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Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-08-15
Angus M. MacNicol
Federal Grant PI
High Impact
Professor
Also affiliated: Arkansas Children's Hospital (2002); Howard Hughes Medical Institute (1993); University of California, San Francisco (1993–1995); Cancer Institute (WIA) (2025); University of Chicago (1994–2001); May Institute (2000–2001); Winthrop Rockefeller Foundation (2008–2025); Arkansas Department of Agriculture (2011); Health and Human Development (2HD) Research Network (2019); Daiichi Sankyo (United States) (1995); National Institute for Medical Research (1987)
Faculty Researcher
Neurobiology & Developmental Science, College of Medicine
27 h-index
104 pubs
2,710 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Angus M. MacNicol's research focuses on understanding the molecular mechanisms that regulate gene expression and protein synthesis, particularly in the context of female reproduction and disease. His work has investigated the role of RNA-binding proteins, such as Musashi, in controlling the translation of key messenger RNAs in the anterior pituitary, which plays a crucial role in the estrous cycle and metabolic control of reproduction.
MacNicol has also explored the potential therapeutic applications of natural compounds. His publications include studies on the anti-glioblastoma activity of monensin and its analogs, as well as the targeting of stem-like cells in breast cancer models using modified salinomycin analogs. Furthermore, his research has examined the impact of diet and oxidative stress on anterior pituitary transcriptomics and cell metabolism, and how maternal undernutrition can influence transcript changes in offspring, potentially affecting their resistance to diet-induced weight gain.
He holds a Professor position in Neurobiology & Developmental Science at the University of Arkansas for Medical Sciences, College of Medicine. MacNicol is a highly cited researcher with an h-index of 27 and over 100 publications. He has served as a principal investigator on federal grants and collaborates extensively with colleagues at his institution, including Melanie C. MacNicol, Gwen V. Childs, Angela K. Odle, and Alex Lagasse.
Metrics
- h-index: 27
- Publications: 104
- Citations: 2,710
Selected Publications
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ELAVL1 and ELAVL4 Are Required for Musashi-Dependent Translational Activation (2026)
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ELAVL1 and ELAVL4 are required for Musashi-dependent translational activation (2026)
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MassIVE MSV000102254 - ELAVL1 and ELAVL4 are required for Musashi1-dependent mRNA translational activation (2026)
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Gonadotrope remodeling in sustained low estrogen states: single-cell transcriptomic analysis reveals gonadotrope subtypes and activation of stem cell populations (2026)
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Secretogranin II–derived peptide secretoneurin differentially stimulates luteinizing hormone secretion by age and sex in ex vivo murine pituitaries (2026)
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OR13-08 Secretoneurin Modulates Gonadotrope Function Cyclically to Regulate LH Secretion (2025)
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SAT-001 Impact of VCD-induced Menopause on Gonadotrope Transcriptomics Reveals Estrogen-dependent Genes in the GnRH Signaling Pathway (2025)
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SAT-016 Musashi Contributes to the Specification and Maintenance of Distinct Pituitary Cell Lineages. (2025)
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Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models (2025)
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High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes (2025)
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Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model (2025)
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Musashi-dependent mRNA translational activation is mediated through association with the Scd6/Like-sm family member, LSM14B (2025)
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Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice (2025)
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8572 A 30% Maternal Caloric Restriction Alters Expression of Musashi Targets in the Neonatal and Adult Pituitary Proteomes of FVB Mice (2024)
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8649 Ablation of Leptin Receptors in Somatotropes Impacts Transcriptomic Plasticity in the Pou1f1 Lineage of Female Pituitary Cells (2024)
Grants & Funding
As listed on this researcher's institutional profile.
- Maternal gene regulation in early vertebrate development NIH Principal Investigator
- Control of pituitary cell plasticity through regulated mRNA translation NIH Principal Investigator
- Molecular mechanisms of pituitary plasticity NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases Principal Investigator
- G-quadruplex DNA as a chemical signaling agent NIH Co-Investigator
- Small Molecule Chemical Screening for Inhibitors of Breast Cancer Tumor-Initiating Cell Self-Renewal Proliferation Arkansas Breast Cancer Research Program Principal Investigator
- RAF-1 REGULATION DURING CELL GROWTH AND DIFFERENTIATION NIH Principal Investigator
- MRNA translational Control of Cell Cycle Progression American Cancer Society, Inc. Principal Investigator
- Leptin Molecular Regulatory Mechanisms That Prevent Growth hormone Deficiency NIH Co-Principal Investigator
- MRNA TRANSLATIONAL REGULATION IN HUMAN OOCYTES NIH Principal Investigator
- Post-transcriptional Pathways that Signal Leptin Regulation of Gonadotropes NIH Co-Principal Investigator
- Tropic Roles for Leptin in the Maturation of Somatotropes NIH Co-Principal Investigator
- Center for Molecular Interactions in Cancer (CMIC) NIH Co-Investigator
- Functions and Mechanisms of Helicases and G-Quadruplex Nucleic Acids NIH Co-Investigator
- The Impact of Obesity on Somatotrope Function NIH Co-Principal Investigator
- Evaluation of Obesity and Physical Inactivity in the “Spit for the Cure” Participants Arkansas Breast Cancer Research Program Principal Investigator
Collaboration Network
Top Collaborators
Melanie C MacNicol
University of Arkansas for Medical Sciences
24 shared publications
In database
- Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Post-Transcriptional Regulation of Gnrhr: A Checkpoint for Metabolic Control of Female Reproduction
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
Showing 5 of 24 shared publications
Gwen V. Childs
University of Arkansas for Medical Sciences
22 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Post-Transcriptional Regulation of Gnrhr: A Checkpoint for Metabolic Control of Female Reproduction
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
Showing 5 of 22 shared publications
Angela K. Odle
University of Arkansas for Medical Sciences
21 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Post-Transcriptional Regulation of Gnrhr: A Checkpoint for Metabolic Control of Female Reproduction
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
Showing 5 of 21 shared publications
Anessa Haney
University of Arkansas for Medical Sciences
15 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
Showing 5 of 15 shared publications
Tiffany K. Miles
Arkansas Children's Hospital
14 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
- Mild Maternal Undernutrition Results in a Premature Neonatal Leptin Surge that Promotes Resistance in Male Offspring to a High Fat Diet
Showing 5 of 14 shared publications
Alex Lagasse
University of Arkansas for Medical Sciences
13 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
Showing 5 of 13 shared publications
Stephanie D. Byrum
St. Jude Children's Research Hospital
8 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
- OR20-03 Leptin-mediated Regulation Of Gene Regulatory Networks In Gonadotropes
- FRI290 Proteomic Identification Of Secretoneurin-Stimulated Proteins In Purified Mouse Gonadotropes
Showing 5 of 8 shared publications
Ashley Herdman
University of Arkansas for Medical Sciences
8 shared publications
In database
- Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism
- Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice
- FRI290 Proteomic Identification Of Secretoneurin-Stimulated Proteins In Purified Mouse Gonadotropes
- 8649 Ablation of Leptin Receptors in Somatotropes Impacts Transcriptomic Plasticity in the Pou1f1 Lineage of Female Pituitary Cells
- High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes
Showing 5 of 8 shared publications
Alicja Urbaniak
Cancer Institute (WIA)
7 shared publications
In database
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- Abstract PS18-46: Inhibition of breast cancer stem cells in 2- and 3-dimensional culture by novel salinomycin analogs
- Monensin and its analogues show anti‐glioblastoma activity in an organoid model of cancer
Showing 5 of 7 shared publications
Megan R. Reed
University of Arkansas for Medical Sciences
6 shared publications
In database
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models
- Abstract PS18-46: Inhibition of breast cancer stem cells in 2- and 3-dimensional culture by novel salinomycin analogs
- Monensin and its analogues show anti‐glioblastoma activity in an organoid model of cancer
- Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model
Showing 5 of 6 shared publications
Adam Huczyński
Adam Mickiewicz University in Poznań (PL)
6 shared publications
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models
- Abstract PS18-46: Inhibition of breast cancer stem cells in 2- and 3-dimensional culture by novel salinomycin analogs
- Monensin and its analogues show anti‐glioblastoma activity in an organoid model of cancer
- Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model
Showing 5 of 6 shared publications
Robert L. Eoff
University of Arkansas for Medical Sciences
6 shared publications
In database
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models
- Abstract PS18-46: Inhibition of breast cancer stem cells in 2- and 3-dimensional culture by novel salinomycin analogs
- Monensin and its analogues show anti‐glioblastoma activity in an organoid model of cancer
- Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model
Showing 5 of 6 shared publications
Timothy C. Chambers
University of Arkansas for Medical Sciences
6 shared publications
In database
- Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer
- Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models
- Abstract PS18-46: Inhibition of breast cancer stem cells in 2- and 3-dimensional culture by novel salinomycin analogs
- Monensin and its analogues show anti‐glioblastoma activity in an organoid model of cancer
- Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model
Showing 5 of 6 shared publications
Ana Rita Silva Moreira
University of Arkansas for Medical Sciences (US)
6 shared publications
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain
- Mild Maternal Undernutrition Results in a Premature Neonatal Leptin Surge that Promotes Resistance in Male Offspring to a High Fat Diet
- Musashi as a Regulator of the Follicle-Stimulating Hormone in the Gonadotropes
Showing 5 of 6 shared publications
Ulrich Boehm
Saarland University (DE)
6 shared publications
- Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle
- The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs
- Musashi as a Regulator of the Follicle-Stimulating Hormone in the Gonadotropes
- OR20-03 Leptin-mediated Regulation Of Gene Regulatory Networks In Gonadotropes
- OR13-08 Secretoneurin Modulates Gonadotrope Function Cyclically to Regulate LH Secretion
Showing 5 of 6 shared publications
Similar Researchers
Based on overlapping research topics
Melanie C MacNicol
University of Arkansas for Medical Sciences
Reproductive Biology and Fertility
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University of Arkansas for Medical Sciences
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Elizabeth A Duplechain
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