P
Prabhash Nath Tripathi
High Impact
Postdoctoral researcher
postdoc
20 h-index
56 pubs
1,696 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Prabhash Nath Tripathi's research focuses on the development of potential inhibitors for acetylcholinesterase (AChE) and amyloid-beta (Aβ) aggregation, primarily targeting Alzheimer's disease. His work involves extensive in vitro biochemical assays and in vivo model testing, complemented by computational methods for validating experimental findings. Tripathi has explored various chemical scaffolds, including 1,3,4-oxadiazole, 2-pyridylpiperazine, N-benzylpiperidine, and ferulic acid, to identify compounds with inhibitory activity against cholinesterases, β-secretase-1, amyloid-β, and oxidative stress.
His research methodology includes the synthesis and evaluation of rationally designed compounds through in vitro enzyme and cell-based assays, preclinical in vivo studies, and ex vivo studies using rat brains. Tripathi has also contributed to collaborative research efforts aimed at discovering hybrid ligands for Alzheimer's disease treatment. Prior to his current research, he accumulated three years of industrial experience in the synthesis of organic molecules, such as carbohydrate-based molecules (nucleosides and nucleotides) and biological dyes.
Tripathi has an h-index of 20, with over 1,673 citations across 54 publications. He is recognized as a highly cited researcher and leads a research group at the University of Arkansas for Medical Sciences. His collaborators include Amit K. Tiwari, Amit Tiwari, Sanjana Sood, and Saloni Sood.
Metrics
- h-index: 20
- Publications: 56
- Citations: 1,696
Selected Publications
-
Exploring promising pharmaceutical candidates for antiaging (2025)
-
Therapeutic approaches to age related cognitive decline and neurodegenerative diseases (2025)
-
Mitochondrial dysfunction and aging (2025)
-
Neuronal loss and synaptic dysfunction (2025)
-
Nutrient-Sensing Pathways: Gatekeepers of Longevity (2025)
-
Intellectual Property Rights in Neuroprotective Biomaterials (2025)
-
Emerging Trends: Neurofilament Biomarkers in Precision Neurology (2024)
Collaboration Network
Top Collaborators
Abdel‐Nasser El‐Shorbagi
6 shared publications
- Review of Pharmacotherapeutic Targets in Alzheimer’s Disease and Its Management Using Traditional Medicinal Plants
- Marine Antineoplastic Templates: Clinical trials (I-III) and Motifs Carried via Antibodies to Target Specific Cancerous Tissues
- The Recent Updates on Neoteric Variants of Covid-19 Virus and Therapeutic Effectiveness of Vaccines against the Variants.
- Beta-Lactamases Inhibitors: A Perspective on the Existing and the Potential Admixtures to Synergize Beta-lactams Versus Resistant Superbugs
- Structural Variance of Doxorubicin and Anthracycline Analogues as Topoisomerase Alpha and Beta (Top2a and Top2b) Inhibitors. Potential Design of Analogue Candidates of Less Side Effects on Cardiomyocytes.
Showing 5 of 6 shared publications
Anurag Chaudhary
6 shared publications
- Multifaceted Neuroprotective Role of Punicalagin: A Review
- Marine Antineoplastic Templates: Clinical trials (I-III) and Motifs Carried via Antibodies to Target Specific Cancerous Tissues
- The Recent Updates on Neoteric Variants of Covid-19 Virus and Therapeutic Effectiveness of Vaccines against the Variants.
- Beta-Lactamases Inhibitors: A Perspective on the Existing and the Potential Admixtures to Synergize Beta-lactams Versus Resistant Superbugs
- Nanofertilizers
Showing 5 of 6 shared publications
Nazia Siddiqui
6 shared publications
- Multifaceted Neuroprotective Role of Punicalagin: A Review
- Therapeutic potential of baicalein against neurodegenerative diseases: An updated review
- Ameliorative Role of Phosphodiesterase-5 (PDE-5) Inhibitor “Avanafil” via Modulating cAMP & cGMP Pathway Against Alzheimer’s Disease
- Preclinical Studies of Euphorbia lactea Aerial Extract on Atherogenic-Diet-Induced Atherosclerosis
- Ameliorative role of Phosphodiesterase-5 (PDE-5) inhibitor “Avanafil” via modulating cAMP & cGMP Pathway against Alzheimer’s disease
Showing 5 of 6 shared publications
Digambar Kumar Waiker
Banaras Hindu University (IN)
5 shared publications
- Design, synthesis, and evaluation of some novel biphenyl imidazole derivatives for the treatment of Alzheimer's disease
- Novel 5,6-diphenyl-1,2,4-triazine-3-thiol derivatives as dual COX-2/5-LOX inhibitors devoid of cardiotoxicity
- Drug reposition-based design, synthesis, and biological evaluation of dual inhibitors of acetylcholinesterase and β-Secretase for treatment of Alzheimer's disease
- Synthesis, characterization, and biological evaluation of some novel ϒ-aminobutyric acid aminotransferase (GABA-AT) inhibitors
- Synthesis, characterization, and biological evaluation of some novel ϒ-aminobutyric acid aminotransferase (GABA-AT) inhibitors
Sushant K. Shrivastava
Banaras Hindu University (IN)
5 shared publications
- Design, synthesis, and evaluation of some novel biphenyl imidazole derivatives for the treatment of Alzheimer's disease
- Novel 5,6-diphenyl-1,2,4-triazine-3-thiol derivatives as dual COX-2/5-LOX inhibitors devoid of cardiotoxicity
- Drug reposition-based design, synthesis, and biological evaluation of dual inhibitors of acetylcholinesterase and β-Secretase for treatment of Alzheimer's disease
- Synthesis, characterization, and biological evaluation of some novel ϒ-aminobutyric acid aminotransferase (GABA-AT) inhibitors
- Synthesis, characterization, and biological evaluation of some novel ϒ-aminobutyric acid aminotransferase (GABA-AT) inhibitors
Mohd Talib
Chaudhary Charan Singh University (IN)
5 shared publications
- Therapeutic potential of baicalein against neurodegenerative diseases: An updated review
- Nanofertilizers
- Ameliorative Role of Phosphodiesterase-5 (PDE-5) Inhibitor “Avanafil” via Modulating cAMP & cGMP Pathway Against Alzheimer’s Disease
- Ameliorative role of Phosphodiesterase-5 (PDE-5) inhibitor “Avanafil” via modulating cAMP & cGMP Pathway against Alzheimer’s disease
- Correction to: Ameliorative Role of Phosphodiesterase-5 (PDE-5) Inhibitor “Avanafil” Via Modulating cAMP & cGMP Pathway Against Alzheimer’s Disease
Akash Verma
Banaras Hindu University (IN)
4 shared publications
- Design, synthesis, and evaluation of some novel biphenyl imidazole derivatives for the treatment of Alzheimer's disease
- Drug reposition-based design, synthesis, and biological evaluation of dual inhibitors of acetylcholinesterase and β-Secretase for treatment of Alzheimer's disease
- Synthesis, characterization, and biological evaluation of some novel ϒ-aminobutyric acid aminotransferase (GABA-AT) inhibitors
- Synthesis, characterization, and biological evaluation of some novel ϒ-aminobutyric acid aminotransferase (GABA-AT) inhibitors
Poorvi Saraf
Banaras Hindu University (IN)
4 shared publications
- Novel 5,6-diphenyl-1,2,4-triazine-3-thiol derivatives as dual COX-2/5-LOX inhibitors devoid of cardiotoxicity
- Drug reposition-based design, synthesis, and biological evaluation of dual inhibitors of acetylcholinesterase and β-Secretase for treatment of Alzheimer's disease
- Synthesis, characterization, and biological evaluation of some novel ϒ-aminobutyric acid aminotransferase (GABA-AT) inhibitors
- Synthesis, characterization, and biological evaluation of some novel ϒ-aminobutyric acid aminotransferase (GABA-AT) inhibitors
Garima Agarwal
Chaudhary Charan Singh University (IN)
4 shared publications
- Marine Antineoplastic Templates: Clinical trials (I-III) and Motifs Carried via Antibodies to Target Specific Cancerous Tissues
- The Recent Updates on Neoteric Variants of Covid-19 Virus and Therapeutic Effectiveness of Vaccines against the Variants.
- Beta-Lactamases Inhibitors: A Perspective on the Existing and the Potential Admixtures to Synergize Beta-lactams Versus Resistant Superbugs
- Structural Variance of Doxorubicin and Anthracycline Analogues as Topoisomerase Alpha and Beta (Top2a and Top2b) Inhibitors. Potential Design of Analogue Candidates of Less Side Effects on Cardiomyocytes.
Shweta Dumoga
Chaudhary Charan Singh University (IN)
4 shared publications
- Marine Antineoplastic Templates: Clinical trials (I-III) and Motifs Carried via Antibodies to Target Specific Cancerous Tissues
- The Recent Updates on Neoteric Variants of Covid-19 Virus and Therapeutic Effectiveness of Vaccines against the Variants.
- Beta-Lactamases Inhibitors: A Perspective on the Existing and the Potential Admixtures to Synergize Beta-lactams Versus Resistant Superbugs
- Structural Variance of Doxorubicin and Anthracycline Analogues as Topoisomerase Alpha and Beta (Top2a and Top2b) Inhibitors. Potential Design of Analogue Candidates of Less Side Effects on Cardiomyocytes.
Ankit Chaudhary
4 shared publications
- Multifaceted Neuroprotective Role of Punicalagin: A Review
- Ameliorative Role of Phosphodiesterase-5 (PDE-5) Inhibitor “Avanafil” via Modulating cAMP & cGMP Pathway Against Alzheimer’s Disease
- Ameliorative role of Phosphodiesterase-5 (PDE-5) inhibitor “Avanafil” via modulating cAMP & cGMP Pathway against Alzheimer’s disease
- Correction to: Ameliorative Role of Phosphodiesterase-5 (PDE-5) Inhibitor “Avanafil” Via Modulating cAMP & cGMP Pathway Against Alzheimer’s Disease
Bhagwati Bhardwaj
Banaras Hindu University (IN)
3 shared publications
- Drug reposition-based design, synthesis, and biological evaluation of dual inhibitors of acetylcholinesterase and β-Secretase for treatment of Alzheimer's disease
- Synthesis, characterization, and biological evaluation of some novel ϒ-aminobutyric acid aminotransferase (GABA-AT) inhibitors
- Synthesis, characterization, and biological evaluation of some novel ϒ-aminobutyric acid aminotransferase (GABA-AT) inhibitors
Sachin Chaudhary
University of Sharjah (AE)
3 shared publications
- Marine Antineoplastic Templates: Clinical trials (I-III) and Motifs Carried via Antibodies to Target Specific Cancerous Tissues
- The Recent Updates on Neoteric Variants of Covid-19 Virus and Therapeutic Effectiveness of Vaccines against the Variants.
- Beta-Lactamases Inhibitors: A Perspective on the Existing and the Potential Admixtures to Synergize Beta-lactams Versus Resistant Superbugs
Ankit Lodhi
Shobhit University (IN)
3 shared publications
- Review of Pharmacotherapeutic Targets in Alzheimer’s Disease and Its Management Using Traditional Medicinal Plants
- Nanofertilizers
- Exploring promising pharmaceutical candidates for antiaging
Sachchida Nand
Banaras Hindu University (IN)
3 shared publications
- Review of Pharmacotherapeutic Targets in Alzheimer’s Disease and Its Management Using Traditional Medicinal Plants
- Intellectual Property Rights in Neuroprotective Biomaterials
- Baicalein's neuroprotective effects in a lansoprazole-induced Alzheimer's model in Wistar rats
Similar Researchers
Based on overlapping research topics
Nouf Masarweh
University of Arkansas at Little Rock
Alzheimer's disease research and treatments
Neurological disorders and treatments
Computational Drug Discovery Methods
Andrew N. Shen
National Center for Toxicological Research
Alzheimer's disease research and treatments
Neurological disorders and treatments
Neuroscience and Neuropharmacology Research
Alejandro Ramirez-Lee
National Center for Toxicological Research
Neurological disorders and treatments
Neuroscience and Neuropharmacology Research
Protein Degradation and Inhibitors
Steven W. Barger
University of Arkansas for Medical Sciences
Alzheimer's disease research and treatments
Neurological disorders and treatments
Neuroscience and Neuropharmacology Research
Gurjit Nagra
University of Arkansas – Fort Smith
Neurological disorders and treatments
Neuroscience and Neuropharmacology Research
Meta-analysis and systematic reviews
Sumit Sarkar
National Center for Toxicological Research
Alzheimer's disease research and treatments
Neurological disorders and treatments
Neuroscience and Neuropharmacology Research