Sangeeta Khare Source Confirmed
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Research Microbiologist
National Center for Toxicological Research
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Biography and Research Information
OverviewAI-generated summary
Sangeeta Khare's research focuses on assessing the toxicological effects of various substances and materials on biological systems, particularly the gastrointestinal tract and its associated microbiota. Her work investigates how exposures to nanoparticles, pesticides, pharmaceuticals, and environmental contaminants impact cellular function, gene expression, and intestinal permeability.
Khare's publications explore the molecular mechanisms underlying these toxicological responses. This includes examining alterations in cell junction gene expression, immune response pathways, and the role of the gut microbiome in mediating or influencing toxicity. She has utilized in vitro models, such as intestinal epithelial cell lines and continuous flow bioreactors, to simulate human exposure scenarios and evaluate cellular and microbial changes. Her research also extends to understanding the impact of chronic exposures and the differential effects based on the route of administration.
Key collaborators in her work include Kuppan Gokulan, Yaswanthi Yanamadala, Kumari Karn, and Pravin Parajuli, all affiliated with the National Center for Toxicological Research. Khare has authored 115 publications, accumulating over 8,500 citations, and holds an h-index of 27, signifying her impact in the field. Her recent research in 2021-2025 indicates continued activity in these areas.
Metrics
- h-index: 27
- Publications: 115
- Citations: 8,571
Selected Publications
- Zileuton nanocrystals alter intestinal phase I/II metabolic enzymes and epithelial permeability in a sex-dependent manner (2025) DOI
- Gestational exposure to HIV drugs alters intestinal mucosa-associated microbial diversity in adult rat offspring (2025) DOI
- Potential link of high fat diet and mRNA expression of Alzheimer's disease-related genes in the enteric mucosa of a rat model of Alzheimer's disease (2025) DOI
- Effect of in utero and lactational exposure to antiretroviral therapy on the gut microbial composition and metabolic function in aged rat offspring (2025) DOI
- Strategies to Enhance Nanocrystal Formulations for Overcoming Physiological Barriers Across Diverse Routes of Administration (2025) DOI
- Relevance of gut microbiome research in food safety assessment (2024) DOI
- Evaluation of gender differences in the pharmacokinetics of oral zileuton nanocrystalline formulation using a rat model (2024) DOI
- Early Developmental Exposure to Triclosan Impacts Fecal Microbial Populations, IgA and Functional Activities of the Rat Microbiome (2024) DOI
- Evaluation of mucosal immune profile associated with Zileuton nanocrystal-formulated BCS-II drug upon oral administration in Sprague Dawley rats (2023) DOI
- Relevance of gut microbiome research in food safety assessment (2023) DOI
- Route of Arsenic Exposure Differentially Impacts the Expression of Genes Involved in Gut-Mucosa-Associated Immune Responses and Gastrointestinal Permeability (2023) DOI
- Structural analysis of VirD4 a type IV ATPase encoded by transmissible plasmids of Salmonella enterica isolated from poultry products (2022) DOI
- The Mucosal Microbiome: Impact of Nanoparticles and Nanomaterials (2022) DOI
- Preclinical In Vitro Model to Assess the Changes in Permeability and Cytotoxicity of Polarized Intestinal Epithelial Cells during Exposure Mimicking Oral or Intravenous Routes: An Example of Arsenite Exposure (2022) DOI
- Ex Vivo Human Colon Tissue Exposure to Pristine Graphene Activates Genes Involved in the Binding, Adhesion and Proliferation of Epithelial Cells (2021) DOI
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