Laura James Institution Verified
Sourced from institutional research profiles (UAMS TRI or ARA).
Professor
University of Arkansas for Medical Sciences
faculty
Peds Pediatrics, College of Medicine
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Laura James' research at the University of Arkansas for Medical Sciences focuses on translational studies of acetaminophen toxicity. She has developed novel approaches for quantifying acetaminophen protein adducts in peripheral blood samples. Dr. James also directs clinical trials in children, aiming to establish safe and effective drug dosing strategies across various disease areas. Her work contributes to the fields of pediatric pharmacology and health sciences research.
Prior to her role at UAMS, James' doctoral research involved behavioral ecology and the connection between observed behavioral phenotypes and underlying molecular mechanisms, particularly in response to agricultural stressors. Using bees as a model species, her research investigated the molecular impacts of chronic pesticide exposure on bumblebee learning and memory. This multidisciplinary background encompasses ecotoxicology, entomology, behavior, and molecular biology, allowing her to study the effects of environmental stressors on beneficial invertebrates in both field and laboratory settings.
Research Overview
Dr. James is the Director of the Translational Research Institute at the University of Arkansas for Medical Sciences. Her research interest is in translational studies of acetaminophen toxicity. She and her collaborators developed novel approaches for the quantitation of acetaminophen protein adducts in peripheral blood samples. She also directs clinical trials in children to develop safe and effective drug dosing strategies in a number of disease areas.
ARA Academy 2015 ARA Fellow
Dr. James has served as a pediatrician and UAMS faculty member since 1994. Her research training focused on pediatric pharmacology studies in children, supported by the NIH through the Pediatric Pharmacology Research Unit Network, with emphasis on guiding the dosing of a number of pediatric therapeutics. She now leads the Translational Research Institute at UAMS.
Policy Impact
Leads the UAMS Translational Research Institute, accelerating the translation of laboratory discoveries into clinical treatments that benefit patients across Arkansas.
Growth Areas
['Population Health Innovations & Clinical Research']
Grants & Funding
- Adduct Dipstick for Diagnosis of Acetaminophen Toxicity NIH/NIDDK Principal Investigator
- Engaging Cooperative Sites for Trial Acceleration, Trust, Innovation, and Capability (ECSTATIC) NIH/National Center for Advancing Translational Sciences - Pass Through: Vanderbilt University Principal Investigator
- Synthetic Cannabinoid Toxicity: Role of Biotransformation NIH Co-Investigator
- AcetaSTAT Rapid Assay for Acetaminophen Liver Injury NIH Principal Investigator
- COVID-19 PREVENT (Partnership for Rapid Engagement to enhance Vaccine uptake for Everyone: Neighbors working Together) Project NIH/Nat. Heart, Lung & Blood Institute - Pass Through: Westat Principal Investigator
- No FP attached UAMS ACHRI Flow Through Principal Investigator
- COVID-19 PREVENT (Partnership for Rapid Engagement to enhance Vaccine uptake for Everyone: Neighbors working Together) Project NIH/Nat. Heart, Lung & Blood Institute - Pass Through: Westat Principal Investigator
- COVID-19 PREVENT (Partnership for Rapid Engagement to enhance Vaccine uptake for Everyone: Neighbors working Together) Project NIH/Nat. Heart, Lung & Blood Institute - Pass Through: Westat Principal Investigator
Frequent Collaborators
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