Match tier
Likely match
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
K
Kuppan Gokulan
This is a likely match — the affiliation was inferred from OpenAlex, ORCID, and web sources but has not been fully confirmed. Treat with appropriate caution.
High Impact
Staff Fellow
Also affiliated: Lawrence Livermore National Laboratory (2005); United States Food and Drug Administration (2013–2026); All India Institute of Medical Sciences (1996–1999); Texas A&M University (1998–2011)
25 h-index
106 pubs
7,902 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Kuppan Gokulan's research focuses on the toxicological effects of nanomaterials, particularly silver nanoparticles, on the gastrointestinal system and associated immune responses. His work investigates how factors such as nanoparticle size and dose influence intestinal permeability and the gut microbiome. In studies involving Sprague-Dawley rats, Gokulan has examined the impact of subchronic exposure to silver nanoparticles on the intestinal microbiota and gut-associated immune responses in the ileum.
Further research by Gokulan explores the effects of other ingested materials, such as nanocellulose, on rat intestinal microbiota and homeostasis. He has also investigated the influence of arsenite exposure during juvenile and adult stages in mice, assessing its effects on intestinal microbiota and gut-associated immune status. Gokulan's research extends to antiviral applications, including evaluating the dose and size-dependent antiviral effects of silver nanoparticles against feline calicivirus, a surrogate for human norovirus.
Gokulan is a highly cited researcher with an h-index of 25 and over 104 publications. He has collaborated with several researchers at the National Center for Toxicological Research, including Sangeeta Khare, Chandra Mohan Reddy Muthumula, Yaswanthi Yanamadala, and Kumari Karn, with whom he shares multiple publications.
Metrics
- h-index: 25
- Publications: 106
- Citations: 7,902
Positions
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Staff Fellow 2010–presentNational Center for Toxicological Research Microbiology ORCID
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Research Associate 2000–2010Texas A&M University System Biochemistry and Biophysics ORCID
Selected Publications
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Gestational and lactational exposure to HIV tri-combination therapy induces sex- and dose-dependent changes in inflammatory cytokine profiles, intestinal permeability, and villi morphology in adult rat offspring (2026)
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Silver nanoparticles at sub-cytotoxic levels increase enteric pathogen invasion by compromising intestinal epithelial barrier integrity (2026)
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Zileuton nanocrystals alter intestinal phase I/II metabolic enzymes and epithelial permeability in a sex-dependent manner (2025)
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Gestational exposure to HIV drugs alters intestinal mucosa-associated microbial diversity in adult rat offspring (2025)
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Potential link of high fat diet and mRNA expression of Alzheimer's disease-related genes in the enteric mucosa of a rat model of Alzheimer's disease (2025)
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Effect of in utero and lactational exposure to antiretroviral therapy on the gut microbial composition and metabolic function in aged rat offspring (2025)
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Strategies to Enhance Nanocrystal Formulations for Overcoming Physiological Barriers Across Diverse Routes of Administration (2025)
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Biodistribution and toxic potential of silver nanoparticles when introduced to the female rat reproductive tract (2024)
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Evaluation of gender differences in the pharmacokinetics of oral zileuton nanocrystalline formulation using a rat model (2024)
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Early Developmental Exposure to Triclosan Impacts Fecal Microbial Populations, IgA and Functional Activities of the Rat Microbiome (2024)
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Evaluation of mucosal immune profile associated with Zileuton nanocrystal-formulated BCS-II drug upon oral administration in Sprague Dawley rats (2023)
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Route of Arsenic Exposure Differentially Impacts the Expression of Genes Involved in Gut-Mucosa-Associated Immune Responses and Gastrointestinal Permeability (2023)
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Structural analysis of VirD4 a type IV ATPase encoded by transmissible plasmids of Salmonella enterica isolated from poultry products (2022)
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The Mucosal Microbiome: Impact of Nanoparticles and Nanomaterials (2022)
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Preclinical In Vitro Model to Assess the Changes in Permeability and Cytotoxicity of Polarized Intestinal Epithelial Cells during Exposure Mimicking Oral or Intravenous Routes: An Example of Arsenite Exposure (2022)
Collaboration Network
Top Collaborators
Sangeeta Khare
National Center for Toxicological Research
49 shared publications
In database
- Size and dose dependent effects of silver nanoparticle exposure on intestinal permeability in an in vitro model of the human gut epithelium
- Effects of ingested nanocellulose on intestinal microbiota and homeostasis in Wistar Han rats
- Dose and Size-Dependent Antiviral Effects of Silver Nanoparticles on Feline Calicivirus, a Human Norovirus Surrogate
- Exposure to Arsenite in CD-1 Mice during Juvenile and Adult Stages: Effects on Intestinal Microbiota and Gut-Associated Immune Status
- Impact of Plasmids, Including Those EncodingVirB4/D4 Type IV Secretion Systems, on Salmonella enterica serovar Heidelberg Virulence in Macrophages and Epithelial Cells
Showing 5 of 49 shared publications
Katherine M. Williams
National Center for Toxicological Research (US)
16 shared publications
- Size and dose dependent effects of silver nanoparticle exposure on intestinal permeability in an in vitro model of the human gut epithelium
- Dose and Size-Dependent Antiviral Effects of Silver Nanoparticles on Feline Calicivirus, a Human Norovirus Surrogate
- Graphene and carbon nanotubes activate different cell surface receptors on macrophages before and after deactivation of endotoxins
- Assessment of silver release and biocidal capacity from silver nanocomposite food packaging materials
- Human Intestinal Tissue Explant Exposure to Silver Nanoparticles Reveals Sex Dependent Alterations in Inflammatory Responses and Epithelial Cell Permeability
Showing 5 of 16 shared publications
Carl E. Cerniglia
National Center for Toxicological Research
14 shared publications
In database
- Size and dose dependent effects of silver nanoparticle exposure on intestinal permeability in an in vitro model of the human gut epithelium
- Exposure to Arsenite in CD-1 Mice during Juvenile and Adult Stages: Effects on Intestinal Microbiota and Gut-Associated Immune Status
- METABOLIC PATHWAYS | Production of Secondary Metabolites of Bacteria
- An in vitro study to assess the impact of tetracycline on the human intestinal microbiome
- Effects of residual levels of tetracycline on the barrier functions of human intestinal epithelial cells
Showing 5 of 14 shared publications
Kottayil I. Varughese
University of Arkansas for Medical Sciences (US)
6 shared publications
- Structure-based Design Targeted at LOX-1, a Receptor for Oxidized Low-Density Lipoprotein
- Structure and Inhibitor Specificity of L,D-Transpeptidase (LdtMt2) from Mycobacterium tuberculosis and Antibiotic Resistance: Calcium Binding Promotes Dimer Formation
- Structural Characterization of a Therapeutic Anti-Methamphetamine Antibody Fragment: Oligomerization and Binding of Active Metabolites
- Drug resistance in <i>Mycobacterium tuberculosis</i> and targeting the <scp>l,d</scp>‐transpeptidase enzyme
- Malic enzyme is a target for drug design to combat obesity and cancer
Showing 5 of 6 shared publications
Steven L. Foley
National Center for Toxicological Research
6 shared publications
In database
- Impact of Plasmids, Including Those EncodingVirB4/D4 Type IV Secretion Systems, on Salmonella enterica serovar Heidelberg Virulence in Macrophages and Epithelial Cells
- Evaluation of Virulence and Antimicrobial Resistance in <i>Salmonella enterica</i> Serovar Enteritidis Isolates from Humans and Chicken- and Egg-Associated Sources
- Structure and Inhibitor Specificity of L,D-Transpeptidase (LdtMt2) from Mycobacterium tuberculosis and Antibiotic Resistance: Calcium Binding Promotes Dimer Formation
- Transmissible Plasmid Containing <i>Salmonella enterica</i> Heidelberg Isolates Modulate Cytokine Production During Early Stage of Interaction with Intestinal Epithelial Cells
- Draft Genome Sequences of Four Salmonella enterica Strains Isolated from Turkey-Associated Sources
Showing 5 of 6 shared publications
Mohamed H. Lahiani
National Center for Toxicological Research
5 shared publications
In database
- Graphene and carbon nanotubes activate different cell surface receptors on macrophages before and after deactivation of endotoxins
- Impact of Pristine Graphene on Intestinal Microbiota Assessed Using a Bioreactor-Rotary Cell Culture System
- Differential Toxicological Outcome of Corn Oil Exposure in Rats and Mice as Assessed by Microbial Composition, Epithelial Permeability, and Ileal Mucosa-Associated Immune Status
- Ex Vivo Human Colon Tissue Exposure to Pristine Graphene Activates Genes Involved in the Binding, Adhesion and Proliferation of Epithelial Cells
- Early Developmental Exposure to Triclosan Impacts Fecal Microbial Populations, IgA and Functional Activities of the Rat Microbiome
Silvia A. Piñeiro
Center for Veterinary Medicine (US)
5 shared publications
- An in vitro study to assess the impact of tetracycline on the human intestinal microbiome
- Effects of residual levels of tetracycline on the barrier functions of human intestinal epithelial cells
- Impact of Chronic Tetracycline Exposure on Human Intestinal Microbiota in a Continuous Flow Bioreactor Model
- In vitro test systems to determine tetracycline residue binding to human feces
- Effects of Acute and Chronic Exposure to Residual Level Erythromycin on Human Intestinal Epithelium Cell Permeability and Cytotoxicity
Vicki Sutherland
National Institute of Environmental Health Sciences (US)
5 shared publications
- Differential Toxicological Outcome of Corn Oil Exposure in Rats and Mice as Assessed by Microbial Composition, Epithelial Permeability, and Ileal Mucosa-Associated Immune Status
- Early Developmental Exposure to Triclosan Impacts Fecal Microbial Populations, IgA and Functional Activities of the Rat Microbiome
- Effect of in utero and lactational exposure to antiretroviral therapy on the gut microbial composition and metabolic function in aged rat offspring
- Gestational exposure to HIV drugs alters intestinal mucosa-associated microbial diversity in adult rat offspring
- Gestational and lactational exposure to HIV tri-combination therapy induces sex- and dose-dependent changes in inflammatory cytokine profiles, intestinal permeability, and villi morphology in adult rat offspring
Yaswanthi Yanamadala
National Center for Toxicological Research
5 shared publications
In database
- Strategies to Enhance Nanocrystal Formulations for Overcoming Physiological Barriers Across Diverse Routes of Administration
- Effect of in utero and lactational exposure to antiretroviral therapy on the gut microbial composition and metabolic function in aged rat offspring
- Gestational exposure to HIV drugs alters intestinal mucosa-associated microbial diversity in adult rat offspring
- Zileuton nanocrystals alter intestinal phase I/II metabolic enzymes and epithelial permeability in a sex-dependent manner
- Gestational and lactational exposure to HIV tri-combination therapy induces sex- and dose-dependent changes in inflammatory cytokine profiles, intestinal permeability, and villi morphology in adult rat offspring
Helen Cunny
National Institute of Environmental Health Sciences (US)
4 shared publications
- Early Developmental Exposure to Triclosan Impacts Fecal Microbial Populations, IgA and Functional Activities of the Rat Microbiome
- Effect of in utero and lactational exposure to antiretroviral therapy on the gut microbial composition and metabolic function in aged rat offspring
- Gestational exposure to HIV drugs alters intestinal mucosa-associated microbial diversity in adult rat offspring
- Gestational and lactational exposure to HIV tri-combination therapy induces sex- and dose-dependent changes in inflammatory cytokine profiles, intestinal permeability, and villi morphology in adult rat offspring
Chandra Mohan Reddy Muthumula
National Center for Toxicological Research
4 shared publications
In database
- Strategies to Enhance Nanocrystal Formulations for Overcoming Physiological Barriers Across Diverse Routes of Administration
- Effect of in utero and lactational exposure to antiretroviral therapy on the gut microbial composition and metabolic function in aged rat offspring
- Evaluation of gender differences in the pharmacokinetics of oral zileuton nanocrystalline formulation using a rat model
- Gestational exposure to HIV drugs alters intestinal mucosa-associated microbial diversity in adult rat offspring
Kumari Karn
National Center for Toxicological Research
4 shared publications
In database
- Effect of in utero and lactational exposure to antiretroviral therapy on the gut microbial composition and metabolic function in aged rat offspring
- Potential link of high fat diet and mRNA expression of Alzheimer's disease-related genes in the enteric mucosa of a rat model of Alzheimer's disease
- Gestational exposure to HIV drugs alters intestinal mucosa-associated microbial diversity in adult rat offspring
- Gestational and lactational exposure to HIV tri-combination therapy induces sex- and dose-dependent changes in inflammatory cytokine profiles, intestinal permeability, and villi morphology in adult rat offspring
Aschalew Z. Bekele
National Center for Toxicological Research (US)
3 shared publications
- Dose and Size-Dependent Antiviral Effects of Silver Nanoparticles on Feline Calicivirus, a Human Norovirus Surrogate
- Responses of intestinal virome to silver nanoparticles: safety assessment by classical virology, whole-genome sequencing and bioinformatics approaches
- Human Intestinal Microbial Biofilm and its Correlation with Intestinal Mucin Secretion
Jing Han
National Center for Toxicological Research
3 shared publications
In database
- Impact of Plasmids, Including Those EncodingVirB4/D4 Type IV Secretion Systems, on Salmonella enterica serovar Heidelberg Virulence in Macrophages and Epithelial Cells
- Evaluation of Virulence and Antimicrobial Resistance in <i>Salmonella enterica</i> Serovar Enteritidis Isolates from Humans and Chicken- and Egg-Associated Sources
- Draft Genome Sequences of Four Salmonella enterica Strains Isolated from Turkey-Associated Sources
Ji Young Jung
National Center for Toxicological Research (US)
3 shared publications
- An in vitro study to assess the impact of tetracycline on the human intestinal microbiome
- Impact of Chronic Tetracycline Exposure on Human Intestinal Microbiota in a Continuous Flow Bioreactor Model
- In vitro test systems to determine tetracycline residue binding to human feces
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