Prabhash Nath Tripathi

High Impact

Postdoctoral researcher

UAMS

Also affiliated: Indian Institute of Chemical Biology (2012); Chaudhary Charan Singh University (2025); Indian Institute of Technology BHU (2017–2022); Banaras Hindu University (2017–2022)

20 h-index 51 pubs 1,765 cited

Research Areas

Biomedical Subjects

Links

ORCID Research Group

OverviewAI-generated summary

Prabhash Nath Tripathi's research focuses on the development of potential inhibitors for acetylcholinesterase (AChE) and amyloid-beta (Aβ) aggregation, primarily targeting therapeutic strategies for Alzheimer's disease. His work involves screening compounds through in vitro biochemical assays and in vivo models. Tripathi also employs computational methods, including Schrodinger software, and analytical tools such as UV-Vis, FTIR, and NMR to validate experimental findings. He has investigated various molecular scaffolds, including 1,3,4-oxadiazole, 2-pyridylpiperazine, N-benzylpiperidine, and ferulic acid, to identify compounds with inhibitory activity against cholinesterases, beta-secretase-1, amyloid-beta, and oxidative stress.

His research methodology includes the synthesis and evaluation of rationally designed compounds using in vitro enzyme and cell-based assays, as well as in vivo preclinical and ex vivo studies. Tripathi has collaborated with other researchers at the University of Arkansas for Medical Sciences, including Amit Kumar Tiwari and Sanjana Sood, on projects related to hybrid ligands for Alzheimer's disease treatment. Prior to his current research, he accumulated three years of industrial experience in the synthesis of organic molecules, including carbohydrate-based compounds and biological dyes.

Tripathi leads a research group and has an h-index of 20 with over 1,700 citations across his 59 publications. He has been recognized as a highly cited researcher. His recent publications include reviews on Alzheimer's disease pathogenesis and therapeutic strategies, as well as research articles detailing the design and development of novel molecular hybrids and derivatives with potential applications in treating Alzheimer's disease and inflammation.

Metrics

h-index: 20
Publications: 51
Citations: 1,765

Positions

Postdoctoral researcher 2024–present

University of Arkansas for Medical Sciences Department of Pharmaceutical Sciences ORCID
Assistant Professor 2021–present

Meerut Institute of Engineering and Technology Department of Pharmaceutical Technology ORCID
Research Scholar 2013–present

Indian Institute of Technology BHU Department of Pharmaceutical Engineering and Technology ORCID

Selected Publications

Mustard seeds and curry leaves: Flavorful defenders of blood sugar (2026)

Elsevier eBooks DOI OpenAlex
A Macropinocytosis-Driven Approach for Efficient Delivery of Small- and Macromolecular Cancer Therapeutics in Cancer (Abstract ID: 227830) (2026)

Journal of Pharmacology and Experimental Therapeutics DOI OpenAlex
Abstract LB315: Targeting endolysosomal trafficking to overcome paclitaxel resistance in triple-negative breast cancer (2026)

Cancer Research DOI OpenAlex
Exploring promising pharmaceutical candidates for antiaging (2025)

Neurobiology of Aging DOI OpenAlex
Therapeutic approaches to age related cognitive decline and neurodegenerative diseases (2025)

Neurobiology of Aging DOI OpenAlex
Mitochondrial dysfunction and aging (2025)

Neurobiology of Aging 3 citations DOI OpenAlex
Neuronal loss and synaptic dysfunction (2025)

Neurobiology of Aging DOI OpenAlex
Nutrient-Sensing Pathways: Gatekeepers of Longevity (2025)

Nutritional neurosciences 3 citations DOI OpenAlex
Intellectual Property Rights in Neuroprotective Biomaterials (2025)

40 citations DOI OpenAlex
Emerging Trends: Neurofilament Biomarkers in Precision Neurology (2024)

Neurochemical Research 31 citations DOI OpenAlex