Angus M. MacNicol
Federal Grant PI
High Impact
Professor
faculty
Neurobiology & Developmental Science, College of Medicine
27 h-index
101 pubs
2,585 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Angus M. MacNicol studies the post-transcriptional regulation of gene expression, particularly focusing on the role of RNA-binding proteins in controlling protein synthesis. His research investigates how these proteins, such as Musashi, influence cellular processes by directing the translation of specific messenger RNAs (mRNAs). This work has implications for understanding fundamental biological mechanisms and has been applied to investigate disease states, including cancer and metabolic disorders.
MacNicol's laboratory has explored the anti-cancer activity of compounds like monensin and salinomycin analogs in various cancer models, including organoids and 3D cultures. His recent publications also examine the impact of diet on anterior pituitary transcriptomics and cell metabolism, as well as the influence of maternal undernutrition on offspring gene expression. He has collaborated extensively with researchers at the University of Arkansas for Medical Sciences, including Melanie Clair Macnicol, Gwen V. Childs, Angela K. Odle, and Anessa Haney, with whom he has co-authored numerous publications.
His scholarly contributions are recognized through a high-impact researcher designation, indicating high citation counts. MacNicol serves as a principal investigator on federal grants, further underscoring the significance of his research endeavors. His work contributes to the fields of neurobiology, developmental science, and cancer research, with a specific emphasis on molecular mechanisms and translational control.
Metrics
- h-index: 27
- Publications: 101
- Citations: 2,585
Selected Publications
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Secretogranin II-Derived Peptide Secretoneurin Differentially Stimulates Luteinizing Hormone Secretion by Age and Sex in Ex Vivo Murine Pituitaries (2026)
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OR13-08 Secretoneurin Modulates Gonadotrope Function Cyclically to Regulate LH Secretion (2025)
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SAT-001 Impact of VCD-induced Menopause on Gonadotrope Transcriptomics Reveals Estrogen-dependent Genes in the GnRH Signaling Pathway (2025)
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SAT-016 Musashi Contributes to the Specification and Maintenance of Distinct Pituitary Cell Lineages. (2025)
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Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models (2025)
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High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes (2025)
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Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model (2025)
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Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice (2025)
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8572 A 30% Maternal Caloric Restriction Alters Expression of Musashi Targets in the Neonatal and Adult Pituitary Proteomes of FVB Mice (2024)
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8649 Ablation of Leptin Receptors in Somatotropes Impacts Transcriptomic Plasticity in the Pou1f1 Lineage of Female Pituitary Cells (2024)
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The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs (2024)
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Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain (2024)
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Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism (2023)
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FRI289 It Takes A Village: Musashi And Its Associated Proteins In The Adenohypophysis (2023)
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FRI290 Proteomic Identification Of Secretoneurin-Stimulated Proteins In Purified Mouse Gonadotropes (2023)
Grants & Funding
- Maternal gene regulation in early vertebrate development NIH Principal Investigator
- Control of pituitary cell plasticity through regulated mRNA translation NIH Principal Investigator
- Molecular mechanisms of pituitary plasticity NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases Principal Investigator
- G-quadruplex DNA as a chemical signaling agent NIH Co-Investigator
- Small Molecule Chemical Screening for Inhibitors of Breast Cancer Tumor-Initiating Cell Self-Renewal Proliferation Arkansas Breast Cancer Research Program Principal Investigator
- RAF-1 REGULATION DURING CELL GROWTH AND DIFFERENTIATION NIH Principal Investigator
- Molecular mechanisms of pituitary plasticity NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases Principal Investigator
- Small Molecule Chemical Screening for Inhibitors of Breast Cancer Tumor-Initiating Cell Self-Renewal Proliferation Arkansas Breast Cancer Research Program Principal Investigator
Collaboration Network
Top Collaborators
Melanie C MacNicol
University of Arkansas for Medical Sciences
30 shared publications
In database
- Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Post-Transcriptional Regulation of Gnrhr: A Checkpoint for Metabolic Control of Female Reproduction
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
Showing 5 of 30 shared publications
Gwen V. Childs
University of Arkansas for Medical Sciences
28 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Post-Transcriptional Regulation of Gnrhr: A Checkpoint for Metabolic Control of Female Reproduction
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Musashi-dependent mRNA translational activation is mediated through association with the Scd6/Like-sm family member, LSM14B
Showing 5 of 28 shared publications
Angela K. Odle
University of Arkansas for Medical Sciences
22 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Post-Transcriptional Regulation of Gnrhr: A Checkpoint for Metabolic Control of Female Reproduction
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
Showing 5 of 22 shared publications
Anessa Haney
University of Arkansas for Medical Sciences
16 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
Showing 5 of 16 shared publications
Tiffany K. Miles
Arkansas Children's Hospital
14 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
- Mild Maternal Undernutrition Results in a Premature Neonatal Leptin Surge that Promotes Resistance in Male Offspring to a High Fat Diet
Showing 5 of 14 shared publications
Alex Lagasse
University of Arkansas for Medical Sciences
14 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
Showing 5 of 14 shared publications
Jewel Banik
Stanford University
11 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Musashi-dependent mRNA translational activation is mediated through association with the Scd6/Like-sm family member, LSM14B
- The Musashi1 RNA-Binding Protein Functions as a Leptin-Regulated Enforcer of Pituitary Cell Fate and Hormone Production
Showing 5 of 11 shared publications
Linda Hardy
University of Arkansas for Medical Sciences
10 shared publications
In database
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Musashi-dependent mRNA translational activation is mediated through association with the Scd6/Like-sm family member, LSM14B
- The Cell Fate Determinant Musashi Is Controlled Through Dynamic Protein:Protein Interactions
- PMON29 A Comparative Analysis of Musashi-Dependent Control of Mouse and Human Pituitary mRNA Translation
Showing 5 of 10 shared publications
Alicja Urbaniak
Cancer Institute (WIA)
9 shared publications
In database
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- Abstract PS18-46: Inhibition of breast cancer stem cells in 2- and 3-dimensional culture by novel salinomycin analogs
- Monensin and its analogues show anti‐glioblastoma activity in an organoid model of cancer
Showing 5 of 9 shared publications
Ashley Herdman
University of Arkansas for Medical Sciences
9 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
- PMON55 Calcium Imaging in the Intact Mouse Pituitary: A Novel Design for Understanding the Formation and Modulation of the Gonadotrope Network
- FRI290 Proteomic Identification Of Secretoneurin-Stimulated Proteins In Purified Mouse Gonadotropes
- 8649 Ablation of Leptin Receptors in Somatotropes Impacts Transcriptomic Plasticity in the Pou1f1 Lineage of Female Pituitary Cells
Showing 5 of 9 shared publications
Stephanie D. Byrum
St. Jude Children's Research Hospital
9 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
- RF25 | PMON50 Insight into Integrated Control of Pituitary Function Revealed Through Analysis of Musashi Target mRNAs
- OR20-03 Leptin-mediated Regulation Of Gene Regulatory Networks In Gonadotropes
Showing 5 of 9 shared publications
Juchan Lim
Symbiosis International University
8 shared publications
In database
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Musashi-dependent mRNA translational activation is mediated through association with the Scd6/Like-sm family member, LSM14B
- The Musashi1 RNA-Binding Protein Functions as a Leptin-Regulated Enforcer of Pituitary Cell Fate and Hormone Production
- OR08-2 Functional Association of the Stem Cell Protein Musashi With LSM14B in Control of mRNA Translation
Showing 5 of 8 shared publications
Megan R. Reed
University of Arkansas for Medical Sciences
6 shared publications
In database
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models
- Abstract PS18-46: Inhibition of breast cancer stem cells in 2- and 3-dimensional culture by novel salinomycin analogs
- Monensin and its analogues show anti‐glioblastoma activity in an organoid model of cancer
- Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model
Showing 5 of 6 shared publications
Adam Huczyński
Adam Mickiewicz University in Poznań (PL)
6 shared publications
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models
- Abstract PS18-46: Inhibition of breast cancer stem cells in 2- and 3-dimensional culture by novel salinomycin analogs
- Monensin and its analogues show anti‐glioblastoma activity in an organoid model of cancer
- Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model
Showing 5 of 6 shared publications
Robert L. Eoff
University of Arkansas for Medical Sciences
6 shared publications
In database
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models
- Abstract PS18-46: Inhibition of breast cancer stem cells in 2- and 3-dimensional culture by novel salinomycin analogs
- Monensin and its analogues show anti‐glioblastoma activity in an organoid model of cancer
- Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model
Showing 5 of 6 shared publications
Similar Researchers
Based on overlapping research topics
Melanie C MacNicol
University of Arkansas for Medical Sciences
RNA and protein synthesis mechanisms
Diet and metabolism studies
Neuroscience and Neuropharmacology Research
Yuntao Dai
University of Arkansas at Fayetteville
Cancer Treatment and Pharmacology
Molecular Biology Techniques and Applications
Cancer-related molecular mechanisms research
Gwen V. Childs
University of Arkansas for Medical Sciences
RNA and protein synthesis mechanisms
Diet and metabolism studies
Neuroscience and Neuropharmacology Research
Robin Eluvathingal
University of Arkansas for Medical Sciences
Cancer Treatment and Pharmacology
Diet and metabolism studies
Cancer-related molecular mechanisms research
Angus Macnicol
University of Arkansas for Medical Sciences
RNA and protein synthesis mechanisms
Diet and metabolism studies
Neuroscience and Neuropharmacology Research
Megan R. Reed
University of Arkansas for Medical Sciences
Cancer Treatment and Pharmacology
Neuroscience and Neuropharmacology Research
Molecular Biology Techniques and Applications