Match tier
Confirmed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-08
S
Shilpa Iyer
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Federal Grant PI
Associate Professor
Also affiliated: University of Pennsylvania (2016)
1 h-index
3 pubs
37 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Shilpa Iyer's research focuses on mitochondrial function and its role in human diseases, particularly neurodegenerative disorders. She investigates how mitochondrial gene therapy can improve cellular respiration, biogenesis, and transcription in cells affected by conditions like Leber's hereditary optic neuropathy and Leigh syndrome. Her work also extends to quantifying mitochondrial dynamics in patient fibroblasts with developmental defects and mitochondrial disorders.
Dr. Iyer is currently serving as Principal Investigator on a $606,257 NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development grant. This project investigates the metabolic regulation of Multiple Organ Dysfunction Syndrome (MODS) in pediatric mitochondrial disorders. Her scholarly network includes frequent collaborators at the University of Arkansas at Fayetteville, such as Raj R. Rao, Fibi Meshrkey, Bibhuti Ballav Saikia, and Joshua Stabach, with whom she has co-authored numerous publications.
Her previous research has explored topics such as telomere function in yeast and the role of specific genes in mitochondrial health. She has published on recombinant mitochondrial transcription factor A and its impact on cellular respiration and gene expression, as well as the implications of short telomeres in yeast recombination.
Metrics
- h-index: 1
- Publications: 3
- Citations: 37
Positions
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Associate Professor publications 2022University of Arkansas Biological Sciences ORCID
Selected Publications
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Evaluation of Human Stem Cell Conditioned Medium and Culture Conditions on Alleviating Elastase-Compromised Human Aortic Smooth Muscle Cell Function (2026)
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Mitochondrial morphology in human fibroblasts and induced pluripotent stem cells in Leigh syndrome: A comparative analysis (2026)
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Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A) (2026)
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Additional file 4 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A) (2026)
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Additional file 3 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A) (2026)
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Additional file 4 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A) (2026)
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Additional file 5 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A) (2026)
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Additional file 1 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A) (2026)
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Additional file 2 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A) (2026)
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Additional file 3 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A) (2026)
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Additional file 1 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A) (2026)
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Additional file 5 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A) (2026)
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Additional file 2 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A) (2026)
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Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A) (2026)
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Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A) (2026)
Federal Grants 1 $606,257 total
NIH
Contact PI
Aug 2023 - May 2028
Metabolic regulation of MODS in pediatric mitochondrial disorders
Collaboration Network
Top Collaborators
Fibi Meshrkey
University of Kansas
18 shared publications
In database
- Quantitative analysis of mitochondrial morphologies in human induced pluripotent stem cells for Leigh syndrome
- Induced pluripotent stem cells derived from patients carrying mitochondrial mutations exhibit altered bioenergetics and aberrant differentiation potential
- MitoCellPhe reveals mitochondrial morphologies in single fibroblasts and clustered stem cells
- Induced pluripotent stem cell models for mitochondrial disorders
- List of contributors
Showing 5 of 18 shared publications
Kelly M. Scheulin
15 shared publications
- Induced pluripotent stem cells derived from patients carrying mitochondrial mutations exhibit altered bioenergetics and aberrant differentiation potential
- Creating patient-specific stem cell models and characterizing metabolic changes in Leigh’s Syndrome
- Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
- Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
- Additional file 2 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
Showing 5 of 15 shared publications
Joshua Stabach
University of Arkansas at Fayetteville
15 shared publications
In database
- Quantifying Mitochondrial Dynamics in Patient Fibroblasts with Multiple Developmental Defects and Mitochondrial Disorders
- Induced pluripotent stem cells derived from patients carrying mitochondrial mutations exhibit altered bioenergetics and aberrant differentiation potential
- Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
- Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
- Additional file 2 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
Showing 5 of 15 shared publications
Bibhuti Ballav Saikia
University of Arkansas at Fayetteville
15 shared publications
In database
- The Saga of Endocrine FGFs
- Induced pluripotent stem cells derived from patients carrying mitochondrial mutations exhibit altered bioenergetics and aberrant differentiation potential
- Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
- Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
- Additional file 2 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
Showing 5 of 15 shared publications
Raj R. Rao
University of Arkansas at Fayetteville
14 shared publications
In database
- Quantitative analysis of mitochondrial morphologies in human induced pluripotent stem cells for Leigh syndrome
- Induced pluripotent stem cells derived from patients carrying mitochondrial mutations exhibit altered bioenergetics and aberrant differentiation potential
- Knockdown of CDK2AP1 in human embryonic stem cells reduces the threshold of differentiation
- MitoCellPhe reveals mitochondrial morphologies in single fibroblasts and clustered stem cells
- Cell-Permeable Succinate Increases Mitochondrial Membrane Potential and Glycolysis in Leigh Syndrome Patient Fibroblasts
Showing 5 of 14 shared publications
Franklin D. West
13 shared publications
- Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
- Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
- Additional file 2 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
- Additional file 5 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
- Additional file 1 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
Showing 5 of 13 shared publications
Raj R. Rao
University of Arkansas at Fayetteville
10 shared publications
In database
- Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
- Additional file 2 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
- Additional file 1 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
- Additional file 3 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
- Additional file 2 of Impaired mitochondrial morphology and respiratory dysfunction in human induced pluripotent stem cells with mitochondrial tRNA mutations (m.3243A>G and m.14739G>A)
Showing 5 of 10 shared publications
Ajibola B. Bakare
University of Arkansas Medical Center
7 shared publications
In database
- Leigh Syndrome: A Tale of Two Genomes
- Quantifying Mitochondrial Dynamics in Patient Fibroblasts with Multiple Developmental Defects and Mitochondrial Disorders
- Evaluating the Bioenergetics Health Index Ratio in Leigh Syndrome Fibroblasts to Understand Disease Severity
- MitoCellPhe reveals mitochondrial morphologies in single fibroblasts and clustered stem cells
- Cell-Permeable Succinate Increases Mitochondrial Membrane Potential and Glycolysis in Leigh Syndrome Patient Fibroblasts
Showing 5 of 7 shared publications
Edward J. Lesnefsky
Virginia Commonwealth University (US)
6 shared publications
- Leigh Syndrome: A Tale of Two Genomes
- mRNA Reprogramming of T8993G Leigh's Syndrome Fibroblast Cells to Create Induced Pluripotent Stem Cell Models for Mitochondrial Disorders
- Evaluating the Bioenergetics Health Index Ratio in Leigh Syndrome Fibroblasts to Understand Disease Severity
- Induced pluripotent stem cells derived from patients carrying mitochondrial mutations exhibit altered bioenergetics and aberrant differentiation potential
- Creating patient-specific stem cell models and characterizing metabolic changes in Leigh’s Syndrome
Showing 5 of 6 shared publications
Franklin D. West
University of Georgia (US)
4 shared publications
- mRNA Reprogramming of T8993G Leigh's Syndrome Fibroblast Cells to Create Induced Pluripotent Stem Cell Models for Mitochondrial Disorders
- Induced pluripotent stem cells derived from patients carrying mitochondrial mutations exhibit altered bioenergetics and aberrant differentiation potential
- Creating patient-specific stem cell models and characterizing metabolic changes in Leigh’s Syndrome
- Induced pluripotent stem cell models for mitochondrial disorders
Harrison E. Grace
University of Georgia (US)
2 shared publications
- mRNA Reprogramming of T8993G Leigh's Syndrome Fibroblast Cells to Create Induced Pluripotent Stem Cell Models for Mitochondrial Disorders
- Creating patient-specific stem cell models and characterizing metabolic changes in Leigh’s Syndrome
Vedant Thorat
University School (US)
2 shared publications
- Evaluating the Bioenergetics Health Index Ratio in Leigh Syndrome Fibroblasts to Understand Disease Severity
- Induced pluripotent stem cells derived from patients carrying mitochondrial mutations exhibit altered bioenergetics and aberrant differentiation potential
Thomas LaFramboise
University School (US)
2 shared publications
- Evaluating the Bioenergetics Health Index Ratio in Leigh Syndrome Fibroblasts to Understand Disease Severity
- Induced pluripotent stem cells derived from patients carrying mitochondrial mutations exhibit altered bioenergetics and aberrant differentiation potential
Christofer Baldwin
University of Arkansas at Fayetteville
2 shared publications
In database
- The Challenges and Prospects of Smooth Muscle Tissue Engineering
- Evaluation of Human Stem Cell Conditioned Medium and Culture Conditions on Alleviating Elastase-Compromised Human Aortic Smooth Muscle Cell Function
Khaled Alsayegh
Virginia Commonwealth University (US)
1 shared publication
- Knockdown of CDK2AP1 in human embryonic stem cells reduces the threshold of differentiation
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