Pravin Parajuli
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Also affiliated: United States Food and Drug Administration (2021–2022); University of Louisiana at Monroe (2017–2022)
Research Areas
Biomedical Subjects
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Biography and Research Information
OverviewAI-generated summary
Pravin Parajuli's research investigates the development and application of peptidomimetics, which are small molecules designed to mimic the structure and function of peptides. His work has focused on targeting protein-protein interactions for immunomodulation, as demonstrated by his research on a sunflower trypsin inhibitor analog peptidomimetic that suppresses rheumatoid arthritis progression in a collagen-induced arthritis model. Parajuli has also explored the use of peptidomimetics in cancer treatment, specifically in vivo studies of a peptidomimetic targeting epidermal growth factor receptor (EGFR) dimerization in non-small cell lung cancer (NSCLC). His research also includes preclinical in vitro models to assess the changes in intestinal epithelial cell permeability and cytotoxicity during exposure to substances like arsenite. Collaborations include work with Sangeeta Khare, Kuppan Gokulan, and Marli S.P. Azevedo, all from the National Center for Toxicological Research, with whom he has co-authored multiple publications.
Metrics
- h-index: 5
- Publications: 8
- Citations: 178
Selected Publications
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Preclinical In Vitro Model to Assess the Changes in Permeability and Cytotoxicity of Polarized Intestinal Epithelial Cells during Exposure Mimicking Oral or Intravenous Routes: An Example of Arsenite Exposure (2022)
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Conformational Changes of the Receptor Binding Domain of SARS-CoV-2 Spike Protein and Prediction of a B-Cell Antigenic Epitope Using Structural Data (2021)
Collaboration Network
Top Collaborators
- Conformational Changes of the Receptor Binding Domain of SARS-CoV-2 Spike Protein and Prediction of a B-Cell Antigenic Epitope Using Structural Data
- Preclinical In Vitro Model to Assess the Changes in Permeability and Cytotoxicity of Polarized Intestinal Epithelial Cells during Exposure Mimicking Oral or Intravenous Routes: An Example of Arsenite Exposure
- Conformational Changes of the Receptor Binding Domain of SARS-CoV-2 Spike Protein and Prediction of a B-Cell Antigenic Epitope Using Structural Data
- Preclinical In Vitro Model to Assess the Changes in Permeability and Cytotoxicity of Polarized Intestinal Epithelial Cells during Exposure Mimicking Oral or Intravenous Routes: An Example of Arsenite Exposure
- Conformational Changes of the Receptor Binding Domain of SARS-CoV-2 Spike Protein and Prediction of a B-Cell Antigenic Epitope Using Structural Data
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