 shared publications
Jessica Webber
University of Arkansas for Medical Sciences
7 shared publications
In database
- Photothermal nanodrugs: potential of TNF-gold nanospheres for cancer theranostics
- Tumor-Endothelial Cell Three-dimensional Spheroids: New Aspects to Enhance Radiation and Drug Therapeutics
- Hyperthermia-enhanced indocyanine green delivery for laser-induced thermal ablation of carcinomas
- Synthesis of [18F]anginex with high specific activity [18F]fluorobenzaldehyde for targeting angiogenic activity in solid tumors
- Spatially Fractionated Radiotherapy using an Image-guided Small Animal Irradiation System
Showing 5 of 7 shared publications
Azemat Jamshidi‐Parsian
University of Arkansas for Medical Sciences
6 shared publications
In database
- Tumor-Endothelial Cell Three-dimensional Spheroids: New Aspects to Enhance Radiation and Drug Therapeutics
- Combination of Gold Nanoparticle-Conjugated Tumor Necrosis Factor-α and Radiation Therapy Results in a Synergistic Antitumor Response in Murine Carcinoma Models
- Radiation-induced galectin-1 by endothelial cells: a promising molecular target for preferential drug delivery to the tumor vasculature
- Targeting Artificial Tumor Stromal Targets for Molecular Imaging of Tumor Vascular Hypoxia
- Abstract 2330: Murine interferon-α inhibits aortic endothelial outgrowth
Showing 5 of 6 shared publications
Ruud P.M. Dings
University of Arkansas for Medical Sciences
6 shared publications
In database
- Microbeam Radiation Therapy Alters Vascular Architecture and Tumor Oxygenation and is Enhanced by a Galectin-1 Targeted Anti-Angiogenic Peptide
- Combination of Gold Nanoparticle-Conjugated Tumor Necrosis Factor-α and Radiation Therapy Results in a Synergistic Antitumor Response in Murine Carcinoma Models
- Galectin-1 Inhibitor OTX008 Induces Tumor Vessel Normalization and Tumor Growth Inhibition in Human Head and Neck Squamous Cell Carcinoma Models
- Real-time monitoring of circulating tumor cell (CTC) release after nanodrug or tumor radiotherapy using in vivo flow cytometry
- Targeting Artificial Tumor Stromal Targets for Molecular Imaging of Tumor Vascular Hypoxia
Showing 5 of 6 shared publications
Meenakshi Upreti
University of Arkansas for Medical Sciences
6 shared publications
In database
- Tumor-Endothelial Cell Three-dimensional Spheroids: New Aspects to Enhance Radiation and Drug Therapeutics
- Radiation-induced galectin-1 by endothelial cells: a promising molecular target for preferential drug delivery to the tumor vasculature
- Pegylated IFN-α sensitizes melanoma cells to chemotherapy and causes premature senescence in endothelial cells by IRF-1-mediated signaling
- Vascular Disrupting Agent Arsenic Trioxide Enhances Thermoradiotherapy of Solid Tumors
- Abstract 2330: Murine interferon-α inhibits aortic endothelial outgrowth
Showing 5 of 6 shared publications
Peter M. Corry
University of Arkansas for Medical Sciences (US)
5 shared publications
- Microbeam Radiation Therapy Alters Vascular Architecture and Tumor Oxygenation and is Enhanced by a Galectin-1 Targeted Anti-Angiogenic Peptide
- Prevention and Mitigation of Acute Death of Mice after Abdominal Irradiation by the Antioxidant N-Acetyl-cysteine (NAC)
- Repression of Multiple Myeloma Growth and Preservation of Bone with Combined Radiotherapy and Anti-angiogenic Agent
- PET AND MRI-GUIDED FOCUSED ULTRASOUND SURGERY FOR HYPOXIC-TISSUE ABLATION COMBINED WITH RADIOTHERAPY IN SOLID TUMORS
- Spatially Fractionated Radiotherapy using an Image-guided Small Animal Irradiation System
Scott M. Apana
University of Arkansas for Medical Sciences
4 shared publications
In database
- Radiation-induced galectin-1 by endothelial cells: a promising molecular target for preferential drug delivery to the tumor vasculature
- Repression of Multiple Myeloma Growth and Preservation of Bone with Combined Radiotherapy and Anti-angiogenic Agent
- Synthesis of [18F]anginex with high specific activity [18F]fluorobenzaldehyde for targeting angiogenic activity in solid tumors
- Abstract 4644: A novel strategy for targeted drug delivery to the tumor vasculature by radiation-induced receptor expression on endothelial cells
Eduardo G. Moros
University of Arkansas for Medical Sciences (US)
3 shared publications
- Microbeam Radiation Therapy Alters Vascular Architecture and Tumor Oxygenation and is Enhanced by a Galectin-1 Targeted Anti-Angiogenic Peptide
- PET AND MRI-GUIDED FOCUSED ULTRASOUND SURGERY FOR HYPOXIC-TISSUE ABLATION COMBINED WITH RADIOTHERAPY IN SOLID TUMORS
- Spatially Fractionated Radiotherapy using an Image-guided Small Animal Irradiation System
Gal Shafirstein
Roswell Park Comprehensive Cancer Center (US)
3 shared publications
- Hyperthermia-enhanced indocyanine green delivery for laser-induced thermal ablation of carcinomas
- PET AND MRI-GUIDED FOCUSED ULTRASOUND SURGERY FOR HYPOXIC-TISSUE ABLATION COMBINED WITH RADIOTHERAPY IN SOLID TUMORS
- A34 Session 10: Adjunctive Therapeutic Approaches
Sunil Sharma
University of Arkansas for Medical Sciences (US)
3 shared publications
- Tumor-Endothelial Cell Three-dimensional Spheroids: New Aspects to Enhance Radiation and Drug Therapeutics
- Targeting Artificial Tumor Stromal Targets for Molecular Imaging of Tumor Vascular Hypoxia
- Spatially Fractionated Radiotherapy using an Image-guided Small Animal Irradiation System
John C. Bischof
University of Minnesota (US)
3 shared publications
- Nanoparticle Delivered Vascular Disrupting Agents (VDAs): Use of TNF-Alpha Conjugated Gold Nanoparticles for Multimodal Cancer Therapy
- Vascular Disrupting Agent Arsenic Trioxide Enhances Thermoradiotherapy of Solid Tumors
- 10. Nanoparticle delivered vascular disrupting agents (VDAs): a new opportunity in multimodal cancer treatment
Leah Hennings
University of Arkansas for Medical Sciences (US)
3 shared publications
- Pegylated IFN-α sensitizes melanoma cells to chemotherapy and causes premature senescence in endothelial cells by IRF-1-mediated signaling
- Repression of Multiple Myeloma Growth and Preservation of Bone with Combined Radiotherapy and Anti-angiogenic Agent
- Abstract 2330: Murine interferon-α inhibits aortic endothelial outgrowth
Marc S. Berridge
University of Arkansas for Medical Sciences (US)
3 shared publications
- Radiation-induced galectin-1 by endothelial cells: a promising molecular target for preferential drug delivery to the tumor vasculature
- Repression of Multiple Myeloma Growth and Preservation of Bone with Combined Radiotherapy and Anti-angiogenic Agent
- Synthesis of [18F]anginex with high specific activity [18F]fluorobenzaldehyde for targeting angiogenic activity in solid tumors
Dmitry A. Nedosekin
University of Arkansas for Medical Sciences
3 shared publications
In database
- Photothermal nanodrugs: potential of TNF-gold nanospheres for cancer theranostics
- Combination of Gold Nanoparticle-Conjugated Tumor Necrosis Factor-α and Radiation Therapy Results in a Synergistic Antitumor Response in Murine Carcinoma Models
- Real-time monitoring of circulating tumor cell (CTC) release after nanodrug or tumor radiotherapy using in vivo flow cytometry
Matthew E. Hardee
University of Arkansas for Medical Sciences (US)
2 shared publications
- Combination of Gold Nanoparticle-Conjugated Tumor Necrosis Factor-α and Radiation Therapy Results in a Synergistic Antitumor Response in Murine Carcinoma Models
- Targeting Artificial Tumor Stromal Targets for Molecular Imaging of Tumor Vascular Hypoxia
Similar Researchers
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