R
Ratan Sadhukhan
Post Doctoral Fellow
postdoc
Radiation Oncology, College of Medicine
11 h-index
30 pubs
455 cited
Research Areas
Biography and Research Information
OverviewAI-generated summary
Ratan Sadhukhan's research focuses on the molecular mechanisms underlying DNA repair, cell survival, and the development of therapeutic strategies for cancer and radiation-induced injuries. His work investigates the roles of key proteins such as PARP1 and SIRT2 in maintaining genomic stability and mitigating treatment side effects. Sadhukhan has studied how dietary factors, like methionine deficiency, can impact genetic instability in immune cells. He has also explored the potential of compounds like nicotinamide riboside to alleviate chemotherapy-induced neuropathy through specific protein activation. His publications indicate a focus on understanding how these molecular pathways influence tumor response to targeted therapies, such as PARP1 inhibitors, and how they can be modulated to protect normal tissues during cancer treatment, particularly in the context of oral mucositis.
Metrics
- h-index: 11
- Publications: 30
- Citations: 455
Selected Publications
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SIRT2 mitigates radiation-induced oral mucositis by promoting homologous recombination-mediated DNA double-strand break repair in epithelial stem cells (2026)
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GSK3B directs DNA repair choice and determines tumor response to PARP1 inhibition independent of BRCA1 (2025)
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Sirt2 Mitigates Radiation-Induced Oral Mucositis by Promoting Homologous Recombination-Mediated DNA Double-Strand Break Repair in Epithelial Stem Cells (2025)
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Screening and identification of gene expression in large cohorts of clinical tissue samples unveils the major involvement of EZH2 and SOX2 in lung cancer (2024)
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376 Inhibition of GSK3β-mediated 53BP1 T334 phosphorylation in T cells enhances infiltration and cytotoxicity against head and neck squamous cell carcinoma (2024)
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Screening and Identification of Gene Expression in Large Cohorts of Clinical Tissue Samples Unveils the Major Involvement of Ezh2 and Sox2 in Lung Cancer (2024)
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Screening and identification of gene expression in large cohorts of clinical lung cancer samples unveils the major involvement of EZH2 and SOX2 (2024)
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Nicotinamide Riboside Alleviates Cisplatin-Induced Peripheral Neuropathy via SIRT2 Activation (2022)
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Nicotinamide riboside alleviates cisplatin-induced peripheral neuropathy via SIRT2 activation (2022)
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Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells (2021)
Grants & Funding
- Safeguarding vascular endothelial damage during deep-space missions by newly designed water-soluble vitamin E formulation National Aeronautics & Space Administration - Pass Through: University of Arkansas at Little Rock Principal Investigator
- Center for Studies of Host Response to Cancer Therapy NIH Co-Investigator
Collaboration Network
Top Collaborators
Mousumi Patra
University of Arkansas for Medical Sciences
5 shared publications
In database
- Nicotinamide riboside alleviates cisplatin-induced peripheral neuropathy via SIRT2 activation
- 376 Inhibition of GSK3β-mediated 53BP1 T334 phosphorylation in T cells enhances infiltration and cytotoxicity against head and neck squamous cell carcinoma
- Sirt2 Mitigates Radiation-Induced Oral Mucositis by Promoting Homologous Recombination-Mediated DNA Double-Strand Break Repair in Epithelial Stem Cells
- The Role of SIRT2 in Oral Stem Cell Resilience in Radiation Mucositis
- GSK3B directs DNA repair choice and determines tumor response to PARP1 inhibition independent of BRCA1
Fen Xia
University of Arkansas for Medical Sciences
4 shared publications
In database
- Nicotinamide riboside alleviates cisplatin-induced peripheral neuropathy via SIRT2 activation
- 376 Inhibition of GSK3β-mediated 53BP1 T334 phosphorylation in T cells enhances infiltration and cytotoxicity against head and neck squamous cell carcinoma
- Sirt2 Mitigates Radiation-Induced Oral Mucositis by Promoting Homologous Recombination-Mediated DNA Double-Strand Break Repair in Epithelial Stem Cells
- GSK3B directs DNA repair choice and determines tumor response to PARP1 inhibition independent of BRCA1
Heba Allam
University of Arkansas for Medical Sciences
4 shared publications
In database
- 376 Inhibition of GSK3β-mediated 53BP1 T334 phosphorylation in T cells enhances infiltration and cytotoxicity against head and neck squamous cell carcinoma
- Sirt2 Mitigates Radiation-Induced Oral Mucositis by Promoting Homologous Recombination-Mediated DNA Double-Strand Break Repair in Epithelial Stem Cells
- The Role of SIRT2 in Oral Stem Cell Resilience in Radiation Mucositis
- GSK3B directs DNA repair choice and determines tumor response to PARP1 inhibition independent of BRCA1
Ankan Roy
National Institute of Technology Rourkela (IN)
3 shared publications
- Screening and identification of gene expression in large cohorts of clinical lung cancer samples unveils the major involvement of EZH2 and SOX2
- Screening and Identification of Gene Expression in Large Cohorts of Clinical Tissue Samples Unveils the Major Involvement of Ezh2 and Sox2 in Lung Cancer
- Screening and identification of gene expression in large cohorts of clinical tissue samples unveils the major involvement of EZH2 and SOX2 in lung cancer
Samir Kumar Patra
National Institute of Technology Rourkela (IN)
3 shared publications
- Screening and identification of gene expression in large cohorts of clinical lung cancer samples unveils the major involvement of EZH2 and SOX2
- Screening and Identification of Gene Expression in Large Cohorts of Clinical Tissue Samples Unveils the Major Involvement of Ezh2 and Sox2 in Lung Cancer
- Screening and identification of gene expression in large cohorts of clinical tissue samples unveils the major involvement of EZH2 and SOX2 in lung cancer
Niharika Niharika
National Institute of Technology Rourkela (IN)
2 shared publications
- Screening and identification of gene expression in large cohorts of clinical lung cancer samples unveils the major involvement of EZH2 and SOX2
- Screening and identification of gene expression in large cohorts of clinical tissue samples unveils the major involvement of EZH2 and SOX2 in lung cancer
Eva Allen
Winthrop Rockefeller Foundation
2 shared publications
In database
- Sirt2 Mitigates Radiation-Induced Oral Mucositis by Promoting Homologous Recombination-Mediated DNA Double-Strand Break Repair in Epithelial Stem Cells
- SIRT2 mitigates radiation-induced oral mucositis by promoting homologous recombination-mediated DNA double-strand break repair in epithelial stem cells
Regina Lichti Binz
University of Arkansas for Medical Sciences
1 shared publication
In database
- Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells
Isabelle R. Miousse
University of Arkansas for Medical Sciences
1 shared publication
In database
- Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells
Sarita Garg
University of Arkansas for Medical Sciences
1 shared publication
In database
- Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells
Igor Koturbash
University of Arkansas for Medical Sciences
1 shared publication
In database
- Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells
Daohong Zhou
University of Florida (US)
1 shared publication
- Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells
Martin Hauer‐Jensen
University of Arkansas for Medical Sciences
1 shared publication
In database
- Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells
Rupak Pathak
University of Arkansas for Medical Sciences
1 shared publication
In database
- Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells
Utpal Ghosh
University of Kalyani (IN)
1 shared publication
- PARP1 modulates telomere sister chromatid exchange and telomere length homeostasis by regulating telomere localization of SLX4 in U2OS cells
Similar Researchers
Based on overlapping research topics
Heba Allam
University of Arkansas for Medical Sciences
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Patricia R. Connor
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Seong-Ok Lee
University of Arkansas for Medical Sciences
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Edward J. Selvik
University of Arkansas for Medical Sciences
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Cancer-related molecular mechanisms research
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Hong-yu Li
University of Arkansas for Medical Sciences
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