Kuppan Gokulan Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

High Impact

Staff Fellow

National Center for Toxicological Research

staff

24 h-index 100 pubs 7,704 cited

Research Areas

Pharmacological Effects and Toxicity Studies Gut microbiota and health Immune Response and Inflammation Nanoparticles: synthesis and applications SARS-CoV-2 and COVID-19 Research Receptor Mechanisms and Signaling Carcinogens and Genotoxicity Assessment Microbial Community Ecology and Physiology

Links

ORCID Lab Website

Is this your profile? Verify and claim your profile

OverviewAI-generated summary

Kuppan Gokulan's research investigates the complex interactions between environmental exposures, biological systems, and human health. His work has focused on understanding how substances like pesticides, nanoparticles, and pharmaceuticals impact cellular function, gene expression, and physiological processes within the gastrointestinal tract and immune system. Gokulan has utilized various in vitro and ex vivo models, including small intestinal epithelium cellular models and continuous flow bioreactors, to assess the effects of chronic or acute exposures.

His publications explore a range of toxicological endpoints, from evaluating the impact of co-exposures on gene regulation and substance translocation to examining the effects of specific compounds, such as arsenic and triclosan, on gut microbiota and immune responses. Gokulan has also contributed to research on SARS-CoV-2, investigating the receptor binding domain of the spike protein and predicting B-cell antigenic epitopes. His work further extends to the development of advanced formulations, such as nanocrystals, to overcome physiological barriers for therapeutic administration.

Gokulan collaborates with several researchers at the National Center for Toxicological Research, including Sangeeta Khare, Yaswanthi Yanamadala, Kumari Karn, and Pravin Parajuli, with whom he has co-authored multiple publications. His research is characterized by a strong publication record, evidenced by an h-index of 24 and over 7,700 citations.

Metrics

  • h-index: 24
  • Publications: 100
  • Citations: 7,704

Selected Publications

  • Zileuton nanocrystals alter intestinal phase I/II metabolic enzymes and epithelial permeability in a sex-dependent manner (2025) DOI
  • Gestational exposure to HIV drugs alters intestinal mucosa-associated microbial diversity in adult rat offspring (2025) DOI
  • Potential link of high fat diet and mRNA expression of Alzheimer's disease-related genes in the enteric mucosa of a rat model of Alzheimer's disease (2025) DOI
  • Effect of in utero and lactational exposure to antiretroviral therapy on the gut microbial composition and metabolic function in aged rat offspring (2025) DOI
  • Strategies to Enhance Nanocrystal Formulations for Overcoming Physiological Barriers Across Diverse Routes of Administration (2025) DOI
  • Biodistribution and toxic potential of silver nanoparticles when introduced to the female rat reproductive tract (2024) DOI
  • Evaluation of gender differences in the pharmacokinetics of oral zileuton nanocrystalline formulation using a rat model (2024) DOI
  • Early Developmental Exposure to Triclosan Impacts Fecal Microbial Populations, IgA and Functional Activities of the Rat Microbiome (2024) DOI
  • Evaluation of mucosal immune profile associated with Zileuton nanocrystal-formulated BCS-II drug upon oral administration in Sprague Dawley rats (2023) DOI
  • Route of Arsenic Exposure Differentially Impacts the Expression of Genes Involved in Gut-Mucosa-Associated Immune Responses and Gastrointestinal Permeability (2023) DOI
  • Structural analysis of VirD4 a type IV ATPase encoded by transmissible plasmids of Salmonella enterica isolated from poultry products (2022) DOI
  • The Mucosal Microbiome: Impact of Nanoparticles and Nanomaterials (2022) DOI
  • Preclinical In Vitro Model to Assess the Changes in Permeability and Cytotoxicity of Polarized Intestinal Epithelial Cells during Exposure Mimicking Oral or Intravenous Routes: An Example of Arsenite Exposure (2022) DOI
  • Ex Vivo Human Colon Tissue Exposure to Pristine Graphene Activates Genes Involved in the Binding, Adhesion and Proliferation of Epithelial Cells (2021) DOI
  • Impact of Chronic Tetracycline Exposure on Human Intestinal Microbiota in a Continuous Flow Bioreactor Model (2021) DOI

Collaborators

Researchers in the database who share publications

Sangeeta Khare National Center for Toxicological Research 18 shared publications Yaswanthi Yanamadala National Center for Toxicological Research 5 shared publications Kumari Karn National Center for Toxicological Research 3 shared publications Pravin Parajuli National Center for Toxicological Research 2 shared publications Carl E. Cerniglia National Center for Toxicological Research 2 shared publications Mohamed H. Lahiani National Center for Toxicological Research 2 shared publications Marli S. P. Azevedo National Center for Toxicological Research 1 shared publication Youngbeom Ahn National Center for Toxicological Research 1 shared publication

Similar Researchers

Based on overlapping research topics

Sangeeta Khare National Center for Toxicological Research
Pharmacological Effects and Toxicity Studies Gut microbiota and health Immune Response and Inflammation
Strong match 7 shared topics
Jia‐Long Fang National Center for Toxicological Research
Pharmacological Effects and Toxicity Studies Gut microbiota and health Immune Response and Inflammation
Good match 5 shared topics
Xiaoqing Guo National Center for Toxicological Research
Pharmacological Effects and Toxicity Studies Immune Response and Inflammation SARS-CoV-2 and COVID-19 Research
Good match 5 shared topics
Kelsey J. Miller University of Arkansas at Little Rock
Pharmacological Effects and Toxicity Studies Gut microbiota and health Immune Response and Inflammation
Good match 4 shared topics
Anshel Bright National Center for Toxicological Research
Pharmacological Effects and Toxicity Studies Immune Response and Inflammation Nanoparticles: synthesis and applications
Good match 3 shared topics
Camila Silva National Center for Toxicological Research
Pharmacological Effects and Toxicity Studies Gut microbiota and health SARS-CoV-2 and COVID-19 Research
Good match 4 shared topics