Match tier
Listed
Presence
Current · Arkansas
Last published
2015
Sources
OpenAlex · ORCID
Refreshed
2026-08-08
S
Subramaniam Ponnappan
Researcher
Also affiliated: Central Arkansas Veterans Healthcare System (2004–2007)
Faculty Researcher
11 h-index
17 pubs
580 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Subramaniam Ponnappan's research has focused on the mechanisms of specific cellular processes, including the role of protein synthesis and degradation in various biological contexts. His work has investigated the ubiquitin-proteasome pathway and its involvement in cellular regulation and disease. Ponnappan has also explored the functions of microRNAs in disease regulation and their potential as therapeutic targets.
Metrics
- h-index: 11
- Publications: 17
- Citations: 580
Selected Publications
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Redox-Regulated Pathway of Tyrosine Phosphorylation Underlies NF-κB Induction by an Atypical Pathway Independent of the 26S Proteasome (2015)
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Compensatory increase in USP14 activity accompanies impaired proteasomal proteolysis during aging (2013)
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Altered regulation of CXCR4 expression during aging contributes to increased CXCL12‐dependent chemotactic migration of CD4<sup>+</sup> T cells (2012)
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Age-associated changes in Non-muscle Myosin IIA and CXCR4 regulates increased migration induced by SDF1 in CD4+ T lymphocytes from elderly human donors. (102.8) (2011)
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Impairment of non-muscle myosin IIA in human CD4+ T cells contributes to functional deficits in the elderly (2011)
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Increased activity of proteasome associated deubiquitinating enzyme, USP14, accompanies lowered proteasomal proteolysis in primary human T lymphocytes during aging. (63.18) (2011)
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Aging and Immune Function: Molecular Mechanisms to Interventions (2010)
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Contribution of HSP90 to the proteasomal dysfunction accompanying immune senescence (35.14) (2009)
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Proteasome inhibition up-regulates inflammatory gene transcription induced by an atypical pathway of NF-κB activation (2009)
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Catalytic activity of the proteasome fine-tunes Brg1-mediated chromatin remodeling to regulate the expression of inflammatory genes (2009)
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Recruitment of proteasome catalytic subunit dictates NFkB-mediated transcriptional termination (136.3) (2009)
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Ca2+ Homeostasis Regulates Xenopus Oocyte Maturation1 (2007)
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Lower expression of catalytic and structural subunits of the proteasome contributes to decreased proteolysis in peripheral blood T lymphocytes during aging (2007)
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Redox regulation of the proteasome in T lymphocytes during aging (2006)
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Constitutive degradation of IκBα in human T lymphocytes is mediated by calpain (2005)
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