Sangeeta Khare
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Research Microbiologist
Also affiliated: Lawrence Livermore National Laboratory (2005); United States Food and Drug Administration (2010–2025); Pt. Jawahar Lal Nehru Memorial Medical College (2015–2025); Mitchell Institute (2003); Instituto de Productos Lácteos de Asturias (2023); Microbiology Society (2025); Czech Academy of Sciences, Institute of Microbiology (2014–2025); Institute of Microbiology (2025); Defence Electronics Application Laboratory (2013–2020); Food and Drug Administration (2020); Ministry of Defence (2016); All India Institute of Medical Sciences (1990–1997); Texas A&M University (1998–2017)
Faculty Researcher
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Sangeeta Khare, a Research Microbiologist at the National Center for Toxicological Research, investigates the impact of various substances and exposures on biological systems, with a particular focus on the gastrointestinal tract and its microbiome. Her work utilizes in vitro models, including polarized intestinal epithelial cells and continuous flow bioreactors, to assess cellular responses and alterations to microbial communities. Recent research has examined the effects of co-exposure to pesticides and nanoparticles, the influence of chronic tetracycline exposure on the human intestinal microbiota, and the impact of pristine graphene on colon tissue gene expression.
Further investigations by Khare explore the relationship between environmental exposures and health outcomes. This includes studies on how routes of arsenic exposure differentially affect immune responses and gut permeability, and the development of preclinical in vitro models to evaluate changes in intestinal epithelial cell permeability and cytotoxicity. Her research also extends to understanding the conformational changes of viral proteins, such as the SARS-CoV-2 spike protein, and predicting antigenic epitopes. Khare's scholarship metrics include an h-index of 28, with 118 total publications and 8,709 total citations, designating her as a highly cited researcher. She collaborates extensively with colleagues at the National Center for Toxicological Research, including Kuppan Gokulan, Chandra Mohan Reddy Muthumula, Yaswanthi Yanamadala, and Kumari Karn.
Metrics
- h-index: 28
- Publications: 119
- Citations: 8,829
Selected Publications
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Gestational and lactational exposure to HIV tri-combination therapy induces sex- and dose-dependent changes in inflammatory cytokine profiles, intestinal permeability, and villi morphology in adult rat offspring (2026)
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Silver nanoparticles at sub-cytotoxic levels increase enteric pathogen invasion by compromising intestinal epithelial barrier integrity (2026)
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Zileuton nanocrystals alter intestinal phase I/II metabolic enzymes and epithelial permeability in a sex-dependent manner (2025)
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Gestational exposure to HIV drugs alters intestinal mucosa-associated microbial diversity in adult rat offspring (2025)
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Potential link of high fat diet and mRNA expression of Alzheimer's disease-related genes in the enteric mucosa of a rat model of Alzheimer's disease (2025)
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Effect of in utero and lactational exposure to antiretroviral therapy on the gut microbial composition and metabolic function in aged rat offspring (2025)
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Strategies to Enhance Nanocrystal Formulations for Overcoming Physiological Barriers Across Diverse Routes of Administration (2025)
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Relevance of gut microbiome research in food safety assessment (2024)
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Evaluation of gender differences in the pharmacokinetics of oral zileuton nanocrystalline formulation using a rat model (2024)
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Early Developmental Exposure to Triclosan Impacts Fecal Microbial Populations, IgA and Functional Activities of the Rat Microbiome (2024)
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Evaluation of mucosal immune profile associated with Zileuton nanocrystal-formulated BCS-II drug upon oral administration in Sprague Dawley rats (2023)
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Relevance of gut microbiome research in food safety assessment (2023)
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Route of Arsenic Exposure Differentially Impacts the Expression of Genes Involved in Gut-Mucosa-Associated Immune Responses and Gastrointestinal Permeability (2023)
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Structural analysis of VirD4 a type IV ATPase encoded by transmissible plasmids of Salmonella enterica isolated from poultry products (2022)
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The Mucosal Microbiome: Impact of Nanoparticles and Nanomaterials (2022)
Collaboration Network
Top Collaborators
- Conformational Changes of the Receptor Binding Domain of SARS-CoV-2 Spike Protein and Prediction of a B-Cell Antigenic Epitope Using Structural Data
- Co-exposure to boscalid and TiO2 (E171) or SiO2 (E551) downregulates cell junction gene expression in small intestinal epithelium cellular model and increases pesticide translocation
- Strategies to Enhance Nanocrystal Formulations for Overcoming Physiological Barriers Across Diverse Routes of Administration
- Impact of Chronic Tetracycline Exposure on Human Intestinal Microbiota in a Continuous Flow Bioreactor Model
- Ex Vivo Human Colon Tissue Exposure to Pristine Graphene Activates Genes Involved in the Binding, Adhesion and Proliferation of Epithelial Cells
Showing 5 of 16 shared publications
- Strategies to Enhance Nanocrystal Formulations for Overcoming Physiological Barriers Across Diverse Routes of Administration
- Effect of in utero and lactational exposure to antiretroviral therapy on the gut microbial composition and metabolic function in aged rat offspring
- Evaluation of gender differences in the pharmacokinetics of oral zileuton nanocrystalline formulation using a rat model
- Gestational exposure to HIV drugs alters intestinal mucosa-associated microbial diversity in adult rat offspring
- Strategies to Enhance Nanocrystal Formulations for Overcoming Physiological Barriers Across Diverse Routes of Administration
- Effect of in utero and lactational exposure to antiretroviral therapy on the gut microbial composition and metabolic function in aged rat offspring
- Gestational exposure to HIV drugs alters intestinal mucosa-associated microbial diversity in adult rat offspring
- Zileuton nanocrystals alter intestinal phase I/II metabolic enzymes and epithelial permeability in a sex-dependent manner
- Early Developmental Exposure to Triclosan Impacts Fecal Microbial Populations, IgA and Functional Activities of the Rat Microbiome
- Effect of in utero and lactational exposure to antiretroviral therapy on the gut microbial composition and metabolic function in aged rat offspring
- Gestational exposure to HIV drugs alters intestinal mucosa-associated microbial diversity in adult rat offspring
- Early Developmental Exposure to Triclosan Impacts Fecal Microbial Populations, IgA and Functional Activities of the Rat Microbiome
- Effect of in utero and lactational exposure to antiretroviral therapy on the gut microbial composition and metabolic function in aged rat offspring
- Gestational exposure to HIV drugs alters intestinal mucosa-associated microbial diversity in adult rat offspring
- Effect of in utero and lactational exposure to antiretroviral therapy on the gut microbial composition and metabolic function in aged rat offspring
- Potential link of high fat diet and mRNA expression of Alzheimer's disease-related genes in the enteric mucosa of a rat model of Alzheimer's disease
- Gestational exposure to HIV drugs alters intestinal mucosa-associated microbial diversity in adult rat offspring
- Conformational Changes of the Receptor Binding Domain of SARS-CoV-2 Spike Protein and Prediction of a B-Cell Antigenic Epitope Using Structural Data
- Preclinical In Vitro Model to Assess the Changes in Permeability and Cytotoxicity of Polarized Intestinal Epithelial Cells during Exposure Mimicking Oral or Intravenous Routes: An Example of Arsenite Exposure
- Impact of Chronic Tetracycline Exposure on Human Intestinal Microbiota in a Continuous Flow Bioreactor Model
- Early Developmental Exposure to Triclosan Impacts Fecal Microbial Populations, IgA and Functional Activities of the Rat Microbiome
- Ex Vivo Human Colon Tissue Exposure to Pristine Graphene Activates Genes Involved in the Binding, Adhesion and Proliferation of Epithelial Cells
- Early Developmental Exposure to Triclosan Impacts Fecal Microbial Populations, IgA and Functional Activities of the Rat Microbiome
- Ex Vivo Human Colon Tissue Exposure to Pristine Graphene Activates Genes Involved in the Binding, Adhesion and Proliferation of Epithelial Cells
- The Mucosal Microbiome: Impact of Nanoparticles and Nanomaterials
- Relevance of gut microbiome research in food safety assessment
- Relevance of gut microbiome research in food safety assessment
- Relevance of gut microbiome research in food safety assessment
- Relevance of gut microbiome research in food safety assessment
- Relevance of gut microbiome research in food safety assessment
- Relevance of gut microbiome research in food safety assessment
- Relevance of gut microbiome research in food safety assessment
- Relevance of gut microbiome research in food safety assessment
- Relevance of gut microbiome research in food safety assessment
- Relevance of gut microbiome research in food safety assessment
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