K
Kuppan Gokulan Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
High Impact
Staff Fellow
staff
24 h-index
103 pubs
7,781 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Kuppan Gokulan's research investigates the impact of various exposures on biological systems, with a particular focus on the gastrointestinal tract and its microbiome. His work has explored the effects of nanoparticles, such as titanium dioxide and silicon dioxide, on gene expression in the small intestinal epithelium, noting potential implications for pesticide translocation. Gokulan has also studied the effects of chronic tetracycline exposure on the human intestinal microbiota using a continuous flow bioreactor model and examined how different routes of arsenic exposure influence immune responses and gastrointestinal permeability.
Further research by Gokulan has included an investigation into the activation of genes related to epithelial cell binding and proliferation following ex vivo human colon tissue exposure to graphene. He has also studied the impact of developmental exposure to triclosan on rat gut microbial populations and functional activities. Additionally, Gokulan has developed preclinical in vitro models to assess changes in intestinal epithelial cell permeability and cytotoxicity under conditions mimicking oral or intravenous routes of exposure, using arsenite as an example.
Gokulan's publication record includes work on the conformational changes of the SARS-CoV-2 spike protein receptor binding domain and the prediction of B-cell antigenic epitopes. His research interests are further reflected in his scholarly metrics, with an h-index of 24 and over 7,700 citations across more than 100 publications, designating him as a highly cited researcher. He collaborates with several researchers at the National Center for Toxicological Research, including Sangeeta Khare, Chandra Mohan Reddy Muthumula, Yaswanthi Yanamadala, and Kumari Karn.
Metrics
- h-index: 24
- Publications: 103
- Citations: 7,781
Selected Publications
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Gestational and lactational exposure to HIV tri-combination therapy induces sex- and dose-dependent changes in inflammatory cytokine profiles, intestinal permeability, and villi morphology in adult rat offspring (2026)
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Silver nanoparticles at sub-cytotoxic levels increase enteric pathogen invasion by compromising intestinal epithelial barrier integrity (2026)
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Zileuton nanocrystals alter intestinal phase I/II metabolic enzymes and epithelial permeability in a sex-dependent manner (2025)
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Gestational exposure to HIV drugs alters intestinal mucosa-associated microbial diversity in adult rat offspring (2025)
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Potential link of high fat diet and mRNA expression of Alzheimer's disease-related genes in the enteric mucosa of a rat model of Alzheimer's disease (2025)
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Effect of in utero and lactational exposure to antiretroviral therapy on the gut microbial composition and metabolic function in aged rat offspring (2025)
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Strategies to Enhance Nanocrystal Formulations for Overcoming Physiological Barriers Across Diverse Routes of Administration (2025)
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Biodistribution and toxic potential of silver nanoparticles when introduced to the female rat reproductive tract (2024)
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Evaluation of gender differences in the pharmacokinetics of oral zileuton nanocrystalline formulation using a rat model (2024)
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Early Developmental Exposure to Triclosan Impacts Fecal Microbial Populations, IgA and Functional Activities of the Rat Microbiome (2024)
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Evaluation of mucosal immune profile associated with Zileuton nanocrystal-formulated BCS-II drug upon oral administration in Sprague Dawley rats (2023)
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Route of Arsenic Exposure Differentially Impacts the Expression of Genes Involved in Gut-Mucosa-Associated Immune Responses and Gastrointestinal Permeability (2023)
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Structural analysis of VirD4 a type IV ATPase encoded by transmissible plasmids of Salmonella enterica isolated from poultry products (2022)
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The Mucosal Microbiome: Impact of Nanoparticles and Nanomaterials (2022)
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Preclinical In Vitro Model to Assess the Changes in Permeability and Cytotoxicity of Polarized Intestinal Epithelial Cells during Exposure Mimicking Oral or Intravenous Routes: An Example of Arsenite Exposure (2022)
Collaboration Network
Top Collaborators
Sangeeta Khare
National Center for Toxicological Research
19 shared publications
In database
- Conformational Changes of the Receptor Binding Domain of SARS-CoV-2 Spike Protein and Prediction of a B-Cell Antigenic Epitope Using Structural Data
- Co-exposure to boscalid and TiO2 (E171) or SiO2 (E551) downregulates cell junction gene expression in small intestinal epithelium cellular model and increases pesticide translocation
- Strategies to Enhance Nanocrystal Formulations for Overcoming Physiological Barriers Across Diverse Routes of Administration
- Impact of Chronic Tetracycline Exposure on Human Intestinal Microbiota in a Continuous Flow Bioreactor Model
- Ex Vivo Human Colon Tissue Exposure to Pristine Graphene Activates Genes Involved in the Binding, Adhesion and Proliferation of Epithelial Cells
Showing 5 of 19 shared publications
Yaswanthi Yanamadala
National Center for Toxicological Research
6 shared publications
In database
- Strategies to Enhance Nanocrystal Formulations for Overcoming Physiological Barriers Across Diverse Routes of Administration
- Effect of in utero and lactational exposure to antiretroviral therapy on the gut microbial composition and metabolic function in aged rat offspring
- Gestational exposure to HIV drugs alters intestinal mucosa-associated microbial diversity in adult rat offspring
- Engineering Nanocrystal Formulations through Excipient Selection Strategies
- Zileuton nanocrystals alter intestinal phase I/II metabolic enzymes and epithelial permeability in a sex-dependent manner
Showing 5 of 6 shared publications
Chandra Mohan Reddy Muthumula
5 shared publications
In database
- Strategies to Enhance Nanocrystal Formulations for Overcoming Physiological Barriers Across Diverse Routes of Administration
- Effect of in utero and lactational exposure to antiretroviral therapy on the gut microbial composition and metabolic function in aged rat offspring
- Evaluation of gender differences in the pharmacokinetics of oral zileuton nanocrystalline formulation using a rat model
- Gestational exposure to HIV drugs alters intestinal mucosa-associated microbial diversity in adult rat offspring
- Engineering Nanocrystal Formulations through Excipient Selection Strategies
Vicki Sutherland
National Institute of Environmental Health Sciences (US)
4 shared publications
- Early Developmental Exposure to Triclosan Impacts Fecal Microbial Populations, IgA and Functional Activities of the Rat Microbiome
- Effect of in utero and lactational exposure to antiretroviral therapy on the gut microbial composition and metabolic function in aged rat offspring
- Gestational exposure to HIV drugs alters intestinal mucosa-associated microbial diversity in adult rat offspring
- Gestational and lactational exposure to HIV tri-combination therapy induces sex- and dose-dependent changes in inflammatory cytokine profiles, intestinal permeability, and villi morphology in adult rat offspring
Helen Cunny
National Institute of Environmental Health Sciences (US)
4 shared publications
- Early Developmental Exposure to Triclosan Impacts Fecal Microbial Populations, IgA and Functional Activities of the Rat Microbiome
- Effect of in utero and lactational exposure to antiretroviral therapy on the gut microbial composition and metabolic function in aged rat offspring
- Gestational exposure to HIV drugs alters intestinal mucosa-associated microbial diversity in adult rat offspring
- Gestational and lactational exposure to HIV tri-combination therapy induces sex- and dose-dependent changes in inflammatory cytokine profiles, intestinal permeability, and villi morphology in adult rat offspring
Kumari Karn
National Center for Toxicological Research
4 shared publications
In database
- Effect of in utero and lactational exposure to antiretroviral therapy on the gut microbial composition and metabolic function in aged rat offspring
- Potential link of high fat diet and mRNA expression of Alzheimer's disease-related genes in the enteric mucosa of a rat model of Alzheimer's disease
- Gestational exposure to HIV drugs alters intestinal mucosa-associated microbial diversity in adult rat offspring
- Gestational and lactational exposure to HIV tri-combination therapy induces sex- and dose-dependent changes in inflammatory cytokine profiles, intestinal permeability, and villi morphology in adult rat offspring
Janine H. Santos
National Institute of Environmental Health Sciences (US)
3 shared publications
- Effect of in utero and lactational exposure to antiretroviral therapy on the gut microbial composition and metabolic function in aged rat offspring
- Gestational exposure to HIV drugs alters intestinal mucosa-associated microbial diversity in adult rat offspring
- Gestational and lactational exposure to HIV tri-combination therapy induces sex- and dose-dependent changes in inflammatory cytokine profiles, intestinal permeability, and villi morphology in adult rat offspring
Pravin Parajuli
United States Food and Drug Administration
2 shared publications
In database
- Conformational Changes of the Receptor Binding Domain of SARS-CoV-2 Spike Protein and Prediction of a B-Cell Antigenic Epitope Using Structural Data
- Preclinical In Vitro Model to Assess the Changes in Permeability and Cytotoxicity of Polarized Intestinal Epithelial Cells during Exposure Mimicking Oral or Intravenous Routes: An Example of Arsenite Exposure
Carl E. Cerniglia
National Center for Toxicological Research
2 shared publications
In database
- Impact of Chronic Tetracycline Exposure on Human Intestinal Microbiota in a Continuous Flow Bioreactor Model
- Early Developmental Exposure to Triclosan Impacts Fecal Microbial Populations, IgA and Functional Activities of the Rat Microbiome
Mohamed H. Lahiani
United States Food and Drug Administration
2 shared publications
In database
- Ex Vivo Human Colon Tissue Exposure to Pristine Graphene Activates Genes Involved in the Binding, Adhesion and Proliferation of Epithelial Cells
- Early Developmental Exposure to Triclosan Impacts Fecal Microbial Populations, IgA and Functional Activities of the Rat Microbiome
Katherine M. Williams
United States Food and Drug Administration (US)
2 shared publications
- Ex Vivo Human Colon Tissue Exposure to Pristine Graphene Activates Genes Involved in the Binding, Adhesion and Proliferation of Epithelial Cells
- The Mucosal Microbiome: Impact of Nanoparticles and Nanomaterials
S. Chakder
Center for Drug Evaluation and Research (US)
2 shared publications
- Evaluation of mucosal immune profile associated with Zileuton nanocrystal-formulated BCS-II drug upon oral administration in Sprague Dawley rats
- P24-25: Comparative Pharmacokinetics and Safety Assessment of Nanocrystal Formulated Zileuton at the Gastrointestinal Tract Reveals Sex-Dependent Mucosal Immune Response, Epithelial Permeability and Drug Metabolism in Sprague Dawley Rats
Rajan Jog
University of Connecticut (US)
2 shared publications
- Evaluation of mucosal immune profile associated with Zileuton nanocrystal-formulated BCS-II drug upon oral administration in Sprague Dawley rats
- Evaluation of gender differences in the pharmacokinetics of oral zileuton nanocrystalline formulation using a rat model
Diane J. Burgess
University of Connecticut (US)
2 shared publications
- Evaluation of mucosal immune profile associated with Zileuton nanocrystal-formulated BCS-II drug upon oral administration in Sprague Dawley rats
- Evaluation of gender differences in the pharmacokinetics of oral zileuton nanocrystalline formulation using a rat model
Xiaoqiong Cao
Harvard University (US)
1 shared publication
- Co-exposure to boscalid and TiO2 (E171) or SiO2 (E551) downregulates cell junction gene expression in small intestinal epithelium cellular model and increases pesticide translocation
Similar Researchers
Based on overlapping research topics
Sangeeta Khare
National Center for Toxicological Research
Gut microbiota and health
Nanoparticles: synthesis and applications
Pharmacological Effects and Toxicity Studies
Mohamed H. Lahiani
National Center for Toxicological Research
Gut microbiota and health
Nanoparticles: synthesis and applications
Pharmacological Effects and Toxicity Studies
Taylor H. McElroy
University of Arkansas for Medical Sciences
Gut microbiota and health
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Disease Models, Animal
Brandon S.B. Canup
National Center for Toxicological Research
Gut microbiota and health
Nanoparticles: synthesis and applications
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Kimberly Gray
University of Arkansas at Fayetteville
Nanoparticles: synthesis and applications
Graphene research and applications
SARS-CoV-2 and COVID-19 Research
Manuel Alejandro Ramirez-Lee
National Center for Toxicological Research
Nanoparticles: synthesis and applications
Pharmacological Effects and Toxicity Studies
SARS-CoV-2 and COVID-19 Research