Match tier
Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
Mohammed S. Orloff
High Impact
Associate Professor
Also affiliated: Cleveland Clinic (2008–2020); University of Michigan (2012); University of Arkansas Medical Center (2024); Cleveland Clinic Lerner College of Medicine (2009–2015); Case Comprehensive Cancer Center (2012); The Ohio State University (2012); Case Western Reserve University (2005–2012)
Epidemiology, College of Public Health
25 h-index
129 pubs
3,765 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Mohammed S. Orloff's research focuses on the genetic underpinnings of various hereditary cancer syndromes and related conditions. He has investigated germline mutations in genes such as PTEN, PIK3CA, and AKT1, which are associated with Cowden and Cowden-like syndromes. His work has explored the lifetime cancer risks and phenotypic heterogeneity observed in individuals carrying these mutations, including a focus on frequent gastrointestinal polyps and colorectal adenocarcinomas in PTEN mutation carriers.
Further research has examined germline mutations in succinate dehydrogenase genes and genes like MSR1, ASCC1, and CTHRC1 in patients with conditions such as Barrett esophagus and esophageal adenocarcinoma. Orloff also studies the upregulation of PARP1 in non-small cell lung cancer tissues in the presence of specific toxins. His scholarly output includes 131 publications with over 3,800 citations, contributing to a high-impact researcher designation. He leads a research group and collaborates with colleagues at the University of Arkansas for Medical Sciences and the University of Arkansas at Little Rock, including Horacio Gómez-Acevedo, David W. Ussery, Yasir Rahmatallah, and Ebrahim Jakoet.
Metrics
- h-index: 25
- Publications: 129
- Citations: 3,765
Positions
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Associate Professor publications 2014–2026University of Arkansas for Medical Sciences Epidemiology, College of Public Health Institutional directory
Selected Publications
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Abstract 7642: Nicotine dependence partially mediates the association between IP6K3 genetic variation and risk of lung squamous cell carcinoma among smokers (2026)
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Maternal Myo‐Inositol Intake and Congenital Heart Defects in Offspring: A Population‐Based Case–Control Study (2025)
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Abstract 4344025: Is Periconceptional Folic Acid Supplementation Associated with Cardiovascular Disease Risk Later in Life among Women who Delivered a Child with Congenital Heart Disease? (2025)
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A Tracts of Homozygosity Approach Identifies Methylation-Regulated CSMD1 Expression Targets in Non–Small Cell Lung Cancers Related to Smoking Behavior (2025)
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Capacity to address determinants of health among a social justice coalition in the United States (2025)
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Evidence-based practices are effective in increasing smoke-free home rules among Black women who smoke (2025)
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Exome Sequencing to Identify Novel Susceptibility Genes for Nonsyndromic Split‐Hand/Ft Malformation: A Report From the National Birth Defects Prevention Study (2025)
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Abstract 1923: A tract of homozygosity analysis reveals methylation-driven CSMD1 expression in non-small cell lung cancers (2025)
Grants & Funding
As listed on this researcher's institutional profile.
- RFA-DD-18-001 Birth Defects Study To Evaluate Pregnancy exposures (BD-STEPS) II Core & Component B Steps -Stillbirth NIH Co-Investigator
- Birth Defects Study to Evaluate Pregnancy exposureS (BD-STEPS) Core? Arkansas Center and Stillbirth NIH Principal Investigator
- Center for Research, Health and Society NIH Co-Investigator
- Community Engagement Research Alliance (CEAL) 2023-2024 Renewal NIH/Nat. Heart, Lung & Blood Institute via Westat Principal Investigator
- Genes,Blood Pressure Variability and Cardiovascular Diseases NIH/Nat. Heart, Lung & Blood Institute Co-Investigator
- Arkansas Center for Health Disparities (ARCHD): An NIMHD COE NIH Co-Investigator
- Interaction of lug microbiome and tobaccorelated insults in lung cancer UAMS Internal Research Awards Principal Investigator
- FOOD AS MEDICINE: ADDRESSING SOCIAL DETERMINANTS OF HEALTH (FOOD INSECURITY) TO EFFECT CLINICAL OUTCOMES (CEAL) Westat via Westat Principal Investigator
Collaboration Network
Top Collaborators
Jing Jin
University of Arkansas for Medical Sciences
11 shared publications
In database
- PARP1 Is Up-Regulated in Non-small Cell Lung Cancer Tissues in the Presence of the Cyanobacterial Toxin Microcystin
- Association of PARP1-specific polymorphisms and haplotypes with non-small cell lung cancer subtypes
- Genome-wide tracts of homozygosity and exome analyses reveal repetitive elements with Barrets esophagus/esophageal adenocarcinoma risk
- Indirect ELISA protocol (abcam) v1
- RNA to cDNA and RT-PCR protocol v1
Showing 5 of 11 shared publications
Pebbles Fagan
Arkansas Department of Health
11 shared publications
In database
- PARP1 Is Up-Regulated in Non-small Cell Lung Cancer Tissues in the Presence of the Cyanobacterial Toxin Microcystin
- Electronic cigarette use and its association with asthma, chronic obstructive pulmonary disease (COPD) and asthma- COPD overlap syndrome among never cigarette smokers
- Electronic cigarette use and its association with asthma, chronic obstructive pulmonary disease (COPD) and asthma- COPD overlap syndrome among never cigarette smokers
- Characterization of Electronic Cigarette Warning Statements Portrayed in YouTube Videos
- Association of PARP1-specific polymorphisms and haplotypes with non-small cell lung cancer subtypes
Showing 5 of 11 shared publications
Emine Bircan
University of Arkansas for Medical Sciences
7 shared publications
In database
- PARP1 Is Up-Regulated in Non-small Cell Lung Cancer Tissues in the Presence of the Cyanobacterial Toxin Microcystin
- Electronic cigarette use and its association with asthma, chronic obstructive pulmonary disease (COPD) and asthma- COPD overlap syndrome among never cigarette smokers
- Electronic cigarette use and its association with asthma, chronic obstructive pulmonary disease (COPD) and asthma- COPD overlap syndrome among never cigarette smokers
- Genome-wide tracts of homozygosity and exome analyses reveal repetitive elements with Barrets esophagus/esophageal adenocarcinoma risk
- Paternal genetic variants and risk of obstructive heart defects: A parent-of-origin approach
Showing 5 of 7 shared publications
Mohammed F. Faramawi
University of Arkansas for Medical Sciences
6 shared publications
In database
- Association between Dietary Salt Intake and Progression in the Gastric Precancerous Process
- Consumption of Vitamin K and Vitamin A Are Associated With Reduced Risk of Developing Emphysema: NHANES 2007–2016
- The Association between Salt and Potential Mediators of the Gastric Precancerous Process
- Using Machine Learning to Predict Progression in the Gastric Precancerous Process in a Population from a Developing Country Who Underwent a Gastroscopy for Dyspeptic Symptoms
- The difference between hypertension determined by self-report versus examination in the adult population of the USA: Continuous NHANES 1999–2016
Showing 5 of 6 shared publications
Austin Porter
Arkansas Department of Health
6 shared publications
In database
- Electronic cigarette use and its association with asthma, chronic obstructive pulmonary disease (COPD) and asthma- COPD overlap syndrome among never cigarette smokers
- Electronic cigarette use and its association with asthma, chronic obstructive pulmonary disease (COPD) and asthma- COPD overlap syndrome among never cigarette smokers
- Temporal dynamics of SARS-CoV-2 genome and detection of variants of concern in wastewater influent from two metropolitan areas in Arkansas
- Crop burning and the prevalence of asthma and COPD emergency department treatments in a rural Arkansas county
- Correction: Electronic cigarette use and its association with asthma, chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap syndrome among never cigarette smokers
Showing 5 of 6 shared publications
Dina M. Jones
Arkansas Department of Health
6 shared publications
In database
- Characterization of Electronic Cigarette Warning Statements Portrayed in YouTube Videos
- Factors associated with smokefree rules in the homes of Black/African American women smokers residing in low-resource rural communities
- Changes in Capacity Building and Sustained Implementation Among a Statewide Coalition to Address Racial/Ethnic COVID-19 Disparities
- Home environment and cigarette quitting behaviors among rural Black/African American women caregivers.
- Evidence-based practices are effective in increasing smoke-free home rules among Black women who smoke
Showing 5 of 6 shared publications
Robert R. Delongchamp
University of Arkansas for Medical Sciences
5 shared publications
In database
- Association between Dietary Salt Intake and Progression in the Gastric Precancerous Process
- The Association between Salt and Potential Mediators of the Gastric Precancerous Process
- Using Machine Learning to Predict Progression in the Gastric Precancerous Process in a Population from a Developing Country Who Underwent a Gastroscopy for Dyspeptic Symptoms
- The difference between hypertension determined by self-report versus examination in the adult population of the USA: Continuous NHANES 1999–2016
- Biological Pathways of Long‐Term Visit‐to‐Visit Blood Pressure Variability in the American Population: Cardiovascular Health Study and Women’s Health Initiatives
Heather Robeson
University of Arkansas for Medical Sciences
5 shared publications
In database
- Association of PARP1-specific polymorphisms and haplotypes with non-small cell lung cancer subtypes
- Indirect ELISA protocol (abcam) v1
- RNA to cDNA and RT-PCR protocol v1
- Qiagen- AllPrep DNA/RNA/protein Mini Kit for tissue v1
- TaqMan SNP genotyping protocol v1
Wendy N. Nembhard
University of Arkansas for Medical Sciences
5 shared publications
In database
- Paternal genetic variants and risk of obstructive heart defects: A parent-of-origin approach
- Exome Sequencing to Identify Novel Susceptibility Genes for Nonsyndromic Split‐Hand/Ft Malformation: A Report From the National Birth Defects Prevention Study
- DNA methylation of the Lamin A/C gene is associated with congenital heart disease
- Abstract 4344025: Is Periconceptional Folic Acid Supplementation Associated with Cardiovascular Disease Risk Later in Life among Women who Delivered a Child with Congenital Heart Disease?
- Maternal Myo‐Inositol Intake and Congenital Heart Defects in Offspring: A Population‐Based Case–Control Study
Katherine Donald
University of Arkansas at Little Rock
5 shared publications
In database
- Factors associated with smokefree rules in the homes of Black/African American women smokers residing in low-resource rural communities
- Changes in Capacity Building and Sustained Implementation Among a Statewide Coalition to Address Racial/Ethnic COVID-19 Disparities
- Home environment and cigarette quitting behaviors among rural Black/African American women caregivers.
- Evidence-based practices are effective in increasing smoke-free home rules among Black women who smoke
- Capacity to address determinants of health among a social justice coalition in the United States
Susan Kadlubar
University of Arkansas for Medical Sciences
4 shared publications
In database
- Germline Genetic Variants in TEK, ANGPT1, ANGPT2, MMP9, FGF2 and VEGFA Are Associated with Pathologic Complete Response to Bevacizumab in Breast Cancer Patients
- 2-amino-1-methyl-6-phenylimidazo(4,5-b) pyridine (PhIP) induces gene expression changes in JAK/STAT and MAPK pathways related to inflammation, diabetes and cancer
- Genotypic and Allelic Variability in CYP19A1 among Populations of African and European Ancestry
- Abstract 2825: Germline genetic variants in ANGPT1 & 2 and FGF2 are associated with pathologic complete response to bevacizumab in breast cancer patients
David W. Ussery
University of Arkansas for Medical Sciences
4 shared publications
In database
- PARP1 Is Up-Regulated in Non-small Cell Lung Cancer Tissues in the Presence of the Cyanobacterial Toxin Microcystin
- Abstract 1923: A tract of homozygosity analysis reveals methylation-driven CSMD1 expression in non-small cell lung cancers
- A Tracts of Homozygosity Approach Identifies Methylation-Regulated CSMD1 Expression Targets in Non–Small Cell Lung Cancers Related to Smoking Behavior
- Abstract 7642: Nicotine dependence partially mediates the association between IP6K3 genetic variation and risk of lung squamous cell carcinoma among smokers
Susan Thapa
University of Arkansas for Medical Sciences (US)
4 shared publications
- Association between Dietary Salt Intake and Progression in the Gastric Precancerous Process
- The Association between Salt and Potential Mediators of the Gastric Precancerous Process
- Using Machine Learning to Predict Progression in the Gastric Precancerous Process in a Population from a Developing Country Who Underwent a Gastroscopy for Dyspeptic Symptoms
- Biological Pathways of Long‐Term Visit‐to‐Visit Blood Pressure Variability in the American Population: Cardiovascular Health Study and Women’s Health Initiatives
Sandilyn Bullock
Arkansas Department of Health
4 shared publications
In database
- Characterization of Electronic Cigarette Warning Statements Portrayed in YouTube Videos
- Factors associated with smokefree rules in the homes of Black/African American women smokers residing in low-resource rural communities
- Home environment and cigarette quitting behaviors among rural Black/African American women caregivers.
- Evidence-based practices are effective in increasing smoke-free home rules among Black women who smoke
Horacio Gómez-Acevedo
University of Arkansas for Medical Sciences
4 shared publications
In database
- Exome Sequencing to Identify Novel Susceptibility Genes for Nonsyndromic Split‐Hand/Ft Malformation: A Report From the National Birth Defects Prevention Study
- Abstract 1923: A tract of homozygosity analysis reveals methylation-driven CSMD1 expression in non-small cell lung cancers
- A Tracts of Homozygosity Approach Identifies Methylation-Regulated CSMD1 Expression Targets in Non–Small Cell Lung Cancers Related to Smoking Behavior
- Abstract 7642: Nicotine dependence partially mediates the association between IP6K3 genetic variation and risk of lung squamous cell carcinoma among smokers
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